{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T13:57:17Z","timestamp":1761919037216},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2007,11,20]],"date-time":"2007-11-20T00:00:00Z","timestamp":1195516800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2007,11,20]],"date-time":"2007-11-20T00:00:00Z","timestamp":1195516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Adoptive transfer of adjuvant-induced arthritis was used in this study to examine local macrophages and dendritic cells (DCs) during T cell-mediated synovial inflammation. We studied the influx of CD11b<jats:sup>+<\/jats:sup>CD11c<jats:sup>+<\/jats:sup> putative myeloid DCs and other non-lymphoid CD45<jats:sup>+<\/jats:sup> cells into synovium-rich tissues (SRTs) of the affected hind paws in response to a pulse of autoreactive thoracic duct cells. Cells were prepared from the SRTs using a collagenase perfusion-digestion technique, thus allowing enumeration and phenotypic analysis by flow cytometry. Numbers of CD45<jats:sup>+<\/jats:sup> cells increased during the first 6 days, with increases in CD45<jats:sup>+<\/jats:sup>MHC (major histocompatibility complex) II<jats:sup>+<\/jats:sup> monocyte-like cells from as early as day 3 after transfer. In contrast, typical MHC II<jats:sup>-<\/jats:sup> monocytes, mainly of the CD4<jats:sup>-<\/jats:sup> subset, did not increase until 12 to 14 days after cell transfer, coinciding with the main influx of polymorphonuclear cells. By day 14, CD45<jats:sup>+<\/jats:sup>MHC II<jats:sup>hi<\/jats:sup> cells constituted approximately half of all CD45<jats:sup>+<\/jats:sup> cells in SRT. Most of the MHC II<jats:sup>hi<\/jats:sup> cells expressed CD11c and CD11b and represented putative myeloid DCs, whereas only approximately 20% were CD163<jats:sup>+<\/jats:sup> macrophages. Less than 5% of the MHC II<jats:sup>hi<\/jats:sup> cells in inflamed SRT were CD11b<jats:sup>-<\/jats:sup>, setting a maximum for any influx of plasmacytoid DCs. Of the putative myeloid DCs, a third expressed CD4 and both the CD4<jats:sup>+<\/jats:sup> and the CD4<jats:sup>-<\/jats:sup> subsets expressed the co-stimulatory molecule CD172a. Early accumulation of MHC II<jats:sup>hi<\/jats:sup>CD11c<jats:sup>+<\/jats:sup> monocyte-like cells during the early phase of T cell-mediated inflammation, relative to typical MHC II<jats:sup>-<\/jats:sup> blood monocytes, suggests that recruited monocytes differentiate rapidly toward the DC lineage at this stage in the disease process. However, it is possible also that the MHC II<jats:sup>hi<\/jats:sup>CD11c<jats:sup>+<\/jats:sup> cells originate from a specific subset of DC-like circulating mononuclear cells.<\/jats:p>","DOI":"10.1186\/ar2328","type":"journal-article","created":{"date-parts":[[2007,11,21]],"date-time":"2007-11-21T07:13:15Z","timestamp":1195629195000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Recruitment of dendritic cells and macrophages during T cell-mediated synovial inflammation"],"prefix":"10.1186","volume":"9","author":[{"given":"Mahin","family":"Moghaddami","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie G","family":"Cleland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gorjana","family":"Radisic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham","family":"Mayrhofer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2007,11,20]]},"reference":[{"key":"2179_CR1","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1002\/stem.150409","volume":"15","author":"K Shortman","year":"1997","unstructured":"Shortman K, Caux C: Dendritic cell development: multiple pathways to nature's adjuvants. Stem Cells. 1997, 15: 409-419.","journal-title":"Stem Cells"},{"key":"2179_CR2","doi-asserted-by":"publisher","first-page":"3038","DOI":"10.1073\/pnas.90.7.3038","volume":"90","author":"K Inaba","year":"1993","unstructured":"Inaba K, Inaba M, Deguchi M, Hagi K, Yasumizu R, Ikehara S, Muramatsu S, Steinman RM: Granulocytes, macrophages, and dendritic cells arise from a common major histocompatibility complex class II-negative progenitor in mouse bone marrow. Proc Natl Acad Sci USA. 1993, 90: 3038-3042. 10.1073\/pnas.90.7.3038.","journal-title":"Proc Natl Acad Sci USA"},{"key":"2179_CR3","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1084\/jem.184.2.695","volume":"184","author":"C Caux","year":"1996","unstructured":"Caux C, Vanbervliet B, Massacrier C, Dezutter-Dambuyant C, de Saint-Vis B, Jacquet C, Yoneda K, Imamura S, Schmitt D, Banchereau J: CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF+TNF alpha. J Exp Med. 1996, 184: 695-706. 10.1084\/jem.184.2.695.","journal-title":"J Exp Med"},{"key":"2179_CR4","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1189\/jlb.72.2.321","volume":"72","author":"HJ Bontkes","year":"2002","unstructured":"Bontkes HJ, De Gruijl TD, Schuurhuis GJ, Scheper RJ, Meijer CJ, Hooijberg E: Expansion of dendritic cell precursors from human CD34(+) progenitor cells isolated from healthy donor blood; growth factor combination determines proliferation rate and functional outcome. J Leukoc Biol. 2002, 72: 321-329.","journal-title":"J Leukoc Biol"},{"key":"2179_CR5","doi-asserted-by":"crossref","first-page":"4587","DOI":"10.4049\/jimmunol.160.9.4587","volume":"160","author":"KA Palucka","year":"1998","unstructured":"Palucka KA, Taquet N, Sanchez-Chapuis F, Gluckman JC: Dendritic cells as the terminal stage of monocyte differentiation. J Immunol. 1998, 160: 4587-4595.","journal-title":"J Immunol"},{"key":"2179_CR6","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/S1074-7613(03)00174-2","volume":"19","author":"F Geissmann","year":"2003","unstructured":"Geissmann F, Jung S, Littman DR: Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity. 2003, 19: 71-82. 10.1016\/S1074-7613(03)00174-2.","journal-title":"Immunity"},{"key":"2179_CR7","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1146\/annurev.immunol.18.1.767","volume":"18","author":"J Banchereau","year":"2000","unstructured":"Banchereau J, Briere F, Caux C, Davoust J, Lebecque S, Liu YJ, Pulendran B, Palucka K: Immunobiology of dendritic cells. Annu Rev Immunol. 2000, 18: 767-811. 10.1146\/annurev.immunol.18.1.767.","journal-title":"Annu Rev Immunol"},{"key":"2179_CR8","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1073\/pnas.231606698","volume":"99","author":"RM Steinman","year":"2002","unstructured":"Steinman RM, Nussenzweig MC: Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance. Proc Natl Acad Sci USA. 2002, 99: 351-358. 10.1073\/pnas.231606698.","journal-title":"Proc Natl Acad Sci USA"},{"key":"2179_CR9","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1038\/15200","volume":"5","author":"S Gallucci","year":"1999","unstructured":"Gallucci S, Lolkema M, Matzinger P: Natural adjuvants: endogenous activators of dendritic cells. Nat Med. 1999, 5: 1249-1255. 10.1038\/15200.","journal-title":"Nat Med"},{"key":"2179_CR10","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1182\/blood-2001-12-0360","volume":"100","author":"T Luft","year":"2002","unstructured":"Luft T, Jefford M, Luetjens P, Toy T, Hochrein H, Masterman KA, Maliszewski C, Shortman K, Cebon J, Maraskovsky E: Functionally distinct dendritic cell (DC) populations induced by physiologic stimuli: prostaglandin E(2) regulates the migratory capacity of specific DC subsets. Blood. 2002, 100: 1362-1372. 10.1182\/blood-2001-12-0360.","journal-title":"Blood"},{"key":"2179_CR11","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1182\/blood-2003-12-4146","volume":"104","author":"T Luft","year":"2004","unstructured":"Luft T, Maraskovsky E, Schnurr M, Knebel K, Kirsch M, Gorner M, Skoda R, Ho AD, Nawroth P, Bierhaus A: Tuning the volume of the immune response: strength and persistence of stimulation determine migration and cytokine secretion of dendritic cells. Blood. 2004, 104: 1066-1074. 10.1182\/blood-2003-12-4146.","journal-title":"Blood"},{"key":"2179_CR12","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/S0167-5699(96)20030-1","volume":"17","author":"R Thomas","year":"1996","unstructured":"Thomas R, Lipsky PE: Could endogenous self-peptides presented by dendritic cells initiate rheumatoid arthritis?. Immunol Today. 1996, 17: 559-564. 10.1016\/S0167-5699(96)20030-1.","journal-title":"Immunol Today"},{"key":"2179_CR13","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1111\/j.1582-4934.2002.tb00520.x","volume":"6","author":"A Balanescu","year":"2002","unstructured":"Balanescu A, Radu E, Nat R, Regalia T, Bojinca V, Predescu V, Predeteanu D: Co-stimulatory and adhesion molecules of dendritic cells in rheumatoid arthritis. J Cell Mol Med. 2002, 6: 415-425. 10.1111\/j.1582-4934.2002.tb00520.x.","journal-title":"J Cell Mol Med"},{"key":"2179_CR14","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1046\/j.1440-1711.1999.00855.x","volume":"77","author":"AR Pettit","year":"1999","unstructured":"Pettit AR, Thomas R: Dendritic cells: the driving force behind autoimmunity in rheumatoid arthritis?. Immunol Cell Biol. 1999, 77: 420-427. 10.1046\/j.1440-1711.1999.00855.x.","journal-title":"Immunol Cell Biol"},{"key":"2179_CR15","doi-asserted-by":"publisher","first-page":"6625","DOI":"10.4049\/jimmunol.169.11.6625","volume":"169","author":"EC Tsark","year":"2002","unstructured":"Tsark EC, Wang W, Teng YC, Arkfeld D, Dodge GR, Kovats S: Differential MHC class II-mediated presentation of rheumatoid arthritis autoantigens by human dendritic cells and macrophages. J Immunol. 2002, 169: 6625-6633.","journal-title":"J Immunol"},{"key":"2179_CR16","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1002\/art.1780300708","volume":"30","author":"R Stanescu","year":"1987","unstructured":"Stanescu R, Lider O, van Eden W, Holoshitz J, Cohen IR: Histopathology of arthritis induced in rats by active immunization to mycobacterial antigens or by systemic transfer of T lymphocyte lines. A light and electron microscopic study of the articular surface using cationized ferritin. Arthritis Rheum. 1987, 30: 779-792. 10.1002\/art.1780300708.","journal-title":"Arthritis Rheum"},{"key":"2179_CR17","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1084\/jem.175.4.907","volume":"175","author":"S Yoshino","year":"1992","unstructured":"Yoshino S, Cleland LG: Depletion of alpha\/beta T cells by a monoclonal antibody against the alpha\/beta T cell receptor suppresses established adjuvant arthritis, but not established collagen-induced arthritis in rats. J Exp Med. 1992, 175: 907-915. 10.1084\/jem.175.4.907.","journal-title":"J Exp Med"},{"key":"2179_CR18","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1046\/j.1365-2249.2001.01704.x","volume":"126","author":"LDJ Spargo","year":"2001","unstructured":"Spargo LDJ, Cleland LG, Wing SJ, Hawkes JS, Mayrhofer G: Characterization of thoracic duct cells that transfer polyarthritis. Clin Exp Immunol. 2001, 126: 560-569. 10.1046\/j.1365-2249.2001.01704.x.","journal-title":"Clin Exp Immunol"},{"key":"2179_CR19","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1093\/intimm\/dxl026","volume":"18","author":"LDJ Spargo","year":"2006","unstructured":"Spargo LDJ, Cleland LG, Cockshell MP, Mayrhofer G: Recruitment and proliferation of CD4+ T cells in synovium following adoptive transfer of adjuvant-induced arthritis. Int Immunol. 2006, 18: 897-910. 10.1093\/intimm\/dxl026.","journal-title":"Int Immunol"},{"key":"2179_CR20","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1093\/intimm\/dxh290","volume":"17","author":"M Moghaddami","year":"2005","unstructured":"Moghaddami M, Cleland LG, Mayrhofer G: MHC II+ CD45+ cells from synovium-rich tissues of normal rats: phenotype, comparison with macrophage and dendritic cell lineages and differentiation into mature dendritic cells in vitro. Int Immunol. 2005, 17: 1103-1115. 10.1093\/intimm\/dxh290.","journal-title":"Int Immunol"},{"key":"2179_CR21","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1093\/intimm\/dxh291","volume":"17","author":"M Moghaddami","year":"2005","unstructured":"Moghaddami M, Mayrhofer G, Cleland LG: MHC class II compartment, endocytosis and phagocytic activity of macrophages and putative dendritic cells isolated from normal tissues rich in synovium. Int Immunol. 2005, 17: 1117-1130. 10.1093\/intimm\/dxh291.","journal-title":"Int Immunol"},{"key":"2179_CR22","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1034\/j.1600-065x.2001.1840110.x","volume":"184","author":"TK van den Berg","year":"2001","unstructured":"van den Berg TK, Puklavec MJ, Barclay AN, Dijkstra CD: Monoclonal antibodies against rat leukocyte surface antigens. Immunol Rev. 2001, 184: 109-116. 10.1034\/j.1600-065x.2001.1840110.x.","journal-title":"Immunol Rev"},{"key":"2179_CR23","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1097\/01.LAB.0000059923.67198.BA","volume":"83","author":"X Zhang","year":"2003","unstructured":"Zhang X, Fitzsimmons RL, Cleland LG, Ey PL, Zannettino AC, Farmer EA, Sincock P, Mayrhofer G: CD36\/fatty acid translocase in rats: distribution, isolation from hepatocytes, and comparison with the scavenger receptor SR-B1. Lab Invest. 2003, 83: 317-332. 10.1097\/01.LAB.0000081589.91390.DF.","journal-title":"Lab Invest"},{"key":"2179_CR24","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1084\/jem.188.7.1359","volume":"188","author":"ML Albert","year":"1998","unstructured":"Albert ML, Pearce SF, Francisco LM, Sauter B, Roy P, Silverstein RL, Bhardwaj N: Immature dendritic cells phagocytose apoptotic cells via alphavbeta5 and CD36, and cross-present antigens to cytotoxic T lymphocytes. J Exp Med. 1998, 188: 1359-1368. 10.1084\/jem.188.7.1359.","journal-title":"J Exp Med"},{"key":"2179_CR25","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.4049\/jimmunol.161.3.1146","volume":"161","author":"L Liu","year":"1998","unstructured":"Liu L, Zhang M, Jenkins C, MacPherson GG: Dendritic cell heterogeneity in vivo: two functionally different dendritic cell populations in rat intestinal lymph can be distinguished by CD4 expression. J Immunol. 1998, 161: 1146-1155.","journal-title":"J Immunol"},{"key":"2179_CR26","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1084\/jem.191.3.435","volume":"191","author":"FP Huang","year":"2000","unstructured":"Huang FP, Platt N, Wykes M, Major JR, Powell TJ, Jenkins CD, MacPherson GG: A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes. J Exp Med. 2000, 191: 435-444. 10.1084\/jem.191.3.435.","journal-title":"J Exp Med"},{"key":"2179_CR27","doi-asserted-by":"publisher","first-page":"4202","DOI":"10.4049\/jimmunol.165.8.4202","volume":"165","author":"B Trinite","year":"2000","unstructured":"Trinite B, Voisine C, Yagita H, Josien R: A subset of cytolytic dendritic cells in rat. J Immunol. 2000, 165: 4202-4208.","journal-title":"J Immunol"},{"key":"2179_CR28","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.4049\/jimmunol.169.5.2284","volume":"169","author":"C Voisine","year":"2002","unstructured":"Voisine C, Hubert FX, Trinite B, Heslan M, Josien R: Two phenotypically distinct subsets of spleen dendritic cells in rats exhibit different cytokine production and T cell stimulatory activity. J Immunol. 2002, 169: 2284-2291.","journal-title":"J Immunol"},{"key":"2179_CR29","doi-asserted-by":"publisher","first-page":"7485","DOI":"10.4049\/jimmunol.172.12.7485","volume":"172","author":"FX Hubert","year":"2004","unstructured":"Hubert FX, Voisine C, Louvet C, Heslan M, Josien R: Rat plasmacytoid dendritic cells are an abundant subset of MHC class II+ CD4+CD11b-OX62- and type I IFN-producing cells that exhibit selective expression of Toll-like receptors 7 and 9 and strong responsiveness to CpG. J Immunol. 2004, 172: 7485-7494.","journal-title":"J Immunol"},{"key":"2179_CR30","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/S1074-7613(03)00171-7","volume":"19","author":"NV Serbina","year":"2003","unstructured":"Serbina NV, Salazar-Mather TP, Biron CA, Kuziel WA, Pamer EG: TNF\/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection. Immunity. 2003, 19: 59-70. 10.1016\/S1074-7613(03)00171-7.","journal-title":"Immunity"},{"key":"2179_CR31","doi-asserted-by":"publisher","first-page":"2639","DOI":"10.1002\/eji.200636426","volume":"36","author":"U Yrlid","year":"2006","unstructured":"Yrlid U, Cerovic V, Milling S, Jenkins CD, Klavinskis LS, MacPherson GG: A distinct subset of intestinal dendritic cells responds selectively to oral TLR7\/8 stimulation. Eur J Immunol. 2006, 36: 2639-2648. 10.1002\/eji.200636426.","journal-title":"Eur J Immunol"},{"key":"2179_CR32","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1084\/jem.20021031","volume":"196","author":"M O'Keeffe","year":"2002","unstructured":"O'Keeffe M, Hochrein H, Vremec D, Caminschi I, Miller JL, Anders EM, Wu L, Lahoud MH, Henri S, Scott B, et al: Mouse plasmacytoid cells: long-lived cells, heterogeneous in surface phenotype and function, that differentiate into CD8(+) dendritic cells only after microbial stimulus. J Exp Med. 2002, 196: 1307-1319. 10.1084\/jem.20021031.","journal-title":"J Exp Med"},{"key":"2179_CR33","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1111\/j.1365-2567.2005.02104.x","volume":"114","author":"ML Scimone","year":"2005","unstructured":"Scimone ML, Lutzky VP, Zittermann SI, Maffia P, Jancic C, Buzzola F, Issekutz AC, Chuluyan HE: Migration of polymorphonuclear leucocytes is influenced by dendritic cells. Immunology. 2005, 114: 375-385. 10.1111\/j.1365-2567.2005.02104.x.","journal-title":"Immunology"},{"key":"2179_CR34","doi-asserted-by":"publisher","first-page":"4155","DOI":"10.4049\/jimmunol.176.7.4155","volume":"176","author":"U Yrlid","year":"2006","unstructured":"Yrlid U, Jenkins CD, MacPherson GG: Relationships between distinct blood monocyte subsets and migrating intestinal lymph dendritic cells in vivo under steady-state conditions. J Immunol. 2006, 176: 4155-4162.","journal-title":"J Immunol"},{"key":"2179_CR35","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1084\/jem.175.6.1457","volume":"175","author":"M Brenan","year":"1992","unstructured":"Brenan M, Puklavec M: The MRC OX-62 antigen: a useful marker in the purification of rat veiled cells with the biochemical properties of an integrin. J Exp Med. 1992, 175: 1457-1465. 10.1084\/jem.175.6.1457.","journal-title":"J Exp Med"},{"key":"2179_CR36","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1084\/jem.186.3.467","volume":"186","author":"R Josien","year":"1997","unstructured":"Josien R, Heslan M, Soulillou JP, Cuturi MC: Rat spleen dendritic cells express natural killer cell receptor protein 1 (NKR-P1) and have cytotoxic activity to select targets via a Ca2+-dependent mechanism. J Exp Med. 1997, 186: 467-472. 10.1084\/jem.186.3.467.","journal-title":"J Exp Med"},{"key":"2179_CR37","doi-asserted-by":"publisher","first-page":"2858","DOI":"10.1182\/blood.V100.8.2858","volume":"100","author":"Y Osugi","year":"2002","unstructured":"Osugi Y, Vuckovic S, Hart DN: Myeloid blood CD11c(+) dendritic cells and monocyte-derived dendritic cells differ in their ability to stimulate T lymphocytes. Blood. 2002, 100: 2858-2866. 10.1182\/blood.V100.8.2858.","journal-title":"Blood"},{"key":"2179_CR38","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/S0171-2985(00)80056-X","volume":"202","author":"V Grau","year":"2000","unstructured":"Grau V, Scriba A, Stehling O, Steiniger B: Monocytes in the rat. Immunobiology. 2000, 202: 94-103.","journal-title":"Immunobiology"},{"key":"2179_CR39","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1002\/jlb.66.5.698","volume":"66","author":"WA Muller","year":"1999","unstructured":"Muller WA, Randolph GJ: Migration of leukocytes across endothelium and beyond: molecules involved in the transmigration and fate of monocytes. J Leukoc Biol. 1999, 66: 698-704.","journal-title":"J Leukoc Biol"},{"key":"2179_CR40","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/jlb.67.1.97","volume":"67","author":"C Buechler","year":"2000","unstructured":"Buechler C, Ritter M, Ors\u00f3 E, Langmann T, Klucken J, Schmitz G: Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by pro- and antiinflammatory stimuli. J Leukoc Biol. 2000, 67: 97-103.","journal-title":"J Leukoc Biol"},{"key":"2179_CR41","doi-asserted-by":"publisher","first-page":"2741","DOI":"10.1182\/blood.V97.9.2741","volume":"97","author":"M Seiffert","year":"2001","unstructured":"Seiffert M, Brossart P, Cant C, Cella M, Colonna M, Brugger W, Kanz L, Ullrich A, Buhring HJ: Signal-regulatory protein alpha (SIRPalpha) but not SIRPbeta is involved in T-cell activation, binds to CD47 with high affinity, and is expressed on immature CD34(+)CD38(-) hematopoietic cells. Blood. 2001, 97: 2741-2749. 10.1182\/blood.V97.9.2741.","journal-title":"Blood"},{"key":"2179_CR42","doi-asserted-by":"publisher","first-page":"R230","DOI":"10.1186\/ar1467","volume":"7","author":"LL Cavanagh","year":"2005","unstructured":"Cavanagh LL, Boyce A, Smith L, Padmanabha J, Filgueira L, Pietschmann P, Thomas R: Rheumatoid arthritis synovium contains plasmacytoid dendritic cells. Arthritis Res Ther. 2005, 7: R230-240. 10.1186\/ar1467.","journal-title":"Arthritis Res Ther"},{"key":"2179_CR43","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1084\/jem.20020991","volume":"196","author":"C Scheinecker","year":"2002","unstructured":"Scheinecker C, McHugh R, Shevach EM, Germain RN: Constitutive presentation of a natural tissue autoantigen exclusively by dendritic cells in the draining lymph node. J Exp Med. 2002, 196: 1079-1090. 10.1084\/jem.20020991.","journal-title":"J Exp Med"}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/ar2328.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/ar2328\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/ar2328.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T10:31:37Z","timestamp":1728383497000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/ar2328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11,20]]},"references-count":43,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2007,12]]}},"alternative-id":["2179"],"URL":"https:\/\/doi.org\/10.1186\/ar2328","relation":{},"ISSN":["1478-6354"],"issn-type":[{"type":"electronic","value":"1478-6354"}],"subject":[],"published":{"date-parts":[[2007,11,20]]},"assertion":[{"value":"19 April 2007","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 October 2007","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 November 2007","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 November 2007","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"R120"}}