{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:24:57Z","timestamp":1787019897784,"version":"build-2736575974"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2006,7,31]],"date-time":"2006-07-31T00:00:00Z","timestamp":1154304000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2006,7,31]],"date-time":"2006-07-31T00:00:00Z","timestamp":1154304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study was conducted to examine the frequency, phenotype, and functional profile of T lymphocytes that proliferate in response to type I collagen (CI) in patients with scleroderma (SSc). Peripheral blood mononuclear cells (PBMCs) from SSc patients, healthy controls, and rheumatoid arthritis disease controls were labeled with carboxy-fluorescein diacetate, succinimidyl ester (CFSE), cultured with or without antigen (bovine CI) for 14 days, and analysed by flow cytometry. Surface markers of proliferating cells were identified by multi-color flow cytometry. T-cell lines were derived after sorting for proliferating T cells (CFSE\n                    <jats:sup>low<\/jats:sup>\n                    ). Cytokine expression in CI-responsive T cells was detected by intracellular staining\/flow cytometry and by multiplex cytokine bead assay (Bio-Plex). A T-cell proliferative response to CI was detected in 8 of 25 (32%) SSc patients, but was infrequent in healthy or disease controls (3.6%;\n                    <jats:italic>p<\/jats:italic>\n                    = 0.009). The proliferating T cells expressed a CD4\n                    <jats:sup>+<\/jats:sup>\n                    , activated (CD25\n                    <jats:sup>+<\/jats:sup>\n                    ), memory (CD45RO\n                    <jats:sup>+<\/jats:sup>\n                    ) phenotype. Proliferation to CI did not correlate with disease duration or extent of skin involvement. T-cell lines were generated using\n                    <jats:italic>in vitro<\/jats:italic>\n                    CI stimulation to study the functional profile of these cells. Following activation of CI-reactive T cells, we detected intracellular interferon (IFN)-\u03b3 but not interleukin (IL)-4 by flow cytometry. Supernatants from the T-cell lines generated\n                    <jats:italic>in vitro<\/jats:italic>\n                    contained IL-2, IFN-\u03b3, GM-CSF (granulocyte macrophage-colony-stimulating factor), and tumour necrosis factor-\u03b1, but little or no IL-4 and IL-10, suggesting that CI-responsive T cells express a predominantly Th1 cytokine pattern. In conclusion, circulating memory CD4 T cells that proliferate to CI are present in a subset of patients with SSc, but are infrequent in healthy or disease controls.\n                  <\/jats:p>","DOI":"10.1186\/ar2025","type":"journal-article","created":{"date-parts":[[2006,8,2]],"date-time":"2006-08-02T04:30:57Z","timestamp":1154493057000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Characterisation of the immune response to type I collagen in scleroderma"],"prefix":"10.1186","volume":"8","author":[{"given":"Kenneth J","family":"Warrington","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usha","family":"Nair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura D","family":"Carbone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew H","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnold E","family":"Postlethwaite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,7,31]]},"reference":[{"key":"1901_CR1","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1002\/art.1780240410","volume":"24","author":"JM Seyer","year":"1981","unstructured":"Seyer JM, Kang AH, Rodnan G: Investigation of type I and type III collagens of the lung in progressive systemic sclerosis. Arthritis Rheum. 1981, 24: 625-631.","journal-title":"Arthritis Rheum"},{"key":"1901_CR2","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/S0889-857X(05)70296-9","volume":"22","author":"B White","year":"1996","unstructured":"White B: Immunopathogenesis of systemic sclerosis. Rheum Dis Clin North Am. 1996, 22: 695-708. 10.1016\/S0889-857X(05)70296-9.","journal-title":"Rheum Dis Clin North Am"},{"key":"1901_CR3","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1136\/ard.52.4.272","volume":"52","author":"U Fiocco","year":"1993","unstructured":"Fiocco U, Rosada M, Cozzi L, Ortolani C, De Silvestro G, Ruffatti A, Cozzi E, Gallo C, Todesco S: Early phenotypic activation of circulating helper memory T cells in scleroderma: correlation with disease activity. Ann Rheum Dis. 1993, 52: 272-277.","journal-title":"Ann Rheum Dis"},{"key":"1901_CR4","first-page":"375","volume":"69","author":"B Freundlich","year":"1987","unstructured":"Freundlich B, Jimenez SA: Phenotype of peripheral blood lymphocytes in patients with progressive systemic sclerosis: activated T lymphocytes and the effect of D-penicillamine therapy. Clin Exp Immunol. 1987, 69: 375-384.","journal-title":"Clin Exp Immunol"},{"key":"1901_CR5","first-page":"646","volume":"23","author":"VD Steen","year":"1996","unstructured":"Steen VD, Engel EE, Charley MR, Medsger TA: Soluble serum interleukin 2 receptors in patients with systemic sclerosis. J Rheumatol. 1996, 23: 646-649.","journal-title":"J Rheumatol"},{"key":"1901_CR6","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1002\/path.1711660307","volume":"166","author":"RJ Prescott","year":"1992","unstructured":"Prescott RJ, Freemont AJ, Jones CJ, Hoyland J, Fielding P: Sequential dermal microvascular and perivascular changes in the development of scleroderma. J Pathol. 1992, 166: 255-263. 10.1002\/path.1711660307.","journal-title":"J Pathol"},{"key":"1901_CR7","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1002\/art.1780200410","volume":"20","author":"R Fleischmajer","year":"1977","unstructured":"Fleischmajer R, Perlish JS, Reeves JR: Cellular infiltrates in scleroderma skin. Arthritis Rheum. 1977, 20: 975-984.","journal-title":"Arthritis Rheum"},{"key":"1901_CR8","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1002\/art.1780270607","volume":"27","author":"AD Roumm","year":"1984","unstructured":"Roumm AD, Whiteside TL, Medsger TA, Rodnan GP: Lymphocytes in the skin of patients with progressive systemic sclerosis. Quantification, subtyping, and clinical correlations. Arthritis Rheum. 1984, 27: 645-653.","journal-title":"Arthritis Rheum"},{"key":"1901_CR9","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1183\/09031936.95.08020266","volume":"8","author":"AU Wells","year":"1995","unstructured":"Wells AU, Lorimer S, Majumdar S, Harrison NK, Corrin B, Black CM, Jeffery PK, du Bois RM: Fibrosing alveolitis in systemic sclerosis: increase in memory T-cells in lung interstitium. Eur Respir J. 1995, 8: 266-271. 10.1183\/09031936.95.08020266.","journal-title":"Eur Respir J"},{"key":"1901_CR10","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1002\/art.20315","volume":"50","author":"LI Sakkas","year":"2004","unstructured":"Sakkas LI, Platsoucas CD: Is systemic sclerosis an antigen-driven T cell disease?. Arthritis Rheum. 2004, 50: 1721-1733. 10.1002\/art.20315.","journal-title":"Arthritis Rheum"},{"key":"1901_CR11","doi-asserted-by":"publisher","first-page":"3649","DOI":"10.4049\/jimmunol.168.7.3649","volume":"168","author":"LI Sakkas","year":"2002","unstructured":"Sakkas LI, Xu B, Artlett CM, Lu S, Jimenez SA, Platsoucas CD: Oligoclonal T cell expansion in the skin of patients with systemic sclerosis. J Immunol. 2002, 168: 3649-3659.","journal-title":"J Immunol"},{"key":"1901_CR12","first-page":"601","volume":"88","author":"JM Stuart","year":"1976","unstructured":"Stuart JM, Postlethwaite AE, Kang AH: Evidence for cell-mediated immunity to collagen in progressive systemic sclerosis. J Lab Clin Med. 1976, 88: 601-607.","journal-title":"J Lab Clin Med"},{"key":"1901_CR13","first-page":"493","volume":"73","author":"M Gurram","year":"1994","unstructured":"Gurram M, Pahwa S, Frieri M: Augmented interleukin-6 secretion in collagen-stimulated peripheral blood mononuclear cells from patients with systemic sclerosis. Ann Allergy. 1994, 73: 493-496.","journal-title":"Ann Allergy"},{"key":"1901_CR14","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1002\/art.1780340510","volume":"34","author":"E Hawrylko","year":"1991","unstructured":"Hawrylko E, Spertus A, Mele CA, Oster N, Frieri M: Increased interleukin-2 production in response to human type I collagen stimulation in patients with systemic sclerosis. Arthritis Rheum. 1991, 34: 580-587.","journal-title":"Arthritis Rheum"},{"key":"1901_CR15","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1002\/1529-0131(200005)43:5<1054::AID-ANR14>3.0.CO;2-W","volume":"43","author":"KM McKown","year":"2000","unstructured":"McKown KM, Carbone LD, Bustillo J, Seyer JM, Kang AH, Postlethwaite AE: Induction of immune tolerance to human type I collagen in patients with systemic sclerosis by oral administration of bovine type I collagen. Arthritis Rheum. 2000, 43: 1054-1061. 10.1002\/1529-0131(200005)43:5<1054::AID-ANR14>3.0.CO;2-W.","journal-title":"Arthritis Rheum"},{"key":"1901_CR16","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1002\/art.1780280708","volume":"28","author":"JE Huffstutter","year":"1985","unstructured":"Huffstutter JE, DeLustro FA, LeRoy EC: Cellular immunity to collagen and laminin in scleroderma. Arthritis Rheum. 1985, 28: 775-780.","journal-title":"Arthritis Rheum"},{"key":"1901_CR17","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1172\/JCI200316142","volume":"111","author":"V Turcanu","year":"2003","unstructured":"Turcanu V, Maleki SJ, Lack G: Characterization of lymphocyte responses to peanuts in normal children, peanut-allergic children, and allergic children who acquired tolerance to peanuts. J Clin Invest. 2003, 111: 1065-1072. 10.1172\/JCI200316142.","journal-title":"J Clin Invest"},{"key":"1901_CR18","doi-asserted-by":"crossref","unstructured":"Preliminary criteria for the classification of systemic sclerosis (scleroderma). Subcommittee for scleroderma criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee. Arthritis Rheum. 1980, 23: 581-590.","DOI":"10.1002\/art.1780230510"},{"key":"1901_CR19","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1002\/art.1780310302","volume":"31","author":"FC Arnett","year":"1988","unstructured":"Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS, et al: The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988, 31: 315-324.","journal-title":"Arthritis Rheum"},{"key":"1901_CR20","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1172\/JCI108634","volume":"59","author":"JM Seyer","year":"1977","unstructured":"Seyer JM, Hutcheson ET, Kang AH: Collagen polymorphism in normal and cirrhotic human liver. J Clin Invest. 1977, 59: 241-248.","journal-title":"J Clin Invest"},{"key":"1901_CR21","doi-asserted-by":"crossref","first-page":"3926","DOI":"10.4049\/jimmunol.162.7.3926","volume":"162","author":"L Rogge","year":"1999","unstructured":"Rogge L, Papi A, Presky DH, Biffi M, Minetti LJ, Miotto D, Agostini C, Semenzato G, Fabbri LM, Sinigaglia F: Antibodies to the IL-12 receptor beta 2 chain mark human Th1 but not Th2 cells in vitro and in vivo. J Immunol. 1999, 162: 3926-3932.","journal-title":"J Immunol"},{"key":"1901_CR22","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/0022-1759(94)90236-4","volume":"171","author":"AB Lyons","year":"1994","unstructured":"Lyons AB, Parish CR: Determination of lymphocyte division by flow cytometry. J Immunol Methods. 1994, 171: 131-137. 10.1016\/0022-1759(94)90236-4.","journal-title":"J Immunol Methods"},{"key":"1901_CR23","first-page":"41","volume-title":"Extracellular Matrix Biochemistry","author":"EJ Miller","year":"1984","unstructured":"Miller EJ: Chemistry of the collagens and their distribution. Extracellular Matrix Biochemistry. Edited by: Piez KA, Reddi AH. 1984, New York: Elsevier, 41-82."},{"key":"1901_CR24","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1172\/JCI108576","volume":"58","author":"TC Kravis","year":"1976","unstructured":"Kravis TC, Ahmed A, Brown TE, Fulmer JD, Crystal RG: Pathogenic mechanisms in pulmonary fibrosis: collagen-induced migration inhibition factor production and cytotoxicity mediated by lymphocytes. J Clin Invest. 1976, 58: 1223-1232.","journal-title":"J Clin Invest"},{"key":"1901_CR25","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.4049\/jimmunol.129.5.2156","volume":"129","author":"DJ Schrier","year":"1982","unstructured":"Schrier DJ, Phan SH, Ward PA: Cellular sensitivity to collagen in bleomycin-treated rats. J Immunol. 1982, 129: 2156-2159.","journal-title":"J Immunol"},{"key":"1901_CR26","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.4049\/jimmunol.163.2.1066","volume":"163","author":"FK Tan","year":"1999","unstructured":"Tan FK, Arnett FC, Antohi S, Saito S, Mirarchi A, Spiera H, Sasaki T, Shoichi O, Takeuchi K, Pandey JP, et al: Autoantibodies to the extracellular matrix microfibrillar protein, fibrillin-1, in patients with scleroderma and other connective tissue diseases. J Immunol. 1999, 163: 1066-1072.","journal-title":"J Immunol"},{"key":"1901_CR27","doi-asserted-by":"publisher","first-page":"233","DOI":"10.3109\/08916939708994732","volume":"25","author":"M Daskalova","year":"1997","unstructured":"Daskalova M, Taskov H, Dimitrova E, Baydanoff S: Humoral and cellular immune response to elastin in patients with systemic sclerosis. Autoimmunity. 1997, 25: 233-241.","journal-title":"Autoimmunity"},{"key":"1901_CR28","doi-asserted-by":"publisher","first-page":"4935","DOI":"10.4049\/jimmunol.165.9.4935","volume":"165","author":"WH Rao","year":"2000","unstructured":"Rao WH, Hales JM, Camp RD: Potent costimulation of effector T lymphocytes by human collagen type I. J Immunol. 2000, 165: 4935-4940.","journal-title":"J Immunol"},{"key":"1901_CR29","doi-asserted-by":"publisher","first-page":"3978","DOI":"10.4049\/jimmunol.174.7.3978","volume":"174","author":"KA Latham","year":"2005","unstructured":"Latham KA, Whittington KB, Zhou R, Qian Z, Rosloniec EF: Ex vivo characterization of the autoimmune T cell response in the HLA-DR1 mouse model of collagen-induced arthritis reveals long-term activation of type II collagen-specific cells and their presence in arthritic joints. J Immunol. 2005, 174: 3978-3985.","journal-title":"J Immunol"},{"key":"1901_CR30","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1172\/JCI200112516","volume":"108","author":"S Markovic-Plese","year":"2001","unstructured":"Markovic-Plese S, Cortese I, Wandinger KP, McFarland HF, Martin R: CD4+ CD28- costimulation-independent T cells in multiple sclerosis. J Clin Invest. 2001, 108: 1185-1194. 10.1172\/JCI200112516.","journal-title":"J Clin Invest"},{"key":"1901_CR31","doi-asserted-by":"publisher","first-page":"2027","DOI":"10.1172\/JCI118638","volume":"97","author":"D Schmidt","year":"1996","unstructured":"Schmidt D, Goronzy JJ, Weyand CM: CD4+ CD7- CD28- T cells are expanded in rheumatoid arthritis and are characterized by autoreactivity. J Clin Invest. 1996, 97: 2027-2037.","journal-title":"J Clin Invest"},{"key":"1901_CR32","doi-asserted-by":"crossref","first-page":"6572","DOI":"10.4049\/jimmunol.162.11.6572","volume":"162","author":"AN Vallejo","year":"1999","unstructured":"Vallejo AN, Brandes JC, Weyand CM, Goronzy JJ: Modulation of CD28 expression: distinct regulatory pathways during activation and replicative senescence. J Immunol. 1999, 162: 6572-6579.","journal-title":"J Immunol"},{"key":"1901_CR33","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1172\/JCI200319607","volume":"112","author":"I Goldstein","year":"2003","unstructured":"Goldstein I, Ben-Horin S, Li J, Bank I, Jiang H, Chess L: Expression of the \u03b11\u03b21 integrin, VLA-1, marks a distinct subset of human CD4+ memory T cells. J Clin Invest. 2003, 112: 1444-1454. 10.1172\/JCI200319607.","journal-title":"J Clin Invest"},{"key":"1901_CR34","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1128\/CDLI.6.5.658-659.1999","volume":"6","author":"SP Atamas","year":"1999","unstructured":"Atamas SP, White B: Interleukin 4 in systemic sclerosis: not just an increase. Clin Diagn Lab Immunol. 1999, 6: 658-659.","journal-title":"Clin Diagn Lab Immunol"},{"key":"1901_CR35","first-page":"328","volume":"24","author":"M Hasegawa","year":"1997","unstructured":"Hasegawa M, Fujimoto M, Kikuchi K, Takehara K: Elevated serum levels of interleukin 4 (IL-4), IL-10, and IL-13 in patients with systemic sclerosis. J Rheumatol. 1997, 24: 328-332.","journal-title":"J Rheumatol"},{"key":"1901_CR36","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1172\/JCI116015","volume":"90","author":"AE Postlethwaite","year":"1992","unstructured":"Postlethwaite AE, Holness MA, Katai H, Raghow R: Human fibroblasts synthesize elevated levels of extracellular matrix proteins in response to interleukin 4. J Clin Invest. 1992, 90: 1479-1485.","journal-title":"J Clin Invest"},{"key":"1901_CR37","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1002\/1529-0131(199906)42:6<1168::AID-ANR13>3.0.CO;2-L","volume":"42","author":"SP Atamas","year":"1999","unstructured":"Atamas SP, Yurovsky VV, Wise R, Wigley FM, Goter Robinson CJ, Henry P, Alms WJ, White B: Production of type 2 cytokines by CD8+ lung cells is associated with greater decline in pulmonary function in patients with systemic sclerosis. Arthritis Rheum. 1999, 42: 1168-1178. 10.1002\/1529-0131(199906)42:6<1168::AID-ANR13>3.0.CO;2-L.","journal-title":"Arthritis Rheum"},{"key":"1901_CR38","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/S0923-1811(01)00128-1","volume":"27","author":"S Sato","year":"2001","unstructured":"Sato S, Hasegawa M, Takehara K: Serum levels of interleukin-6 and interleukin-10 correlate with total skin thickness score in patients with systemic sclerosis. J Dermatol Sci. 2001, 27: 140-146. 10.1016\/S0923-1811(01)00128-1.","journal-title":"J Dermatol Sci"},{"key":"1901_CR39","doi-asserted-by":"publisher","first-page":"2722","DOI":"10.1002\/eji.1830250950","volume":"25","author":"CE Demeure","year":"1995","unstructured":"Demeure CE, Yang LP, Byun DG, Ishihara H, Vezzio N, Delespesse G: Human naive CD4 T cells produce interleukin-4 at priming and acquire a Th2 phenotype upon repetitive stimulations in neutral conditions. Eur J Immunol. 1995, 25: 2722-2725.","journal-title":"Eur J Immunol"},{"key":"1901_CR40","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1046\/j.1365-2567.1996.503575.x","volume":"87","author":"SB Cohen","year":"1996","unstructured":"Cohen SB, Webb LM, Feldmann M: The method of deriving human T-cell clones alters the proportion of IL-10-producing cells. Immunology. 1996, 87: 343-347. 10.1046\/j.1365-2567.1996.503575.x.","journal-title":"Immunology"},{"key":"1901_CR41","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1046\/j.1365-2249.1999.00842.x","volume":"116","author":"M Molteni","year":"1999","unstructured":"Molteni M, Della Bella S, Mascagni B, Bazzi S, Zulian C, Compasso S, Lessi M, Scorza R: Increased interferon-gamma (IFN-\u03b3) levels produced in vitro by alloactivated T lymphocytes in systemic sclerosis and Raynaud's phenomenon. Clin Exp Immunol. 1999, 116: 164-168. 10.1046\/j.1365-2249.1999.00842.x.","journal-title":"Clin Exp Immunol"},{"key":"1901_CR42","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1084\/jem.162.2.516","volume":"162","author":"M R Duncan","year":"1985","unstructured":"Duncan M, Berman B: Gamma interferon is the lymphokine and beta interferon the monokine responsible for inhibition of fibroblast collagen production and late but not early fibroblast proliferation. J Exp Med. 1985, 162: 516-527. 10.1084\/jem.162.2.516.","journal-title":"J Exp Med"},{"key":"1901_CR43","doi-asserted-by":"publisher","first-page":"3855","DOI":"10.4049\/jimmunol.171.7.3855","volume":"171","author":"K Yamane","year":"2003","unstructured":"Yamane K, Ihn H, Asano Y, Jinnin M, Tamaki K: Antagonistic effects of TNF-\u03b1 on TGF-\u03b2 signaling through down-regulation of TGF-\u03b2 receptor type II in human dermal fibroblasts. J Immunol. 2003, 171: 3855-3862.","journal-title":"J Immunol"},{"key":"1901_CR44","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1111\/1523-1747.ep12582818","volume":"107","author":"O Rekdal","year":"1996","unstructured":"Rekdal O, Osterud B, Svendsen JS, Winberg JO: Evidence for exclusive role of the p55 tumor necrosis factor (TNF) receptor in mediating the TNF-induced collagenase expression by human dermal fibroblasts. J Invest Dermatol. 1996, 107: 565-568. 10.1111\/1523-1747.ep12582818.","journal-title":"J Invest Dermatol"},{"key":"1901_CR45","first-page":"4109","volume":"52","author":"AE Postlethwaite","year":"2005","unstructured":"Postlethwaite AE, Furst DE, Wong WK, Clements P: Oral tolerance (OT) induction to type I collagen (CI) significantly reduces the skin score in patients with diffuse systemic sclerosis (SSc) with late-phase disease. Results of a NIAMS\/NIAID multicenter phase II placebo-controlled double blind clinical trial. Arthritis Rheum. 2005, 52: 4109-L28.","journal-title":"Arthritis Rheum"}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/ar2025.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/ar2025\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/ar2025.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T06:26:15Z","timestamp":1728368775000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/ar2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7,31]]},"references-count":45,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2006,8]]}},"alternative-id":["1901"],"URL":"https:\/\/doi.org\/10.1186\/ar2025","relation":{},"ISSN":["1478-6354"],"issn-type":[{"value":"1478-6354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7,31]]},"assertion":[{"value":"21 February 2006","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2006","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2006","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2006","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"R136"}}