{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T04:48:15Z","timestamp":1787806095742,"version":"build-2784847793"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2008,3,11]],"date-time":"2008-03-11T00:00:00Z","timestamp":1205193600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2008,3,11]],"date-time":"2008-03-11T00:00:00Z","timestamp":1205193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Background<\/jats:title>\n                        <jats:p>Mannose-binding lectin (MBL) is an innate immune protein. The aim of our study was to determine whether genetically determined MBL deficiency is associated with susceptibility to juvenile rheumatoid arthritis (JRA) and whether <jats:italic>MBL2<\/jats:italic> genotypes are associated with JRA severity.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Methods<\/jats:title>\n                        <jats:p>In a retrospective cohort study of 218 patients with polyarthritis (n = 67) and oligoarthritis (n = 151), clinical and laboratory disease variables were obtained by clinical examination and chart reviews. Healthy Caucasian adults (n = 194) served as control individuals. <jats:italic>MBL2<\/jats:italic> gene mutations were determined by Taqman analysis to identify genotypes with high, medium and low expression of MBL. Functional MBL plasma concentrations were measured using enzyme-linked immunosorbent assay. Associations between clinical and laboratory variables and <jats:italic>MBL2<\/jats:italic> genotypes were determined by Kruskal-Wallis and \u03c7<jats:sup>2<\/jats:sup> tests.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p><jats:italic>MBL2<\/jats:italic> genotype frequencies were similar in polyarthritis and oligoarthritis patients as compared with control individuals. MBL plasma concentrations were associated with the high, medium and low MBL genotype expression groups (<jats:italic>P<\/jats:italic> &lt; 0.01). In polyarthritis patients, the presence of low-expressing (deficient) <jats:italic>MBL2<\/jats:italic> genotypes was associated with early age at onset of disease (<jats:italic>P<\/jats:italic> = 0.03). In oligoarthritis patients, patients with low-expressing <jats:italic>MBL2<\/jats:italic> genotypes were more often in remission (81%) than patients in the medium (54%) and high (56%) genotype groups (<jats:italic>P<\/jats:italic> = 0.02). The remaining clinical and laboratory variables, such as arthritis severity index, presence of radiographic erosions and antinuclear antibody positivity, were not associated with <jats:italic>MBL2<\/jats:italic> genotypes.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusion<\/jats:title>\n                        <jats:p>Genetically determined MBL deficiency does not increase susceptibility to JRA, but MBL deficiency is associated with a younger age at onset of juvenile polyarthritis. On the other hand, MBL-deficient children with juvenile oligoarthritis are more often in remission. Therefore, MBL appears to play a dual role in JRA.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/ar2386","type":"journal-article","created":{"date-parts":[[2008,3,11]],"date-time":"2008-03-11T20:52:10Z","timestamp":1205268730000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Mannose-binding lectin deficiency is associated with early onset of polyarticular juvenile rheumatoid arthritis: a cohort study"],"prefix":"10.1186","volume":"10","author":[{"given":"Koert M","family":"Dolman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nannette","family":"Brouwer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florine NJ","family":"Frakking","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berit","family":"Flat\u00f8","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul P","family":"Tak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taco W","family":"Kuijpers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d8ystein","family":"F\u00f8rre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Smerdel-Ramoya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,3,11]]},"reference":[{"key":"2236_CR1","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1002\/art.1780380618","volume":"38","author":"R Burgos-Vargas","year":"1995","unstructured":"Burgos-Vargas R, Vazquez-Mellado J: The early clinical recognition of juvenile-onset ankylosing spondylitis and its differentiation from juvenile rheumatoid arthritis. Arthritis Rheum. 1995, 38: 835-844. 10.1002\/art.1780380618.","journal-title":"Arthritis Rheum"},{"key":"2236_CR2","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1002\/art.1780360406","volume":"36","author":"R Ploski","year":"1993","unstructured":"Ploski R, Vinje O, Ronningen KS, Spurkland A, Sorskaar D, Vartdal F, Forre O: HLA class II alleles and heterogeneity of juvenile rheumatoid arthritis. DRB1*0101 may define a novel subset of the disease. Arthritis Rheum. 1993, 36: 465-472. 10.1002\/art.1780360406.","journal-title":"Arthritis Rheum"},{"key":"2236_CR3","first-page":"557","volume":"30","author":"JG Schaller","year":"1983","unstructured":"Schaller JG: Pauciarticular arthritis of childhood (pauciarticular juvenile rheumatoid arthritis). Ann Pediatr (Paris). 1983, 30: 557-563.","journal-title":"Ann Pediatr (Paris)"},{"key":"2236_CR4","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1097\/00003086-199104000-00005","volume":"265","author":"RL Wilder","year":"1991","unstructured":"Wilder RL, Crofford LJ: Do infectious agents cause rheumatoid arthritis?. Clin Orthop Relat Res. 1991, 265: 36-41.","journal-title":"Clin Orthop Relat Res"},{"key":"2236_CR5","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1016\/0167-5699(96)10062-1","volume":"17","author":"MW Turner","year":"1996","unstructured":"Turner MW: Mannose-binding lectin: the pluripotent molecule of the innate immune system. Immunol Today. 1996, 17: 532-540. 10.1016\/0167-5699(96)10062-1.","journal-title":"Immunol Today"},{"key":"2236_CR6","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1128\/IAI.68.2.688-693.2000","volume":"68","author":"O Neth","year":"2000","unstructured":"Neth O, Jack DL, Dodds AW, Holzel H, Klein NJ, Turner MW: Mannose-binding lectin binds to a range of clinically relevant microorganisms and promotes complement deposition. Infect Immun. 2000, 68: 688-693. 10.1128\/IAI.68.2.688-693.2000.","journal-title":"Infect Immun"},{"key":"2236_CR7","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1099\/0022-1317-81-4-949","volume":"81","author":"M Saifuddin","year":"2000","unstructured":"Saifuddin M, Hart ML, Gewurz H, Zhang Y, Spear GT: Interaction of mannose-binding lectin with primary isolates of human immunodeficiency virus type 1. J Gen Virol. 2000, 81: 949-955.","journal-title":"J Gen Virol"},{"key":"2236_CR8","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1093\/hmg\/1.9.709","volume":"1","author":"RJ Lipscombe","year":"1992","unstructured":"Lipscombe RJ, Sumiya M, Hill AV, Lau YL, Levinsky RJ, Summerfield JA, Turner MW: High frequencies in African and non-African populations of independent mutations in the mannose binding protein gene. Hum Mol Genet. 1992, 1: 709-715. 10.1093\/hmg\/1.9.709.","journal-title":"Hum Mol Genet"},{"key":"2236_CR9","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/BF00163962","volume":"40","author":"HO Madsen","year":"1994","unstructured":"Madsen HO, Garred P, Kurtzhals JA, Lamm LU, Ryder LP, Thiel S, Svejgaard A: A new frequent allele is the missing link in the structural polymorphism of the human mannan-binding protein. Immunogenetics. 1994, 40: 37-44. 10.1007\/BF00163962.","journal-title":"Immunogenetics"},{"key":"2236_CR10","doi-asserted-by":"publisher","first-page":"2051","DOI":"10.1016\/j.molimm.2006.01.003","volume":"43","author":"N Brouwer","year":"2006","unstructured":"Brouwer N, Dolman KM, van Zwieten R, Nieuwenhuys E, Hart M, Aarden LA, Roos D, Kuijpers TW: Mannan-binding lectin (MBL)-mediated opsonization is enhanced by the alternative pathway amplification loop. Mol Immunol. 2006, 43: 2051-2060. 10.1016\/j.molimm.2006.01.003.","journal-title":"Mol Immunol"},{"key":"2236_CR11","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1086\/340216","volume":"185","author":"G Kronborg","year":"2002","unstructured":"Kronborg G, Weis N, Madsen HO, Pedersen SS, Wejse C, Nielsen H, Skinhoj P, Garred P: Variant mannose-binding lectin alleles are not associated with susceptibility to or outcome of invasive pneumococcal infection in randomly included patients. J Infect Dis. 2002, 185: 1517-1520. 10.1086\/340216.","journal-title":"J Infect Dis"},{"key":"2236_CR12","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.4049\/jimmunol.155.6.3013","volume":"155","author":"HO Madsen","year":"1995","unstructured":"Madsen HO, Garred P, Thiel S, Kurtzhals JA, Lamm LU, Ryder LP, Svejgaard A: Interplay between promoter and structural gene variants control basal serum level of mannan-binding protein. J Immunol. 1995, 155: 3013-3020.","journal-title":"J Immunol"},{"key":"2236_CR13","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.4049\/jimmunol.161.6.3169","volume":"161","author":"HO Madsen","year":"1998","unstructured":"Madsen HO, Satz ML, Hogh B, Svejgaard A, Garred P: Different molecular events result in low protein levels of mannan-binding lectin in populations from southeast Africa and South America. J Immunol. 1998, 161: 3169-3175.","journal-title":"J Immunol"},{"key":"2236_CR14","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1016\/j.ejca.2005.10.027","volume":"42","author":"FN Frakking","year":"2006","unstructured":"Frakking FN, van de Wetering MD, Brouwer N, Dolman KM, Geissler J, Lemkes B, Caron HN, Kuijpers TW: The role of mannose-binding lectin (MBL) in paediatric oncology patients with febrile neutropenia. Eur J Cancer. 2006, 42: 909-916. 10.1016\/j.ejca.2005.10.027.","journal-title":"Eur J Cancer"},{"key":"2236_CR15","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1001\/jama.285.10.1316","volume":"285","author":"A Koch","year":"2001","unstructured":"Koch A, Melbye M, Sorensen P, Homoe P, Madsen HO, Molbak K, Hansen CH, Andersen LH, Hahn GW, Garred P: Acute respiratory tract infections and mannose-binding lectin insufficiency during early childhood. JAMA. 2001, 285: 1316-1321. 10.1001\/jama.285.10.1316.","journal-title":"JAMA"},{"key":"2236_CR16","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1136\/bmj.314.7089.1229","volume":"314","author":"JA Summerfield","year":"1997","unstructured":"Summerfield JA, Sumiya M, Levin M, Turner MW: Association of mutations in mannose binding protein gene with childhood infection in consecutive hospital series. BMJ. 1997, 314: 1229-1232.","journal-title":"BMJ"},{"key":"2236_CR17","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/S0161-5890(03)00104-4","volume":"40","author":"P Garred","year":"2003","unstructured":"Garred P, Larsen F, Madsen HO, Koch C: Mannose-binding lectin deficiency \u2013 revisited. Mol Immunol. 2003, 40: 73-84. 10.1016\/S0161-5890(03)00104-4.","journal-title":"Mol Immunol"},{"key":"2236_CR18","doi-asserted-by":"publisher","first-page":"3966","DOI":"10.1002\/art.21484","volume":"52","author":"YH Lee","year":"2005","unstructured":"Lee YH, Witte T, Momot T, Schmidt RE, Kaufman KM, Harley JB, Sestak AL: The mannose-binding lectin gene polymorphisms and systemic lupus erythematosus: two case-control studies and a meta-analysis. Arthritis Rheum. 2005, 52: 3966-3974. 10.1002\/art.21484.","journal-title":"Arthritis Rheum"},{"key":"2236_CR19","first-page":"629","volume":"25","author":"NA Graudal","year":"1998","unstructured":"Graudal NA, Homann C, Madsen HO, Svejgaard A, Jurik AG, Graudal HK, Garred P: Mannan binding lectin in rheumatoid arthritis. A longitudinal study. J Rheumatol. 1998, 25: 629-635.","journal-title":"J Rheumatol"},{"key":"2236_CR20","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1002\/1529-0131(200003)43:3<515::AID-ANR6>3.0.CO;2-T","volume":"43","author":"NA Graudal","year":"2000","unstructured":"Graudal NA, Madsen HO, Tarp U, Svejgaard A, Jurik G, Graudal HK, Garred P: The association of variant mannose-binding lectin genotypes with radiographic outcome in rheumatoid arthritis. Arthritis Rheum. 2000, 43: 515-521. 10.1002\/1529-0131(200003)43:3<515::AID-ANR6>3.0.CO;2-T.","journal-title":"Arthritis Rheum"},{"key":"2236_CR21","first-page":"935","volume":"28","author":"S Jacobsen","year":"2001","unstructured":"Jacobsen S, Madsen HO, Klarlund M, Jensen T, Skjodt H, Jensen KE, Svejgaard A, Garred P: The influence of mannose binding lectin polymorphisms on disease outcome in early polyarthritis. TIRA Group. J Rheumatol. 2001, 28: 935-942.","journal-title":"J Rheumatol"},{"key":"2236_CR22","first-page":"728","volume":"28","author":"S Saevarsdottir","year":"2001","unstructured":"Saevarsdottir S, Vikingsdottir T, Vikingsson A, Manfredsdottir V, Geirsson AJ, Valdimarsson H: Low mannose binding lectin predicts poor prognosis in patients with early rheumatoid arthritis. A prospective study. J Rheumatol. 2001, 28: 728-734.","journal-title":"J Rheumatol"},{"key":"2236_CR23","first-page":"26","volume":"27","author":"P Garred","year":"2000","unstructured":"Garred P, Madsen HO, Marquart H, Hansen TM, S\u00f8rensen SF, Petersen J, Volck B, Svejgaard A, Graudal NA, Rudd PM, Dwek RA, Sim RB, Andersen V: Two edged role of mannose binding lectin in rheumatoid arthritis: a cross sectional study. J Rheumatol. 2000, 27: 26-34.","journal-title":"J Rheumatol"},{"key":"2236_CR24","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1093\/rheumatology\/37.2.186","volume":"37","author":"SJ Stanworth","year":"1998","unstructured":"Stanworth SJ, Donn RP, Hassall A, Dawes P, Ollier W, Snowden N: Absence of an association between mannose-binding lectin polymorphism and rheumatoid arthritis. Br J Rheumatol. 1998, 37: 186-188. 10.1093\/rheumatology\/37.2.186.","journal-title":"Br J Rheumatol"},{"key":"2236_CR25","first-page":"442","volume":"31","author":"A Barton","year":"2004","unstructured":"Barton A, Platt H, Salway F, Symmons D, Lunt M, Worthington J, Silman A: Polymorphisms in the mannose binding lectin (MBL) gene are not associated with radiographic erosions in rheumatoid or inflammatory polyarthritis. J Rheumatol. 2004, 31: 442-447.","journal-title":"J Rheumatol"},{"key":"2236_CR26","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/S0140-6736(07)60363-8","volume":"369","author":"A Ravelli","year":"2007","unstructured":"Ravelli A, Martini A: Juvenile idiopathic arthritis. Lancet. 2007, 369: 767-778. 10.1016\/S0140-6736(07)60363-8.","journal-title":"Lancet"},{"key":"2236_CR27","doi-asserted-by":"publisher","first-page":"R85","DOI":"10.1186\/ar1953","volume":"8","author":"M Kang","year":"2006","unstructured":"Kang M, Wang HW, Cheng PX, Yin ZD, Li XO, Shi H, Hu XF: Lack of association between mannose-binding lectin gene polymorphisms and juvenile idiopathic arthritis in a Han population from the Hubei province of China. Arthritis Res Ther. 2006, 8: R85-10.1186\/ar1953.","journal-title":"Arthritis Res Ther"},{"key":"2236_CR28","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1002\/art.10146","volume":"46","author":"B Flato","year":"2002","unstructured":"Flato B, Smerdel A, Johnston V, Lien G, Dale K, Vinje O, Egeland T, Sorskaar D, Forre O: The influence of patient characteristics, disease variables, and HLA alleles on the development of radiographically evident sacroiliitis in juvenile idiopathic arthritis. Arthritis Rheum. 2002, 46: 986-994. 10.1002\/art.10146.","journal-title":"Arthritis Rheum"},{"key":"2236_CR29","first-page":"386","volume":"30","author":"B Flato","year":"2003","unstructured":"Flato B, Lien G, Smerdel A, Vinje O, Dale K, Johnston V, Sorskaar D, Moum T, Ploski R, Forre O: Prognostic factors in juvenile rheumatoid arthritis: a case-control study revealing early predictors and outcome after 14.9 years. J Rheumatol. 2003, 30: 386-393.","journal-title":"J Rheumatol"},{"key":"2236_CR30","first-page":"195","volume":"20","author":"EJ Brewer Jr","year":"1977","unstructured":"Brewer EJ, Bass J, Baum J, Cassidy JT, Fink C, Jacobs J, Hanson V, Levinson JE, Schaller J, Stillman JS: Current proposed revision of JRA Criteria. JRA Criteria Subcommittee of the Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Section of The Arthritis Foundation. Arthritis Rheum. 1977, 20: 195-199.","journal-title":"Arthritis Rheum"},{"key":"2236_CR31","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1002\/art.1780371209","volume":"37","author":"G Singh","year":"1994","unstructured":"Singh G, Athreya BH, Fries JF, Goldsmith DP: Measurement of health status in children with juvenile rheumatoid arthritis. Arthritis Rheum. 1994, 37: 1761-1769. 10.1002\/art.1780371209.","journal-title":"Arthritis Rheum"},{"key":"2236_CR32","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1136\/jcp.56.12.956","volume":"56","author":"AN Tacx","year":"2003","unstructured":"Tacx AN, Groeneveld AB, Hart MH, Aarden LA, Hack CE: Mannan binding lectin in febrile adults: no correlation with microbial infection and complement activation. J Clin Pathol. 2003, 56: 956-959. 10.1136\/jcp.56.12.956.","journal-title":"J Clin Pathol"},{"key":"2236_CR33","first-page":"1","volume-title":"Hum Genet","author":"T Bernig","year":"2005","unstructured":"Bernig T, Breunis W, Brouwer N, Hutchinson A, Welch R, Roos D, Kuijpers T, Chanock S: An analysis of genetic variation across the MBL2 locus in Dutch Caucasians indicates that 3' haplotypes could modify circulating levels of mannose-binding lectin. Hum Genet. 2005, 1-12."},{"key":"2236_CR34","doi-asserted-by":"publisher","first-page":"2143","DOI":"10.1016\/j.molimm.2006.01.008","volume":"43","author":"MI Garcia-Laorden","year":"2006","unstructured":"Garcia-Laorden MI, Pena MJ, Caminero JA, Garcia-Saavedra A, Campos-Herrero MI, Caballero A, Rodriguez-Gallego C: Influence of mannose-binding lectin on HIV infection and tuberculosis in a Western-European population. Mol Immunol. 2006, 43: 2143-2150. 10.1016\/j.molimm.2006.01.008.","journal-title":"Mol Immunol"},{"key":"2236_CR35","doi-asserted-by":"publisher","first-page":"2160","DOI":"10.1002\/1529-0131(200010)43:10<2160::AID-ANR3>3.0.CO;2-T","volume":"43","author":"IA Schrijver","year":"2000","unstructured":"Schrijver IA, Melief MJ, Tak PP, Hazenberg MP, Laman JD: Antigen-presenting cells containing bacterial peptidoglycan in synovial tissues of rheumatoid arthritis patients coexpress costimulatory molecules and cytokines. Arthritis Rheum. 2000, 43: 2160-2168. 10.1002\/1529-0131(200010)43:10<2160::AID-ANR3>3.0.CO;2-T.","journal-title":"Arthritis Rheum"},{"key":"2236_CR36","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1002\/1529-0131(200003)43:3<593::AID-ANR16>3.0.CO;2-1","volume":"43","author":"I van der Heijden","year":"2000","unstructured":"van der Heijden I, Wilbrink B, Tchetverikov I, Schrijver IA, Schouls LM, Hazenberg MP, Breedveld FC, Tak PP: Presence of bacterial DNA and bacterial peptidoglycans in joints of patients with rheumatoid arthritis and other arthritides. Arthritis Rheum. 2000, 43: 593-598. 10.1002\/1529-0131(200003)43:3<593::AID-ANR16>3.0.CO;2-1.","journal-title":"Arthritis Rheum"},{"key":"2236_CR37","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.jaut.2006.07.002","volume":"27","author":"B Gupta","year":"2006","unstructured":"Gupta B, Raghav SK, Agrawal C, Chaturvedi VP, Das RH, Das HR: Anti-MBL autoantibodies in patients with rheumatoid arthritis: prevalence and clinical significance. J Autoimmun. 2006, 27: 125-133. 10.1016\/j.jaut.2006.07.002.","journal-title":"J Autoimmun"},{"key":"2236_CR38","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1111\/j.0300-9475.2004.01437.x","volume":"60","author":"S Saevarsdottir","year":"2004","unstructured":"Saevarsdottir S, Vikingsdottir T, Valdimarsson H: The potential role of mannan-binding lectin in the clearance of self-components including immune complexes. Scand J Immunol. 2004, 60: 23-29. 10.1111\/j.0300-9475.2004.01437.x.","journal-title":"Scand J Immunol"},{"key":"2236_CR39","first-page":"1692","volume":"34","author":"S Saevarsdottir","year":"2007","unstructured":"Saevarsdottir S, Steinsson K, Grondal G, Valdimarsson H: Patients with rheumatoid arthritis have higher levels of mannan-binding lectin than their first-degree relatives and unrelated controls. J Rheumatol. 2007, 34: 1692-1695.","journal-title":"J Rheumatol"},{"key":"2236_CR40","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1038\/nm0395-237","volume":"1","author":"R Malhotra","year":"1995","unstructured":"Malhotra R, Wormald MR, Rudd PM, Fischer PB, Dwek RA, Sim RB: Glycosylation changes of IgG associated with rheumatoid arthritis can activate complement via the mannose-binding protein. Nat Med. 1995, 1: 237-243. 10.1038\/nm0395-237.","journal-title":"Nat Med"},{"key":"2236_CR41","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1002\/art.22302","volume":"56","author":"LN Troelsen","year":"2007","unstructured":"Troelsen LN, Garred P, Madsen HO, Jacobsen S: Genetically determined high serum levels of mannose-binding lectin and agalactosyl IgG are associated with ischemic heart disease in rheumatoid arthritis. Arthritis Rheum. 2007, 56: 21-29. 10.1002\/art.22302.","journal-title":"Arthritis Rheum"},{"key":"2236_CR42","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/S0161-5890(02)00254-7","volume":"39","author":"A Roos","year":"2003","unstructured":"Roos A, Bouwman LH, Munoz J, Zuiverloon T, Faber-Krol MC, Fallaux-van den Houten FC, Klar-Mohamad N, Hack CE, Tilanus MG, Daha MR: Functional characterization of the lectin pathway of complement in human serum. Mol Immunol. 2003, 39: 655-668. 10.1016\/S0161-5890(02)00254-7.","journal-title":"Mol Immunol"},{"key":"2236_CR43","doi-asserted-by":"publisher","first-page":"1570","DOI":"10.2337\/diabetes.53.6.1570","volume":"53","author":"TK Hansen","year":"2004","unstructured":"Hansen TK, Tarnow L, Thiel S, Steffensen R, Stehouwer CD, Schalkwijk CG, Parving HH, Flyvbjerg A: Association between mannose-binding lectin and vascular complications in type 1 diabetes. Diabetes. 2004, 53: 1570-1576. 10.2337\/diabetes.53.6.1570.","journal-title":"Diabetes"},{"key":"2236_CR44","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1161\/hc3601.095578","volume":"104","author":"JE Jordan","year":"2001","unstructured":"Jordan JE, Montalto MC, Stahl GL: Inhibition of mannose-binding lectin reduces postischemic myocardial reperfusion injury. Circulation. 2001, 104: 1413-1418. 10.1161\/hc3601.095578.","journal-title":"Circulation"}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/ar2386.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/ar2386\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/ar2386.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T10:27:28Z","timestamp":1728383248000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/ar2386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3,11]]},"references-count":44,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2008,4]]}},"alternative-id":["2236"],"URL":"https:\/\/doi.org\/10.1186\/ar2386","relation":{},"ISSN":["1478-6354"],"issn-type":[{"value":"1478-6354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3,11]]},"assertion":[{"value":"18 December 2007","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 February 2008","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2008","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2008","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"R32"}}