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The MS\/MS spectral space exploration of these complex compounds using chemoinformatic and computational mass spectrometry tools offers a valuable opportunity to extract and share chemical insights from this emblematic family of natural products (NPs). In this work, we first present a substantially\u00a0updated version of the MIADB, a database\u00a0now containing 422 MS\/MS spectra of MIAs that has been uploaded to the GNPS library\u00a0versus 172 initial entries. We then introduce an innovative workflow that leverages hundreds of fragmentation spectra to support the FAIRification, extraction and dissemination of chemical knowledge. This workflow aims at the extraction of spectral patterns matching finely defined MIA skeletons. These extracted signatures can then be queried against complex biological extract datasets using MassQL. By applying this strategy to an LC-MS\/MS dataset of 75 plant extracts, our results demonstrated the efficiency of this approach in identifying the diversity of MIA skeletons present in the analyzed samples. Additionally, our work enabled the digitization of structural data for diverse MIA skeletons by converting them into machine-readable formats and thereby enhancing their dissemination for the scientific community.<\/jats:p>\n          <jats:p>\n            <jats:bold>Scientific contribution<\/jats:bold> A comprehensive investigation of the monoterpene indole alkaloid chemical space, aiming to highlight skeleton-dependent fragmentation similarity trends and to generate valuable spectrometric signatures that could be used as queries.<\/jats:p>\n          <jats:p>\n            <jats:bold>Graphical Abstract<\/jats:bold>\n          <\/jats:p>","DOI":"10.1186\/s13321-025-01009-0","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T16:29:21Z","timestamp":1745857761000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Translating community-wide spectral library into actionable chemical knowledge: a proof of concept with monoterpene indole alkaloids"],"prefix":"10.1186","volume":"17","author":[{"given":"Sarah","family":"Szwarc","sequence":"first","affiliation":[]},{"given":"Adriano","family":"Rutz","sequence":"additional","affiliation":[]},{"given":"Kyungha","family":"Lee","sequence":"additional","affiliation":[]},{"given":"Yassine","family":"Mejri","sequence":"additional","affiliation":[]},{"given":"Olivier","family":"Bonnet","sequence":"additional","affiliation":[]},{"given":"Hazrina","family":"Hazni","sequence":"additional","affiliation":[]},{"given":"Adrien","family":"Jagora","sequence":"additional","affiliation":[]},{"given":"Rany B.","family":"Mbeng Obame","sequence":"additional","affiliation":[]},{"given":"Jin Kyoung","family":"Noh","sequence":"additional","affiliation":[]},{"given":"Elvis","family":"Otogo N\u2019Nang","sequence":"additional","affiliation":[]},{"given":"Stephenie C.","family":"Alaribe","sequence":"additional","affiliation":[]},{"given":"Khalijah","family":"Awang","sequence":"additional","affiliation":[]},{"given":"Guillaume","family":"Bernadat","sequence":"additional","affiliation":[]},{"given":"Young Hae","family":"Choi","sequence":"additional","affiliation":[]},{"given":"Vincent","family":"Courdavault","sequence":"additional","affiliation":[]},{"given":"Michel","family":"Frederich","sequence":"additional","affiliation":[]},{"given":"Thomas","family":"Gaslonde","sequence":"additional","affiliation":[]},{"given":"Florian","family":"Huber","sequence":"additional","affiliation":[]},{"given":"Toh-Seok","family":"Kam","sequence":"additional","affiliation":[]},{"given":"Yun Yee","family":"Low","sequence":"additional","affiliation":[]},{"given":"Erwan","family":"Poupon","sequence":"additional","affiliation":[]},{"given":"Justin J. 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