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Different strategies for pocket-finding excel in different use cases. Ensemble models that leverage multiple different pocket-finding strategies can best capture diverse pockets at scale. Despite this, no publicly available human-proteome-wide datasets of pocket predictions from multiple pocket-finding methods exist. We present the Human Omnibus of Targetable Pockets (HOTPocket), a dataset of over 2.4 million predicted pockets over the entire human proteome that utilizes both experimentally-determined and computationally-predicted protein structures. We assembled this dataset by running seven diverse, established pocket-finding methods over all PDB and AlphaFold2 structures of the canonical human proteome. We created a novel pocket scoring method,\n                    <jats:italic>hotpocketNN<\/jats:italic>\n                    , which we used to filter candidate pockets and assemble the final proteome-wide dataset. Our\n                    <jats:italic>hotpocketNN<\/jats:italic>\n                    method is able to recover known ligand binding pockets, including those which are dissimilar from any pocket seen in its training set. The\n                    <jats:italic>hotpocketNN<\/jats:italic>\n                    method outperforms all constituent methods, including P2Rank and Fpocket, when assessing the precision with\u00a0DCA\u00a0criterion on the Astex Diverse Set and PoseBusters dataset. Additionally,\n                    <jats:italic>hotpocketNN<\/jats:italic>\n                    was able to identify recently-discovered druggable pockets on KRAS and the mu opioid receptor. We make both the HOTPocket dataset and the\n                    <jats:italic>hotpocketNN<\/jats:italic>\n                    method freely available.\n                  <\/jats:p>","DOI":"10.1186\/s13321-025-01125-x","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T10:49:18Z","timestamp":1766573358000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Human Omnibus of Targetable Pockets"],"prefix":"10.1186","volume":"17","author":[{"given":"Kristy A.","family":"Carpenter","sequence":"first","affiliation":[]},{"given":"Russ B.","family":"Altman","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2025,12,24]]},"reference":[{"issue":"9","key":"1125_CR1","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1001\/jama.2020.1166","volume":"323","author":"OJ Wouters","year":"2020","unstructured":"Wouters OJ, McKee M, Luyten J (2020) Estimated research and development investment needed to bring a new medicine to market, 2009\u20132018. 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