{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T16:27:30Z","timestamp":1789921650597,"version":"4.0.1"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2004,12,7]],"date-time":"2004-12-07T00:00:00Z","timestamp":1102377600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2004,12,7]],"date-time":"2004-12-07T00:00:00Z","timestamp":1102377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>While morphologic and biochemical aspects of degenerative joint disease (osteoarthritis [OA]) have been elucidated by numerous studies, the molecular mechanisms underlying the progressive loss of articular cartilage during OA development remain largely unknown. The main focus of the present study was to gain more insight into molecular changes during the very early stages of mechanically induced cartilage degeneration and to relate molecular alterations to histological changes at distinct localizations of the joint. Studies on human articular cartilage are hampered by the difficulty of obtaining normal tissue and early-stage OA tissue, and they allow no progressive follow-up. An experimental OA model in dogs with a slow natural history of OA (Pond\u2013Nuki model) was therefore chosen. Anterior cruciate ligament transection (ACLT) was performed on 24 skeletally mature dogs to induce joint instability resulting in OA. Samples were taken from different joint areas after 6, 12, 24 and 48 weeks, and gene expression levels of common cartilage molecules were quantified in relation to the histological grading (modified Mankin score) of adjacent tissue. Histological changes reflected early progressive degenerative OA. Soon after ACLT, chondrocytes responded to the altered mechanical conditions by significant and stable elevation of collagen type II, collagen type I and YKL40 expression, which persisted throughout the study. In contrast to the mild to moderate histological alterations, these molecular changes were not progressive and were independent of the joint localization (tibia, femur, lateral, medial) and the extent of matrix degeneration. MMP13 remained unaltered until 24 weeks, and aggrecan and tenascinC remained unaltered until 48 weeks after ACLT. These findings indicate that elevated collagen type II, collagen type I and YKL40 mRNA expression levels are early and sensitive measures of ACLT-induced joint instability independent of a certain grade of morphological cartilage degeneration. A second phase of molecular changes in OA may begin around 48 weeks after ACLT with altered expression of further genes, such as MMP13, aggrecan and tenascin. Molecular changes observed in the present study suggest that dog cartilage responds to degenerative conditions by regulating the same genes in a similar direction as that observed for chondrocytes in late human OA.<\/jats:p>","DOI":"10.1186\/ar1471","type":"journal-article","created":{"date-parts":[[2005,1,12]],"date-time":"2005-01-12T19:28:03Z","timestamp":1105558083000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Early and stable upregulation of collagen type II, collagen type I and YKL40 expression levels in cartilage during early experimental osteoarthritis occurs independent of joint location and histological grading"],"prefix":"10.1186","volume":"7","author":[{"given":"Helga","family":"Lorenz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfram","family":"Wenz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mate","family":"Ivancic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Steck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiltrud","family":"Richter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2004,12,7]]},"reference":[{"key":"1352_CR1","first-page":"818","volume":"16","author":"ME Adams","year":"1989","unstructured":"Adams ME: Cartilage hypertrophy following canine anterior cruciate ligament transection differs among different areas of the joint. J Rheumatol. 1989, 16: 818-824.","journal-title":"J Rheumatol"},{"key":"1352_CR2","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1002\/jor.1100100406","volume":"10","author":"JP Pelletier","year":"1992","unstructured":"Pelletier JP, Martel-Pelletier J, Mehraban F, Malemud CJ: Immunological analysis of proteoglycan structural changes in the early stage of experimental osteoarthritic canine cartilage lesions. J Orthop Res. 1992, 10: 511-523. 10.1002\/jor.1100100406.","journal-title":"J Orthop Res"},{"key":"1352_CR3","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1002\/art.1780260708","volume":"26","author":"JP Pelletier","year":"1983","unstructured":"Pelletier JP, Martel-Pelletier J, Altman RD, Ghandur-Mnaymneh L, Howell DS, Woessner JF: Collagenolytic activity and collagen matrix breakdown of the articular cartilage in the Pond\u2013Nuki dog model of osteoarthritis. Arthritis Rheum. 1983, 26: 866-874.","journal-title":"Arthritis Rheum"},{"key":"1352_CR4","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1302\/0301-620X.59B1.576611","volume":"59","author":"C McDevitt","year":"1977","unstructured":"McDevitt C, Gilbertson E, Muir H: An experimental model of osteoarthritis; early morphological and biochemical changes. J Bone Joint Surg Br. 1977, 59: 24-35.","journal-title":"J Bone Joint Surg Br"},{"key":"1352_CR5","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1002\/jor.1100140314","volume":"14","author":"CB Little","year":"1996","unstructured":"Little CB, Ghosh P, Bellenger CR: Topographic variation in biglycan and decorin synthesis by articular cartilage in the early stages of osteoarthritis: an experimental study in sheep. J Orthop Res. 1996, 14: 433-444. 10.1002\/jor.1100140314.","journal-title":"J Orthop Res"},{"key":"1352_CR6","first-page":"104","volume":"14","author":"E Vignon","year":"1987","unstructured":"Vignon E, Bejui J, Mathieu P, Hartmann JD, Ville G, Evreux JC, Descotes J: Histological cartilage changes in a rabbit model of osteoarthritis. J Rheumatol. 1987, 14: 104-106.","journal-title":"J Rheumatol"},{"key":"1352_CR7","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1136\/ard.32.4.387","volume":"32","author":"MJ Pond","year":"1973","unstructured":"Pond MJ, Nuki G: Experimentally-induced osteoarthritis in the dog. Ann Rheum Dis. 1973, 32: 387-388.","journal-title":"Ann Rheum Dis"},{"key":"1352_CR8","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1002\/jor.1100150207","volume":"15","author":"RL Sah","year":"1997","unstructured":"Sah RL, Yang AS, Chen AC, Hant JJ, Halili RB, Yoshioka M, Amiel D, Coutts RD: Physical properties of rabbit articular cartilage after transection of the anterior cruciate ligament. J Orthop Res. 1997, 15: 197-203. 10.1002\/jor.1100150207.","journal-title":"J Orthop Res"},{"key":"1352_CR9","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1002\/1529-0131(199905)42:5<993::AID-ANR19>3.0.CO;2-U","volume":"42","author":"JR Matyas","year":"1999","unstructured":"Matyas JR, Ehlers PF, Huang D, Adams ME: The early molecular natural history of experimental osteoarthritis. I. Progressive discoordinate expression of aggrecan and type II procollagen messenger RNA in the articular cartilage of adult animals. Arthritis Rheum. 1999, 42: 993-1002. 10.1002\/1529-0131(199905)42:5<993::AID-ANR19>3.0.CO;2-U.","journal-title":"Arthritis Rheum"},{"key":"1352_CR10","doi-asserted-by":"publisher","first-page":"1536","DOI":"10.1002\/art.10331","volume":"46","author":"JR Matyas","year":"2002","unstructured":"Matyas JR, Huang D, Chung M, Adams ME: Regional quantification of cartilage type II collagen and aggrecan messenger RNA in joints with early experimental osteoarthritis. Arthritis Rheum. 2002, 46: 1536-1543. 10.1002\/art.10331.","journal-title":"Arthritis Rheum"},{"key":"1352_CR11","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/S1063-4584(96)80015-X","volume":"4","author":"GS Dourado","year":"1996","unstructured":"Dourado GS, Adams ME, Matyas JR, Huang D: Expression of biglycan, decorin and fibromodulin in the hypertrophic phase of experimental osteoarthritis. Osteoarthritis Cartilage. 1996, 4: 187-196.","journal-title":"Osteoarthritis Cartilage"},{"key":"1352_CR12","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/S0304-4165(01)00122-2","volume":"1526","author":"G Bluteau","year":"2001","unstructured":"Bluteau G, Conrozier T, Mathieu P, Vignon E, Herbage D, Mallein-Gerin F: Matrix metalloproteinase-1, -3, -13 and aggrecanase-1 and -2 are differentially expressed in experimental osteoarthritis. Biochim Biophys Acta. 2001, 1526: 147-158.","journal-title":"Biochim Biophys Acta"},{"key":"1352_CR13","first-page":"247","volume":"39","author":"G Bluteau","year":"2002","unstructured":"Bluteau G, Gouttenoire J, Conrozier T, Mathieu P, Vignon E, Richard M, Herbage D, Mallein-Gerin F: Differential gene expression analysis in a rabbit model of osteoarthritis induced by anterior cruciate ligament (ACL) section. Biorheology. 2002, 39: 247-258.","journal-title":"Biorheology"},{"key":"1352_CR14","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/S0736-0266(01)00126-7","volume":"20","author":"MP Le Graverand","year":"2002","unstructured":"Le Graverand MP, Eggerer J, Vignon E, Otterness IG, Barclay L, Hart DA: Assessment of specific mRNA levels in cartilage regions in a lapine model of osteoarthritis. J Orthop Res. 2002, 20: 535-544. 10.1016\/S0736-0266(01)00126-7.","journal-title":"J Orthop Res"},{"key":"1352_CR15","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1053\/joca.1999.0270","volume":"8","author":"MP Hellio Le Graverand","year":"2000","unstructured":"Hellio Le Graverand MP, Reno C, Hart DA: Heterogenous response of knee cartilage to pregnancy in the rabbit: assessment of specific mRNA levels. Osteoarthritis Cartilage. 2000, 8: 53-62. 10.1053\/joca.1999.0270.","journal-title":"Osteoarthritis Cartilage"},{"key":"1352_CR16","doi-asserted-by":"crossref","first-page":"523","DOI":"10.2106\/00004623-197153030-00009","volume":"53","author":"HJ Mankin","year":"1971","unstructured":"Mankin HJ, Dorfman H, Lippiello L, Zarins A: Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data. J Bone Joint Surg Am. 1971, 53: 523-537.","journal-title":"J Bone Joint Surg Am"},{"key":"1352_CR17","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1097\/00003086-199402000-00039","volume":"299","author":"Y Sakakibara","year":"1994","unstructured":"Sakakibara Y, Miura T, Iwata H, Kikuchi T, Yamaguchi T, Yoshimi T, Itoh H: Effect of high-molecular-weight sodium hyaluronate on immobilized rabbit knee. Clin Orthop. 1994, 299: 282-292.","journal-title":"Clin Orthop"},{"key":"1352_CR18","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1002\/jor.1100180413","volume":"18","author":"W Wenz","year":"2000","unstructured":"Wenz W, Breusch SJ, Graf J, Stratmann U: Ultrastructural findings after intraarticular application of hyaluronan in a canine model of arthropathy. J Orthop Res. 2000, 18: 604-612. 10.1002\/jor.1100180413.","journal-title":"J Orthop Res"},{"key":"1352_CR19","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1002\/art.1780390914","volume":"39","author":"JP Caron","year":"1996","unstructured":"Caron JP, Fernandes JC, Martel-Pelletier J, Tardif G, Mineau F, Geng C, Pelletier JP: Chondroprotective effect of intraarticular injections of interleukin-1 receptor antagonist in experimental osteoarthritis. Suppression of collagenase-1 expression. Arthritis Rheum. 1996, 39: 1535-1544.","journal-title":"Arthritis Rheum"},{"key":"1352_CR20","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1002\/art.1780280515","volume":"28","author":"JP Pelletier","year":"1985","unstructured":"Pelletier JP, Martel-Pelletier J, Ghandur-Mnaymneh L, Howell DS, Woessner JF: Role of synovial membrane inflammation in cartilage matrix breakdown in the Pond\u2013Nuki dog model of osteoarthritis. Arthritis Rheum. 1985, 28: 554-561.","journal-title":"Arthritis Rheum"},{"key":"1352_CR21","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1002\/art.1780370706","volume":"37","author":"X Chevalier","year":"1994","unstructured":"Chevalier X, Groult N, Larget-Piet B, Zardi L, Hornebeck W: Tenascin distribution in articular cartilage from normal subjects and from patients with osteoarthritis and rheumatoid arthritis. Arthritis Rheum. 1994, 37: 1013-1022.","journal-title":"Arthritis Rheum"},{"key":"1352_CR22","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/S1063-4584(02)00368-0","volume":"11","author":"K Veje","year":"2003","unstructured":"Veje K, Hyllested-Winge JL, Ostergaard K: Topographic and zonal distribution of tenascin in human articular cartilage from femoral heads: normal versus mild and severe osteoarthritis. Osteoarthritis Cartilage. 2003, 11: 217-227. 10.1016\/S1063-4584(02)00368-0.","journal-title":"Osteoarthritis Cartilage"},{"key":"1352_CR23","first-page":"386","volume":"26","author":"D Pfander","year":"1999","unstructured":"Pfander D, Rahmanzadeh R, Scheller EE: Presence and distribution of collagen II, collagen I, fibronectin, and tenascin in rabbit normal and osteoarthritic cartilage. J Rheumatol. 1999, 26: 386-394.","journal-title":"J Rheumatol"},{"key":"1352_CR24","doi-asserted-by":"publisher","first-page":"1898","DOI":"10.1126\/science.1086432","volume":"301","author":"EF Kirkness","year":"2003","unstructured":"Kirkness EF, Bafna V, Halpern AL, Levy S, Remington K, Rusch DB, Delcher AL, Pop M, Wang W: The dog genome: survey sequencing and comparative analysis. Science. 2003, 301: 1898-1903. 10.1126\/science.1086432.","journal-title":"Science"},{"key":"1352_CR25","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/S0736-0266(00)00004-8","volume":"19","author":"LJ Bonassar","year":"2001","unstructured":"Bonassar LJ, Grodzinsky AJ, Frank EH, Davila SG, Bhaktav NR, Trippel SB: The effect of dynamic compression on the response of articular cartilage to insulin-like growth factor-I. J Orthop Res. 2001, 19: 11-17. 10.1016\/S0736-0266(00)00004-8.","journal-title":"J Orthop Res"},{"key":"1352_CR26","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1002\/jor.1100070502","volume":"7","author":"RL Sah","year":"1989","unstructured":"Sah RL, Kim YJ, Doong JY, Grodzinsky AJ, Plaas AH, Sandy JD: Biosynthetic response of cartilage explants to dynamic compression. J Orthop Res. 1989, 7: 619-636. 10.1002\/jor.1100070502.","journal-title":"J Orthop Res"},{"key":"1352_CR27","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1002\/art.1780380320","volume":"38","author":"JR Matyas","year":"1995","unstructured":"Matyas JR, Adams ME, Huang D, Sandell LJ: Discoordinate gene expression of aggrecan and type II collagen in experimental osteoarthritis. Arthritis Rheum. 1995, 38: 420-425.","journal-title":"Arthritis Rheum"},{"key":"1352_CR28","doi-asserted-by":"publisher","first-page":"163","DOI":"10.3109\/03008209909005280","volume":"40","author":"JR Matyas","year":"1999","unstructured":"Matyas JR, Huang D, Adams ME: A comparison of various 'housekeeping' probes for northern analysis of normal and osteoarthritic articular cartilage RNA. Connect Tissue Res. 1999, 40: 163-172.","journal-title":"Connect Tissue Res"},{"key":"1352_CR29","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1002\/art.20027","volume":"50","author":"JR Matyas","year":"2004","unstructured":"Matyas JR, Atley L, Ionescu M, Eyre DR, Poole AR: Analysis of cartilage biomarkers in the early phases of canine experimental osteoarthritis. Arthritis Rheum. 2004, 50: 543-552. 10.1002\/art.20027.","journal-title":"Arthritis Rheum"},{"key":"1352_CR30","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1159\/000074419","volume":"71","author":"M Jung","year":"2004","unstructured":"Jung M, Christgau S, Lukoschek M, Henriksen D, Richter W: Increased urinary concentration of collagen type II C-telopeptide fragments in patients with osteoarthritis. Pathobiology. 2004, 71: 70-76. 10.1159\/000074419.","journal-title":"Pathobiology"},{"key":"1352_CR31","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1136\/ard.62.10.939","volume":"62","author":"P Garnero","year":"2003","unstructured":"Garnero P, Conrozier T, Christgau S, Mathieu P, Delmas PD, Vignon E: Urinary type II collagen C-telopeptide levels are increased in patients with rapidly destructive hip osteoarthritis. Ann Rheum Dis. 2003, 62: 939-943. 10.1136\/ard.62.10.939.","journal-title":"Ann Rheum Dis"},{"key":"1352_CR32","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/S0934-8832(11)80055-7","volume":"12","author":"SL Carney","year":"1992","unstructured":"Carney SL, Billingham ME, Caterson B, Ratcliffe A, Bayliss MT, Hardingham TE, Muir H: Changes in proteoglycan turnover in experimental canine osteoarthritic cartilage. Matrix. 1992, 12: 137-147.","journal-title":"Matrix"},{"key":"1352_CR33","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1002\/jor.1100020301","volume":"2","author":"SL Carney","year":"1984","unstructured":"Carney SL, Billingham ME, Muir H, Sandy JD: Demonstration of increased proteoglycan turnover in cartilage explants from dogs with experimental osteoarthritis. J Orthop Res. 1984, 2: 201-206. 10.1002\/jor.1100020301.","journal-title":"J Orthop Res"},{"key":"1352_CR34","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1002\/art.1780270405","volume":"27","author":"JD Sandy","year":"1984","unstructured":"Sandy JD, Adams ME, Billingham ME, Plaas A, Muir H: In vivo and in vitro stimulation of chondrocyte biosynthetic activity in early experimental osteoarthritis. Arthritis Rheum. 1984, 27: 388-397.","journal-title":"Arthritis Rheum"},{"key":"1352_CR35","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1093\/rheumatology\/32.11.949","volume":"32","author":"JS Johansen","year":"1993","unstructured":"Johansen JS, Jensen HS, Price PA: A new biochemical marker for joint injury. Analysis of YKL-40 in serum and synovial fluid. Br J Rheumatol. 1993, 32: 949-955.","journal-title":"Br J Rheumatol"},{"key":"1352_CR36","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/0006-291X(88)90524-4","volume":"150","author":"JJ Rejman","year":"1988","unstructured":"Rejman JJ, Hurley WL: Isolation and characterization of a novel 39 kilodalton whey protein from bovine mammary secretions collected during the nonlactating period. Biochem Biophys Res Commun. 1988, 150: 329-334. 10.1016\/0006-291X(88)90524-4.","journal-title":"Biochem Biophys Res Commun"},{"key":"1352_CR37","doi-asserted-by":"publisher","first-page":"13076","DOI":"10.1074\/jbc.270.22.13076","volume":"270","author":"LM Shackelton","year":"1995","unstructured":"Shackelton LM, Mann DM, Millis AJ: Identification of a 38-kDa heparin-binding glycoprotein (gp38k) in differentiating vascular smooth muscle cells as a member of a group of proteins associated with tissue remodeling. J Biol Chem. 1995, 270: 13076-13083. 10.1074\/jbc.270.22.13076.","journal-title":"J Biol Chem"},{"key":"1352_CR38","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1002\/jlb.60.4.540","volume":"60","author":"SW Krause","year":"1996","unstructured":"Krause SW, Rehli M, Kreutz M, Schwarzfischer L, Paulauskis JD, Andreesen R: Differential screening identifies genetic markers of monocyte to macrophage maturation. J Leukoc Biol. 1996, 60: 540-545.","journal-title":"J Leukoc Biol"},{"key":"1352_CR39","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1161\/01.ATV.19.3.687","volume":"19","author":"RG Boot","year":"1999","unstructured":"Boot RG, van Achterberg TA, van Aken BE, Renkema GH, Jacobs MJ, Aerts JM, de Vries CJ: Strong induction of members of the chitinase family of proteins in atherosclerosis: chitotriosidase and human cartilage gp-39 expressed in lesion macrophages. Arterioscler Thromb Vasc Biol. 1999, 19: 687-694.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"1352_CR40","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1046\/j.1432-1327.1998.2510504.x","volume":"251","author":"GH Renkema","year":"1998","unstructured":"Renkema GH, Boot RG, Au FL, Donker-Koopman WE, Strijland A, Muijsers AO, Hrebicek M, Aerts JM: Chitotriosidase, a chitinase, and the 39-kDa human cartilage glycoprotein, a chitin-binding lectin, are homologues of family 18 glycosyl hydrolases secreted by human macrophages. Eur J Biochem. 1998, 251: 504-509. 10.1046\/j.1432-1327.1998.2510504.x.","journal-title":"Eur J Biochem"},{"key":"1352_CR41","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/S0006-291X(02)02585-8","volume":"299","author":"E Steck","year":"2002","unstructured":"Steck E, Breit S, Breusch SJ, Axt M, Richter W: Enhanced expression of the human chitinase 3-like 2 gene (YKL-39) but not chitinase 3-like 1 gene (YKL-40) in osteoarthritic cartilage. Biochem Biophys Res Commun. 2002, 299: 109-115. 10.1016\/S0006-291X(02)02585-8.","journal-title":"Biochem Biophys Res Commun"},{"key":"1352_CR42","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1136\/ard.62.10.995","volume":"62","author":"T Knorr","year":"2003","unstructured":"Knorr T, Obermayr F, Bartnik E, Zien A, Aigner T: YKL-39 (chitinase 3-like protein 2), but not YKL-40 (chitinase 3-like protein 1), is up regulated in osteoarthritic chondrocytes. Ann Rheum Dis. 2003, 62: 995-998. 10.1136\/ard.62.10.995.","journal-title":"Ann Rheum Dis"},{"key":"1352_CR43","doi-asserted-by":"publisher","first-page":"2777","DOI":"10.1002\/1529-0131(200112)44:12<2777::AID-ART465>3.0.CO;2-H","volume":"44","author":"T Aigner","year":"2001","unstructured":"Aigner T, Zien A, Gehrsitz A, Gebhard PM, McKenna L: Anabolic and catabolic gene expression pattern analysis in normal versus osteoarthritic cartilage using complementary DNA-array technology. Arthritis Rheum. 2001, 44: 2777-2789. 10.1002\/1529-0131(200112)44:12<2777::AID-ART465>3.0.CO;2-H.","journal-title":"Arthritis Rheum"}],"container-title":["Arthritis Res Ther"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/ar1471.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/ar1471\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/ar1471.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T10:25:32Z","timestamp":1728383132000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/ar1471"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12,7]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2004,11]]}},"alternative-id":["1352"],"URL":"https:\/\/doi.org\/10.1186\/ar1471","relation":{},"ISSN":["1478-6354"],"issn-type":[{"value":"1478-6354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,12,7]]},"assertion":[{"value":"20 August 2004","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 November 2004","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 November 2004","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 December 2004","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"R156"}}