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Multiple data sources can use different ontologies for annotating their data and, thus, creating the need for dynamic ontology matching services. In this experimental study, we assessed the performance of ontology matching systems in the context of a real-life application from the rare disease domain. Additionally, we present a method for analyzing top-level classes to improve precision.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>We included three ontologies (NCIt, SNOMED CT, ORDO) and three matching systems (AgreementMakerLight 2.0, FCA-Map, LogMap 2.0). We evaluated the performance of the matching systems against reference alignments from BioPortal and the Unified Medical Language System Metathesaurus (UMLS). Then, we analyzed the top-level ancestors of matched classes, to detect incorrect mappings without consulting a reference alignment. To detect such incorrect mappings, we manually matched semantically equivalent top-level classes of ontology pairs. AgreementMakerLight 2.0, FCA-Map, and LogMap 2.0 had F1-scores of 0.55, 0.46, 0.55 for BioPortal and 0.66, 0.53, 0.58 for the UMLS respectively. Using vote-based consensus alignments increased performance across the board. Evaluation with manually created top-level hierarchy mappings revealed that on average 90% of the mappings\u2019 classes belonged to top-level classes that matched.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Our findings show that the included ontology matching systems automatically produced mappings that were modestly accurate according to our evaluation. The hierarchical analysis of mappings seems promising when no reference alignments are available. All in all, the systems show potential to be implemented as part of an ontology matching service for querying FAIR data. Future research should focus on developing methods for the evaluation of mappings used in such mapping services, leading to their implementation in a FAIR data ecosystem.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13326-022-00273-5","type":"journal-article","created":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T10:04:24Z","timestamp":1657879464000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Performance assessment of ontology matching systems for FAIR data"],"prefix":"10.1186","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7124-8949","authenticated-orcid":false,"given":"Philip","family":"van Damme","sequence":"first","affiliation":[]},{"given":"Jesualdo Tom\u00e1s","family":"Fern\u00e1ndez-Breis","sequence":"additional","affiliation":[]},{"given":"Nirupama","family":"Benis","sequence":"additional","affiliation":[]},{"given":"Jose Antonio","family":"Mi\u00f1arro-Gimenez","sequence":"additional","affiliation":[]},{"given":"Nicolette F.","family":"de Keizer","sequence":"additional","affiliation":[]},{"given":"Ronald","family":"Cornet","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2022,7,15]]},"reference":[{"key":"273_CR1","volume-title":"Guidelines to the Rules on Open Access to Scientific Publications and Open Access to Research Data in Horizon 2020","author":"Directorate-General for Research and Innovation","year":"2017","unstructured":"Directorate-General for Research and Innovation. 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