{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:39:36Z","timestamp":1777527576718,"version":"3.51.4"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"name":"Seventh Framework Programme","award":["EU Marie Curie ITN MultiScaleHuman, FP7-PEOPLE-2011-ITN, Grant agreement no.: 289897"],"award-info":[{"award-number":["EU Marie Curie ITN MultiScaleHuman, FP7-PEOPLE-2011-ITN, Grant agreement no.: 289897"]}]},{"DOI":"10.13039\/501100005416","name":"Research Council of Norway","doi-asserted-by":"crossref","award":["BIGMED project (IKT 259055)"],"award-info":[{"award-number":["BIGMED project (IKT 259055)"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005416","name":"Research Council of Norway","doi-asserted-by":"crossref","award":["SIRIUS Centre for Scalable Data Access (project no: 237889)"],"award-info":[{"award-number":["SIRIUS Centre for Scalable Data Access (project no: 237889)"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004462","name":"Consiglio Nazionale delle Ricerche","doi-asserted-by":"crossref","award":["Modelling and Analysis of anatomical shapes for computer assisted diagnosis DIT.AD009.006"],"award-info":[{"award-number":["Modelling and Analysis of anatomical shapes for computer assisted diagnosis DIT.AD009.006"]}],"id":[{"id":"10.13039\/501100004462","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Portuguese Foundation for Science and Technology","award":["Investigador FCT 2012 (IF\/00423\/2012)"],"award-info":[{"award-number":["Investigador FCT 2012 (IF\/00423\/2012)"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Biomed Semant"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s13326-018-0177-x","type":"journal-article","created":{"date-parts":[[2018,2,8]],"date-time":"2018-02-08T09:56:17Z","timestamp":1518083777000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Supporting shared hypothesis testing in the biomedical domain"],"prefix":"10.1186","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0096-0143","authenticated-orcid":false,"given":"Asan","family":"Agibetov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernesto","family":"Jim\u00e9nez-Ruiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Ondr\u00e9sik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Solimando","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imon","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Guerrini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara E.","family":"Catalano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaquim M.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Patan\u00e8","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui L.","family":"Reis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michela","family":"Spagnuolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,2,8]]},"reference":[{"issue":"2","key":"177_CR1","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1038\/nrrheum.2011.199","volume":"8","author":"LJ Sandell","year":"2012","unstructured":"Sandell LJ. Etiology of osteoarthritis: genetics and synovial joint development. Nat Rev Rheumatol. 2012; 8(2):77\u201389.","journal-title":"Nat Rev Rheumatol"},{"issue":"4","key":"177_CR2","first-page":"1","volume":"1","author":"AR Hafez","year":"2014","unstructured":"Hafez AR, Alenazi AM, Kachanathu SJ, Alroumi AM, Mohamed ES. Knee Osteoarthritis : A Review of Literature. Phys Med Rehabilation Int. 2014; 1(4):1\u20138.","journal-title":"Phys Med Rehabilation Int"},{"key":"177_CR3","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1002\/bit.26182","volume":"114","author":"M Ondr\u00e9sik","year":"2016","unstructured":"Ondr\u00e9sik M, Azevedo Maia FR, da Silva Morais A, Gertrudes AC, Dias Bacelar AH, Correia C, Gon\u00e7alves C, Radhouani H, Amandi Sousa R, Oliveira JM, Reis RL. Management of knee osteoarthritis. current status and future trends. Biotech Bioeng. 2016; 114:717\u201339.","journal-title":"Biotech Bioeng"},{"issue":"1","key":"177_CR4","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1177\/1759720X13514669","volume":"6","author":"Y Henrotin","year":"2014","unstructured":"Henrotin Y, Pesesse L, Lambert C. Targeting the synovial angiogenesis as a novel treatment approach to osteoarthritis. Ther Adv Musculoskele Dis. 2014; 6(1):20\u201334.","journal-title":"Ther Adv Musculoskele Dis"},{"issue":"3","key":"177_CR5","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.joca.2006.11.006","volume":"15","author":"PM van der Kraan","year":"2007","unstructured":"van der Kraan PM, van den Berg WB. Osteophytes: relevance and biology. Osteoarthr Cartil \/ OARS, Osteoarthr Res Soc. 2007; 15(3):237\u201344.","journal-title":"Osteoarthr Cartil \/ OARS, Osteoarthr Res Soc"},{"issue":"3","key":"177_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.13172\/2053-2040-1-3-1116","volume":"1","author":"S Muraki","year":"2013","unstructured":"Muraki S, Tanaka S, Yoshimura N. Epidemiology of knee osteoarthritis. OA Sports Med. 2013; 1(3):1\u20136.","journal-title":"OA Sports Med"},{"issue":"5","key":"177_CR7","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1097\/BOR.0b013e328349c2b1","volume":"23","author":"MB Goldring","year":"2011","unstructured":"Goldring MB, Otero M. Inflammation in osteoarthritis. Curr Opin Rheumatol. 2011; 23(5):471\u20138.","journal-title":"Curr Opin Rheumatol"},{"issue":"1","key":"177_CR8","first-page":"33","volume":"7","author":"M Kapoor","year":"2011","unstructured":"Kapoor M, Martel-pelletier J, Lajeunesse D, Pelletier J-p, Fahmi H. Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Publ Group. 2011; 7(1):33\u201342.","journal-title":"Nat Publ Group"},{"issue":"2","key":"177_CR9","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1007\/s00590-011-0803-0","volume":"22","author":"E Aktas","year":"2012","unstructured":"Aktas E, Sener E, Zengin O, Gocun PU, Deveci MA. Serum TNF-alpha levels: potential use to indicate osteoarthritis progression in a mechanically induced model. Eur J Orthop Surg Traumatol. 2012; 22(2):119\u201322.","journal-title":"Eur J Orthop Surg Traumatol"},{"issue":"6","key":"177_CR10","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1111\/1756-185X.12431","volume":"19","author":"E Kunisch","year":"2014","unstructured":"Kunisch E, Kinne RW, Alsalameh RJ, Alsalameh S. Pro-inflammatory IL-1beta and\/or TNF-alpha up-regulate matrix metalloproteases-1 and -3 mRNA in chondrocyte subpopulations potentially pathogenic in osteoarthritis: in situ hybridization studies on a single cell level. Int J Rheum Dis. 2014; 19(6):557\u201366.","journal-title":"Int J Rheum Dis"},{"issue":"4","key":"177_CR11","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1177\/1759720X12448454","volume":"4","author":"MB Goldring","year":"2012","unstructured":"Goldring MB. Chondrogenesis, chondrocyte differentiation, and articular cartilage metabolism in health and osteoarthritis. Ther Adv Musculoskelet Dis. 2012; 4(4):269\u201385.","journal-title":"Ther Adv Musculoskelet Dis"},{"issue":"1","key":"177_CR12","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.bbapap.2011.06.020","volume":"1824","author":"L Troeberg","year":"2012","unstructured":"Troeberg L, Nagase H. Proteases involved in cartilage matrix degradation in osteoarthritis. Biochim Biophys Acta. 2012; 1824(1):133\u201345.","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"177_CR13","first-page":"23","volume":"223","author":"GE Kempson","year":"1972","unstructured":"Kempson GE. Mechanical properties of articular cartilage. J Physiol. 1972; 223(1):23.","journal-title":"J Physiol"},{"issue":"3","key":"177_CR14","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/j.jbiomech.2013.11.050","volume":"47","author":"S Grenier","year":"2014","unstructured":"Grenier S, Bhargava MM, Torzilli PA. An in vitro model for the pathological degradation of articular cartilage in osteoarthritis. J Biomech. 2014; 47(3):645\u201352.","journal-title":"J Biomech"},{"issue":"1","key":"177_CR15","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.joca.2016.08.008","volume":"25","author":"B Doyran","year":"2017","unstructured":"Doyran B, Tong W, Li Q, Jia H, Zhang X, Chen C, Enomoto-Iwamoto M, Lu XL, Qin L, Han L. Nanoindentation modulus of murine cartilage: A sensitive indicator of the initiation and progression of post-traumatic osteoarthritis. Osteoarthr Cartil. 2017; 25(1):108\u201317.","journal-title":"Osteoarthr Cartil."},{"issue":"3","key":"177_CR16","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1021\/bm401611b","volume":"15","author":"FP Rojas","year":"2014","unstructured":"Rojas FP, Batista MA, Lindburg CA, Dean D, Grodzinsky AJ, Ortiz C, Han L. Molecular adhesion between cartilage extracellular matrix macromolecules. Biomacromolecules. 2014; 15(3):772\u201380.","journal-title":"Biomacromolecules"},{"issue":"11","key":"177_CR17","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1038\/nrrheum.2016.148","volume":"12","author":"SR Goldring","year":"2016","unstructured":"Goldring SR, Goldring MB. Changes in the osteochondral unit during osteoarthritis: structure, function and cartilage\u2013bone crosstalk. Nat Rev Rheumatol. 2016; 12(11):632\u201344.","journal-title":"Nat Rev Rheumatol"},{"issue":"6","key":"177_CR18","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1302\/0301-620X.95B6.31414","volume":"95-B","author":"AJR Palmer","year":"2013","unstructured":"Palmer AJR, Brown CP, McNally EG, Price AJ, Tracey I, Jezzard P, Carr AJ, Glyn-Jones S. Non-invasive imaging of cartilage in early osteoarthritis. Bone Joint J. 2013; 95-B(6):738\u201346.","journal-title":"Bone Joint J"},{"issue":"10","key":"177_CR19","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1302\/2058-5241.1.000051","volume":"1","author":"J Favre","year":"2016","unstructured":"Favre J, Jolles BM. Gait analysis of patients with knee osteoarthritis highlights a pathological mechanical pathway and provides a basis for therapeutic interventions. EFORT Open Rev. 2016; 1(10):368\u201374.","journal-title":"EFORT Open Rev"},{"issue":"1","key":"177_CR20","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/75556","volume":"25","author":"M Ashburner","year":"2000","unstructured":"Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, et al. Gene Ontology: tool for the unification of biology. Nat Genet. 2000; 25(1):25\u20139.","journal-title":"Nat Genet"},{"issue":"4","key":"177_CR21","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.websem.2008.05.001","volume":"6","author":"B Cuenca Grau","year":"2008","unstructured":"Cuenca Grau B, Horrocks I, Motik B, Parsia B, Patel-Schneider P, Sattler U. OWL 2: The next step for OWL. J Web Semant. 2008; 6(4):309\u201322.","journal-title":"J Web Semant"},{"key":"177_CR22","volume-title":"Tenth International Conference on Principles of Knowledge Representation and Reasoning (KR).","author":"I Horrocks","year":"2006","unstructured":"Horrocks I, Kutz O, Sattler U. The even more irresistible SROIQ. In: Tenth International Conference on Principles of Knowledge Representation and Reasoning (KR).Palo Alto: AAAI Press: 2006. p. 57\u201367."},{"issue":"1","key":"177_CR23","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1002\/cfg.255","volume":"4","author":"AT McCray","year":"2003","unstructured":"McCray AT. An Upper-Level Ontology for the Biomedical Domain. Comp Funct Genomics. 2003; 4(1):80\u20134.","journal-title":"Comp Funct Genomics"},{"issue":"5","key":"177_CR24","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/gb-2005-6-5-r46","volume":"6","author":"B Smith","year":"2005","unstructured":"Smith B, Ceusters W, Klagges B, K\u00f6hler J, Kumar A, Lomax J, Mungall C, Neuhaus F, Rector AL, Rosse C. Relations in biomedical ontologies. Genome Biol. 2005; 6(5):46.","journal-title":"Genome Biol"},{"issue":"2","key":"177_CR25","doi-asserted-by":"publisher","first-page":"79","DOI":"10.3233\/AO-150147","volume":"10","author":"RJ Rovetto","year":"2015","unstructured":"Rovetto RJ, Mizoguchi R. Causality and the ontology of disease. Appl Ontol. 2015; 10(2):79\u2013105.","journal-title":"Appl Ontol"},{"key":"177_CR26","volume-title":"Proceedings of the 13th International Conference on Knowledge Engineering and Knowledge Management. Ontologies and the Semantic Web.","author":"A Gangemi","year":"2002","unstructured":"Gangemi A, Guarino N, Masolo C, Oltramari A, Schneider L. Sweetening ontologies with dolce. In: Proceedings of the 13th International Conference on Knowledge Engineering and Knowledge Management. Ontologies and the Semantic Web.London: Springer: 2002. p. 166\u201381."},{"key":"177_CR27","doi-asserted-by":"publisher","DOI":"10.7551\/mitpress\/9780262527811.001.0001","volume-title":"Building Ontologies with Basic Formal Ontology","author":"R Arp","year":"2015","unstructured":"Arp R, Smith B, Spear AD. Building Ontologies with Basic Formal Ontology. Cambridge: The MIT Press; 2015."},{"key":"177_CR28","volume-title":"The Semantic Web: Semantics and Big Data","author":"D Lembo","year":"2013","unstructured":"Lembo D, Santarelli V, Savo DF. Graph-Based Ontology Classification in OWL 2 QL. In: The Semantic Web: Semantics and Big Data. Berlin: Springer: 2013. p. 320\u201334."},{"key":"177_CR29","volume-title":"Proceedings of the 15th International Conference on World Wide Web.","author":"J Seidenberg","year":"2006","unstructured":"Seidenberg J, Rector A. Web Ontology Segmentation: Analysis, Classification and Use. In: Proceedings of the 15th International Conference on World Wide Web.New York: ACM: 2006. p. 13\u201322."},{"key":"177_CR30","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511811395","volume-title":"Models and Methods in Social Network Analysis","author":"PJ Carrington","year":"2005","unstructured":"Carrington PJ, Scott J, Wasserman S. Models and Methods in Social Network Analysis. Cambridge: Cambridge University Press; 2005."},{"key":"177_CR31","volume-title":"Proceedings of the 3rd European Conference on The Semantic Web: Research And Applications.","author":"B Hoser","year":"2006","unstructured":"Hoser B, Hotho A, J\u00e4schke R, Schmitz C, Stumme G. Semantic Network Analysis of Ontologies. In: Proceedings of the 3rd European Conference on The Semantic Web: Research And Applications.Berlin: Springer: 2006. p. 514\u201329."},{"issue":"1","key":"177_CR32","first-page":"522","volume":"5","author":"P Mika","year":"2011","unstructured":"Mika P. Ontologies Are Us: A unified model of social networks and semantics. Web Semant Sci Serv Agents World Wide Web. 2011; 5(1):522\u201336.","journal-title":"Web Semant Sci Serv Agents World Wide Web"},{"key":"177_CR33","volume-title":"In: International Semantic Web Conference.","author":"H Stuckenschmidt","year":"2004","unstructured":"Stuckenschmidt H, Klein M. Structure-Based Partitioning of Large Concept Hierarchies. In: In: International Semantic Web Conference.Berlin: Springer: 2004. p. 289\u2013303."},{"key":"177_CR34","volume-title":"Proceedings of Smart Tools and Apps for Graphics - Eurographics Italian Chapter Conference.","author":"A Agibetov","year":"2015","unstructured":"Agibetov A, Patan\u00e8 G, Spagnuolo M. Grontocrawler: Graph-Based Ontology Exploration. In: Proceedings of Smart Tools and Apps for Graphics - Eurographics Italian Chapter Conference.Geneve: The Eurographics Association: 2015. p. 67\u201376."},{"key":"177_CR35","volume-title":"In Proc, of IJCAI 2005.","author":"F Baader","year":"2005","unstructured":"Baader F, Brand S, Lutz C. Pushing the EL envelope. In: In Proc, of IJCAI 2005.London: Springer: 2005. p. 364\u20139."},{"key":"177_CR36","doi-asserted-by":"crossref","unstructured":"Solimando A, Jimenez-Ruiz E, Guerrini G. Minimizing conservativity violations in ontology alignments: Algorithms and evaluation. Knowledge and Information Systems. 2017. (in press).","DOI":"10.1007\/s10115-016-0983-3"},{"key":"177_CR37","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.websem.2015.12.002","volume":"37-38","author":"M Arenas","year":"2016","unstructured":"Arenas M, Cuenca Grau B, Kharlamov E, Marciu\u0161ka \u0160, Zheleznyakov D. Faceted search over RDF-based knowledge graphs. Web Semant Sci Serv Agents World Wide Web. 2016; 37-38:55\u201374.","journal-title":"Web Semant Sci Serv Agents World Wide Web"},{"key":"177_CR38","doi-asserted-by":"crossref","unstructured":"Soylu A, et al. Optiquevqs: a visual query system over ontologies for industry. Semantic Web Journal. 2016. (submitted).","DOI":"10.1007\/978-3-319-47602-5_32"},{"key":"177_CR39","volume-title":"OWLED.","author":"SD Larson","year":"2007","unstructured":"Larson SD, Martone ME. Rule-Based Reasoning With A Multi-Scale Neuroanatomical Ontology. In: OWLED.Aachen: CEUR Workshop Proceedings: 2007."},{"key":"177_CR40","volume-title":"ICBO, CEUR Workshop Proceedings, vol. 897.","author":"H Oberkampf","year":"2012","unstructured":"Oberkampf H, Zillner S, Bauer B. Interpreting Patient Data using Medical Background Knowledge In: Cornet R, Stevens R, editors. ICBO, CEUR Workshop Proceedings, vol. 897.Aachen: CEUR Workshop Proceedings: 2012."},{"issue":"1-2","key":"177_CR41","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/s10994-006-5833-1","volume":"62","author":"M Richardson","year":"2006","unstructured":"Richardson M, Domingos P. Markov Logic Networks. Mach Learn. 2006; 62(1-2):107\u201336.","journal-title":"Mach Learn"},{"key":"177_CR42","volume-title":"NIPS Workshop on Probabilistic Programming: Foundations and Applications.","author":"A Kimmig","year":"2012","unstructured":"Kimmig A, Bach SH, Broecheler M, Huang B, Getoor L. A Short Introduction to Probabilistic Soft Logic. In: NIPS Workshop on Probabilistic Programming: Foundations and Applications.La Jolla: Neural Information Processing Systems Foundation: 2012."},{"key":"177_CR43","volume-title":"20th Annual IEEE Symposium on Logic in Computer Science, 2005. LICS 2005. Proceedings.","author":"J Hillston","year":"2005","unstructured":"Hillston J. Process algebras for quantitative analysis. In: 20th Annual IEEE Symposium on Logic in Computer Science, 2005. LICS 2005. Proceedings.Piscataway: IEEE: 2005. p. 239\u201348."},{"issue":"3","key":"177_CR44","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.entcs.2007.12.008","volume":"194","author":"F Ciocchetta","year":"2008","unstructured":"Ciocchetta F, Hillston J. Bio-PEPA: An Extension of the Process Algebra PEPA for Biochemical Networks. Electron Notes Theor Comput Sci. 2008; 194(3):103\u201317.","journal-title":"Electron Notes Theor Comput Sci"},{"key":"177_CR45","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1214\/09-SS057","volume":"3","author":"J Pearl","year":"2009","unstructured":"Pearl J. Causal inference in statistics: An overview. Statistics Surveys. 2009; 3:96\u2013146.","journal-title":"Statistics Surveys"},{"key":"177_CR46","volume-title":"Causality: Models, Reasoning, and Inference","author":"J Pearl","year":"2000","unstructured":"Pearl J. Causality: Models, Reasoning, and Inference. UK: Cambridge University Press; 2000."},{"issue":"3","key":"177_CR47","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/s10817-014-9305-1","volume":"53","author":"B Glimm","year":"2014","unstructured":"Glimm B, Horrocks I, Motik B, Stoilos G, Wang Z. Hermit: An OWL 2 reasoner. J Autom Reason. 2014; 53(3):245\u201369.","journal-title":"J Autom Reason"},{"key":"177_CR48","first-page":"29","volume":"17","author":"K Spackman","year":"2000","unstructured":"Spackman K. SNOMED RT and SNOMED CT. promise of an international clinical ontology. MD Computing. 2000; 17:29.","journal-title":"MD Computing"},{"issue":"Database issue","key":"177_CR49","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1093\/nar\/gkh061","volume":"32","author":"O Bodenreider","year":"2004","unstructured":"Bodenreider O. The unified medical language system (UMLS): integrating biomedical terminology. Nucleic Acids Res. 2004; 32(Database issue):267\u201370.","journal-title":"Nucleic Acids Res"},{"key":"177_CR50","doi-asserted-by":"crossref","unstructured":"Fridman Noy N, Shah NH, Whetzel PL, Dai B, Dorf M, Griffith N, Jonquet C, Rubin DL, Storey M-AD, Chute CG, Musen MA. BioPortal: ontologies and integrated data resources at the click of a mouse. Nucleic Acids Res. 2009;37(Web-Server-Issue).","DOI":"10.1093\/nar\/gkp440"},{"issue":"3","key":"177_CR51","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3233\/SW-2012-0086","volume":"4","author":"M Salvadores","year":"2013","unstructured":"Salvadores M, Alexander PR, Musen MA, Noy NF. BioPortal as a dataset of linked biomedical ontologies and terminologies in RDF. Semant Web. 2013; 4(3):277\u201384.","journal-title":"Semant Web"},{"key":"177_CR52","volume-title":"Int\u2019l Sem. Web Conf. (ISWC).","author":"E Jim\u00e9nez-Ruiz","year":"2011","unstructured":"Jim\u00e9nez-Ruiz E, Cuenca Grau B. LogMap: Logic-based and Scalable Ontology Matching. In: Int\u2019l Sem. Web Conf. (ISWC).Berlin: Springer: 2011. p. 273\u201388."},{"key":"177_CR53","volume-title":"OTM Conferences.","author":"D Faria","year":"2013","unstructured":"Faria D, Pesquita C, Santos E, Palmonari M, Cruz IF, Couto FM. The agreementmakerlight ontology matching system. In: OTM Conferences.Berlin: Springer: 2013. p. 527\u201341."},{"key":"177_CR54","volume-title":"Digraphs, Springer Monographs in Mathematics","author":"J Bang-Jensen","year":"2009","unstructured":"Bang-Jensen J, Gutin GZ. Digraphs, Springer Monographs in Mathematics. London: Springer; 2009."},{"key":"177_CR55","unstructured":"EU FP7 MultiScaleHuman. Multi-scale Biological Modalities for Physiological Human Articulation (MSH). http:\/\/multiscalehuman.miralab.ch . Accessed 26 Jan 2018."},{"issue":"6","key":"177_CR56","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1016\/j.berh.2011.11.013","volume":"25","author":"F Guilak","year":"2011","unstructured":"Guilak F. Biomechanical factors in osteoarthritis. Best Pract Res Clin Rheumatol. 2011; 25(6):815\u201323.","journal-title":"Best Pract Res Clin Rheumatol"},{"issue":"1","key":"177_CR57","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.joca.2009.08.005","volume":"18","author":"GD Nicodemus","year":"2010","unstructured":"Nicodemus GD, Bryant SJ. Mechanical loading regimes affect the anabolic and catabolic activities by chondrocytes encapsulated in PEG hydrogels. Osteoarthr Cartil. 2010; 18(1):126\u201337.","journal-title":"Osteoarthr Cartil"},{"issue":"11","key":"177_CR58","first-page":"1129","volume":"21","author":"TMJ Fruchterman","year":"1991","unstructured":"Fruchterman TMJ, Reingold EM. Graph drawing by force-directed placement. Softw: Pract Experience. 1991; 21(11):1129\u201364.","journal-title":"Softw: Pract Experience"},{"key":"177_CR59","unstructured":"Ontology for General Medical Science (OGMS). Available at https:\/\/github.com\/OGMS\/ogms . Accessed Apr 2017."},{"key":"177_CR60","first-page":"116","volume":"2009","author":"RH Scheuermann","year":"2009","unstructured":"Scheuermann RH, Ceusters W, Smith B. Toward an Ontological Treatment of Disease and Diagnosis. Summit Transl Bioinform. 2009; 2009:116\u201320.","journal-title":"Summit Transl Bioinform"},{"issue":"11","key":"177_CR61","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1145\/182.358434","volume":"26","author":"JF Allen","year":"1983","unstructured":"Allen JF. Maintaining knowledge about temporal intervals. Commun ACM. 1983; 26(11):832\u201343.","journal-title":"Commun ACM"},{"key":"177_CR62","doi-asserted-by":"crossref","unstructured":"Bruskiewich R, Huellas-Bruskiewicz K, Ahmed F, Kaliyaperumal R, Thompson M, Schultes E, Hettne KM, Su AI, Good BM. Knowledge.Bio: A Web application for exploring, building and sharing webs of biomedical relationships mined from PubMed. bioRxiv. 2016;055525.","DOI":"10.1101\/055525"},{"key":"177_CR63","doi-asserted-by":"publisher","first-page":"015","DOI":"10.1093\/database\/baw015","volume":"2016","author":"S Burgstaller-Muehlbacher","year":"2016","unstructured":"Burgstaller-Muehlbacher S, Waagmeester A, Mitraka E, Turner J, Putman T, Leong J, Naik C, Pavlidis P, Schriml L, Good BM, Su AI. Wikidata as a semantic framework for the Gene Wiki initiative. Database. 2016; 2016:015.","journal-title":"Database"}],"container-title":["Journal of Biomedical Semantics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13326-018-0177-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T22:35:08Z","timestamp":1603838108000},"score":1,"resource":{"primary":{"URL":"https:\/\/jbiomedsem.biomedcentral.com\/articles\/10.1186\/s13326-018-0177-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,8]]},"references-count":63,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["177"],"URL":"https:\/\/doi.org\/10.1186\/s13326-018-0177-x","relation":{},"ISSN":["2041-1480"],"issn-type":[{"value":"2041-1480","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,8]]},"assertion":[{"value":"1 June 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 January 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 February 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"9"}}