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Recent challenges of health systems reflect the need for innovative approaches that can minimize adverse consequences of policies. Hence, there is compelling evidence of a distinct outlook on the health ecosystem using artificial intelligence (AI). Therefore, this study aimed to investigate the roles of AI and its applications in health system governance through an interpretive scoping review of current evidence.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Method<\/jats:title>\n                <jats:p>This study intended to offer a research agenda and framework for the applications of AI in health systems governance. To include shreds of evidence with a greater focus on the application of AI in health governance from different perspectives, we searched the published literature from 2000 to 2023 through PubMed, Scopus, and Web of Science Databases.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Our findings showed that integrating AI capabilities into health systems governance has the potential to influence three cardinal dimensions of health. These include social determinants of health, elements of governance, and health system tasks and goals. AI paves the way for strengthening the health system's governance through various aspects, i.e., intelligence innovations, flexible boundaries, multidimensional analysis, new insights, and cognition modifications to the health ecosystem area.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>AI is expected to be seen as a tool with new applications and capabilities, with the potential to change each component of governance in the health ecosystem, which can eventually help achieve health-related goals.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13040-023-00346-w","type":"journal-article","created":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T04:30:48Z","timestamp":1698726648000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Research agenda for using artificial intelligence in health governance: interpretive scoping review and framework"],"prefix":"10.1186","volume":"16","author":[{"given":"Maryam","family":"Ramezani","sequence":"first","affiliation":[]},{"given":"Amirhossein","family":"Takian","sequence":"additional","affiliation":[]},{"given":"Ahad","family":"Bakhtiari","sequence":"additional","affiliation":[]},{"given":"Hamid R.","family":"Rabiee","sequence":"additional","affiliation":[]},{"given":"Sadegh","family":"Ghazanfari","sequence":"additional","affiliation":[]},{"given":"Saharnaz","family":"Sazgarnejad","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2023,10,31]]},"reference":[{"issue":"5","key":"346_CR1","first-page":"544","volume":"27","author":"R Payne","year":"2021","unstructured":"Payne R, Esse T, Qian J, Mohan A, Vadhariya A, Becho-Dominguez G, et al. 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