{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T05:12:56Z","timestamp":1658725976593},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,3,4]],"date-time":"2017-03-04T00:00:00Z","timestamp":1488585600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cheminform"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s13321-017-0201-7","type":"journal-article","created":{"date-parts":[[2017,3,4]],"date-time":"2017-03-04T04:59:32Z","timestamp":1488603572000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Modeling framework for isotopic labeling of heteronuclear moieties"],"prefix":"10.1186","volume":"9","author":[{"given":"Mark I.","family":"Borkum","sequence":"first","affiliation":[]},{"given":"Patrick N.","family":"Reardon","sequence":"additional","affiliation":[]},{"given":"Ronald C.","family":"Taylor","sequence":"additional","affiliation":[]},{"given":"Nancy G.","family":"Isern","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2017,3,4]]},"reference":[{"issue":"15","key":"201_CR1","doi-asserted-by":"crossref","first-page":"6964","DOI":"10.1016\/S0021-9258(18)68590-4","volume":"263","author":"CR Malloy","year":"1988","unstructured":"Malloy CR, Sherry AD, Jeffrey FM (1988) Evaluation of carbon flux and substrate selection through alternate pathways involving the citric acid cycle of the heart by 13 $${\\textsf{C}}$$ C NMR spectroscopy. J Biol Chem 263(15):6964\u20136971","journal-title":"J Biol Chem"},{"issue":"2","key":"201_CR2","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1002\/(SICI)1097-0290(1999)66:2<69::AID-BIT1>3.0.CO;2-6","volume":"66","author":"W Wiechert","year":"1999","unstructured":"Wiechert W, M\u00f6llney M, Isermann N, Wurzel M, de Graaf AA (1999) Bidirectional reaction steps in metabolic networks: III. Explicit solution and analysis of isotopomer labeling systems. Biotechnol Bioeng 66(2):69\u201385","journal-title":"Biotechnol Bioeng"},{"issue":"1","key":"201_CR3","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.ymben.2006.09.001","volume":"9","author":"MR Antoniewicz","year":"2007","unstructured":"Antoniewicz MR, Kelleher JK, Stephanopoulos G (2007) Elementary metabolite units (EMU): a novel framework for modeling isotopic distributions. Metab Eng 9(1):68\u201386","journal-title":"Metab Eng"},{"issue":"3","key":"201_CR4","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.jbiotec.2009.07.010","volume":"144","author":"CM Metallo","year":"2009","unstructured":"Metallo CM, Walther JL, Stephanopoulos G (2009) Evaluation of 13 $${\\textsf{C}}$$ C isotopic tracers for metabolic flux analysis in mammalian cells. J Biotechnol 144(3):167\u2013174","journal-title":"J Biotechnol"},{"issue":"2","key":"201_CR5","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.ymben.2011.12.004","volume":"14","author":"JL Walther","year":"2012","unstructured":"Walther JL, Metallo CM, Zhang J, Stephanopoulos G (2012) Optimization of 13 $${\\textsf{C}}$$ C isotopic tracers for metabolic flux analysis in mammalian cells. Metab Eng 14(2):162\u2013171","journal-title":"Metab Eng"},{"issue":"9","key":"201_CR6","doi-asserted-by":"publisher","first-page":"1004363","DOI":"10.1371\/journal.pcbi.1004363","volume":"11","author":"HG Mart\u00edn","year":"2015","unstructured":"Mart\u00edn HG, Kumar VS, Weaver D, Ghosh A, Chubukov V, Mukhopadhyay A, Arkin A, Keasling JD (2015) A method to constrain genome-scale models with 13 $${\\textsf{C}}$$ C labeling data. PLoS Comput Biol 11(9):1004363","journal-title":"PLoS Comput Biol"},{"issue":"1","key":"201_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1475-2859-8-25","volume":"8","author":"L-E Quek","year":"2009","unstructured":"Quek L-E, Wittmann C, Nielsen LK, Kr\u00f6mer JO (2009) OpenFLUX: efficient modelling software for 13 $${\\textsf{C}}$$ C -based metabolic flux analysis. Microb Cell Fact 8(1):1\u201315","journal-title":"Microb Cell Fact"},{"issue":"1","key":"201_CR8","first-page":"152","volume":"13","author":"MS Shupletsov","year":"2014","unstructured":"Shupletsov MS, Golubeva LI, Rubina SS, Podvyaznikov DA, Iwatani S, Mashko SV (2014) OpenFLUX2: 13 $${\\textsf{C}}$$ C -MFA modeling software package adjusted for the comprehensive analysis of single and parallel labeling experiments. Microb Cell Fact 13(1):152","journal-title":"Microb Cell Fact"},{"issue":"9","key":"201_CR9","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1093\/bioinformatics\/btu015","volume":"30","author":"JD Young","year":"2014","unstructured":"Young JD (2014) INCA: a computational platform for isotopically non-stationary metabolic flux analysis. Bioinformatics 30(9):1333\u20131335","journal-title":"Bioinformatics"},{"key":"201_CR10","doi-asserted-by":"crossref","unstructured":"Kajihata S, Furusawa C, Matsuda F, Shimizu H (2014) OpenMebius: an open source software for isotopically nonstationary 13 $${\\textsf{C}}$$ C -based metab olic flux analysis. BioMed Res Int 2014. https:\/\/www.hindawi.com\/journals\/bmri\/2014\/627014\/","DOI":"10.1155\/2014\/627014"},{"issue":"1","key":"201_CR11","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1186\/1752-0509-5-129","volume":"5","author":"O Srour","year":"2011","unstructured":"Srour O, Young JD, Eldar YC (2011) Fluxomers: a new approach for 13 $${\\textsf{C}}$$ C metabolic flux analysis. BMC Syst Biol 5(1):129","journal-title":"BMC Syst Biol"},{"issue":"6","key":"201_CR12","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1039\/C6MB00009F","volume":"12","author":"R Nilsson","year":"2016","unstructured":"Nilsson R, Jain M (2016) Simultaneous tracing of carbon and nitrogen isotopes in human cells. Mol BioSyst 12(6):1929\u20131937","journal-title":"Mol BioSyst"},{"issue":"4","key":"201_CR13","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1109\/TIT.1954.1057465","volume":"4","author":"I Reed","year":"1954","unstructured":"Reed I (1954) A class of multiple-error-correcting codes and the decoding scheme. Trans IRE Prof Group Inf Theory 4(4):38\u201349","journal-title":"Trans IRE Prof Group Inf Theory"},{"issue":"3","key":"201_CR14","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1109\/IREPGELC.1954.6499441","volume":"3","author":"DE Muller","year":"1954","unstructured":"Muller DE (1954) Application of Boolean algebra to switching circuit design and to error detection. Trans IRE Prof Group Electron Comput 3(3):6\u201312","journal-title":"Trans IRE Prof Group Electron Comput"},{"issue":"4","key":"201_CR15","first-page":"642","volume":"57","author":"D Kuzmin","year":"2015","unstructured":"Kuzmin D, H\u00e4m\u00e4l\u00e4inen J (2015) Finite element methods for computational fluid dynamics: a practical guide. SIAM Rev 57(4):642","journal-title":"SIAM Rev"},{"key":"201_CR16","unstructured":"Felippa C (2013) Matrix finite element methods in dynamics (course in preparation). http:\/\/www.colorado.edu\/engineering\/CAS\/courses.d\/MFEMD.d\/ . Accessed 1 Apr 2016"}],"container-title":["Journal of Cheminformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13321-017-0201-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13321-017-0201-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13321-017-0201-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T04:56:37Z","timestamp":1658724997000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcheminf.biomedcentral.com\/articles\/10.1186\/s13321-017-0201-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,4]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["201"],"URL":"https:\/\/doi.org\/10.1186\/s13321-017-0201-7","relation":{},"ISSN":["1758-2946"],"issn-type":[{"value":"1758-2946","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,4]]},"assertion":[{"value":"22 September 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 February 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 March 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"14"}}