{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:48:56Z","timestamp":1789980536930,"version":"4.0.1"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2009,5,14]],"date-time":"2009-05-14T00:00:00Z","timestamp":1242259200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2009,5,14]],"date-time":"2009-05-14T00:00:00Z","timestamp":1242259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Introduction<\/jats:title>\n                        <jats:p>Beh\u00e7et's disease is a chronic systemic inflammatory disease that remains incompletely understood. Herein, we perform the first genome-wide association study in Beh\u00e7et's disease.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Methods<\/jats:title>\n                        <jats:p>Using DNA pooling technology and the Affymetrix 500K arrays, we identified possible candidate gene associations with Beh\u00e7et's disease in a cohort of 152 Beh\u00e7et's disease patients and 172 healthy ethnically matched controls. Genetic loci that were identified in the pooling study were genotyped in patients and controls using TaqMan genotyping technology.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>We identified genetic associations between Beh\u00e7et's disease and single-nucleotide polymorphisms (SNPs) in <jats:italic>KIAA1529<\/jats:italic>, <jats:italic>CPVL<\/jats:italic>, <jats:italic>LOC100129342<\/jats:italic>, <jats:italic>UBASH3B<\/jats:italic>, and <jats:italic>UBAC2<\/jats:italic> (odds ratio = 2.04, 2.26, 1.84, 1.71, and 1.61, respectively; <jats:italic>P<\/jats:italic> value = 4.2 \u00d7 10<jats:sup>-5<\/jats:sup>, 1.0 \u00d7 10<jats:sup>-4<\/jats:sup>, 3.0 \u00d7 10<jats:sup>-4<\/jats:sup>, 1.5 \u00d7 10<jats:sup>-3<\/jats:sup>, and 5.8 \u00d7 10<jats:sup>-3<\/jats:sup>, respectively). Among the associated SNPs, the Beh\u00e7et's disease-risk allele in rs2061634 leads to substitution of serine to cysteine at amino acid position 995 (S995C) in the KIAA1529 protein.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusions<\/jats:title>\n                        <jats:p>Using an unbiased whole-genome genetic association approach, we identified novel candidate genetic loci that are associated with increased susceptibility for Beh\u00e7et's disease. These findings will help to better understand the pathogenesis of Beh\u00e7et's disease and identify novel targets for therapeutic intervention.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/ar2695","type":"journal-article","created":{"date-parts":[[2009,5,14]],"date-time":"2009-05-14T19:30:41Z","timestamp":1242329441000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":124,"title":["Identification of novel genetic susceptibility loci for Beh\u00e7et's disease using a genome-wide association study"],"prefix":"10.1186","volume":"11","author":[{"given":"Yiping","family":"Fei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Webb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth L","family":"Cobb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haner","family":"Direskeneli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcher","family":"Saruhan-Direskeneli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr H","family":"Sawalha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,5,14]]},"reference":[{"key":"2535_CR1","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1038\/ncprheum0436","volume":"3","author":"H Yazici","year":"2007","unstructured":"Yazici H, Fresko I, Yurdakul S: Behcet's syndrome: disease manifestations, management, and advances in treatment. 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