{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:58:16Z","timestamp":1791248296032,"version":"4.1.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2012,9,24]],"date-time":"2012-09-24T00:00:00Z","timestamp":1348444800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2012,9,24]],"date-time":"2012-09-24T00:00:00Z","timestamp":1348444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Alz Res Therapy"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Introduction<\/jats:title>\n                        <jats:p>Frontotemporal dementia (FTD) is a common cause of early-onset dementia with a significant genetic component, as underlined by the recent identification of repeat expansions in the gene <jats:italic>C9ORF72<\/jats:italic> as a major cause of FTD and motor neuron disease. Understanding the neurobiology and clinical phenomenology of this novel mutation is currently a major research focus. However, few data are available concerning the longitudinal evolution of this genetic disease. Here we present longitudinal neuropsychological and neuroimaging data on a cohort of patients with pathological repeat expansions in <jats:italic>C9ORF72<\/jats:italic>.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Methods<\/jats:title>\n                        <jats:p>Following a review of the University College London FTD DNA database, 20 cases were retrospectively identified with a <jats:italic>C9ORF72<\/jats:italic> expansion. Twelve cases had longitudinal neuropsychology data available and six of these cases also had longitudinal volumetric brain magnetic resonance imaging. Cortical and subcortical volumes were extracted using FreeSurfer. Rates of whole brain, hemispheric, cerebellar and ventricular change were calculated for each subject. Nonlinear fluid registration of follow-up to baseline scan was performed to visualise longitudinal intra-subject patterns of brain atrophy and ventricular expansion.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>Patients had low average verbal and performance IQ at baseline that became impaired (&lt; 5th percentile) at follow-up. In particular, visual memory, naming and dominant parietal skills all showed deterioration. Mean rates of whole brain atrophy (1.4%\/year) and ventricular expansion (3.2 ml\/year) were substantially greater in patients with the <jats:italic>C9ORF72<\/jats:italic> mutation than in healthy controls; atrophy was symmetrical between the cerebral hemispheres within the <jats:italic>C9ORF72<\/jats:italic> mutation group. The thalamus and cerebellum showed significant atrophy whereas no cortical areas were preferentially affected. Longitudinal fluid imaging in individual patients demonstrated heterogeneous patterns of progressive volume loss; however, ventricular expansion and cerebellar volume loss were consistent findings.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusion<\/jats:title>\n                        <jats:p>Disease evolution in <jats:italic>C9ORF72<\/jats:italic>-associated FTD is linked neuropsychologically with increasing involvement of parietal and amnestic functions, and neuroanatomically with rather diffuse and variable cortical and central atrophy but more consistent involvement of the cerebellum and thalamus. These longitudinal profiles are consistent with disease spread within a distributed subcortical network and demonstrate the feasibility of longitudinal biomarkers for tracking the evolution of the <jats:italic>C9ORF72<\/jats:italic> mutation phenotype.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/alzrt144","type":"journal-article","created":{"date-parts":[[2012,9,24]],"date-time":"2012-09-24T14:14:16Z","timestamp":1348496056000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":95,"title":["Longitudinal neuroimaging and neuropsychological profiles of frontotemporal dementia with C9ORF72 expansions"],"prefix":"10.1186","volume":"4","author":[{"given":"Colin J","family":"Mahoney","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura E","family":"Downey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard R","family":"Ridgway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Beck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shona","family":"Clegg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Blair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Finnegan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelvin K","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Yeatman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Golden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Mead","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan D","family":"Rohrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick C","family":"Fox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason D","family":"Warren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,9,24]]},"reference":[{"key":"119_CR1","doi-asserted-by":"publisher","first-page":"2456","DOI":"10.1093\/brain\/awr179","volume":"134","author":"K Rascovsky","year":"2011","unstructured":"Rascovsky K, Hodges JR, Knopman D, Mendez MF, Kramer JH, Neuhaus J, van Swieten JC, Seelaar H, Dopper EGP, Onyike CU, Hillis AE, Josephs KA, Boeve BF, Kertesz A, Seeley WW, Rankin KP, Johnson JK, Gorno-Tempini M-L, Rosen H, Prioleau-Latham CE, Lee A, Kipps CM, Lillo P, Piguet O, Rohrer JD, Rossor MN, Warren JD, Fox NC, Galasko D, Salmon DP: Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain. 2011, 134: 2456-2477. 10.1093\/brain\/awr179.","journal-title":"Brain"},{"key":"119_CR2","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1212\/WNL.0b013e3181bf997a","volume":"73","author":"JD Rohrer","year":"2009","unstructured":"Rohrer JD, Guerreiro R, Vandrovcova J, Uphill J, Reiman D, Beck J, Isaacs AM, Authier A, Ferrari R, Fox NC, Mackenzie IRA, Warren JD, de Silva R, Holton J, Revesz T, Hardy J, Mead S, Rossor MN: The heritability and genetics of frontotemporal lobar degeneration. Neurology. 2009, 73: 1451-1456. 10.1212\/WNL.0b013e3181bf997a.","journal-title":"Neurology"},{"key":"119_CR3","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.neuron.2011.09.011","volume":"72","author":"M Dejesus-Hernandez","year":"2011","unstructured":"Dejesus-Hernandez M, Mackenzie IR, Boeve BF, Boxer AL, Baker M, Rutherford NJ, Nicholson AM, Finch NA, Flynn H, Adamson J, Kouri N, Wojtas A, Sengdy P, Hsiung G-YR, Karydas A, Seeley WW, Josephs KA, Coppola G, Geschwind DH, Wszolek ZK, Feldman H, Knopman DS, Petersen RC, Miller BL, Dickson DW, Boylan KB, Graff-Radford NR, Rademakers R: Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS. Neuron. 2011, 72: 245-256. 10.1016\/j.neuron.2011.09.011.","journal-title":"Neuron"},{"key":"119_CR4","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.neuron.2011.09.010","volume":"72","author":"AE Renton","year":"2011","unstructured":"Renton AE, Majounie E, Waite A, Sim\u00f3n-S\u00e1nchez J, Rollinson S, Gibbs JR, Schymick JC, Laaksovirta H, van Swieten JC, Myllykangas L, Kalimo H, Paetau A, Abramzon Y, Remes AM, Kaganovich A, Scholz SW, Duckworth J, Ding J, Harmer DW, Hernandez DG, Johnson JO, Mok K, Ryten M, Trabzuni D, Guerreiro RJ, Orrell RW, Neal J, Murray A, Pearson J, Jansen IE: A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD. Neuron. 2011, 72: 257-268. 10.1016\/j.neuron.2011.09.010.","journal-title":"Neuron"},{"key":"119_CR5","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/S1474-4422(12)70043-1","volume":"11","author":"E Majounie","year":"2012","unstructured":"Majounie E, Renton AE, Mok K, Dopper EGP, Waite A, Rollinson S, Chi\u00f2 A, Restagno G, Nicolaou N, Simon-Sanchez J, van Swieten JC, Abramzon Y, Johnson JO, Sendtner M, Pamphlett R, Orrell RW, Mead S, Sidle KC, Houlden H, Rohrer JD, Morrison KE, Pall H, Talbot K, Ansorge O, Hernandez DG, Arepalli S, Sabatelli M, Mora G, Corbo M, Giannini F: Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study. Lancet Neurol. 2012, 11: 323-330. 10.1016\/S1474-4422(12)70043-1.","journal-title":"Lancet Neurol"},{"key":"119_CR6","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1093\/brain\/awr361","volume":"135","author":"CJ Mahoney","year":"2012","unstructured":"Mahoney CJ, Beck J, Rohrer JD, Lashley T, Mok K, Shakespeare T, Yeatman T, Warrington EK, Schott JM, Fox NC, Rossor MN, Hardy J, Collinge J, Revesz T, Mead S, Warren JD: Frontotemporal dementia with the C9ORF72 hexanucleotide repeat expansion: clinical, neuroanatomical and neuropathological features. Brain. 2012, 135: 736-750. 10.1093\/brain\/awr361.","journal-title":"Brain"},{"key":"119_CR7","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1093\/brain\/awr355","volume":"135","author":"JS Snowden","year":"2012","unstructured":"Snowden JS, Rollinson S, Thompson JC, Harris JM, Stopford CL, Richardson AMT, Jones M, Gerhard A, Davidson YS, Robinson A, Gibbons L, Hu Q, DuPlessis D, Neary D, Mann DMA, Pickering-Brown SM: Distinct clinical and pathological characteristics of frontotemporal dementia associated with C9ORF72 mutations. Brain. 2012, 135: 693-708. 10.1093\/brain\/awr355.","journal-title":"Brain"},{"key":"119_CR8","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1136\/jnnp.2009.204081","volume":"82","author":"AL Boxer","year":"2011","unstructured":"Boxer AL, Mackenzie IR, Boeve BF, Baker M, Seeley WW, Crook R, Feldman H, Hsiung G-YR, Rutherford N, Laluz V, Whitwell J, Foti D, McDade E, Molano J, Karydas A, Wojtas A, Goldman J, Mirsky J, Sengdy P, Dearmond S, Miller BL, Rademakers R: Clinical, neuroimaging and neuropathological features of a new chromosome 9p-linked FTD-ALS family. J Neurol Neurosurg Psychiatry. 2011, 82: 196-203. 10.1136\/jnnp.2009.204081.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"119_CR9","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1093\/brain\/aws001","volume":"135","author":"JL Whitwell","year":"2012","unstructured":"Whitwell JL, Weigand SD, Boeve BF, Senjem ML, Gunter JL, DeJesus-Hernandez M, Rutherford NJ, Baker M, Knopman DS, Wszolek ZK, Parisi JE, Dickson DW, Petersen RC, Rademakers R, Jack CR, Josephs KA: Neuroimaging signatures of frontotemporal dementia genetics: C9ORF72, tau, progranulin and sporadics. Brain. 2012, 135: 794-806. 10.1093\/brain\/aws001.","journal-title":"Brain"},{"key":"119_CR10","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1212\/WNL.0b013e3181a55fa2","volume":"72","author":"JMS Pereira","year":"2009","unstructured":"Pereira JMS, Williams GB, Acosta-Cabronero J, Pengas G, Spillantini MG, Xuereb JH, Hodges JR, Nestor PJ: Atrophy patterns in histologic vs clinical groupings of frontotemporal lobar degeneration. Neurology. 2009, 72: 1653-1660. 10.1212\/WNL.0b013e3181a55fa2.","journal-title":"Neurology"},{"key":"119_CR11","volume-title":"Manual for the Wechsler Adult Intelligence Scale","author":"D Wechsler","year":"1981","unstructured":"Wechsler D: Manual for the Wechsler Adult Intelligence Scale. 1981, New York: Psychological Corporation"},{"key":"119_CR12","volume-title":"Wechsler Abbreviated Scale of Intelligence","author":"D Wechsler","year":"1999","unstructured":"Wechsler D: Wechsler Abbreviated Scale of Intelligence. 1999, Psychological Corporation; San Antonio, Texas"},{"key":"119_CR13","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1037\/h0055544","volume":"36","author":"E Weigl","year":"1927","unstructured":"Weigl E: On the psychology of the so called processes of abstraction. J Abnorm Soc Psychol. 1927, 36: 3-33.","journal-title":"J Abnorm Soc Psychol"},{"key":"119_CR14","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1037\/h0054651","volume":"18","author":"J Stroop","year":"1935","unstructured":"Stroop J: Studies of interference in serial verbal reactions. J Exp Psychol. 1935, 18: 643-662.","journal-title":"J Exp Psychol"},{"key":"119_CR15","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/0028-3932(95)00104-2","volume":"34","author":"PW Burgess","year":"1996","unstructured":"Burgess PW, Shallice T: Response suppression, initiation and strategy use following frontal lobe lesions. Neuropsychologia. 1996, 34: 263-272. 10.1016\/0028-3932(95)00104-2.","journal-title":"Neuropsychologia"},{"key":"119_CR16","volume-title":"Manual for the Recognition Memory Test for Words and Faces","author":"E Warrington","year":"1984","unstructured":"Warrington E: Manual for the Recognition Memory Test for Words and Faces. 1984, Windsor, UK: NFER-Nelson"},{"key":"119_CR17","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1136\/jnnp.43.9.781","volume":"43","author":"P McKenna","year":"1980","unstructured":"McKenna P, Warrington EK: Testing for nominal dysphasia. J Neurol Neurosurg Psychiatry. 1980, 43: 781-788. 10.1136\/jnnp.43.9.781.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"119_CR18","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1080\/17470216508416445","volume":"Series A","author":"R Oldfield","year":"1965","unstructured":"Oldfield R, Wingfield A: Response latencies in naming objects. Q J Exp Psychol. 1965, Series A: 273-281.","journal-title":"Q J Exp Psychol"},{"key":"119_CR19","volume-title":"The Visual Object and Space Perception Battery","author":"E Warrington","year":"1991","unstructured":"Warrington E, James M: The Visual Object and Space Perception Battery. 1991, Bury St Edmunds, UK: Thames Valley Test Company"},{"key":"119_CR20","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/S0010-9452(86)80020-X","volume":"22","author":"M Jackson","year":"1986","unstructured":"Jackson M, Warrington EK: Arithmetic skills in patients with unilateral cerebral lesions. Cortex. 1986, 22: 611-620.","journal-title":"Cortex"},{"key":"119_CR21","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1155\/1994\/659593","volume":"3-4","author":"D Baxter","year":"1994","unstructured":"Baxter D, Warrington E: Measuring dysgraphia: a graded-difficulty spelling test. Behav Neurol. 1994, 3-4: 107-116.","journal-title":"Behav Neurol"},{"key":"119_CR22","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/S0169-2607(97)01803-8","volume":"53","author":"PA Freeborough","year":"1997","unstructured":"Freeborough PA, Fox NC, Kitney RI: Interactive algorithms for the segmentation and quantitation of 3-D MRI brain scans. Comput Methods Programs Biomed. 1997, 53: 15-25. 10.1016\/S0169-2607(97)01803-8.","journal-title":"Comput Methods Programs Biomed"},{"key":"119_CR23","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.neuroimage.2009.12.059","volume":"50","author":"KK Leung","year":"2010","unstructured":"Leung KK, Clarkson MJ, Bartlett JW, Clegg S, Jack CR, Weiner MW, Fox NC, Ourselin S: Robust atrophy rate measurement in Alzheimer's disease using multi-site serial MRI: tissue-specific intensity normalization and parameter selection. NeuroImage. 2010, 50: 516-523. 10.1016\/j.neuroimage.2009.12.059.","journal-title":"NeuroImage"},{"key":"119_CR24","unstructured":"Statistical Parametric Mapping. [http:\/\/www.fil.ion.ucl.ac.uk\/spm]"},{"key":"119_CR25","doi-asserted-by":"publisher","first-page":"S62","DOI":"10.1016\/j.jalz.2011.05.099","volume":"7","author":"G Ridgway","year":"2011","unstructured":"Ridgway G, Barnes J, Pepple T, Fox N: Estimation of total intracranial volume; a comparison of methods. Alzheimer's Dementia. 2011, 7: S62-S63.","journal-title":"Alzheimer's Dementia"},{"key":"119_CR26","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1016\/j.neuroimage.2012.02.084","volume":"61","author":"M Reuter","year":"2012","unstructured":"Reuter M, Schmansky NJ, Rosas HD, Fischl B: Within-subject template estimation for unbiased longitudinal image analysis. NeuroImage. 2012, 61: 1402-1418. 10.1016\/j.neuroimage.2012.02.084.","journal-title":"NeuroImage"},{"key":"119_CR27","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1016\/j.neuroimage.2006.01.021","volume":"31","author":"RS Desikan","year":"2006","unstructured":"Desikan RS, S\u00e9gonne F, Fischl B, Quinn BT, Dickerson BC, Blacker D, Buckner RL, Dale AM, Maguire RP, Hyman BT, Albert MS, Killiany RJ: An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest. NeuroImage. 2006, 31: 968-980. 10.1016\/j.neuroimage.2006.01.021.","journal-title":"NeuroImage"},{"key":"119_CR28","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1097\/00004728-199809000-00031","volume":"22","author":"PA Freeborough","year":"1998","unstructured":"Freeborough PA, Fox NC: Modeling brain deformations in Alzheimer disease by fluid registration of serial 3D MR images. J Comput Assist Tomogr. 1998, 22: 838-843. 10.1097\/00004728-199809000-00031.","journal-title":"J Comput Assist Tomogr"},{"key":"119_CR29","doi-asserted-by":"publisher","first-page":"1843","DOI":"10.1212\/WNL.0b013e3181a71236","volume":"72","author":"DS Knopman","year":"2009","unstructured":"Knopman DS, Jack CR, Kramer JH, Boeve BF, Caselli RJ, Graff-Radford NR, Mendez MF, Miller BL, Mercaldo ND: Brain and ventricular volumetric changes in frontotemporal lobar degeneration over 1 year. Neurology. 2009, 72: 1843-1849. 10.1212\/WNL.0b013e3181a71236.","journal-title":"Neurology"},{"key":"119_CR30","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1212\/WNL.0b013e3181d1a879","volume":"74","author":"E Gordon","year":"2010","unstructured":"Gordon E, Rohrer JD, Kim LG, Omar R, Rossor MN, Fox NC, Warren JD: Measuring disease progression in frontotemporal lobar degeneration: a clinical and MRI study. Neurology. 2010, 74: 666-673. 10.1212\/WNL.0b013e3181d1a879.","journal-title":"Neurology"},{"key":"119_CR31","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1093\/brain\/awm320","volume":"131","author":"J Beck","year":"2008","unstructured":"Beck J, King A, Scahill R, Warren JD, Fox NC, Rossor MN, Collinge J, Mead S: A distinct clinical, neuropsychological and radiological phenotype is associated with progranulin gene mutations in a large UK series. Brain. 2008, 131: 706-720. 10.1093\/brain\/awm320.","journal-title":"Brain"},{"key":"119_CR32","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3233\/NRE-2011-0633","volume":"28","author":"ED Bigler","year":"2011","unstructured":"Bigler ED, Maxwell WL: Neuroimaging and neuropathology of TBI. NeuroRehabilitation. 2011, 28: 63-74.","journal-title":"NeuroRehabilitation"},{"key":"119_CR33","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1093\/brain\/aws004","volume":"135","author":"BF Boeve","year":"2012","unstructured":"Boeve BF, Boylan KB, Graff-Radford NR, DeJesus-Hernandez M, Knopman DS, Pedraza O, Vemuri P, Jones D, Lowe V, Murray ME, Dickson DW, Josephs KA, Rush BK, Machulda MM, Fields JA, Ferman TJ, Baker M, Rutherford NJ, Adamson J, Wszolek ZK, Adeli A, Savica R, Boot B, Kuntz KM, Gavrilova R, Reeves A, Whitwell J, Kantarci K, Jack CR, Parisi JE: Characterization of frontotemporal dementia and\/or amyotrophic lateral sclerosis associated with the GGGGCC repeat expansion in C9ORF72. Brain. 2012, 135: 765-783. 10.1093\/brain\/aws004.","journal-title":"Brain"},{"key":"119_CR34","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/j.cortex.2008.04.004","volume":"44","author":"J Schmahmann","year":"2008","unstructured":"Schmahmann J, Pandya D: Disconnection syndromes of basal ganglia, thalamus, and cerebrocerebellar systems. Cortex. 2008, 44: 1037-1066. 10.1016\/j.cortex.2008.04.004.","journal-title":"Cortex"},{"key":"119_CR35","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1126\/science.7939688","volume":"266","author":"F Middleton","year":"1994","unstructured":"Middleton F, Strick P: Anatomical evidence for cerebellar and basal ganglia involvement in higher cognitive function. Science. 1994, 266: 458-461. 10.1126\/science.7939688.","journal-title":"Science"},{"key":"119_CR36","doi-asserted-by":"publisher","first-page":"1482","DOI":"10.1212\/WNL.41.9.1482","volume":"41","author":"K Jendroska","year":"1991","unstructured":"Jendroska K, Heinzel FP, Torchia M, Stowring L, Kretzschmar HA, Kon A, Stern A, Prusiner SB, DeArmond SJ: Proteinase-resistant prion protein accumulation in Syrian hamster brain correlates with regional pathology and scrapie infectivity. Neurology. 1991, 41: 1482-1490. 10.1212\/WNL.41.9.1482.","journal-title":"Neurology"},{"key":"119_CR37","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1111\/j.1750-3639.1998.tb00177.x","volume":"8","author":"JL Velayos","year":"1998","unstructured":"Velayos JL, Oliva M, Alfageme F: Afferent projections to the mediodorsal and anterior thalamic nuclei in the cat. Anatomical-clinical correlations. Brain Pathol. 1998, 8: 549-552.","journal-title":"Brain Pathol"},{"key":"119_CR38","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1016\/j.neuron.2011.12.040","volume":"73","author":"A Raj","year":"2012","unstructured":"Raj A, Kuceyeski A, Weiner M: A network diffusion model of disease progression in dementia. Neuron. 2012, 73: 1204-1215. 10.1016\/j.neuron.2011.12.040.","journal-title":"Neuron"},{"key":"119_CR39","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1007\/s00401-011-0907-y","volume":"122","author":"ME Murray","year":"2011","unstructured":"Murray ME, Dejesus-Hernandez M, Rutherford NJ, Baker M, Duara R, Graff-Radford NR, Wszolek ZK, Ferman TJ, Josephs KA, Boylan KB, Rademakers R, Dickson DW: Clinical and neuropathologic heterogeneity of c9FTD\/ALS associated with hexanucleotide repeat expansion in C9ORF72. Acta Neuropathologica. 2011, 122: 673-690. 10.1007\/s00401-011-0907-y.","journal-title":"Acta Neuropathologica"}],"container-title":["Alzheimer's Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/alzrt144.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/alzrt144\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/alzrt144.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T10:28:32Z","timestamp":1728383312000},"score":1,"resource":{"primary":{"URL":"https:\/\/alzres.biomedcentral.com\/articles\/10.1186\/alzrt144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,24]]},"references-count":39,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2012,10]]}},"alternative-id":["119"],"URL":"https:\/\/doi.org\/10.1186\/alzrt144","relation":{},"ISSN":["1758-9193"],"issn-type":[{"value":"1758-9193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,24]]},"assertion":[{"value":"31 May 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2012","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 August 2012","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 September 2012","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"41"}}