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One common application of chemical similarity measurements, based on the principle that similar molecules have similar properties, is the read-across approach, where an estimation of a specific endpoint for a chemical is provided using experimental data available from highly similar compounds.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>This paper reports the comparison of multiple combinations of binary fingerprints and similarity metrics for computing the chemical similarity in the context of two different applications of the read-across technique.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Our analysis demonstrates that the classical similarity measurements can be improved with a generalizable model of similarity. The proposed approach has already been used to build similarity indices in two open-source software tools (CAESAR and VEGA) that make several QSAR models available. In these tools, the similarity index plays a key role for the assessment of the applicability domain.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s13321-014-0039-1","type":"journal-article","created":{"date-parts":[[2014,10,17]],"date-time":"2014-10-17T20:06:27Z","timestamp":1413576387000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":92,"title":["A generalizable definition of chemical similarity for read-across"],"prefix":"10.1186","volume":"6","author":[{"given":"Matteo","family":"Floris","sequence":"first","affiliation":[]},{"given":"Alberto","family":"Manganaro","sequence":"additional","affiliation":[]},{"given":"Orazio","family":"Nicolotti","sequence":"additional","affiliation":[]},{"given":"Ricardo","family":"Medda","sequence":"additional","affiliation":[]},{"given":"Giuseppe Felice","family":"Mangiatordi","sequence":"additional","affiliation":[]},{"given":"Emilio","family":"Benfenati","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2014,10,18]]},"reference":[{"key":"39_CR1","doi-asserted-by":"publisher","first-page":"3204","DOI":"10.1039\/b409813g","volume":"2","author":"A Bender","year":"2004","unstructured":"Bender A, Glen RC: Molecular similarity: a key technique in molecular informatics. 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