{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:12:09Z","timestamp":1777594329594,"version":"3.51.4"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2010,5,27]],"date-time":"2010-05-27T00:00:00Z","timestamp":1274918400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2010,5,27]],"date-time":"2010-05-27T00:00:00Z","timestamp":1274918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Introduction<\/jats:title>\n                        <jats:p>Lung involvement is a common extra-articular manifestation of rheumatoid arthritis (RA) that confers significant morbidity and mortality. The objective of the present study is to assess which respiratory symptoms and patient and disease characteristics are most highly associated with pulmonary function test (PFT) abnormalities in an RA patient cohort without clinical cardiovascular disease.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Methods<\/jats:title>\n                        <jats:p>A total of 159 individuals with RA and without clinically evident cardiovascular disease were evaluated. Respiratory symptoms were assessed with the Lung Tissue Research Consortium questionnaire and all patients underwent evaluation with PFTs. Demographic, lifestyle, RA disease and treatment characteristics were collected. Subclinical coronary artery disease was assessed by cardiac computed tomography. Multivariable regression analysis was used to identify pulmonary symptoms and nonpulmonary parameters associated with PFT abnormalities. Areas under the receiver operating characteristic curves (AUC) were calculated to evaluate the discrimination of these variables for identifying patients with PFT abnormalities.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>Respiratory symptoms were reported by 42% of the patient population. Although only 6% carried a prior diagnosis of lung disease, PFT abnormalities were identified in 28% of the subjects. Symptoms combined with other patient and RA characteristics (body mass index, current smoking, anti-cyclic citrullinated peptide antibodies, and current prednisone use) performed satisfactorily in predicting the PFT abnormalities of obstruction (AUC = 0.91, 95% confidence interval = 0.78 to 0.98), restriction (AUC = 0.79, 95% confidence interval = 0.75 to 0.93) and impaired diffusion (AUC = 0.85, 95% confidence interval = 0.59 to 0.92). Co-morbid subclinical coronary artery disease did not modify these relationships.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusions<\/jats:title>\n                        <jats:p>Assessment of respiratory symptoms along with a limited number of clinical parameters may serve as a useful and inexpensive clinical tool for identifying RA patients in need of further pulmonary investigation.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/ar3037","type":"journal-article","created":{"date-parts":[[2010,7,13]],"date-time":"2010-07-13T06:13:56Z","timestamp":1279001636000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Respiratory symptoms and disease characteristics as predictors of pulmonary function abnormalities in patients with rheumatoid arthritis: an observational cohort study"],"prefix":"10.1186","volume":"12","author":[{"given":"Dimitrios A","family":"Pappas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon T","family":"Giles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey","family":"Connors","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noah","family":"Lechtzin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan M","family":"Bathon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonye K","family":"Danoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,5,27]]},"reference":[{"key":"2872_CR1","first-page":"1196","volume":"30","author":"DJ Watson","year":"2003","unstructured":"Watson DJ, Rhodes T, Guess HA: All-cause mortality and vascular events among patients with rheumatoid arthritis, osteoarthritis, or no arthritis in the UK general practice research database. J Rheumatol. 2003, 30: 1196-1202.","journal-title":"J Rheumatol"},{"key":"2872_CR2","first-page":"1072","volume":"25","author":"DP Symmons","year":"1998","unstructured":"Symmons DP, Jones MA, Scott DL, Prior P: Longterm mortality outcome in patients with rheumatoid arthritis: early presenters continue to do well. J Rheumatol. 1998, 25: 1072-1077.","journal-title":"J Rheumatol"},{"key":"2872_CR3","doi-asserted-by":"publisher","first-page":"S9","DOI":"10.1016\/j.amjmed.2008.06.011","volume":"121","author":"SE Gabriel","year":"2008","unstructured":"Gabriel SE: Cardiovascular morbidity and mortality in rheumatoid arthritis. Am J Med. 2008, 121: S9-S14. 10.1016\/j.amjmed.2008.06.011.","journal-title":"Am J Med"},{"key":"2872_CR4","doi-asserted-by":"publisher","first-page":"3583","DOI":"10.1002\/art.22979","volume":"56","author":"A Gonzalez","year":"2007","unstructured":"Gonzalez A, Maradit Kremers H, Crowson CS, Nicola PJ, Davis JM, Therneau TM, Roger VL, Gabriel SE: The widening mortality gap between rheumatoid arthritis patients and the general population. Arthritis Rheum. 2007, 56: 3583-3587. 10.1002\/art.22979.","journal-title":"Arthritis Rheum"},{"key":"2872_CR5","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1002\/art.10705","volume":"48","author":"SE Gabriel","year":"2003","unstructured":"Gabriel SE, Crowson CS, Kremers HM, Doran MF, Turesson C, O'Fallon WM, Matteson EL: Survival in rheumatoid arthritis: a population-based analysis of trends over 40 years. Arthritis Rheum. 2003, 48: 54-58. 10.1002\/art.10705.","journal-title":"Arthritis Rheum"},{"key":"2872_CR6","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1080\/03009740310004621","volume":"33","author":"C Turesson","year":"2004","unstructured":"Turesson C, Jacobsson LT: Epidemiology of extra-articular manifestations in rheumatoid arthritis. Scand J Rheumatol. 2004, 33: 65-72. 10.1080\/03009740310004621.","journal-title":"Scand J Rheumatol"},{"key":"2872_CR7","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1093\/rheumatology\/38.7.668","volume":"38","author":"C Turesson","year":"1999","unstructured":"Turesson C, Jacobsson L, Bergstrom U: Extra-articular rheumatoid arthritis: prevalence and mortality. Rheumatology (Oxford). 1999, 38: 668-674. 10.1093\/rheumatology\/38.7.668.","journal-title":"Rheumatology (Oxford)"},{"key":"2872_CR8","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1097\/BOR.0b013e3282f798ed","volume":"20","author":"C Nannini","year":"2008","unstructured":"Nannini C, Ryu JH, Matteson EL: Lung disease in rheumatoid arthritis. Curr Opin Rheumatol. 2008, 20: 340-346. 10.1097\/BOR.0b013e3282f798ed.","journal-title":"Curr Opin Rheumatol"},{"key":"2872_CR9","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/S0049-0172(95)80034-4","volume":"24","author":"JM Anaya","year":"1995","unstructured":"Anaya JM, Diethelm L, Ortiz LA, Gutierrez M, Citera G, Welsh RA, Espinoza LR: Pulmonary involvement in rheumatoid arthritis. Semin Arthritis Rheum. 1995, 24: 242-254. 10.1016\/S0049-0172(95)80034-4.","journal-title":"Semin Arthritis Rheum"},{"key":"2872_CR10","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1136\/thorax.56.8.622","volume":"56","author":"JK Dawson","year":"2001","unstructured":"Dawson JK, Fewins HE, Desmond J, Lynch MP, Graham DR: Fibrosing alveolitis in patients with rheumatoid arthritis as assessed by high resolution computed tomography, chest radiography, and pulmonary function tests. Thorax. 2001, 56: 622-627. 10.1136\/thorax.56.8.622.","journal-title":"Thorax"},{"key":"2872_CR11","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1136\/ard.56.10.596","volume":"56","author":"B Cortet","year":"1997","unstructured":"Cortet B, Perez T, Roux N, Flipo RM, Duquesnoy B, Delcambre B, R\u00e9my-Jardin M: Pulmonary function tests and high resolution computed tomography of the lungs in patients with rheumatoid arthritis. Ann Rheum Dis. 1997, 56: 596-600. 10.1136\/ard.56.10.596.","journal-title":"Ann Rheum Dis"},{"key":"2872_CR12","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1164\/ajrccm.156.2.9609016","volume":"156","author":"E Gabbay","year":"1997","unstructured":"Gabbay E, Tarala R, Will R, Carroll G, Adler B, Cameron D, Lake FR: Interstitial lung disease in recent onset rheumatoid arthritis. Am J Respir Crit Care Med. 1997, 156: 528-535.","journal-title":"Am J Respir Crit Care Med"},{"key":"2872_CR13","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1378\/chest.93.1.114","volume":"93","author":"M Hakala","year":"1988","unstructured":"Hakala M: Poor prognosis in patients with rheumatoid arthritis hospitalized for interstitial lung fibrosis. Chest. 1988, 93: 114-118. 10.1378\/chest.93.1.114.","journal-title":"Chest"},{"key":"2872_CR14","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1093\/rheumatology\/kel253","volume":"46","author":"A Young","year":"2007","unstructured":"Young A, Koduri G, Batley M, Kulinskaya E, Gough A, Norton S, Dixey J, Early Rheumatoid Arthritis Study Group: Mortality in rheumatoid arthritis. increased in the early course of disease, in ischaemic heart disease and in pulmonary fibrosis. Rheumatology (Oxford). 2007, 46: 350-357. 10.1093\/rheumatology\/kel253.","journal-title":"Rheumatology (Oxford)"},{"key":"2872_CR15","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.3899\/jrheum.080322","volume":"35","author":"A Gonzalez","year":"2008","unstructured":"Gonzalez A, Icen M, Kremers HM, Crowson CS, Davis JM, Therneau TM, Roger VL, Gabriel SE: Mortality trends in rheumatoid arthritis: the role of rheumatoid factor. J Rheumatol. 2008, 35: 1009-1014. 10.3899\/jrheum.080322.","journal-title":"J Rheumatol"},{"key":"2872_CR16","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1136\/ard.38.3.222","volume":"38","author":"DM Geddes","year":"1979","unstructured":"Geddes DM, Webley M, Emerson PA: Airways obstruction in rheumatoid arthritis. Ann Rheum Dis. 1979, 38: 222-225. 10.1136\/ard.38.3.222.","journal-title":"Ann Rheum Dis"},{"key":"2872_CR17","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1001\/archinternmed.2007.59","volume":"168","author":"BR Gochuico","year":"2008","unstructured":"Gochuico BR, Avila NA, Chow CK, Novero LJ, Wu HP, Ren P, MacDonald SD, Travis WD, Stylianou MP, Rosas IO: Progressive preclinical interstitial lung disease in rheumatoid arthritis. Arch Intern Med. 2008, 168: 159-166. 10.1001\/archinternmed.2007.59.","journal-title":"Arch Intern Med"},{"key":"2872_CR18","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1093\/rheumatology\/keg466","volume":"43","author":"V Saravanan","year":"2004","unstructured":"Saravanan V, Kelly CA: Reducing the risk of methotrexate pneumonitis in rheumatoid arthritis. Rheumatology (Oxford). 2004, 43: 143-147. 10.1093\/rheumatology\/keg466.","journal-title":"Rheumatology (Oxford)"},{"key":"2872_CR19","doi-asserted-by":"publisher","first-page":"3221","DOI":"10.1517\/14656560802591430","volume":"9","author":"C Kelly","year":"2008","unstructured":"Kelly C, Saravanan V: Treatment strategies for a rheumatoid arthritis patient with interstitial lung disease. Expert Opin Pharmacother. 2008, 9: 3221-3230. 10.1517\/14656560802591430.","journal-title":"Expert Opin Pharmacother"},{"key":"2872_CR20","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1259\/bjr\/01948454","volume":"81","author":"EJ Hall","year":"2008","unstructured":"Hall EJ, Brenner DJ: Cancer risks from diagnostic radiology. Br J Radiol. 2008, 81: 362-378. 10.1259\/bjr\/01948454.","journal-title":"Br J Radiol"},{"key":"2872_CR21","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1093\/rheumatology\/ken450a","volume":"48","author":"R Luqmani","year":"2009","unstructured":"Luqmani R, Hennell S, Estrach C, Basher D, Birrell F, Bosworth A, Burke F, Callaghan C, Candal-Couto J, Fokke C, Goodson N, Homer D, Jackman J, Jeffreson P, Oliver S, Reed M, Sanz L, Stableford Z, Taylor P, Todd N, Warburton L, Washbrook C, Wilkinson M, British Society for Rheumatology, British Health Professionals in Rheumatology Standards, Guidelines and Audit Working Group: British society for rheumatology and british health professionals in rheumatology guideline for the management of rheumatoid arthritis (after the first 2 years). Rheumatology (Oxford). 2009, 48: 436-439. 10.1093\/rheumatology\/ken450a.","journal-title":"Rheumatology (Oxford)"},{"key":"2872_CR22","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1002\/art.20853","volume":"52","author":"H Maradit-Kremers","year":"2005","unstructured":"Maradit-Kremers H, Crowson CS, Nicola PJ, Ballman KV, Roger VL, Jacobsen SJ, Gabriel SE: Increased unrecognized coronary heart disease and sudden deaths in rheumatoid arthritis: a population-based cohort study. Arthritis Rheum. 2005, 52: 402-411. 10.1002\/art.20853.","journal-title":"Arthritis Rheum"},{"key":"2872_CR23","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1002\/art.20855","volume":"52","author":"PJ Nicola","year":"2005","unstructured":"Nicola PJ, Maradit-Kremers H, Roger VL, Jacobsen SJ, Crowson CS, Ballman KV, Gabriel SE: The risk of congestive heart failure in rheumatoid arthritis: a population-based study over 46 years. Arthritis Rheum. 2005, 52: 412-420. 10.1002\/art.20855.","journal-title":"Arthritis Rheum"},{"key":"2872_CR24","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1002\/art.23719","volume":"59","author":"JT Giles","year":"2008","unstructured":"Giles JT, Ling SM, Ferrucci L, Bartlett SJ, Andersen RE, Towns M, Muller D, Fontaine KR, Bathon JM: Abnormal body composition phenotypes in older rheumatoid arthritis patients: association with disease characteristics and pharmacotherapies. Arthritis Rheum. 2008, 59: 807-815. 10.1002\/art.23719.","journal-title":"Arthritis Rheum"},{"key":"2872_CR25","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1002\/art.1780310302","volume":"31","author":"FC Arnett","year":"1988","unstructured":"Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS, Medsger TA, RL Hunder: The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988, 31: 315-324. 10.1002\/art.1780310302.","journal-title":"Arthritis Rheum"},{"key":"2872_CR26","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1183\/09031936.05.00035205","volume":"26","author":"R Pellegrino","year":"2005","unstructured":"Pellegrino R, Viegi G, Brusasco V, Crapo RO, Burgos F, Casaburi R, Coates A, van der Grinten CP, Gustafsson P, Hankinson J, Jensen R, Johnson DC, MacIntyre N, McKay R, Miller MR, Navajas D, Pedersen OF, Wanger J: Interpretative strategies for lung function tests. Eur Respir J. 2005, 26: 948-968. 10.1183\/09031936.05.00035205.","journal-title":"Eur Respir J"},{"key":"2872_CR27","unstructured":"Lung Tissue Research Consortium consent form. [http:\/\/www.ltrcpublic.com\/forms\/LTRC_PDF_forms.pdf]"},{"key":"2872_CR28","unstructured":"Recommended respiratory disease questionnaires for use with adults and children in epidemiological research. [http:\/\/www.thoracic.org\/statements\/resources\/archive\/rrdquacer.pdf]"},{"key":"2872_CR29","first-page":"32","volume-title":"A statement by the committee on standards for epidemiology surveys on chronic respiratory disease of the American Thoracic Society","author":"C LeMaistre","year":"1969","unstructured":"LeMaistre C: A statement by the committee on standards for epidemiology surveys on chronic respiratory disease of the American Thoracic Society. 1969, New York: National Tuberculosis and Respiratory Disease Association, 32-"},{"key":"2872_CR30","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1148\/radiol.2341040439","volume":"234","author":"JJ Carr","year":"2005","unstructured":"Carr JJ, Nelson JC, Wong ND, McNitt-Gray M, Arad Y, Jacobs DR, Sidney S, Bild DE, Williams OD, Detrano RC: Calcified coronary artery plaque measurement with cardiac CT in population-based studies: standardized protocol of multi-ethnic study of atherosclerosis (MESA) and coronary artery risk development in young adults (CARDIA) study. Radiology. 2005, 234: 35-43. 10.1148\/radiol.2341040439.","journal-title":"Radiology"},{"key":"2872_CR31","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/0735-1097(90)90282-T","volume":"15","author":"AS Agatston","year":"1990","unstructured":"Agatston AS, Janowitz WR, Hildner FJ, Zusmer NR, Viamonte M, Detrano R: Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol. 1990, 15: 827-832. 10.1016\/0735-1097(90)90282-T.","journal-title":"J Am Coll Cardiol"},{"key":"2872_CR32","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1148\/radiol.2352040515","volume":"235","author":"JC Nelson","year":"2005","unstructured":"Nelson JC, Kronmal RA, Carr JJ, McNitt-Gray MF, Wong ND, Loria CM, Goldin JG, Williams OD, Detrano R: Measuring coronary calcium on CT images adjusted for attenuation differences. Radiology. 2005, 235: 403-414. 10.1148\/radiol.2352040515.","journal-title":"Radiology"},{"key":"2872_CR33","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1161\/CIRCULATIONAHA.107.688739","volume":"116","author":"K Nasir","year":"2007","unstructured":"Nasir K, Budoff MJ, Wong ND, Scheuner M, Herrington D, Arnett DK, Szklo M, Greenland P, Blumenthal R: Family history of premature coronary heart disease and coronary artery calcification: multi-ethnic study of atherosclerosis (MESA). Circulation. 2007, 116: 619-626. 10.1161\/CIRCULATIONAHA.107.688739.","journal-title":"Circulation"},{"key":"2872_CR34","doi-asserted-by":"publisher","first-page":"243","DOI":"10.4065\/74.3.243","volume":"74","author":"JA Rumberger","year":"1999","unstructured":"Rumberger JA, Brundage BH, Rader DJ, Kondos G: Electron beam computed tomographic coronary calcium scanning: a review and guidelines for use in asymptomatic persons. Mayo Clin Proc. 1999, 74: 243-252. 10.4065\/74.3.243.","journal-title":"Mayo Clin Proc"},{"key":"2872_CR35","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.jacc.2008.07.072","volume":"53","author":"MJ Budoff","year":"2009","unstructured":"Budoff MJ, Nasir K, McClelland RL, Detrano R, Wong N, Blumenthal RS, Kondos G, Kronmal RA: Coronary calcium predicts events better with absolute calcium scores than age-sex-race\/ethnicity percentiles: MESA (multi-ethnic study of atherosclerosis). J Am Coll Cardiol. 2009, 53: 345-352. 10.1016\/j.jacc.2008.07.072.","journal-title":"J Am Coll Cardiol"},{"key":"2872_CR36","first-page":"1480","volume":"15","author":"F Wolfe","year":"1988","unstructured":"Wolfe F, Kleinheksel SM, Cathey MA, Hawley DJ, Spitz PW, Fries JF: The clinical value of the stanford health assessment questionnaire functional disability index in patients with rheumatoid arthritis. J Rheumatol. 1988, 15: 1480-1488.","journal-title":"J Rheumatol"},{"key":"2872_CR37","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1002\/art.1780380107","volume":"38","author":"ML Prevoo","year":"1995","unstructured":"Prevoo ML, van 't Hof MA, Kuper HH, van Leeuwen MA, van de Putte LB, van Riel PL: Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum. 1995, 38: 44-48. 10.1002\/art.1780380107.","journal-title":"Arthritis Rheum"},{"key":"2872_CR38","first-page":"1792","volume":"22","author":"DM van der Heijde","year":"1995","unstructured":"van der Heijde DM, van Leeuwen MA, van Riel PL, van de Putte LB: Radiographic progression on radiographs of hands and feet during the first 3 years of rheumatoid arthritis measured according to sharp's method (van der heijde modification). J Rheumatol. 1995, 22: 1792-1796.","journal-title":"J Rheumatol"},{"key":"2872_CR39","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1148\/radiology.143.1.7063747","volume":"143","author":"JA Hanley","year":"1982","unstructured":"Hanley JA, McNeil BJ: The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology. 1982, 143: 29-36.","journal-title":"Radiology"},{"key":"2872_CR40","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1016\/S0895-4356(01)00341-9","volume":"54","author":"EW Steyerberg","year":"2001","unstructured":"Steyerberg EW, Harrell FE, Borsboom GJ, Eijkemans MJ, Vergouwe Y, Habbema JD: Internal validation of predictive models: efficiency of some procedures for logistic regression analysis. J Clin Epidemiol. 2001, 54: 774-781. 10.1016\/S0895-4356(01)00341-9.","journal-title":"J Clin Epidemiol"},{"key":"2872_CR41","doi-asserted-by":"publisher","first-page":"837","DOI":"10.2307\/2531595","volume":"44","author":"ER DeLong","year":"1988","unstructured":"DeLong ER, DeLong DM, Clarke-Pearson DL: Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics. 1988, 44: 837-845. 10.2307\/2531595.","journal-title":"Biometrics"},{"key":"2872_CR42","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1007\/s10067-007-0800-1","volume":"27","author":"I Alexiou","year":"2008","unstructured":"Alexiou I, Germenis A, Koutroumpas A, Kontogianni A, Theodoridou K, Sakkas LI: Anti-cyclic citrullinated peptide-2 (CCP2) autoantibodies and extra-articular manifestations in greek patients with rheumatoid arthritis. Clin Rheumatol. 2008, 27: 511-513. 10.1007\/s10067-007-0800-1.","journal-title":"Clin Rheumatol"},{"key":"2872_CR43","first-page":"795","volume":"85","author":"J Banks","year":"1992","unstructured":"Banks J, Banks C, Cheong B, Umachandran V, Smith AP, Jessop JD, Pritchard MH: An epidemiological and clinical investigation of pulmonary function and respiratory symptoms in patients with rheumatoid arthritis. Q J Med. 1992, 85: 795-806.","journal-title":"Q J Med"},{"key":"2872_CR44","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1002\/art.1780391014","volume":"39","author":"KG Saag","year":"1996","unstructured":"Saag KG, Kolluri S, Koehnke RK, Georgou TA, Rachow JW, Hunninghake GW, Schwartz DA: Rheumatoid arthritis lung disease. determinants of radiographic and physiologic abnormalities. Arthritis Rheum. 1996, 39: 1711-1719. 10.1002\/art.1780391014.","journal-title":"Arthritis Rheum"},{"key":"2872_CR45","first-page":"97","volume":"9","author":"PJ Charles","year":"1991","unstructured":"Charles PJ, Sweatman MC, Markwick JR, Maini RN: HLA-B40: a marker for susceptibility to lung disease in rheumatoid arthritis. Dis Markers. 1991, 9: 97-101.","journal-title":"Dis Markers"},{"key":"2872_CR46","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1093\/toxsci\/kfg167","volume":"75","author":"JW Card","year":"2003","unstructured":"Card JW, Racz WJ, Brien JF, Margolin SB, Massey TE: Differential effects of pirfenidone on acute pulmonary injury and ensuing fibrosis in the hamster model of amiodarone-induced pulmonary toxicity. Toxicol Sci. 2003, 75: 169-180. 10.1093\/toxsci\/kfg167.","journal-title":"Toxicol Sci"},{"key":"2872_CR47","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/S1096-7192(02)00044-6","volume":"76","author":"WA Gahl","year":"2002","unstructured":"Gahl WA, Brantly M, Troendle J, Avila NA, Padua A, Montalvo C, Cardona H, Calis KA, Gochuico B: Effect of pirfenidone on the pulmonary fibrosis of hermansky-pudlak syndrome. Mol Genet Metab. 2002, 76: 234-242. 10.1016\/S1096-7192(02)00044-6.","journal-title":"Mol Genet Metab"}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/ar3037.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/ar3037\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/ar3037.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T11:01:30Z","timestamp":1728385290000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/ar3037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5,27]]},"references-count":47,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2010,6]]}},"alternative-id":["2872"],"URL":"https:\/\/doi.org\/10.1186\/ar3037","relation":{},"ISSN":["1478-6354"],"issn-type":[{"value":"1478-6354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5,27]]},"assertion":[{"value":"15 January 2010","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 April 2010","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2010","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2010","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"R104"}}