{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T13:48:53Z","timestamp":1761918533568},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2003,11,6]],"date-time":"2003-11-06T00:00:00Z","timestamp":1068076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2003,11,6]],"date-time":"2003-11-06T00:00:00Z","timestamp":1068076800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"DOI":"10.1186\/ar1018","type":"journal-article","created":{"date-parts":[[2003,11,14]],"date-time":"2003-11-14T07:19:20Z","timestamp":1068794360000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Novel approaches to gene expression analysis of active polyarticular juvenile rheumatoid arthritis"],"prefix":"10.1186","volume":"6","author":[{"given":"James N","family":"Jarvis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor","family":"Dozmorov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaiyu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark Barton","family":"Frank","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Szodoray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Alex","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Centola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2003,11,6]]},"reference":[{"key":"1010_CR1","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1097\/00002281-199809000-00011","volume":"10","author":"JN Jarvis","year":"1998","unstructured":"Jarvis JN: Pathogenesis and mechanisms of inflammation in the childhood rheumatic diseases. Curr Opin Rheumatol. 1998, 10: 459-467.","journal-title":"Curr Opin Rheumatol"},{"key":"1010_CR2","doi-asserted-by":"publisher","first-page":"2224","DOI":"10.1002\/1529-0131(200110)44:10<2224::AID-ART384>3.0.CO;2-H","volume":"44","author":"WP Arend","year":"2001","unstructured":"Arend WP: The innate immune system in rheumatoid arthritis. Arthritis Rheum. 2001, 44: 2224-2234. 10.1002\/1529-0131(200110)44:10<2224::AID-ART384>3.3.CO;2-8.","journal-title":"Arthritis Rheum"},{"key":"1010_CR3","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1111\/j.1600-065X.1999.tb01318.x","volume":"169","author":"D Lo","year":"1999","unstructured":"Lo D, Feng L, Li L, Carson MJ, Crowley M, Pauza M, Nguyen A, Reilly CR: Integrating innate and adaptive immunity in the whole animal. Immunol Rev. 1999, 169: 225-239.","journal-title":"Immunol Rev"},{"key":"1010_CR4","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1126\/science.272.5258.50","volume":"72","author":"DT Fearon","year":"1996","unstructured":"Fearon DT, Locksley RM: The instructive role of innate immunity in the acquired immune response. Science. 1996, 72: 50-53.","journal-title":"Science"},{"key":"1010_CR5","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1002\/1529-0131(200101)44:1<13::AID-ANR3>3.0.CO;2-6","volume":"44","author":"KJ Warrington","year":"2001","unstructured":"Warrington KJ, Seisuke T, Goronzy JJ, Weyand CM: CD4+, CD28-T cells in rheumatoid arthritis patients combine features of innate and adaptive immune systems. Arthritis Rheum. 2001, 44: 13-20. 10.1002\/1529-0131(200101)44:1<13::AID-ANR3>3.0.CO;2-6.","journal-title":"Arthritis Rheum"},{"key":"1010_CR6","doi-asserted-by":"publisher","first-page":"437","DOI":"10.3928\/0090-4481-20020701-08","volume":"31","author":"JN Jarvis","year":"2002","unstructured":"Jarvis JN: Juvenile rheumatoid arthritis: a guide for practitioners. Pediatr Ann. 2002, 31: 437-446.","journal-title":"Pediatr Ann"},{"key":"1010_CR7","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1093\/hmg\/10.17.1793","volume":"10","author":"AM Bowcock","year":"2001","unstructured":"Bowcock AM, Shannon W, Du F, Duncan J, Cao K, Aftergut K, Catier J, Fernandez-Vina MA, Menter A: Insights into psoriasis and other inflammatory diseases from large-scale gene expression studies. Hum Mol Genet. 2001, 10: 1793-1805. 10.1093\/hmg\/10.17.1793.","journal-title":"Hum Mol Genet"},{"key":"1010_CR8","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1093\/hmg\/10.5.445","volume":"10","author":"IC Lawrance","year":"2001","unstructured":"Lawrance IC, Fiocchi C, Chakravarti S: Ulcerative colitis and Crohn's disease: distinctive gene expression profiles and novel susceptibility candidate genes. Hum Mol Genet. 2001, 10: 445-456. 10.1093\/hmg\/10.5.445.","journal-title":"Hum Mol Genet"},{"key":"1010_CR9","doi-asserted-by":"publisher","first-page":"2150","DOI":"10.1073\/pnas.94.6.2150","volume":"94","author":"RA Heller","year":"1997","unstructured":"Heller RA, Schena M, Chai A, Shalon D, Bedilion T, Gilmore J, Woolley DE, Davis RW: Discovery and analysis of inflammatory disease-related genes using cDNA microarrays. Proc Natl Acad Sci USA. 1997, 94: 2150-2155. 10.1073\/pnas.94.6.2150.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1010_CR10","first-page":"1","volume":"38","author":"JT Cassidy","year":"1989","unstructured":"Cassidy JT, Levinson JE, Brewer EJ: The development of classification criteria for children with juvenile rheumatoid arthritis. Bull Rheum Dis. 1989, 38: 1-7.","journal-title":"Bull Rheum Dis"},{"key":"1010_CR11","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1542\/peds.90.6.945","volume":"90","author":"JN Jarvis","year":"1992","unstructured":"Jarvis JN, Pousak T, Krenz M: Detection of IgM rheumatoid factors by ELISA in children with juvenile rheumatoid arthritis: correlation with articular disease and laboratory abnormalities. Pediatrics. 1992, 90: 945-949.","journal-title":"Pediatrics"},{"key":"1010_CR12","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1056\/NEJM198605153142001","volume":"314","author":"EJ Brewer","year":"1986","unstructured":"Brewer EJ, Giannini EH, Kuzmina N, Alekseev L: Penicillamine and hydroxychloroquine in the treatment of severe juvenile rheumatoid arthritis. Results of the USA\u2013USSR double-blind controlled trial. N Engl J Med. 1986, 314: 1269-1276.","journal-title":"N Engl J Med"},{"key":"1010_CR13","first-page":"114","volume":"20","author":"JN Jarvis","year":"1993","unstructured":"Jarvis JN, Pousak T, Krenz M, Iobidze MV, Taylor H: Complement activation and immune complexes in juvenile rheumatoid arthritis. J Rheumatol. 1993, 20: 114-117.","journal-title":"J Rheumatol"},{"key":"1010_CR14","first-page":"1124","volume":"21","author":"JN Jarvis","year":"1994","unstructured":"Jarvis JN, Iobidze M, Taylor H, Krenz M: Complement activation and immune complexes in children with polyarticular JRA: a longitudinal study. J Rheumatol. 1994, 21: 1124-1127.","journal-title":"J Rheumatol"},{"key":"1010_CR15","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1093\/bioinformatics\/19.2.204","volume":"19","author":"I Dozmorov","year":"2003","unstructured":"Dozmorov I, Centola M: An associative of gene expression array data. Bioinformatics. 2003, 19: 204-211. 10.1093\/bioinformatics\/19.2.204.","journal-title":"Bioinformatics"},{"key":"1010_CR16","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1089\/106652701753307485","volume":"8","author":"DM Rocke","year":"2001","unstructured":"Rocke DM, Durbin B: A model for measurement error for gene expression arrays. Comput Biol. 2001, 8: 557-569. 10.1089\/106652701753307485.","journal-title":"Comput Biol"},{"key":"1010_CR17","doi-asserted-by":"publisher","first-page":"S323","DOI":"10.1093\/bioinformatics\/17.suppl_1.S323","volume":"Suppl 1","author":"A Zien","year":"2001","unstructured":"Zien A, Aigner T, Zimmer R, Lengauer T: Centralization: a new method for the normalization of gene expression data. Bioinformatics. 2001, Suppl 1: S323-331.","journal-title":"Bioinformatics"},{"key":"1010_CR18","doi-asserted-by":"publisher","first-page":"9834","DOI":"10.1073\/pnas.97.18.9834","volume":"97","author":"ML Lee","year":"2000","unstructured":"Lee ML, Kuo FC, Whitmore GA, Sklar J: Importance of replication in microarray gene expression studies: statistical methods and evidence from repetitive cDNA hybridizations. Proc Natl Acad Sci USA. 2000, 97: 9834-9839. 10.1073\/pnas.97.18.9834.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1010_CR19","doi-asserted-by":"publisher","first-page":"335","DOI":"10.2165\/00128072-200204050-00006","volume":"4","author":"IC Chikanza","year":"2002","unstructured":"Chikanza IC: Juvenile rheumatoid arthritis: therapeutic perspectives. Paediatr Drugs. 2002, 4: 335-348.","journal-title":"Paediatr Drugs"},{"key":"1010_CR20","first-page":"1071","volume":"29","author":"MA Muzaffer","year":"2002","unstructured":"Muzaffer MA, Dayer JM, Feldman BM, Pruzanski W, Roux-Lombard P, Schneider R, Laxer RM, Silverman ED: Differences in the profiles of circulating levels of soluble tumor necrosis factor receptors and interleukin 1 receptor antagonist reflect the heterogeneity of the subgroups of juvenile rheumatoid arthritis. J Rheumatol. 2002, 29: 1071-1078.","journal-title":"J Rheumatol"},{"key":"1010_CR21","doi-asserted-by":"publisher","first-page":"3645","DOI":"10.4049\/jimmunol.170.7.3645","volume":"170","author":"R Bommireddy","year":"2003","unstructured":"Bommireddy R, Ormsby I, Yin M, Boivin GP, Babcock GF, Doetschman T: TGFbeta1 inhibits Ca(2+)-calcineurin-mediated activation in thymocytes. J Immunol. 2003, 170: 3645-3652.","journal-title":"J Immunol"},{"key":"1010_CR22","doi-asserted-by":"crossref","first-page":"4612","DOI":"10.4049\/jimmunol.163.8.4612","volume":"163","author":"Z Khalkhali-Ellis","year":"1999","unstructured":"Khalkhali-Ellis Z, Bulla GA, Schlesinger LS, Kirschmann DA, Moore TL, Hendrix MJ: C1q-containing immune complexes purified from sera of juvenile rheumatoid arthritis patients mediate IL-8 production by human synoviocytes: role of C1q receptors. J Immunol. 1999, 163: 4612-4620.","journal-title":"J Immunol"},{"key":"1010_CR23","first-page":"425","volume":"26","author":"F De Benedetti","year":"1999","unstructured":"De Benedetti F, Pignatti P, Bernasconi S, Gerloni V, Matsushima K, Caporali R, Montecucco CM, Sozzani S, Fantini F, Martini A: Interleukin 8 and monocyte chemoattractant protein-1 in patients with juvenile rheumatoid arthritis. Relation to onset types, disease activity, and synovial fluid leukocytes. J Rheumatol. 1999, 26: 425-431.","journal-title":"J Rheumatol"},{"key":"1010_CR24","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1007\/BF02229700","volume":"15","author":"B Kirel","year":"1996","unstructured":"Kirel B, Yetgin S, Saatci U, Ozen S, Bakkaloglu A, Besbas N: Anaemia in juvenile chronic arthritis. Clin Rheumatol. 1996, 15: 236-241.","journal-title":"Clin Rheumatol"},{"key":"1010_CR25","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1136\/ard.57.8.487","volume":"57","author":"S Wakisaka","year":"1998","unstructured":"Wakisaka S, Suzuki N, Takeno M, Takeba Y, Nagafuchi H, Saito N, Hashimoto H, Tomita T, Ochi T, Sakane T: Involvement of simultaneous multiple transcription factor expression, including cAMP responsive element binding protein and OCT-1, for synovial cell outgrowth in patients with rheumatoid arthritis. Ann Rheum Dis. 1998, 57: 487-494.","journal-title":"Ann Rheum Dis"},{"key":"1010_CR26","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1046\/j.1365-3083.2002.01179.x","volume":"56","author":"T Matsunaga","year":"2002","unstructured":"Matsunaga T, Ishida T, Takekawa M, Nishimura S, Adachi M, Imai K: Analysis of gene expression during maturation of immature dendritic cells derived from peripheral blood monocytes. Scand J Immunol. 2002, 56: 593-601. 10.1046\/j.1365-3083.2002.01179.x.","journal-title":"Scand J Immunol"},{"key":"1010_CR27","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1111\/j.1365-2249.1995.tb02272.x","volume":"101","author":"S Lopez","year":"1995","unstructured":"Lopez S, Halbwachs-Mecarelli L, Ravaud P, Bessou G, Dougados M, Porteu F: Neutrophil expression of tumour necrosis factor receptors (TNF-R) and of activation markers (CD11b, CD43, CD63) in rheumatoid arthritis. Clin Exp Immunol. 1995, 101: 25-32.","journal-title":"Clin Exp Immunol"},{"key":"1010_CR28","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1006\/bbrc.1998.8725","volume":"246","author":"Y Koyama","year":"1998","unstructured":"Koyama Y, Suzuki M, Yoshida T: CD63, a member of tetraspan transmembrane protein family, induces cellular spreading by reaction with monoclonal antibody on substrata. Biochem Biophys Res Commun. 1998, 246: 841-846. 10.1006\/bbrc.1998.8725.","journal-title":"Biochem Biophys Res Commun"},{"key":"1010_CR29","first-page":"1239","volume":"17","author":"A Mobasheri","year":"2002","unstructured":"Mobasheri A, Vannucci SJ, Bondy CA, Carter SD, Innes JF, Arteaga MF, Trujillo E, Ferraz I, Shakibaei M, Martin-Vasallo P: Glucose transport and metabolism in chondrocytes: a key to understanding chondrogenesis, skeletal development and cartilage degradation in osteoarthritis. Histol Histopathol. 2002, 17: 1239-1267.","journal-title":"Histol Histopathol"},{"key":"1010_CR30","first-page":"369","volume":"29","author":"MP Scola","year":"2002","unstructured":"Scola MP, Thompson SD, Brunner HI, Tsoras MK, Witte D, Van D, Grom AA, Passo MH, Glass DN: Interferon-gamma:interleukin 4 ratios and associated type 1 cytokine expression in juvenile rheumatoid arthritis synovial tissue. J Rheumatol. 2002, 29: 369-378.","journal-title":"J Rheumatol"},{"key":"1010_CR31","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1002\/biof.5520080126","volume":"8","author":"V Araujo","year":"1998","unstructured":"Araujo V, Arnal C, Boronat M, Ruiz E, Dominguez C: Oxidant-antioxidant imbalance in blood of children with juvenile rheumatoid arthritis. Biofactors. 1998, 8: 155-159.","journal-title":"Biofactors"},{"key":"1010_CR32","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1111\/j.1574-695X.1994.tb00450.x","volume":"8","author":"JJ Robinson","year":"1994","unstructured":"Robinson JJ, Watson F, Bucknall RC, Edwards SW: Stimulation of reactive oxidant production in neutrophils by soluble and insoluble immune complexes occurs via different receptors\/ signal transduction systems. FEMS Immunol Med Microbiol. 1994, 8: 249-257. 10.1016\/0928-8244(94)90057-4.","journal-title":"FEMS Immunol Med Microbiol"},{"key":"1010_CR33","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1006\/cimm.1999.1481","volume":"194","author":"A Amit","year":"1999","unstructured":"Amit A, Kindzelskii AL, Zanoni J, Jarvis JN, Petty HR: Complement deposition on immune complexes reduces the frequencies of metabolic, proteolytic, and superoxide oscillations of migrating neutrophils. Cell Immunol. 1999, 194: 47-53. 10.1006\/cimm.1999.1481.","journal-title":"Cell Immunol"},{"key":"1010_CR34","first-page":"176","volume":"40","author":"SJ Lin","year":"1999","unstructured":"Lin SJ, Huang JL, Chao HC, Lee WY, Yang MH: A follow-up study of systemic-onset juvenile rheumatoid arthritis in children. Acta Paediatr Taiwan. 1999, 40: 176-181.","journal-title":"Acta Paediatr Taiwan"},{"key":"1010_CR35","first-page":"75","volume":"40","author":"A Sikora","year":"1994","unstructured":"Sikora A, Brozik H, Sikora JP, Golebiowska M: Chemiluminescence of peripheral blood leukocytes and activity of an inflammatory process in juvenile chronic arthritis (JCA). Acta Univ Carol [Med] (Praha). 1994, 40: 75-79.","journal-title":"Acta Univ Carol [Med] (Praha)"},{"key":"1010_CR36","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1007\/BF01534440","volume":"18","author":"G Egger","year":"1994","unstructured":"Egger G, Klemt C, Spendel S, Kaulfersch W, Kenzian H: Migratory activity of blood polymorphonuclear leukocytes during juvenile rheumatoid arthritis, demonstrated with a new whole-blood membrane filter assay. Inflammation. 1994, 18: 427-441. 10.1007\/BF01534440.","journal-title":"Inflammation"},{"key":"1010_CR37","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1080\/08916930290031676","volume":"35","author":"H Taubert","year":"2002","unstructured":"Taubert H, Riemann D, Kehlen A, Meye A, Bartel F, John V, Brandt J, Bache M, Wurl P, Schmidt H, Weber E: Expression of cathepsin B, D and L protein in juvenile idiopathic arthritis. Autoimmunity. 2002, 35: 221-224. 10.1080\/08916930290031676.","journal-title":"Autoimmunity"},{"key":"1010_CR38","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1002\/art.1780380714","volume":"38","author":"GM Keyszer","year":"1995","unstructured":"Keyszer GM, Heer AH, Kriegsmann J, Geiler T, Trabandt A, Keysser M, Gay RE, Gay S: Comparative analysis of cathepsin L, cathepsin D, and collagenase messenger RNA expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis, by in situ hybridization. Arthritis Rheum. 1995, 38: 976-984.","journal-title":"Arthritis Rheum"},{"key":"1010_CR39","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1002\/art.1780190610","volume":"19","author":"AR Poole","year":"1976","unstructured":"Poole AR, Hembry RM, Dingle JT, Pinder I, Ring EF, Cosh J: Secretion and localization of cathepsin D in synovial tissues removed from rheumatoid and traumatized joints. An immunohistochemical study. Arthritis Rheum. 1976, 19: 1295-1307.","journal-title":"Arthritis Rheum"},{"key":"1010_CR40","first-page":"655","volume":"19","author":"T Matsumoto","year":"2001","unstructured":"Matsumoto T, Tsurumoto T: Serum YKL-40 levels in rheumatoid arthritis: correlations between clinical and laborarory parameters. Clin Exp Rheumatol. 2001, 19: 655-660.","journal-title":"Clin Exp Rheumatol"},{"key":"1010_CR41","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.1093\/rheumatology\/39.12.1326","volume":"39","author":"K Vos","year":"2000","unstructured":"Vos K, Miltenburg AM, van Meijgaarden KE, van den Heuvel M, Elferink DG, van Galen PJ, van Hogezand RA, van Vliet-Daskalopoulou E, Ottenhoff TH, Breedveld FC, Boots AM, de Vries RR: Cellular immune response to human cartilage glycoprotein-39 (HC gp-39)-derived peptides in rheumatoid arthritis and other inflammatory conditions. Rheumatology (Oxford). 2000, 39: 1326-1331. 10.1093\/rheumatology\/39.12.1326.","journal-title":"Rheumatology (Oxford)"},{"key":"1010_CR42","doi-asserted-by":"publisher","first-page":"33","DOI":"10.4049\/jimmunol.166.1.33","volume":"166","author":"NS Patil","year":"2001","unstructured":"Patil NS, Sonderstrup G, Mellins ED: Autoantigenic HCgp39 epitopes are presented by the HLA-DM-dependent presentation pathway in human B cells. J Immunol. 2001, 166: 33-41.","journal-title":"J Immunol"},{"key":"1010_CR43","doi-asserted-by":"crossref","first-page":"25803","DOI":"10.1016\/S0021-9258(19)74461-5","volume":"268","author":"BE Hakala","year":"1993","unstructured":"Hakala BE, White C, Recklies AD: Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family. J Biol Chem. 1993, 268: 25803-25810.","journal-title":"J Biol Chem"},{"key":"1010_CR44","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1172\/JCI10905","volume":"106","author":"Y Liu","year":"2000","unstructured":"Liu Y, Wada R, Yamashita T, Mi Y, Deng CX, Hobson JP, Rosenfeldt HM, Nava VE, Chae SS, Lee MJ, Liu CH, Hla T, Spiegel S, Proia RL: Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. J Clin Invest. 2000, 106: 951-961.","journal-title":"J Clin Invest"}],"container-title":["Arthritis Res Ther"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/ar1018.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/ar1018\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/ar1018.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T16:07:34Z","timestamp":1714061254000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/ar1018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,11,6]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2003,2]]}},"alternative-id":["1010"],"URL":"https:\/\/doi.org\/10.1186\/ar1018","relation":{},"ISSN":["1478-6354"],"issn-type":[{"value":"1478-6354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,11,6]]},"assertion":[{"value":"30 May 2003","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 September 2003","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 October 2003","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 November 2003","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"R15"}}