{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:29:02Z","timestamp":1780471742915,"version":"3.54.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2007,5,2]],"date-time":"2007-05-02T00:00:00Z","timestamp":1178064000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2007,5,2]],"date-time":"2007-05-02T00:00:00Z","timestamp":1178064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We explored the relationship of antibodies to the whole ribosomal P proteins (P0, P1, and P2) in cerebrospinal fluid (CSF) with diffuse psychiatric\/neuropsychological syndromes in systemic lupus erythematosus (SLE). CSF samples were obtained from 71 SLE patients (52 patients with diffuse psychiatric\/neuropsychological syndromes [diffuse NP-SLE] and 19 patients with neurological syndromes or peripheral neuropathy [focal NP-SLE]) as well as from 24 patients with non-inflammatory neurological disease. Immunoglobulin G (IgG) antibodies to the C-terminal 22-amino acid ribosomal P synthetic peptide (anti-P<jats:sub>C22<\/jats:sub>) and those to purified bovine ribosomal P proteins (P0, P1, and P2) (anti-whole P) were determined by enzyme-linked immunosorbent assay; affinity-purified IgG anti-P<jats:sub>C22<\/jats:sub> were used as the standard. The concentrations of antibodies to epitopes other than the C-terminal 22 amino acids of ribosomal P proteins were calculated by subtracting anti-P<jats:sub>C22<\/jats:sub> from anti-whole P (anti-P<jats:sub>EX.C22<\/jats:sub>). CSF anti-whole P levels were significantly elevated in diffuse NP-SLE compared with focal NP-SLE or control patients. By contrast, there were no significant differences in CSF anti-P<jats:sub>C22<\/jats:sub> levels among the three groups. Of note, CSF anti-P<jats:sub>EX.C22<\/jats:sub> levels were significantly elevated in diffuse NP-SLE compared with the other two groups. CSF anti-P<jats:sub>EX.C22<\/jats:sub> levels were not significantly correlated with CSF anti-P<jats:sub>C22<\/jats:sub> levels, but with CSF antibodies against the recombinant ribosomal P0 protein lacking the C-terminal 22 amino acids (C22-depleted rP0). Moreover, levels of CSF anti-P<jats:sub>EX.C22<\/jats:sub> or CSF anti-C22-depleted rP0, but not CSF anti-P<jats:sub>C22<\/jats:sub>, were significantly correlated with CSF anti-neuronal cell antibodies (anti-N). These results indicate that CSF IgG antibodies to the epitopes other than the C-terminal 22 amino acids of ribosomal P proteins, which might contain one of the major targets of CSF anti-N, are associated with the development of diffuse NP-SLE.<\/jats:p>","DOI":"10.1186\/ar2184","type":"journal-article","created":{"date-parts":[[2007,5,2]],"date-time":"2007-05-02T15:24:05Z","timestamp":1178119445000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Association of cerebrospinal fluid anti-ribosomal P protein antibodies with diffuse psychiatric\/neuropsychological syndromes in systemic lupus erythematosus"],"prefix":"10.1186","volume":"9","author":[{"given":"Shunsei","family":"Hirohata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Arinuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maki","family":"Takayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taku","family":"Yoshio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2007,5,2]]},"reference":[{"key":"2035_CR1","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1136\/ard.35.5.398","volume":"35","author":"T Gibson","year":"1975","unstructured":"Gibson T, Myers AR: Nervous system involvement in systemic lupus erythematosus. Ann Rheum Dis. 1975, 35: 398-406.","journal-title":"Ann Rheum Dis"},{"key":"2035_CR2","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/BF00197299","volume":"8","author":"EN Harris","year":"1985","unstructured":"Harris EN, Hughes GR: Cerebral disease in systemic lupus erythematosus. Springer Semin Immunopathol. 1985, 8: 251-266. 10.1007\/BF00197299.","journal-title":"Springer Semin Immunopathol"},{"key":"2035_CR3","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1056\/NEJM198707303170503","volume":"317","author":"E Bonfa","year":"1987","unstructured":"Bonfa E, Golombek SJ, Kaufman LD, Skelly S, Weissbach H, Brot N, Elkon KB: Association between lupus psychosis and anti-ribosomal P protein antibodies. N Engl J Med. 1987, 317: 265-271.","journal-title":"N Engl J Med"},{"key":"2035_CR4","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/0002-9343(91)90506-S","volume":"90","author":"AB Schneebaum","year":"1991","unstructured":"Schneebaum AB, Singleton JD, West SG, Blodgett JK, Allen LG, Cheronis JC, Kotzin BL: Association of psychiatric manifestations with antibodies to ribosomal P proteins in systemic lupus erythematosus. Am J Med. 1991, 90: 54-62. 10.1016\/0002-9343(91)90506-S.","journal-title":"Am J Med"},{"key":"2035_CR5","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1002\/art.1780390907","volume":"39","author":"K Isshi","year":"1996","unstructured":"Isshi K, Hirohata S: Association of anti-ribosomal P protein antibodies with neuropsychiatric systemic lupus erythematosus. Arthritis Rheum. 1996, 39: 1483-1490. 10.1002\/art.1780390907.","journal-title":"Arthritis Rheum"},{"key":"2035_CR6","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1002\/art.1780290906","volume":"29","author":"SJ Golombek","year":"1986","unstructured":"Golombek SJ, Graus F, Elkon KB: Autoantibodies in the cerebrospinal fluid of patients with systemic lupus erythematosus. Arthritis Rheum. 1986, 29: 1090-1097. 10.1002\/art.1780290906.","journal-title":"Arthritis Rheum"},{"key":"2035_CR7","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.1002\/1529-0131(199810)41:10<1819::AID-ART14>3.0.CO;2-Y","volume":"41","author":"K Isshi","year":"1998","unstructured":"Isshi K, Hirohata S: Differential roles of the anti-ribosomal P antibody and antineuronal antibody in the pathogenesis of central nervous system involvement in systemic lupus erythematosus. Arthritis Rheum. 1998, 41: 1819-1827. 10.1002\/1529-0131(199810)41:10<1819::AID-ART14>3.0.CO;2-Y.","journal-title":"Arthritis Rheum"},{"key":"2035_CR8","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1172\/JCI108303","volume":"57","author":"HG Bluestein","year":"1976","unstructured":"Bluestein HG, Zvaifler NJ: Brain-reactive lymphocytotoxic antibodies in the serum of patients with systemic lupus erythematosus. J Clin Invest. 1976, 57: 509-516.","journal-title":"J Clin Invest"},{"key":"2035_CR9","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1002\/art.1780220504","volume":"22","author":"HA Wilson","year":"1979","unstructured":"Wilson HA, Winfield JB, Lahita RG, Koffler D: Association of IgG anti-brain antibodies with central nervous system dysfunction in systemic lupus erythematosus. Arthritis Rheum. 1979, 22: 458-462. 10.1002\/art.1780220504.","journal-title":"Arthritis Rheum"},{"key":"2035_CR10","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1136\/ard.49.4.249","volume":"49","author":"AA Long","year":"1990","unstructured":"Long AA, Denburg SD, Carbotte RM, Singal DP, Denburg JA: Serum lymphocytotoxic antibodies and neurocognitive function in systemic lupus erythematosus. Ann Rheum Dis. 1990, 49: 249-253.","journal-title":"Ann Rheum Dis"},{"key":"2035_CR11","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/0002-9343(81)90756-7","volume":"70","author":"HG Bluestein","year":"1981","unstructured":"Bluestein HG, Williams GW, Steinberg AD: Cerebrospinal fluid antibodies to neuronal cells: association with neuropsychiatric manifestations of systemic lupus erythematosus. Am J Med. 1981, 70: 240-246. 10.1016\/0002-9343(81)90756-7.","journal-title":"Am J Med"},{"key":"2035_CR12","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1172\/JCI115707","volume":"89","author":"E Koren","year":"1992","unstructured":"Koren E, Reichlin MW, Koscec M, Fugate RD, Reichlin M: Autoantibodies to the ribosomal P proteins react with a plasma membrane-related target on human cells. J Clin Invest. 1992, 89: 1236-1241.","journal-title":"J Clin Invest"},{"key":"2035_CR13","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1006\/jaut.1999.0291","volume":"13","author":"N Fabien","year":"1999","unstructured":"Fabien N, Moreira A, Lavergne JP, Desbos A, Surgey P, Alves de Olivera C, Gonzalo P, Venot A, Bienvenu J, Perrier H, et al: Autoantibodies directed against the ribosomal P proteins are not only directed against a common epitope of the P0, P1 and P2 proteins. J Autoimmun. 1999, 13: 103-110. 10.1006\/jaut.1999.0291.","journal-title":"J Autoimmun"},{"key":"2035_CR14","first-page":"34","volume":"32","author":"T Yoshio","year":"2005","unstructured":"Yoshio T, Hirata D, Onda K, Nara H, Minota S: Antiribosomal P protein antibodies in cerebrospinal fluid are associated with neuropsychiatric systemic lupus erythematosus. J Rheumatol. 2005, 32: 34-39.","journal-title":"J Rheumatol"},{"key":"2035_CR15","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1002\/art.1780251101","volume":"25","author":"EM Tan","year":"1982","unstructured":"Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, Schaller JG, Talal N, Winchester RJ: The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1982, 25: 1271-1277. 10.1002\/art.1780251101.","journal-title":"Arthritis Rheum"},{"key":"2035_CR16","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1002\/1529-0131(199904)42:4<599::AID-ANR2>3.0.CO;2-F","volume":"42","author":"ACR Ad Hoc Committee on Neuropsychiatric Lupus Nomenclature","year":"1999","unstructured":"ACR Ad Hoc Committee on Neuropsychiatric Lupus Nomenclature: The American College of Rheumatology nomenclature and case definitions for neuropsychiatric lupus syndromes. Arthritis Rheum. 1999, 42: 599-608. 10.1002\/1529-0131(199904)42:4<599::AID-ANR2>3.0.CO;2-F.","journal-title":"Arthritis Rheum"},{"key":"2035_CR17","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1016\/0002-9343(83)91075-6","volume":"74","author":"JB Winfield","year":"1983","unstructured":"Winfield JB, Shaw M, Silverman LM, Eisenberg RA, Wilson HA, Koffler D: Intrathecal IgG synthesis and blood-brain barrier impairment in patients with systemic lupus erythematosus and central nervous system dysfunction. Am J Med. 1983, 74: 837-844. 10.1016\/0002-9343(83)91075-6.","journal-title":"Am J Med"},{"key":"2035_CR18","doi-asserted-by":"publisher","first-page":"1843","DOI":"10.1001\/archinte.1985.00360100105017","volume":"145","author":"S Hirohata","year":"1985","unstructured":"Hirohata S, Hirose S, Miyamoto T: Cerebrospinal fluid IgM, IgA, and IgG indexes in systemic lupus erythematosus. Their use as estimates of central nervous system disease activity. Arch Intern Med. 1985, 145: 1843-1846. 10.1001\/archinte.145.10.1843.","journal-title":"Arch Intern Med"},{"key":"2035_CR19","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1002\/art.1780330506","volume":"33","author":"S Hirohata","year":"1990","unstructured":"Hirohata S, Miyamoto T: Elevated levels of interleukin-6 in cerebrospinal fluid from patients with systemic lupus erythematosus and central nervous system involvement. Arthritis Rheum. 1990, 33: 644-649. 10.1002\/art.1780330506.","journal-title":"Arthritis Rheum"},{"key":"2035_CR20","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1002\/art.20869","volume":"52","author":"T Nagai","year":"2005","unstructured":"Nagai T, Arinuma Y, Yanagida T, Yamamoto K, Hirohata S: Anti-ribosomal P protein antibody in human systemic lupus erythematosus up-regulates the expression of proinflammatory cytokines by human peripheral blood monocytes. Arthritis Rheum. 2005, 52: 847-855. 10.1002\/art.20869.","journal-title":"Arthritis Rheum"},{"key":"2035_CR21","first-page":"1364","volume":"40","author":"T Yoshio","year":"1997","unstructured":"Yoshio T, Masuyama J, Minota S, Iwamoto M, Mimori A, Takeda A, Okazaki H, Kano S: Correlation of serum IgG antibodies to recombinant P0 fusion protein with IgG antibodies to carboxyl-terminal 22 synthetic peptides and carboxyl-terminal 22 amino acid-depleted recombinant P0 fusion protein in patients with systemic lupus erythematosus. Arthritis Rheum. 1997, 40: 1364-1365.","journal-title":"Arthritis Rheum"},{"key":"2035_CR22","doi-asserted-by":"publisher","first-page":"7419","DOI":"10.1073\/pnas.83.19.7419","volume":"83","author":"K Elkon","year":"1986","unstructured":"Elkon K, Skelly S, Parnassa A, Moller W, Danho W, Weissbach H, Brot N: Identification and chemical synthesis of a ribosomal protein antigenic determinant in systemic lupus erythematosus. Proc Natl Acad Sci USA. 1986, 83: 7419-7423. 10.1073\/pnas.83.19.7419.","journal-title":"Proc Natl Acad Sci USA"},{"key":"2035_CR23","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1038\/nm1101-1189","volume":"7","author":"LA DeGiorgio","year":"2001","unstructured":"DeGiorgio LA, Konstantinov KN, Lee SC, Hardin JA, Volpe BT, Diamond B: A subset of lupus anti-DNA antibodies cross-reacts with the NR2 glutamate receptor in systemic lupus erythematosus. Nat Med. 2001, 7: 1189-1193. 10.1038\/nm1101-1189.","journal-title":"Nat Med"},{"key":"2035_CR24","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1002\/art.21539","volume":"54","author":"FB Karassa","year":"2006","unstructured":"Karassa FB, Afeltra A, Ambrozic A, Chang DM, De Keyser F, Doria A, Galeazzi M, Hirohata S, Hoffman IE, Inanc M, et al: Accuracy of anti-ribosomal P protein antibody testing for the diagnosis of neuropsychiatric systemic lupus erythematosus: an international meta-analysis. Arthritis Rheum. 2006, 54: 312-324. 10.1002\/art.21539.","journal-title":"Arthritis Rheum"},{"key":"2035_CR25","doi-asserted-by":"publisher","first-page":"2729","DOI":"10.1002\/1529-0131(199912)42:12<2729::AID-ANR35>3.0.CO;2-I","volume":"42","author":"S Hirohata","year":"1999","unstructured":"Hirohata S, Hayakawa K: Enhanced interleukin-6 messenger RNA expression by neuronal cells in a patient with neuropsychiatric systemic lupus erythematosus. Arthritis Rheum. 1999, 42: 2729-2730. 10.1002\/1529-0131(199912)42:12<2729::AID-ANR35>3.0.CO;2-I.","journal-title":"Arthritis Rheum"}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/ar2184.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/ar2184\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/ar2184.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T10:35:02Z","timestamp":1728383702000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/ar2184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5,2]]},"references-count":25,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2007,6]]}},"alternative-id":["2035"],"URL":"https:\/\/doi.org\/10.1186\/ar2184","relation":{},"ISSN":["1478-6354"],"issn-type":[{"value":"1478-6354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,5,2]]},"assertion":[{"value":"28 July 2006","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 March 2007","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 May 2007","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 May 2007","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"R44"}}