{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:03:44Z","timestamp":1791180224702,"version":"4.1.0"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2008,3,2]],"date-time":"2008-03-02T00:00:00Z","timestamp":1204416000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2008,3,2]],"date-time":"2008-03-02T00:00:00Z","timestamp":1204416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Introduction<\/jats:title>\n                        <jats:p>Prognosis in rheumatoid arthritis (RA) is difficult to assess. The aim of this study was to examine whether serum levels of a spectrum of cytokines were predictive of radiographic progression in early RA patients.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Methods<\/jats:title>\n                        <jats:p>A total of 82 early RA patients (disease duration &lt; 1 year) were followed for 12 months. Clinical assessments, X-rays of hands and magnetic resonance imaging (MRI) of the dominant wrist were assessed at baseline and after 3, 6 and 12 months. The X-rays were scored according to the van der Heijde modified Sharp score (vdHSS). Cytokine analyses were performed with multiplex technology. Associations between cytokines and radiographic progression were examined by logistic regression.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>In all, 49% of the patients developed radiographic progression. The median (interquartile range (IQR)) baseline eotaxin level (pg\/ml) was significantly lower in patients with (193 (119 to 247)) than without progression (265 (166 to 360)). In the univariate logistic regression analyses, eotaxin was negatively associated to radiographic progression, and this association was maintained in the multivariate model with an odds ratio (OR) (95% confidence interval (CI)) for progression of 0.58 (0.41 to 0.82) per 50 pg\/ml increase in eotaxin level. None of the other measured cytokines showed any association to radiographic progression.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusion<\/jats:title>\n                        <jats:p>This study raises the hypothesis that high serum levels of eotaxin predict less radiographic progression in early RA patients.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/ar2381","type":"journal-article","created":{"date-parts":[[2008,3,4]],"date-time":"2008-03-04T07:13:38Z","timestamp":1204614818000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["A high serum level of eotaxin (CCL 11) is associated with less radiographic progression in early rheumatoid arthritis patients"],"prefix":"10.1186","volume":"10","author":[{"given":"Silje W","family":"Syversen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guro L","family":"Goll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Espen A","family":"Haavardsholm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pernille","family":"B\u00f8yesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tor","family":"Lea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tore K","family":"Kvien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,3,2]]},"reference":[{"key":"2231_CR1","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/S1359-6101(02)00018-7","volume":"13","author":"ET Andreakos","year":"2002","unstructured":"Andreakos ET, Foxwell BM, Brennan FM, Maini RN, Feldmann M: Cytokines and anti-cytokine biologicals in autoimmunity: present and future. Cytokine Growth Factor Rev. 2002, 13: 299-313. 10.1016\/S1359-6101(02)00018-7.","journal-title":"Cytokine Growth Factor Rev"},{"key":"2231_CR2","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1146\/annurev.immunol.14.1.397","volume":"14","author":"M Feldmann","year":"1996","unstructured":"Feldmann M, Brennan FM, Maini RN: Role of cytokines in rheumatoid arthritis. Ann Rev Immunol. 1996, 14: 397-440. 10.1146\/annurev.immunol.14.1.397.","journal-title":"Ann Rev Immunol"},{"key":"2231_CR3","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/S0022-1759(99)00069-1","volume":"227","author":"RT Carson","year":"1999","unstructured":"Carson RT, Vignali DA: Simultaneous quantitation of 15 cytokines using a multiplexed flow cytometric assay. J Immunol Methods. 1999, 227: 41-52. 10.1016\/S0022-1759(99)00069-1.","journal-title":"J Immunol Methods"},{"key":"2231_CR4","volume-title":"Ann Rheum Dis","author":"EA Haavardsholm","year":"2007","unstructured":"Haavardsholm EA, Boyesen P, Ostergaard M, Schildvold A, Kvien TK: MRI findings in 84 early rheumatoid arthritis patients : bone marrow edema predicts erosive progression. Ann Rheum Dis. 2007, doi: 10.1136\/ard.2007.071977."},{"key":"2231_CR5","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.jri.2005.03.005","volume":"66","author":"NC Dupont","year":"2005","unstructured":"Dupont NC, Wang K, Wadhwa PD, Culhane JF, Nelson EL: Validation and comparison of luminex multiplex cytokine analysis kits with ELISA: determinations of a panel of nine cytokines in clinical sample culture supernatants. J Reprod Immunol. 2005, 66: 175-191. 10.1016\/j.jri.2005.03.005.","journal-title":"J Reprod Immunol"},{"key":"2231_CR6","doi-asserted-by":"publisher","first-page":"3860","DOI":"10.1002\/art.21493","volume":"52","author":"EA Haavardsholm","year":"2005","unstructured":"Haavardsholm EA, \u00d8stergaard M, Ejbjerg BJ, Kvan NP, Uhlig TA, Lilleas FG, Kvein TK: Reliability and sensitivity to change of the OMERACT rheumatoid arthritis magnetic resonance imaging score in a multireader, longitudinal setting. Arthritis Rheum. 2005, 52: 3860-3867. 10.1002\/art.21493.","journal-title":"Arthritis Rheum"},{"key":"2231_CR7","first-page":"1385","volume":"30","author":"M \u00d8stergaard","year":"2003","unstructured":"\u00d8stergaard M, Peterfy C, Conaghan P, McQueen F, Bird P, Ejbjerg B, Shnier R, O'Connor P, Klarlund M, Emery P, Genant H, Lassere M, Edmonds J: OMERACT rheumatoid arthritis magnetic resonance imaging studies. Core set of MRI acquisitions, joint pathology definitions, and the OMERACT RA-MRI scoring system. J Rheumatol. 2003, 30: 1385-1386.","journal-title":"J Rheumatol"},{"key":"2231_CR8","first-page":"1666","volume":"32","author":"PA Klimiuk","year":"2005","unstructured":"Klimiuk PA, Sierakowski S, Latosiewicz R, Skowronski J, Cylwik JP, Cylwik B, Chwiecko J: Histological patterns of synovitis and serum chemokines in patients with rheumatoid arthritis. J Rheumatol. 2005, 32: 1666-1672.","journal-title":"J Rheumatol"},{"key":"2231_CR9","doi-asserted-by":"publisher","first-page":"2585","DOI":"10.1002\/art.21962","volume":"54","author":"TC Yao","year":"2006","unstructured":"Yao TC, Kuo ML, See LC, Ou LS, Lee WI, Chan CK, Huang JL: RANTES and monocyte chemoattractant protein 1 as sensitive markers of disease activity in patients with juvenile rheumatoid arthritis: a six-year longitudinal study. Arthritis Rheum. 2006, 54: 2585-2593. 10.1002\/art.21962.","journal-title":"Arthritis Rheum"},{"key":"2231_CR10","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1136\/ard.2006.054924","volume":"66","author":"W Hueber","year":"2007","unstructured":"Hueber W, Tomooka BH, Zhao X, Kidd BA, Drijfhout JW, Fries JF, Van Venrooij WJ, Metzger AL, Genovese MC, Robinson WH: Proteomic analysis of secreted proteins in early rheumatoid arthritis: anti-citrulline reactivity is associated with upregulation of proinflammatory cytokines. Ann Rheum Dis. 2007, 66: 712-719. 10.1136\/ard.2006.054924.","journal-title":"Ann Rheum Dis"},{"key":"2231_CR11","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/S1359-6101(99)00005-2","volume":"10","author":"E Van Coillie","year":"1999","unstructured":"Van Coillie E, Van Damme J, Opdenakker G: The MCP\/eotaxin subfamily of CC chemokines. Cytokine Growth Factor Rev. 1999, 10: 61-86. 10.1016\/S1359-6101(99)00005-2.","journal-title":"Cytokine Growth Factor Rev"},{"key":"2231_CR12","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1002\/jcb.10319","volume":"87","author":"JM Lean","year":"2002","unstructured":"Lean JM, Murphy C, Fuller K, Chambers TJ: CCL9\/MIP-1gamma and its receptor CCR1 are the major chemokine ligand\/receptor species expressed by osteoclasts. J Cell Biochem. 2002, 87: 386-393. 10.1002\/jcb.10319.","journal-title":"J Cell Biochem"},{"key":"2231_CR13","doi-asserted-by":"publisher","first-page":"29011","DOI":"10.1074\/jbc.M501164200","volume":"280","author":"YZ Liu","year":"2005","unstructured":"Liu YZ, Dvornyk V, Lu Y, Shen H, Lappe JM, Recker RR, Deng HW: A novel pathophysiological mechanism for osteoporosis suggested by an in vivo gene expression study of circulating monocytes. J Biol Chem. 2005, 280: 29011-29016. 10.1074\/jbc.M501164200.","journal-title":"J Biol Chem"},{"key":"2231_CR14","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.humimm.2005.01.002","volume":"66","author":"SC Chae","year":"2005","unstructured":"Chae SC, Park YR, Shim SC, Lee IK, Chung HT: Eotaxin-3 gene polymorphisms are associated with rheumatoid arthritis in a Korean population. Hum Immunol. 2005, 66: 314-320. 10.1016\/j.humimm.2005.01.002.","journal-title":"Hum Immunol"},{"key":"2231_CR15","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1136\/ard.2006.061853","volume":"66","author":"W de Jaeger","year":"2007","unstructured":"de Jaeger W, Hoppenreijs EP, Wulffraat NM, Wedderburn LR, Kuis W, Prakken BJ: Blood and synovial fluid cytokine signatures in patients with juvenile idiopathic arthritis: a cross-sectional study. Ann Rheum Dis. 2007, 66: 589-598. 10.1136\/ard.2006.061853.","journal-title":"Ann Rheum Dis"}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/ar2381.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/ar2381\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/ar2381.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T10:27:01Z","timestamp":1728383221000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/ar2381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3,2]]},"references-count":15,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2008,4]]}},"alternative-id":["2231"],"URL":"https:\/\/doi.org\/10.1186\/ar2381","relation":{},"ISSN":["1478-6354"],"issn-type":[{"value":"1478-6354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3,2]]},"assertion":[{"value":"21 November 2007","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 February 2008","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 March 2008","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 March 2008","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"R28"}}