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The Local Interpretable Model-agnostic Explanations (LIME) and Shaply Additive exPlanation (SHAP) frameworks have grown as popular interpretive tools for ML and DL models. This article provides a systematic review of the application of LIME and SHAP in interpreting the detection of Alzheimer\u2019s disease (AD). Adhering to PRISMA and Kitchenham\u2019s guidelines, we identified 23 relevant articles and investigated these frameworks\u2019 prospective capabilities, benefits, and challenges in depth. The results emphasise XAI\u2019s crucial role in strengthening the trustworthiness of AI-based AD predictions. This review aims to provide fundamental capabilities of LIME and SHAP XAI frameworks in enhancing fidelity within clinical decision support systems for AD prognosis.<\/jats:p>","DOI":"10.1186\/s40708-024-00222-1","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T11:02:03Z","timestamp":1712314923000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":336,"title":["Interpreting artificial intelligence models: a systematic review on the application of LIME and SHAP in Alzheimer\u2019s disease detection"],"prefix":"10.1186","volume":"11","author":[{"given":"Viswan","family":"Vimbi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noushath","family":"Shaffi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mufti","family":"Mahmud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,5]]},"reference":[{"key":"222_CR1","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.neurobiolaging.2016.10.027","volume":"50","author":"R Fontana","year":"2017","unstructured":"Fontana R, Agostini M, Murana E, Mahmud M, Scremin E, Rubega M, Sparacino G, Vassanelli S, Fasolato C (2017) Early hippocampal hyperexcitability in PS2APP mice: role of mutant PS2 and APP. 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