{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:28:05Z","timestamp":1785324485121,"version":"3.55.0"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2006,12,13]],"date-time":"2006-12-13T00:00:00Z","timestamp":1165968000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2006,12,13]],"date-time":"2006-12-13T00:00:00Z","timestamp":1165968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of the present study was to evaluate the relative contribution of human leukocyte antigen (HLA)-C locus alleles in determining the risk and the clinical expression of psoriatic arthritis (PsA). One hundred PsA patients were randomly selected and grouped into three disease subsets: oligoarthritis (<jats:italic>n<\/jats:italic> = 40), polyarthritis (<jats:italic>n<\/jats:italic> = 25) and spondylitis (<jats:italic>n<\/jats:italic> = 35). The HLA-C locus profile of this cohort was studied by methods based on molecular biology and was compared with that of 45 patients with psoriasis vulgaris and 177 healthy blood donors from the same ethnic origin. HLA-Cw*0602 was found associated with both psoriasis (odds ratio (OR) 6.2; 95% confidence interval (CI) 3.1 to 12.5; <jats:italic>p<\/jats:italic> &lt; 0.0001) and PsA (OR 6.2; 95% CI 3.6 to 10.8; <jats:italic>p<\/jats:italic> &lt; 0.0001); however, this allele was equally found among the PsA subsets. HLA-Cw6-positive patients showed a longer psoriasis-arthritis latency period (<jats:italic>p<\/jats:italic> = 0.012). HLA-Cw*0701 was found under-represented in PsA in comparison with controls (OR 0.5; 95% CI 0.3 to 0.9; <jats:italic>p<\/jats:italic> = 0.04), as was HLA-Cw*0802 (OR 0.3; 95% CI 0.08 to 1; <jats:italic>p<\/jats:italic> = 0.05). A positive association was found between psoriatic spondylitis and HLA-Cw*0702 (OR 5.0; 95% CI 1.4 to 25; <jats:italic>p<\/jats:italic> = 0.01). HLA-Cw*0602 seems to confer a general risk for psoriasis, but the presence of other HLA-C locus alleles may explain an additional arthritogenic risk. HLA-C alleles may modulate some aspects of the clinical expression of PsA, but these findings need confirmation.<\/jats:p>","DOI":"10.1186\/ar2097","type":"journal-article","created":{"date-parts":[[2006,12,14]],"date-time":"2006-12-14T07:15:32Z","timestamp":1166080532000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["HLA-C locus alleles may modulate the clinical expression of psoriatic arthritis"],"prefix":"10.1186","volume":"8","author":[{"given":"Ruben","family":"Queiro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Segundo","family":"Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"L\u00f3pez-Larrea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Alperi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Sarasqueta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Luis","family":"Riestra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Ballina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,12,13]]},"reference":[{"key":"1961_CR1","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1097\/00002281-199907000-00005","volume":"11","author":"R Winchester","year":"1999","unstructured":"Winchester R: Psoriatic arthritis and the spectrum of syndromes related to the SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome. Curr Opin Rheumatol. 1999, 11: 251-256. 10.1097\/00002281-199907000-00005.","journal-title":"Curr Opin Rheumatol"},{"key":"1961_CR2","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1038\/sj.jid.5700357","volume":"126","author":"JT Elder","year":"2006","unstructured":"Elder JT: PSORS1: linking genetics and immunology. J Invest Dermatol. 2006, 126: 1205-1206. 10.1038\/sj.jid.5700357.","journal-title":"J Invest Dermatol"},{"key":"1961_CR3","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1086\/503821","volume":"78","author":"RP Nair","year":"2006","unstructured":"Nair RP, Stuart PE, Nistor I, Hiremagalore R, Chia NV, Jenisch S, Weichenthal M, Abecasis GR, Lim HW, Christophers E, et al: Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene. Am J Hum Genet. 2006, 78: 827-851. 10.1086\/503821.","journal-title":"Am J Hum Genet"},{"key":"1961_CR4","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1111\/1523-1747.ep12476080","volume":"100","author":"M Schmitt-Egenolf","year":"1993","unstructured":"Schmitt-Egenolf M, Boehncke WH, Stander M, Eiermann TH, Sterry W: Oligonucleotide typing reveals association of type I psoriasis with HLA-DRB1*0701\/2, -DQA1*0201-DQB1*0303 extended haplotype. J Invest Dermatol. 1993, 100: 749-752. 10.1111\/1523-1747.ep12476080.","journal-title":"J Invest Dermatol"},{"key":"1961_CR5","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/0198-8859(92)90023-G","volume":"34","author":"MA Degli Eposti","year":"1992","unstructured":"Degli Eposti MA, Leaver AL, Christiansen FT, Witt CS, Abraham LJ, Dawkins RL: Ancestral haplotypes: conserved population MHC haplotypes. Hum Immunol. 1992, 34: 242-252. 10.1016\/0198-8859(92)90023-G.","journal-title":"Hum Immunol"},{"key":"1961_CR6","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1093\/rheumatology\/keg304","volume":"42","author":"J Martinez-Borra","year":"2003","unstructured":"Martinez-Borra J, Gonzalez S, Santos-Juanes J, Sanchez del Rio J, Torre-Alonso JC, Lopez-Vasquez A, Blanco-Gelaz MA, Lopez-Larrea C: Psoriasis vulgaris and psoriatic arthritis share a 100 Kb susceptibility region telomeric to HLA-C. Rheumatology. 2003, 42: 1089-1092. 10.1093\/rheumatology\/keg304.","journal-title":"Rheumatology"},{"key":"1961_CR7","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/0049-0172(73)90035-8","volume":"3","author":"JM Moll","year":"1973","unstructured":"Moll JM, Wright V: Psoriatic arthritis. Semin Arthritis Rheum. 1973, 3: 55-78. 10.1016\/0049-0172(73)90035-8.","journal-title":"Semin Arthritis Rheum"},{"key":"1961_CR8","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/S0198-8859(98)00123-2","volume":"60","author":"DD Gladman","year":"1999","unstructured":"Gladman DD, Cheung C, Ng CM, Wade JA: HLA-C locus alleles in patients with psoriatic arthritis (PsA). Hum Immunol. 1999, 60: 259-261. 10.1016\/S0198-8859(98)00123-2.","journal-title":"Hum Immunol"},{"key":"1961_CR9","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1111\/j.1744-313X.2005.00543.x","volume":"32","author":"A Szczerkowska Dobosz","year":"2005","unstructured":"Szczerkowska Dobosz A, Rebala K, Szczerkowska Z, Nedoszytko B: HLA-C locus alleles distribution in patients from northern Poland with psoriatic arthritis: preliminary report. Int J Immunogenet. 2005, 32: 389-391. 10.1111\/j.1744-313X.2005.00543.x.","journal-title":"Int J Immunogenet"},{"key":"1961_CR10","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1002\/1529-0131(199905)42:5<1010::AID-ANR21>3.0.CO;2-H","volume":"42","author":"S Gonzalez","year":"1999","unstructured":"Gonzalez S, Martinez-Borra J, Torre-Alonso JC, Gonzalez-Roces S, Sanchez del Rio J, Rodriguez-Perez A, Brautbar C, Lopez-Larrea C: The MICA-A9 triplet repeat polymorphism in the transmembrane region confers additional susceptibility to the development of psoriatic arthritis and is independent of the association of Cw*0602 in psoriasis. Arthritis Rheum. 1999, 42: 1010-1016. 10.1002\/1529-0131(199905)42:5<1010::AID-ANR21>3.0.CO;2-H.","journal-title":"Arthritis Rheum"},{"key":"1961_CR11","first-page":"505","volume":"30","author":"R Queiro","year":"2003","unstructured":"Queiro R, Torre JC, Gonzalez S, Lopez-Larrea C, Tinture T, Lopez-Lagunas I: HLA antigens may influence the age of onset of psoriasis and psoriatic arthritis. J Rheumatol. 2003, 30: 505-507.","journal-title":"J Rheumatol"},{"key":"1961_CR12","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1053\/sarh.2002.33470","volume":"31","author":"R Queiro","year":"2002","unstructured":"Queiro R, Sarasqueta C, Belzunegui J, Gonzalez C, Figueroa M, Torre-Alonso JC: Psoriatic spondyloarthropathy: a comparative study between HLA-B27 positive and HLA-B27 negative disease. Semin Arthritis Rheum. 2002, 31: 413-418. 10.1053\/sarh.2002.33470.","journal-title":"Semin Arthritis Rheum"},{"key":"1961_CR13","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/0198-8859(94)90005-1","volume":"41","author":"S Gonzalez-Roces","year":"1994","unstructured":"Gonzalez-Roces S, Brautbar C, Pena M, Dominguez O, Coto E, Alvarez V, Segal R, Lopez-Larrea C: Molecular analysis of HLA-B27 haplotypes in Caucasoids. Frequencies of B27-Cw in Jewish and Spanish populations. Hum Immunol. 1994, 41: 127-134. 10.1016\/0198-8859(94)90005-1.","journal-title":"Hum Immunol"},{"key":"1961_CR14","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1136\/ard.49.5.318","volume":"49","author":"C Lopez Larrea","year":"1990","unstructured":"Lopez Larrea C, Torre Alonso JC, Rodriguez Perez A, Coto E: HLA antigens in psoriatic arthritis subtypes of a Spanish population. Ann Rheum Dis. 1990, 49: 318-319.","journal-title":"Ann Rheum Dis"},{"key":"1961_CR15","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1034\/j.1399-0039.1999.530203.x","volume":"53","author":"S Jenisch","year":"1999","unstructured":"Jenisch S, Westphal E, Nair RP, Stuart P, Voorhees JJ, Christophers E, Kronke M, Elder JT, Henseler T: Linkage disequilibrium analysis of familial psoriasis: identification of multiple disease-associated MHC haplotypes. Tissue Antigens. 1999, 53: 135-146. 10.1034\/j.1399-0039.1999.530203.x.","journal-title":"Tissue Antigens"}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/ar2097.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/ar2097\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/ar2097.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T10:49:16Z","timestamp":1728384556000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/ar2097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12,13]]},"references-count":15,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2006,12]]}},"alternative-id":["1961"],"URL":"https:\/\/doi.org\/10.1186\/ar2097","relation":{},"ISSN":["1478-6354"],"issn-type":[{"value":"1478-6354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12,13]]},"assertion":[{"value":"15 August 2006","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2006","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 December 2006","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 December 2006","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"R185"}}