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HA or mepivacaine was administered twice (once a month) under ultrasound guidance. Efficacy measurements included the Lequesne's algofunctional index, a visual analog scale for pain, concomitant use of analgesia, patient and physician global measurement, and safety.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>Patients in the HA group exhibited a significantly reduced Lequesne's algofunctional index 3 and 6 months after treatment (<jats:italic>P<\/jats:italic> &lt; 0.001) and significantly reduced visual analog scale pain scores 3 and 6 months after treatment (<jats:italic>P<\/jats:italic> &lt; 0.05) compared with the local anesthetic group. All primary and secondary measures were significantly improved versus baseline, but other than the above were not different from each other at 3 or 6 months. Adverse effects were minimal.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusions<\/jats:title>\n                        <jats:p>This comparative study suggests a beneficial effect and safety of intra-articular HA in the management of hip OA.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Trial registration number<\/jats:title>\n                        <jats:p>ISRCTN39397064.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/ar2875","type":"journal-article","created":{"date-parts":[[2009,12,10]],"date-time":"2009-12-10T12:54:47Z","timestamp":1260449687000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Comparative, double-blind, controlled study of intra-articular hyaluronic acid (Hyalubrix\u00ae) injections versus local anesthetic in osteoarthritis of the hip"],"prefix":"10.1186","volume":"11","author":[{"given":"Alberto","family":"Migliore","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Massafra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Bizzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Vacca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Severino","family":"Martin-Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Granata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Alimonti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro","family":"Tormenta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,12,9]]},"reference":[{"key":"2711_CR1","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1002\/1529-0131(199805)41:5<778::AID-ART4>3.0.CO;2-V","volume":"41","author":"RC Lawrence","year":"1998","unstructured":"Lawrence RC, Helmick CG, Arnett FC, Deyo RA, Felson DT, Giannini EH, Heyse SP, Hirsch R, Hochberg MC, Hunder GG, Liang MH, Pillemer SR, Steen VD, Wolfe F: Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States. 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