{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:04:23Z","timestamp":1791180263132,"version":"4.1.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2006,1,9]],"date-time":"2006-01-09T00:00:00Z","timestamp":1136764800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2006,1,9]],"date-time":"2006-01-09T00:00:00Z","timestamp":1136764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Polyclonal B cell activation might be related to pathogenic over-expression of B-cell-activating factor (BAFF) in primary Sj\u00f6gren's syndrome (pSS) and other autoimmune diseases. We therefore investigated whether BAFF over-expression in pSS could be a primary, genetically determined event that leads to the disease. The complete BAFF gene was sequenced in Caucasian pSS patients and control individuals. The only single nucleotide polymorphism frequently observed, namely -871 T\/C in the promoter region, was then genotyped in 162 French patients with pSS and 90 French control individuals. No significant differences in allele (T allele frequency: 49.7% in patients with pSS versus 50% in controls; <jats:italic>P<\/jats:italic> = 0.94) and genotype frequencies of BAFF polymorphism were detected between pSS patients and control individuals. BAFF gene polymorphism was not associated with a specific pattern of antibody secretion either. T allele carriers had significantly increased BAFF protein serum levels (mean values of 8.6 and 5.7 ng\/ml in patients with TT and TC genotypes, respectively, versus 3.3 ng\/ml in patients with CC genotype; <jats:italic>P<\/jats:italic> = 0.01), although no correlation was observed between BAFF polymorphism and mRNA level. In conclusion, BAFF gene polymorphism is neither involved in genetic predisposition to pSS nor associated with a specific pattern of antibody production.<\/jats:p>","DOI":"10.1186\/ar1884","type":"journal-article","created":{"date-parts":[[2006,1,23]],"date-time":"2006-01-23T12:43:36Z","timestamp":1138020216000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["No evidence for an association between the -871 T\/C promoter polymorphism in the B-cell-activating factor gene and primary Sj\u00f6gren's syndrome"],"prefix":"10.1186","volume":"8","author":[{"given":"Jacques-Eric","family":"Gottenberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00e9mie","family":"Sellam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Ittah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Lavie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Proust","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Habib","family":"Zouali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christelle","family":"Sordet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Sibilia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert P","family":"Kimberly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Mariette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Miceli-Richard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,1,9]]},"reference":[{"key":"1762_CR1","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1146\/annurev.immunol.21.120601.141152","volume":"21","author":"F Mackay","year":"2003","unstructured":"Mackay F, Schneider P, Rennert P, Browning J: BAFF AND APRIL: a tutorial on B cell survival. Annu Rev Immunol. 2003, 21: 231-264. 10.1146\/annurev.immunol.21.120601.141152.","journal-title":"Annu Rev Immunol"},{"key":"1762_CR2","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1136\/ard.62.2.168","volume":"62","author":"X Mariette","year":"2003","unstructured":"Mariette X, Roux S, Zhang J, Bengoufa D, Lavie F, Zhou T, Kimberly RP: The level of BLyS (BAFF) correlates with the titre of autoantibodies in human Sjogren's syndrome. Ann Rheum Dis. 2003, 62: 168-171. 10.1136\/ard.62.2.168.","journal-title":"Ann Rheum Dis"},{"key":"1762_CR3","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1007\/s10875-004-6240-7","volume":"24","author":"P Szodoray","year":"2004","unstructured":"Szodoray P, Jellestad S, Alex P, Zhou T, Wilson PC, Centola M, Brun JG, Jonsson R: Programmed cell death of peripheral blood B cells determined by laser scanning cytometry in Sjogren's syndrome with a special emphasis on BAFF. J Clin Immunol. 2004, 24: 600-611. 10.1007\/s10875-004-6240-7.","journal-title":"J Clin Immunol"},{"key":"1762_CR4","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1172\/JCI0214121","volume":"109","author":"J Groom","year":"2002","unstructured":"Groom J, Kalled SL, Cutler AH, Olson C, Woodcock SA, Schneider P, Tschopp J, Cachero TG, Batten M, Wheway J, et al: Association of BAFF\/BLyS overexpression and altered B cell differentiation with Sjogren's syndrome. J Clin Invest. 2002, 109: 59-68. 10.1172\/JCI200214121.","journal-title":"J Clin Invest"},{"key":"1762_CR5","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/s10875-005-4091-5","volume":"25","author":"MV Jonsson","year":"2005","unstructured":"Jonsson MV, Szodoray P, Jellestad S, Jonsson R, Skarstein K: Association between circulating levels of the novel TNF family members APRIL and BAFF and lymphoid organization in Primary Sjogren's syndrome. J Clin Immunol. 2005, 25: 189-201. 10.1007\/s10875-005-4091-5.","journal-title":"J Clin Immunol"},{"key":"1762_CR6","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1002\/path.1533","volume":"202","author":"F Lavie","year":"2004","unstructured":"Lavie F, Miceli-Richard C, Quillard J, Roux S, Leclerc P, Mariette X: Expression of BAFF (BLyS) in T cells infiltrating labial salivary glands from patients with Sjogren's syndrome. J Pathol. 2004, 202: 496-502. 10.1002\/path.1533.","journal-title":"J Pathol"},{"key":"1762_CR7","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1038\/sj.gene.6363923","volume":"3","author":"A Kawasaki","year":"2002","unstructured":"Kawasaki A, Tsuchiya N, Fukazawa T, Hashimoto H, Tokunaga K: Analysis on the association of human BLYS (BAFF, TNFSF13B) polymorphisms with systemic lupus erythematosus and rheumatoid arthritis. Genes Immun. 2002, 3: 424-427. 10.1038\/sj.gene.6363923.","journal-title":"Genes Immun"},{"key":"1762_CR8","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1136\/ard.2004.030643","volume":"64","author":"JE Gottenberg","year":"2005","unstructured":"Gottenberg JE, Busson M, Cohen-Solal J, Lavie F, Abbed K, Kimberly RP, Sibilia J, Mariette X: Correlation of serum B lymphocyte stimulator and beta2 microglobulin with autoantibody secretion and systemic involvement in primary Sjogren's syndrome. Ann Rheum Dis. 2005, 64: 1050-1055. 10.1136\/ard.2004.030643.","journal-title":"Ann Rheum Dis"},{"key":"1762_CR9","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.1084\/jem.190.11.1697","volume":"190","author":"F Mackay","year":"1999","unstructured":"Mackay F, Woodcock SA, Lawton P, Ambrose C, Baetscher M, Schneider P, Tschopp J, Browning JL: Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations. J Exp Med. 1999, 190: 1697-1710. 10.1084\/jem.190.11.1697.","journal-title":"J Exp Med"},{"key":"1762_CR10","doi-asserted-by":"publisher","first-page":"748","DOI":"10.7326\/0003-4819-101-6-748","volume":"101","author":"JD Reveille","year":"1984","unstructured":"Reveille JD, Wilson RW, Provost TT, Bias WB, Arnett FC: Primary Sj\u00f6gren's syndrome and other autoimmune diseases in families. Prevalence and immunogenetic studies in six kindreds. Ann Intern Med. 1984, 101: 748-756.","journal-title":"Ann Intern Med"},{"key":"1762_CR11","doi-asserted-by":"publisher","first-page":"4314","DOI":"10.4049\/jimmunol.169.8.4314","volume":"169","author":"V Roschke","year":"2002","unstructured":"Roschke V, Sosnovtseva S, Ward CD, Hong JS, Smith R, Albert V, Stohl W, Baker KP, Ullrich S, Nardelli B, et al: BLyS and APRIL form biologically active heterotrimers that are expressed in patients with systemic immune-based rheumatic diseases. J Immunol. 2002, 169: 4314-4321.","journal-title":"J Immunol"},{"key":"1762_CR12","doi-asserted-by":"publisher","first-page":"3475","DOI":"10.1002\/art.11354","volume":"48","author":"W Stohl","year":"2003","unstructured":"Stohl W, Metyas S, Tan SM, Cheema GS, Oamar B, Xu D, Roschke V, Wu Y, Baker KP, Hilbert DM: B lymphocyte stimulator overexpression in patients with systemic lupus erythematosus: longitudinal observations. Arthritis Rheum. 2003, 48: 3475-3486. 10.1002\/art.11354.","journal-title":"Arthritis Rheum"},{"key":"1762_CR13","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1038\/nature03723","volume":"435","author":"JD Rioux","year":"2005","unstructured":"Rioux JD, Abbas AK: Paths to understanding the genetic basis of autoimmune disease. Nature. 2005, 435: 584-589. 10.1038\/nature03723.","journal-title":"Nature"},{"key":"1762_CR14","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1038\/sj.gene.6363770","volume":"2","author":"A Kawasaki","year":"2001","unstructured":"Kawasaki A, Tsuchiya N, Fukazawa T, Hashimoto H, Tokunaga K: Presence of four major haplotypes in human BCMA gene lack of association with systemic lupus erythematosus and rheumatoid arthritis. Genes Immun. 2001, 2: 276-279. 10.1038\/sj.gene.6363770.","journal-title":"Genes Immun"},{"key":"1762_CR15","first-page":"S383","volume-title":"Arthritis Rheum","author":"A Kawasaki","year":"2003","unstructured":"Kawasaki A, Tsuchiya T, Fukazawa T, Matsuta K, Hase H, Kobata T, Hashimoto H, Tokunaga K: Association of TACI polymorphisms with systemic lupus erythematosus and rheumatoid arthritis. Arthritis Rheum. 2003, S383-938."},{"key":"1762_CR16","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1038\/ng1600","volume":"37","author":"U Salzer","year":"2005","unstructured":"Salzer U, Chapel HM, Webster AD, Pan-Hammarstrom Q, Schmitt-Graeff A, Schlesier M, Peter HH, Rockstroh JK, Schneider P, Schaffer AA, et al: Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans. Nat Gen. 2005, 37: 820-828. 10.1038\/ng1600.","journal-title":"Nat Gen"},{"key":"1762_CR17","doi-asserted-by":"publisher","first-page":"2080","DOI":"10.1002\/art.21138","volume":"52","author":"W Stohl","year":"2005","unstructured":"Stohl W, Xu D, Kim KS, Koss MN, Jorgensen TN, Deocharan B, Metzger TE, Bixler SA, Hong YS, Ambrose CM, Mackay F, et al: BAFF overexpression and accelerated glomerular disease in mice with an incomplete genetic predisposition to systemic lupus erythematosus. Arthritis Rheum. 2005, 52: 2080-2091. 10.1002\/art.21138.","journal-title":"Arthritis Rheum"},{"key":"1762_CR18","doi-asserted-by":"publisher","first-page":"38220","DOI":"10.1074\/jbc.M306852200","volume":"278","author":"AL Gavin","year":"2003","unstructured":"Gavin AL, Ait-Azzouzene D, Ware CF, Nemazee D: DeltaBAFF, an alternate splice isoform that regulates receptor binding and biopresentation of the B cell survival cytokine, BAFF. J Biol Chem. 2003, 278: 38220-38228. 10.1074\/jbc.M306852200.","journal-title":"J Biol Chem"},{"key":"1762_CR19","doi-asserted-by":"publisher","first-page":"864","DOI":"10.4049\/jimmunol.174.2.864","volume":"174","author":"J Ohata","year":"2005","unstructured":"Ohata J, Zvaifler NJ, Nishio M, Boyle DL, Kalled SL, Carson DA, Kipps TJ: Fibroblast-like synoviocytes of mesenchymal origin express functional B cell-activating factor of the TNF family in response to proinflammatory cytokines. J Immunol. 2005, 174: 864-870.","journal-title":"J Immunol"},{"key":"1762_CR20","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1084\/jem.20041674","volume":"201","author":"M Krumbholz","year":"2005","unstructured":"Krumbholz M, Theil D, Derfuss T, Rosenwald A, Schrader F, Monoranu CM, Kalled SL, Hess DM, Serafini B, Aloisi F, et al: BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphoma. J Exp Med. 2005, 201: 195-200. 10.1084\/jem.20041674.","journal-title":"J Exp Med"},{"key":"1762_CR21","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1002\/art.21006","volume":"52","author":"TO Hjelmervik","year":"2005","unstructured":"Hjelmervik TO, Petersen K, Jonassen I, Jonsson R, Bolstad AI: Gene expression profiling of minor salivary glands clearly distinguishes primary Sjogren's syndrome patients from healthy control subjects. Arthritis Rheum. 2005, 52: 1534-1544. 10.1002\/art.21006.","journal-title":"Arthritis Rheum"},{"key":"1762_CR22","volume-title":"PNAS","author":"JE Gottenberg","year":"2006","unstructured":"Gottenberg JE, Cagnard N, Lucchesi C, Letourneur F, Mistou S, Lazure T, Ittah M, Ba N, Lepajollec C, Labetoulle M, et al: Activation of interferon pathways and recruitment of plasmacytoid dendritic cells in target organs of primary Sj\u00f6gren's syndrome. PNAS. 2006."}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/ar1884.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/ar1884\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/ar1884.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T10:49:56Z","timestamp":1728384596000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/ar1884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1,9]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2006,2]]}},"alternative-id":["1762"],"URL":"https:\/\/doi.org\/10.1186\/ar1884","relation":{},"ISSN":["1478-6354"],"issn-type":[{"value":"1478-6354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1,9]]},"assertion":[{"value":"29 August 2005","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 October 2005","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 December 2005","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 January 2006","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"R30"}}