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Towards this end, a class of anomaly detectors, created using data-centric approaches, are gaining attention. Using machine learning algorithms such approaches can automatically learn the process dynamics and control strategies deployed in an ICS. The use of these approaches leads to relatively easier and faster creation of anomaly detectors compared to the use of design-centric approaches that are based on plant physics and design. Despite the advantages, there exist significant challenges and implementation issues in the creation and deployment of detectors generated using machine learning for city-scale plants. In this work, we enumerate and discuss such challenges. Also presented is a series of lessons learned in our attempt to meet these challenges in an operational plant.<\/jats:p>","DOI":"10.1186\/s42400-021-00095-5","type":"journal-article","created":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T23:03:25Z","timestamp":1627859005000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Machine learning for intrusion detection in industrial control systems: challenges and lessons from experimental evaluation"],"prefix":"10.1186","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5285-9330","authenticated-orcid":false,"given":"Gauthama Raman","family":"M. 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