{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T17:25:56Z","timestamp":1773422756593,"version":"3.50.1"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,6,3]],"date-time":"2016-06-03T00:00:00Z","timestamp":1464912000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004963","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["601725"],"award-info":[{"award-number":["601725"]}],"id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cheminform"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1186\/s13321-016-0143-5","type":"journal-article","created":{"date-parts":[[2016,6,3]],"date-time":"2016-06-03T04:25:21Z","timestamp":1464927921000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Are the physicochemical properties of antibacterial compounds really different from other drugs?"],"prefix":"10.1186","volume":"8","author":[{"given":"Jean-Paul","family":"Ebejer","sequence":"first","affiliation":[]},{"given":"Michael H.","family":"Charlton","sequence":"additional","affiliation":[]},{"given":"Paul W.","family":"Finn","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2016,6,3]]},"reference":[{"key":"143_CR1","unstructured":"European Centre for Disease Prevention and Control ECDC\/European Medicines Agency (2009) EMEA joint technical report: the bacterial challenge: time to react. ECDC, Stockholm Sweden. \n                    http:\/\/www.ecdc.europa.eu\/en\/publications\/Publications\/0909_TER_The_Bacterial_Challenge_Time_to_React.pdf"},{"key":"143_CR2","unstructured":"http:\/\/www.pewtrusts.org\/en\/research-and-analysis\/issue-briefs\/2014\/03\/12\/tracking-the-pipeline-of-antibiotics-in-development\n                    \n                  . Accessed 10th Sept 2015"},{"key":"143_CR3","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1038\/nrd2201","volume":"6","author":"DJ Payne","year":"2007","unstructured":"Payne DJ, Gwynn MN, Holmes DJ, Pompliano DL (2007) Drugs for bad bugs: confronting the challenges of antibacterial drug discovery. Nat Rev Drug Discov 6:29\u201340","journal-title":"Nat Rev Drug Discov"},{"key":"143_CR4","doi-asserted-by":"publisher","first-page":"10144","DOI":"10.1021\/jm501552x","volume":"57","author":"DG Brown","year":"2014","unstructured":"Brown DG, May-Dracka TL, Gagnon MM, Tommasi R (2014) Trends and exceptions of physical properties on antibacterial activity for gram-positive and gram-negative pathogens. J Med Chem 57:10144\u201310161","journal-title":"J Med Chem"},{"key":"143_CR5","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0169-409X(96)00423-1","volume":"23","author":"CA Lipinski","year":"2001","unstructured":"Lipinski CA, Lombardo F, Dominy BW, Feeney PJ (2001) Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev 23:3\u201325","journal-title":"Adv Drug Deliv Rev"},{"key":"143_CR6","doi-asserted-by":"publisher","first-page":"2871","DOI":"10.1021\/jm700967e","volume":"51","author":"R O\u2019Shea","year":"2008","unstructured":"O\u2019Shea R, Moser HE (2008) Physicochemical properties of antibacterial compounds: implications for drug discovery. J Med Chem 51:2871\u20132878","journal-title":"J Med Chem"},{"key":"143_CR7","doi-asserted-by":"publisher","first-page":"2535","DOI":"10.1021\/cb5003015","volume":"9","author":"TD Davis","year":"2014","unstructured":"Davis TD, Gerry CJ, Tan DS (2014) General platform for systematic quantitative evaluation of small-molecule permeability in bacteria. ACS Chem Biol 9:2535\u20132544","journal-title":"ACS Chem Biol"},{"key":"143_CR8","doi-asserted-by":"publisher","first-page":"5218","DOI":"10.1016\/j.bmc.2015.04.063","volume":"23","author":"G Mugumbate","year":"2015","unstructured":"Mugumbate G, Overington JP (2015) The relationship between target class and the physicochemical properties of antibacterial drugs. Bioorg Med Chem 23:5218\u20135224","journal-title":"Bioorg Med Chem"},{"issue":"42","key":"143_CR9","first-page":"1083","volume":"42","author":"AP Bento","year":"1083","unstructured":"Bento AP, Gaulton A, Hersey A, Bellis LJ, Chambers J, Davies M, Kruger FA, Light Y, Mak L, McGlinchey S, Nowotka M, Papadatos G, Santos R, Overington JP (2014) The ChEMBL bioactivity database: an update. Nucleic Acids Res 42:1083\u20131090","journal-title":"Nucleic Acids Res"},{"key":"143_CR10","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1021\/id500013t","volume":"1","author":"GS Bisacchi","year":"2015","unstructured":"Bisacchi GS, Manchester JI (2015) A new-class antibacterial\u2014almost. Lessons in drug discovery and development: a critical analysis of more than 50 Years of effort toward ATPase inhibitors of DNA gyrase and topoisomerase IV. ACS Infect Dis 1:4\u201341","journal-title":"ACS Infect Dis"},{"key":"143_CR11","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1038\/ja.2014.163","volume":"68","author":"JI Montgomery","year":"2015","unstructured":"Montgomery JI, Smith JF, Tomaras AP, Zaniewski R, McPherson CJ, McAllister LA, Hartman-Neumann S, Arcari JT, Lescoe M, Gutierrez J, Yuan Y, Limberakis C, Miller AA (2015) Discovery and characterization of a novel class of pyrazolopyrimidinedione tRNA synthesis inhibitors. J Antibiot 68:361\u2013367","journal-title":"J Antibiot"},{"key":"143_CR12","doi-asserted-by":"publisher","first-page":"3618","DOI":"10.1128\/JB.00172-11","volume":"193","author":"GHM Vondenhoff","year":"2011","unstructured":"Vondenhoff GHM, Blanchaert B, Geboers S, Kazakov T, Datsenko KA, Wanner BL, Rozenski J, Severinov K, Van Aerschot A (2011) Characterization of peptide chain length and constituency requirements for YejABEF-mediated uptake of microcin C analogues. J Bacteriol 193:3618\u20133623","journal-title":"J Bacteriol"},{"key":"143_CR13","doi-asserted-by":"publisher","first-page":"2875","DOI":"10.1016\/j.bmc.2014.03.040","volume":"22","author":"B Gadakh","year":"2014","unstructured":"Gadakh B, Vondenhoff G, Lescrinier E, Rozenski J, Froeyen M, Van Aerschot A (2014) Base substituted 5\u2032-O-(N-isoleucyl)sulfamoyl nucleoside analogues as potential antibacterial agents. Bioorg Med Chem 22:2875\u20132886","journal-title":"Bioorg Med Chem"},{"key":"143_CR14","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.chembiol.2015.03.018","volume":"22","author":"VM Isabella","year":"2015","unstructured":"Isabella VM, Campbell AJ, Manchester J, Sylvester M, Nayar AS, Ferguson KE, Tommasi R, Miller AA (2015) Toward the rational design of carbapenem uptake in Pseudomonas aeruginosa. Chem Biol 22:535\u2013547","journal-title":"Chem Biol"},{"key":"143_CR15","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1038\/nrd4572","volume":"14","author":"R Tommasi","year":"2015","unstructured":"Tommasi R, Brown DG, Walkup GK, Manchester JI, Miller AA (2015) ESKAPEing the labyrinth of antibacterial discovery. Nat Rev Drug Discov 14:529\u2013542","journal-title":"Nat Rev Drug Discov"},{"key":"143_CR16","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/s10822-007-9167-2","volume":"22","author":"AC Good","year":"2008","unstructured":"Good AC, Oprea TI (2008) Optimization of CAMD techniques 3. Virtual screening enrichment studies: a help or hindrance in tool selection? J Comput Aided Mol Des 22:169\u2013178","journal-title":"J Comput Aided Mol Des"},{"key":"143_CR17","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1021\/ci970056l","volume":"38","author":"CH Reynolds","year":"1998","unstructured":"Reynolds CH, Druker R, Pfahler LB (1998) Lead discovery using stochastic cluster analysis (SCA): a new method for clustering structurally similar compounds. J Chem Inf Comput Sci 38:305\u2013312","journal-title":"J Chem Inf Comput Sci"}],"container-title":["Journal of Cheminformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13321-016-0143-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13321-016-0143-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13321-016-0143-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13321-016-0143-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T06:40:58Z","timestamp":1569220858000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcheminf.biomedcentral.com\/articles\/10.1186\/s13321-016-0143-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,3]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["143"],"URL":"https:\/\/doi.org\/10.1186\/s13321-016-0143-5","relation":{},"ISSN":["1758-2946"],"issn-type":[{"value":"1758-2946","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,3]]},"assertion":[{"value":"1 February 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"30"}}