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In addition, experimental data of selected species can also be used as an independent variable along with other structural as well as physicochemical variables to predict the response for different species formulating quantitative activity\u2013activity relationship (QAAR)\/quantitative structure\u2013activity\u2013activity relationship (QSAAR) approach. Irrespective of the models' type, the developed model's quality, and reliability need to be checked through multiple classical stringent validation metrics. Among the validation metrics, error-based metrics are more significant as the basic idea of a good predictive model is to improve the predictions' quality by lowering the predicted residuals for new query compounds. Following the concept, we have checked the predictive quality of the QSAR and QSAAR models employing kernel-weighted local polynomial regression (KwLPR) approach over the traditional linear and non-linear regression-based approaches tools such as multiple linear regression (MLR) and<jats:italic>k<\/jats:italic>nearest neighbors (<jats:italic>k<\/jats:italic>NN). Five datasets which were previously modeled using linear and non-linear regression method were considered to implement the KwPLR approach, followed by comparison of their validation metrics outcomes. For all five cases, the KwLPR based models reported better results over the traditional approaches. The present study's focus is not to develop a better or improved QSAR\/QSAAR model over the previous ones, but to demonstrate the advantage, prediction power, and reliability of the KwLPR algorithm and establishing it as a novel, powerful cheminformatic tool. To facilitate the use of the KwLPR algorithm for QSAR\/QSPR\/QSTR\/QSAAR modeling, the authors provide an in-house developed<jats:italic>KwLPR.RMD<\/jats:italic>script under the open-source<jats:italic>R<\/jats:italic>programming language.<\/jats:p>","DOI":"10.1186\/s13321-021-00484-5","type":"journal-article","created":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T18:00:14Z","timestamp":1613152814000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["The kernel-weighted local polynomial regression (KwLPR) approach: an efficient, novel tool for development of QSAR\/QSAAR toxicity extrapolation models"],"prefix":"10.1186","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7702-210X","authenticated-orcid":false,"given":"Agnieszka","family":"Gajewicz-Skretna","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9411-2091","authenticated-orcid":false,"given":"Supratik","family":"Kar","sequence":"additional","affiliation":[]},{"given":"Magdalena","family":"Piotrowska","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5290-6136","authenticated-orcid":false,"given":"Jerzy","family":"Leszczynski","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2021,2,12]]},"reference":[{"issue":"3","key":"484_CR1","doi-asserted-by":"publisher","first-page":"61","DOI":"10.4018\/IJQSPR.20200701.oa1","volume":"5","author":"P Gramatica","year":"2020","unstructured":"Gramatica P (2020) Principles of QSAR modeling: comments and suggestions from personal experience. 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