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However, phenotypic screening does not rely on knowledge of specific drug targets and needs to be combined with chemical biology approaches to identify therapeutic targets and mechanisms of actions induced by drugs and associated with an observable phenotype. In this study, we developed a system pharmacology network integrating drug-target-pathway-disease relationships as well as morphological profile from an existing high content imaging-based high-throughput phenotypic profiling assay known as \u201cCell Painting\u201d. Furthermore, from this network, a chemogenomic library of 5000 small molecules that represent a large and diverse panel of drug targets involved in diverse biological effects and diseases has been developed. Such a platform and a chemogenomic library could assist in the target identification and mechanism deconvolution of some phenotypic assays. The usefulness of the platform is illustrated through examples.<\/jats:p>","DOI":"10.1186\/s13321-021-00569-1","type":"journal-article","created":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T12:03:17Z","timestamp":1637755397000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Development of a chemogenomics library for phenotypic screening"],"prefix":"10.1186","volume":"13","author":[{"given":"Bryan","family":"Dafniet","sequence":"first","affiliation":[]},{"given":"Natacha","family":"Cerisier","sequence":"additional","affiliation":[]},{"given":"Batiste","family":"Boezio","sequence":"additional","affiliation":[]},{"given":"Anaelle","family":"Clary","sequence":"additional","affiliation":[]},{"given":"Pierre","family":"Ducrot","sequence":"additional","affiliation":[]},{"given":"Thierry","family":"Dorval","sequence":"additional","affiliation":[]},{"given":"Arnaud","family":"Gohier","sequence":"additional","affiliation":[]},{"given":"David","family":"Brown","sequence":"additional","affiliation":[]},{"given":"Karine","family":"Audouze","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7081-2491","authenticated-orcid":false,"given":"Olivier","family":"Taboureau","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2021,11,24]]},"reference":[{"issue":"7","key":"569_CR1","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1038\/nbt1228","volume":"24","author":"GV Paolini","year":"2006","unstructured":"Paolini GV, Shapland RH, van Hoorn WP, Mason JS, Hopkins AL (2006) Global mapping of pharmacological space. 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