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The integration provides a new disruptive approach for vertical integration and optimization of the greenhouse production processes to improve energy efficiency, production throughput, and productivity without compromising product quality or sustainability. Applying the Industry 4.0 Digital Twin concept to the Danish horticulture greenhouse industry provides digital models for simulating and evaluating the physical greenhouse facility\u2019s performance. A Digital Twin combines modeling, AI, and Big Data analytics with IoT and traditional sensor data from the production and cloud-based enterprise data to predict how the physical twin will perform under varying operational conditions. The Digital Twins support the co-optimization of the production schedule, energy consumption, and labor cost by considering influential factors, including production deadlines, quality grading, heating, artificial lighting, energy prices (gas and electricity), and weather forecasts. 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