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However, how personal influence varies across multiple domains is rarely addressed. This study introduces a concept called Domain-Relevance of Influence to describe the relation between influence and domains, and establishes a methodological framework with a sample of 8,520,933 Weibo users to explore the cross-domain characteristics of influence. The results show that generalists with cross-domain attributes possess significantly higher influence than specialists in most domains, whereas in a single domain such as sports or technology, specialists and generalists can possess comparable influence. We further show that influence is positively associated with cross-domain capability in overall domains, but not necessarily in each single domain. 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