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Successful application of this technique relies on a good knowledge of physicochemical properties of common organic substituents and an efficient way to navigate their space. In this study the properties of the most common substituents present in bioactive molecules are analysed and a freely-available web tool <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/bit.ly\/craigplot\">https:\/\/bit.ly\/craigplot<\/jats:ext-link> that allows visualization, analysis and selection of bioisosteric substituents is presented.<\/jats:p>","DOI":"10.1186\/s13321-020-0412-1","type":"journal-article","created":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T11:02:56Z","timestamp":1580209376000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Craig plot 2.0: an interactive navigation in the substituent bioisosteric space"],"prefix":"10.1186","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6496-4448","authenticated-orcid":false,"given":"Peter","family":"Ertl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,1,28]]},"reference":[{"key":"412_CR1","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1002\/minf.201000019","volume":"29","author":"SR Langdon","year":"2010","unstructured":"Langdon SR, Ertl P, Brown N (2010) Bioisosteric replacement and scaffold hopping in lead generation and optimization. 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