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However, segmenting small regions such as limbic structures is challenging due to their low inter-regional contrast and high curvature. MRI studies of the adult brain have successfully applied deep learning techniques to segment limbic structures, and similar deep learning models are being leveraged for infant studies. However, these deep learning-based infant MRI segmentation models have generally been derived from small datasets, and may suffer from generalization problems. Moreover, the accuracy of segmentations derived from these deep learning models relative to more standard Expectation\u2013Maximization approaches has not been characterized. To address these challenges, we leveraged a large, public infant MRI dataset (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009473) and the transfer-learning technique to first pre-train a deep convolutional neural network model on two limbic structures: amygdala and hippocampus. Then we used a leave-one-out cross-validation strategy to fine-tune the pre-trained model and evaluated it separately on two independent datasets with manual labels. We term this new approach the\n                    <jats:bold>I<\/jats:bold>\n                    nfant\n                    <jats:bold>D<\/jats:bold>\n                    eep learning\n                    <jats:bold>SEG<\/jats:bold>\n                    mentation Framework (\n                    <jats:bold>ID-Seg<\/jats:bold>\n                    ). ID-Seg performed well on both datasets with a mean dice similarity score (DSC) of 0.87, a mean intra-class correlation (ICC) of 0.93, and a mean average surface distance (ASD) of 0.31\u00a0mm. Compared to the Developmental Human Connectome pipeline (dHCP) pipeline, ID-Seg significantly improved segmentation accuracy. In a third infant MRI dataset (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200950), we used ID-Seg and dHCP separately to estimate amygdala and hippocampus volumes and shapes. The estimates derived from ID-seg, relative to those from the dHCP, showed stronger associations with behavioral problems assessed in these infants at age 2. In sum, ID-Seg consistently performed well on two different datasets with an 0.87 DSC, however, multi-site testing and extension for brain regions beyond the amygdala and hippocampus are still needed.\n                  <\/jats:p>","DOI":"10.1186\/s40708-022-00161-9","type":"journal-article","created":{"date-parts":[[2022,5,28]],"date-time":"2022-05-28T09:05:43Z","timestamp":1653728743000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["ID-Seg: an infant deep learning-based segmentation framework to improve limbic structure estimates"],"prefix":"10.1186","volume":"9","author":[{"given":"Yun","family":"Wang","sequence":"first","affiliation":[]},{"given":"Fateme Sadat","family":"Haghpanah","sequence":"additional","affiliation":[]},{"given":"Xuzhe","family":"Zhang","sequence":"additional","affiliation":[]},{"given":"Katie","family":"Santamaria","sequence":"additional","affiliation":[]},{"given":"Gabriela Koch","family":"da Costa Aguiar Alves","sequence":"additional","affiliation":[]},{"given":"Elizabeth","family":"Bruno","sequence":"additional","affiliation":[]},{"given":"Natalie","family":"Aw","sequence":"additional","affiliation":[]},{"given":"Alexis","family":"Maddocks","sequence":"additional","affiliation":[]},{"given":"Cristiane S.","family":"Duarte","sequence":"additional","affiliation":[]},{"given":"Catherine","family":"Monk","sequence":"additional","affiliation":[]},{"given":"Andrew","family":"Laine","sequence":"additional","affiliation":[]},{"given":"Jonathan","family":"Posner","sequence":"additional","affiliation":[]},{"name":"program collaborators for Environmental influences on Child Health Outcomes","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2022,5,28]]},"reference":[{"issue":"2","key":"161_CR1","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1002\/wps.20733","volume":"19","author":"CS Duarte","year":"2020","unstructured":"Duarte CS et al (2020) Intergenerational psychiatry: a new look at a powerful perspective. 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