{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T11:43:43Z","timestamp":1792410223007,"version":"4.4.0"},"reference-count":91,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2010,7,6]],"date-time":"2010-07-06T00:00:00Z","timestamp":1278374400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2010,7,6]],"date-time":"2010-07-06T00:00:00Z","timestamp":1278374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Obesity is a major risk factor for the development of osteoarthritis in both weight-bearing and nonweight-bearing joints. The mechanisms by which obesity influences the structural or symptomatic features of osteoarthritis are not well understood, but may include systemic inflammation associated with increased adiposity. In this study, we examined biomechanical, neurobehavioral, inflammatory, and osteoarthritic changes in C57BL\/6J mice fed a high-fat diet.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Female C57BL\/6J mice were fed either a 10% kcal fat or a 45% kcal fat diet from 9 to 54 weeks of age. Longitudinal changes in musculoskeletal function and inflammation were compared with endpoint neurobehavioral and osteoarthritic disease states. Bivariate and multivariate analyses were conducted to determine independent associations with diet, percentage body fat, and knee osteoarthritis severity. We also examined healthy porcine cartilage explants treated with physiologic doses of leptin, alone or in combination with IL-1\u03b1 and palmitic and oleic fatty acids, to determine the effects of leptin on cartilage extracellular matrix homeostasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>High susceptibility to dietary obesity was associated with increased osteoarthritic changes in the knee and impaired musculoskeletal force generation and motor function compared with controls. A high-fat diet also induced symptomatic characteristics of osteoarthritis, including hyperalgesia and anxiety-like behaviors. Controlling for the effects of diet and percentage body fat with a multivariate model revealed a significant association between knee osteoarthritis severity and serum levels of leptin, adiponectin, and IL-1\u03b1. Physiologic doses of leptin, in the presence or absence of IL-1\u03b1 and fatty acids, did not substantially alter extracellular matrix homeostasis in healthy cartilage explants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results indicate that diet-induced obesity increases the risk of symptomatic features of osteoarthritis through changes in musculoskeletal function and pain-related behaviors. Furthermore, the independent association of systemic adipokine levels with knee osteoarthritis severity supports a role for adipose-associated inflammation in the molecular pathogenesis of obesity-induced osteoarthritis. Physiologic levels of leptin do not alter extracellular matrix homeostasis in healthy cartilage, suggesting that leptin may be a secondary mediator of osteoarthritis pathogenesis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/ar3068","type":"journal-article","created":{"date-parts":[[2010,7,6]],"date-time":"2010-07-06T14:18:50Z","timestamp":1278425930000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":186,"title":["Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice"],"prefix":"10.1186","volume":"12","author":[{"given":"Timothy M","family":"Griffin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beverley","family":"Fermor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet L","family":"Huebner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia B","family":"Kraus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramona M","family":"Rodriguiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William C","family":"Wetsel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori A","family":"Setton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farshid","family":"Guilak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,7,6]]},"reference":[{"key":"2903_CR1","doi-asserted-by":"publisher","first-page":"18","DOI":"10.7326\/0003-4819-109-1-18","volume":"109","author":"DT Felson","year":"1988","unstructured":"Felson DT, Anderson JJ, Naimark A, Walker AM, Meenan RF: Obesity and knee osteoarthritis. The Framingham Study. Ann Intern Med. 1988, 109: 18-24.","journal-title":"Ann Intern Med"},{"key":"2903_CR2","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1097\/00001648-199903000-00013","volume":"10","author":"SA Oliveria","year":"1999","unstructured":"Oliveria SA, Felson DT, Cirillo PA, Reed JI, Walker AM: Body weight, body mass index, and incident symptomatic osteoarthritis of the hand, hip, and knee. Epidemiology. 1999, 10: 161-166. 10.1097\/00001648-199903000-00013.","journal-title":"Epidemiology"},{"key":"2903_CR3","doi-asserted-by":"publisher","first-page":"3904","DOI":"10.1002\/art.20726","volume":"50","author":"DT Felson","year":"2004","unstructured":"Felson DT, Goggins J, Niu J, Zhang Y, Hunter DJ: The effect of body weight on progression of knee osteoarthritis is dependent on alignment. Arthritis Rheum. 2004, 50: 3904-3909. 10.1002\/art.20726.","journal-title":"Arthritis Rheum"},{"key":"2903_CR4","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1001\/jama.286.2.188","volume":"286","author":"L Sharma","year":"2001","unstructured":"Sharma L, Song J, Felson DT, Cahue S, Shamiyeh E, Dunlop DD: The role of knee alignment in disease progression and functional decline in knee osteoarthritis. JAMA. 2001, 286: 188-195. 10.1001\/jama.286.2.188.","journal-title":"JAMA"},{"key":"2903_CR5","doi-asserted-by":"publisher","first-page":"1951","DOI":"10.1002\/1529-0131(199811)41:11<1951::AID-ART9>3.0.CO;2-9","volume":"41","author":"C Slemenda","year":"1998","unstructured":"Slemenda C, Heilman DK, Brandt KD, Katz BP, Mazzuca SA, Braunstein EM, Byrd D: Reduced quadriceps strength relative to body weight: a risk factor for knee osteoarthritis in women?. Arthritis Rheum. 1998, 41: 1951-1959. 10.1002\/1529-0131(199811)41:11<1951::AID-ART9>3.0.CO;2-9.","journal-title":"Arthritis Rheum"},{"key":"2903_CR6","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/oxfordjournals.aje.a116974","volume":"139","author":"WJ Carman","year":"1994","unstructured":"Carman WJ, Sowers M, Hawthorne VM, Weissfeld LA: Obesity as a risk factor for osteoarthritis of the hand and wrist: a prospective study. Am J Epidemiol. 1994, 139: 119-129.","journal-title":"Am J Epidemiol"},{"key":"2903_CR7","first-page":"1221","volume":"23","author":"FM Cicuttini","year":"1996","unstructured":"Cicuttini FM, Baker JR, Spector TD: The association of obesity with osteoarthritis of the hand and knee in women: a twin study. J Rheumatol. 1996, 23: 1221-1226.","journal-title":"J Rheumatol"},{"key":"2903_CR8","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1038\/oby.2006.145","volume":"14","author":"LM Abbate","year":"2006","unstructured":"Abbate LM, Stevens J, Schwartz TA, Renner JB, Helmick CG, Jordan JM: Anthropometric measures, body composition, body fat distribution, and knee osteoarthritis in women. Obesity (Silver Spring). 2006, 14: 1274-1281. 10.1038\/oby.2006.145.","journal-title":"Obesity (Silver Spring)"},{"key":"2903_CR9","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1136\/ard.2005.045724","volume":"66","author":"S Dahaghin","year":"2007","unstructured":"Dahaghin S, Bierma-Zeinstra SM, Koes BW, Hazes JM, Pols HA: Do metabolic factors add to the effect of overweight on hand osteoarthritis? The Rotterdam Study. Ann Rheum Dis. 2007, 66: 916-920. 10.1136\/ard.2005.045724.","journal-title":"Ann Rheum Dis"},{"key":"2903_CR10","first-page":"1827","volume":"15","author":"MA Davis","year":"1988","unstructured":"Davis MA, Ettinger WH, Neuhaus JM: The role of metabolic factors and blood pressure in the association of obesity with osteoarthritis of the knee. J Rheumatol. 1988, 15: 1827-1832.","journal-title":"J Rheumatol"},{"key":"2903_CR11","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1093\/oxfordjournals.aje.a115711","volume":"132","author":"MA Davis","year":"1990","unstructured":"Davis MA, Neuhaus JM, Ettinger WH, Mueller WH: Body fat distribution and osteoarthritis. Am J Epidemiol. 1990, 132: 701-707.","journal-title":"Am J Epidemiol"},{"key":"2903_CR12","first-page":"488","volume":"22","author":"MC Hochberg","year":"1995","unstructured":"Hochberg MC, Lethbridge-Cejku M, Scott WW, Reichle R, Plato CC, Tobin JD: The association of body weight, body fatness and body fat distribution with osteoarthritis of the knee: data from the Baltimore Longitudinal Study of Aging. J Rheumatol. 1995, 22: 488-493.","journal-title":"J Rheumatol"},{"key":"2903_CR13","first-page":"702","volume":"24","author":"K Martin","year":"1997","unstructured":"Martin K, Lethbridge-Cejku M, Muller DC, Elahi D, Andres R, Tobin JD, Hochberg MC: Metabolic correlates of obesity and radiographic features of knee osteoarthritis: data from the Baltimore Longitudinal Study of Aging. J Rheumatol. 1997, 24: 702-707.","journal-title":"J Rheumatol"},{"key":"2903_CR14","first-page":"1118","volume":"22","author":"DJ Hart","year":"1995","unstructured":"Hart DJ, Doyle DV, Spector TD: Association between metabolic factors and knee osteoarthritis in women: the Chingford Study. J Rheumatol. 1995, 22: 1118-1123.","journal-title":"J Rheumatol"},{"key":"2903_CR15","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1172\/JCI200525102","volume":"115","author":"KE Wellen","year":"2005","unstructured":"Wellen KE, Hotamisligil GS: Inflammation, stress, and diabetes. J Clin Invest. 2005, 115: 1111-1119.","journal-title":"J Clin Invest"},{"key":"2903_CR16","doi-asserted-by":"publisher","first-page":"3118","DOI":"10.1002\/art.11303","volume":"48","author":"H Dumond","year":"2003","unstructured":"Dumond H, Presle N, Terlain B, Mainard D, Loeuille D, Netter P, Pottie P: Evidence for a key role of leptin in osteoarthritis. Arthritis Rheum. 2003, 48: 3118-3129. 10.1002\/art.11303.","journal-title":"Arthritis Rheum"},{"key":"2903_CR17","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1002\/art.10811","volume":"48","author":"M Otero","year":"2003","unstructured":"Otero M, Gomez Reino JJ, Gualillo O: Synergistic induction of nitric oxide synthase type II: in vitro effect of leptin and interferon-gamma in human chondrocytes and ATDC5 chondrogenic cells. Arthritis Rheum. 2003, 48: 404-409. 10.1002\/art.10811.","journal-title":"Arthritis Rheum"},{"key":"2903_CR18","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1016\/j.joca.2006.01.009","volume":"14","author":"N Presle","year":"2006","unstructured":"Presle N, Pottie P, Dumond H, Guillaume C, Lapicque F, Pallu S, Mainard D, Netter P, Terlain B: Differential distribution of adipokines between serum and synovial fluid in patients with osteoarthritis. Contribution of joint tissues to their articular production. Osteoarthritis Cartilage. 2006, 14: 690-695. 10.1016\/j.joca.2006.01.009.","journal-title":"Osteoarthritis Cartilage"},{"key":"2903_CR19","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1186\/1471-2474-9-116","volume":"9","author":"J Bedson","year":"2008","unstructured":"Bedson J, Croft PR: The discordance between clinical and radiographic knee osteoarthritis: a systematic search and summary of the literature. BMC Musculoskelet Disord. 2008, 9: 116-10.1186\/1471-2474-9-116.","journal-title":"BMC Musculoskelet Disord"},{"key":"2903_CR20","first-page":"1513","volume":"27","author":"MT Hannan","year":"2000","unstructured":"Hannan MT, Felson DT, Pincus T: Analysis of the discordance between radiographic changes and knee pain in osteoarthritis of the knee. J Rheumatol. 2000, 27: 1513-1517.","journal-title":"J Rheumatol"},{"key":"2903_CR21","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1126\/science.288.5472.1769","volume":"288","author":"DD Price","year":"2000","unstructured":"Price DD: Psychological and neural mechanisms of the affective dimension of pain. Science. 2000, 288: 1769-1772. 10.1126\/science.288.5472.1769.","journal-title":"Science"},{"key":"2903_CR22","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.ejpain.2004.11.001","volume":"9","author":"AV Apkarian","year":"2005","unstructured":"Apkarian AV, Bushnell MC, Treede RD, Zubieta JK: Human brain mechanisms of pain perception and regulation in health and disease. Eur J Pain. 2005, 9: 463-484. 10.1016\/j.ejpain.2004.11.001.","journal-title":"Eur J Pain"},{"key":"2903_CR23","doi-asserted-by":"publisher","first-page":"2510","DOI":"10.1038\/oby.2008.407","volume":"16","author":"N Heim","year":"2008","unstructured":"Heim N, Snijder MB, Deeg DJ, Seidell JC, Visser M: Obesity in older adults is associated with an increased prevalence and incidence of pain. Obesity (Silver Spring). 2008, 16: 2510-2517. 10.1038\/oby.2008.407.","journal-title":"Obesity (Silver Spring)"},{"key":"2903_CR24","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1016\/j.jpain.2008.05.008","volume":"9","author":"RA Shelby","year":"2008","unstructured":"Shelby RA, Somers TJ, Keefe FJ, Pells JJ, Dixon KE, Blumenthal JA: Domain specific self-efficacy mediates the impact of pain catastrophizing on pain and disability in overweight and obese osteoarthritis patients. J Pain. 2008, 9: 912-919. 10.1016\/j.jpain.2008.05.008.","journal-title":"J Pain"},{"key":"2903_CR25","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.physbeh.2004.02.006","volume":"81","author":"S Collins","year":"2004","unstructured":"Collins S, Martin TL, Surwit RS, Robidoux J: Genetic vulnerability to diet-induced obesity in the C57BL\/6J mouse: physiological and molecular characteristics. Physiol Behav. 2004, 81: 243-248. 10.1016\/j.physbeh.2004.02.006.","journal-title":"Physiol Behav"},{"key":"2903_CR26","first-page":"828","volume":"50","author":"M Silberberg","year":"1950","unstructured":"Silberberg M, Silberberg R: Effects of a high fat diet on the joints of aging mice. AMA Arch Pathol. 1950, 50: 828-846.","journal-title":"AMA Arch Pathol"},{"key":"2903_CR27","doi-asserted-by":"crossref","first-page":"387","DOI":"10.3233\/BIR-2008-0485","volume":"45","author":"TM Griffin","year":"2008","unstructured":"Griffin TM, Guilak F: Why is obesity associated with osteoarthritis? Insights from mouse models of obesity. Biorheology. 2008, 45: 387-398.","journal-title":"Biorheology"},{"key":"2903_CR28","doi-asserted-by":"publisher","first-page":"e81","DOI":"10.1371\/journal.pgen.0020081","volume":"2","author":"RA Koza","year":"2006","unstructured":"Koza RA, Nikonova L, Hogan J, Rim JS, Mendoza T, Faulk C, Skaf J, Kozak LP: Changes in gene expression foreshadow diet-induced obesity in genetically identical mice. PLoS Genet. 2006, 2: e81-10.1371\/journal.pgen.0020081.","journal-title":"PLoS Genet"},{"key":"2903_CR29","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1002\/art.23288","volume":"58","author":"BD Ward","year":"2008","unstructured":"Ward BD, Furman BD, Huebner JL, Kraus VB, Guilak F, Olson SA: Absence of posttraumatic arthritis following intraarticular fracture in the MRL\/MpJ mouse. Arthritis Rheum. 2008, 58: 744-753. 10.1002\/art.23288.","journal-title":"Arthritis Rheum"},{"key":"2903_CR30","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1115\/1.2246237","volume":"128","author":"L Cao","year":"2006","unstructured":"Cao L, Youn I, Guilak F, Setton LA: Compressive properties of mouse articular cartilage determined in a novel micro-indentation test method and biphasic finite element model. J Biomech Eng. 2006, 128: 766-771. 10.1115\/1.2246237.","journal-title":"J Biomech Eng"},{"key":"2903_CR31","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1201\/9781420004335.ch12","volume-title":"Animal Models of Cognitive Impairment","author":"RM Rodriguiz","year":"2006","unstructured":"Rodriguiz RM, Wetsel WC: Assessments of cognitive deficits in mutant mice. Animal Models of Cognitive Impairment. Edited by: Levin E, Buccafusco JJ. 2006, Boca Raton, FL: CRC Press, 223-284."},{"key":"2903_CR32","doi-asserted-by":"publisher","first-page":"2877","DOI":"10.1016\/j.jbiomech.2005.10.006","volume":"39","author":"AC Zumwalt","year":"2006","unstructured":"Zumwalt AC, Hamrick M, Schmitt D: Force plate for measuring the ground reaction forces in small animal locomotion. J Biomech. 2006, 39: 2877-2881. 10.1016\/j.jbiomech.2005.10.006.","journal-title":"J Biomech"},{"key":"2903_CR33","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1016\/j.joca.2005.07.003","volume":"13","author":"JL Piscoya","year":"2005","unstructured":"Piscoya JL, Fermor B, Kraus VB, Stabler TV, Guilak F: The influence of mechanical compression on the induction of osteoarthritis-related biomarkers in articular cartilage explants. Osteoarthritis Cartilage. 2005, 13: 1092-1099. 10.1016\/j.joca.2005.07.003.","journal-title":"Osteoarthritis Cartilage"},{"key":"2903_CR34","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1053\/joca.2002.0832","volume":"10","author":"B Fermor","year":"2002","unstructured":"Fermor B, Weinberg JB, Pisetsky DS, Misukonis MA, Fink C, Guilak F: Induction of cyclooxygenase-2 by mechanical stress through a nitric oxide-regulated pathway. Osteoarthritis Cartilage. 2002, 10: 792-798. 10.1053\/joca.2002.0832.","journal-title":"Osteoarthritis Cartilage"},{"key":"2903_CR35","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","volume":"57","author":"Y Benjamini","year":"1995","unstructured":"Benjamini Y, Hochberg Y: Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Ser B (Methodol). 1995, 57: 289-300.","journal-title":"J R Stat Soc Ser B (Methodol)"},{"key":"2903_CR36","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1038\/oby.2007.550","volume":"15","author":"SL Johnston","year":"2007","unstructured":"Johnston SL, Souter DM, Tolkamp BJ, Gordon IJ, Illius AW, Kyriazakis I, Speakman JR: Intake compensates for resting metabolic rate variation in female C57BL\/6J mice fed high-fat diets. Obesity (Silver Spring). 2007, 15: 600-606. 10.1038\/oby.2007.550.","journal-title":"Obesity (Silver Spring)"},{"key":"2903_CR37","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1002\/jor.1100180309","volume":"18","author":"MA LeRoux","year":"2000","unstructured":"LeRoux MA, Arokoski J, Vail TP, Guilak F, Hyttinen MM, Kiviranta I, Setton LA: Simultaneous changes in the mechanical properties, quantitative collagen organization, and proteoglycan concentration of articular cartilage following canine meniscectomy. J Orthop Res. 2000, 18: 383-392. 10.1002\/jor.1100180309.","journal-title":"J Orthop Res"},{"key":"2903_CR38","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1242\/jeb.185.1.71","volume":"185","author":"CT Farley","year":"1993","unstructured":"Farley CT, Glasheen J, McMahon TA: Running springs: speed and animal size. J Exp Biol. 1993, 185: 71-86.","journal-title":"J Exp Biol"},{"key":"2903_CR39","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1002\/jor.1100120203","volume":"12","author":"I Kiviranta","year":"1994","unstructured":"Kiviranta I, Tammi M, Jurvelin J, Arokoski J, Saamanen AM, Helminen HJ: Articular cartilage thickness and glycosaminoglycan distribution in the young canine knee joint after remobilization of the immobilized limb. J Orthop Res. 1994, 12: 161-167. 10.1002\/jor.1100120203.","journal-title":"J Orthop Res"},{"key":"2903_CR40","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1002\/jor.1100120406","volume":"12","author":"FJ Muller","year":"1994","unstructured":"Muller FJ, Setton LA, Manicourt DH, Mow VC, Howell DS, Pita JC: Centrifugal and biochemical comparison of proteoglycan aggregates from articular cartilage in experimental joint disuse and joint instability. J Orthop Res. 1994, 12: 498-508. 10.1002\/jor.1100120406.","journal-title":"J Orthop Res"},{"key":"2903_CR41","doi-asserted-by":"publisher","first-page":"3507","DOI":"10.1002\/art.21415","volume":"52","author":"EM Roos","year":"2005","unstructured":"Roos EM, Dahlberg L: Positive effects of moderate exercise on glycosaminoglycan content in knee cartilage: a four-month, randomized, controlled trial in patients at risk of osteoarthritis. Arthritis Rheum. 2005, 52: 3507-3514. 10.1002\/art.21415.","journal-title":"Arthritis Rheum"},{"key":"2903_CR42","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.pain.2007.01.036","volume":"130","author":"R Torres","year":"2007","unstructured":"Torres R, Croll SD, Vercollone J, Reinhardt J, Griffiths J, Zabski S, Anderson KD, Adams NC, Gowen L, Sleeman MW, Valenzuela DM, Wiegand SJ, Yancopoulos GD, Murphy AJ: Mice genetically deficient in neuromedin U receptor 2, but not neuromedin U receptor 1, have impaired nociceptive responses. Pain. 2007, 130: 267-278. 10.1016\/j.pain.2007.01.036.","journal-title":"Pain"},{"key":"2903_CR43","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/BF00428203","volume":"85","author":"L Steru","year":"1985","unstructured":"Steru L, Chermat R, Thierry B, Simon P: The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacology (Berl). 1985, 85: 367-370. 10.1007\/BF00428203.","journal-title":"Psychopharmacology (Berl)"},{"key":"2903_CR44","first-page":"237","volume":"39","author":"JC Fernandes","year":"2002","unstructured":"Fernandes JC, Martel-Pelletier J, Pelletier JP: The role of cytokines in osteoarthritis pathophysiology. Biorheology. 2002, 39: 237-246.","journal-title":"Biorheology"},{"key":"2903_CR45","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1038\/nrendo.2009.62","volume":"5","author":"B Feve","year":"2009","unstructured":"Feve B, Bastard JP: The role of interleukins in insulin resistance and type 2 diabetes mellitus. Nat Rev Endocrinol. 2009, 5: 305-311. 10.1038\/nrendo.2009.62.","journal-title":"Nat Rev Endocrinol"},{"key":"2903_CR46","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1038\/nm1295-1311","volume":"1","author":"RC Frederich","year":"1995","unstructured":"Frederich RC, Hamann A, Anderson S, Lollmann B, Lowell BB, Flier JS: Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat Med. 1995, 1: 1311-1314. 10.1038\/nm1295-1311.","journal-title":"Nat Med"},{"key":"2903_CR47","doi-asserted-by":"publisher","first-page":"1616","DOI":"10.1136\/ard.2007.069377","volume":"66","author":"D Iliopoulos","year":"2007","unstructured":"Iliopoulos D, Malizos KN, Tsezou A: Epigenetic regulation of leptin affects MMP-13 expression in osteoarthritic chondrocytes: possible molecular target for osteoarthritis therapeutic intervention. Ann Rheum Dis. 2007, 66: 1616-1621. 10.1136\/ard.2007.069377.","journal-title":"Ann Rheum Dis"},{"key":"2903_CR48","doi-asserted-by":"publisher","first-page":"R581","DOI":"10.1186\/ar1708","volume":"7","author":"M Otero","year":"2005","unstructured":"Otero M, Lago R, Lago F, Reino JJ, Gualillo O: Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin-1. Arthritis Res Ther. 2005, 7: R581-R591. 10.1186\/ar1708.","journal-title":"Arthritis Res Ther"},{"key":"2903_CR49","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1016\/j.joca.2007.01.018","volume":"15","author":"T Simopoulou","year":"2007","unstructured":"Simopoulou T, Malizos KN, Iliopoulos D, Stefanou N, Papatheodorou L, Ioannou M, Tsezou A: Differential expression of leptin and leptin's receptor isoform (Ob-Rb) mRNA between advanced and minimally affected osteoarthritic cartilage; effect on cartilage metabolism. Osteoarthritis Cartilage. 2007, 15: 872-883. 10.1016\/j.joca.2007.01.018.","journal-title":"Osteoarthritis Cartilage"},{"key":"2903_CR50","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1097\/00003677-200510000-00008","volume":"33","author":"TM Griffin","year":"2005","unstructured":"Griffin TM, Guilak F: The role of mechanical loading in the onset and progression of osteoarthritis. Exerc Sport Sci Rev. 2005, 33: 195-200. 10.1097\/00003677-200510000-00008.","journal-title":"Exerc Sport Sci Rev"},{"key":"2903_CR51","doi-asserted-by":"publisher","first-page":"e4331","DOI":"10.1371\/journal.pone.0004331","volume":"4","author":"A Bartolomucci","year":"2009","unstructured":"Bartolomucci A, Cabassi A, Govoni P, Ceresini G, Cero C, Berra D, Dadomo H, Franceschini P, Dell'Omo G, Parmigiani S, Palanza P: Metabolic consequences and vulnerability to diet-induced obesity in male mice under chronic social stress. PLoS One. 2009, 4: e4331-10.1371\/journal.pone.0004331.","journal-title":"PLoS One"},{"key":"2903_CR52","doi-asserted-by":"publisher","first-page":"2999","DOI":"10.1002\/art.22836","volume":"56","author":"JW Watters","year":"2007","unstructured":"Watters JW, Cheng C, Pickarski M, Wesolowski GA, Zhuo Y, Hayami T, Wang W, Szumiloski J, Phillips RL, le Duong T: Inverse relationship between matrix remodeling and lipid metabolism during osteoarthritis progression in the STR\/Ort mouse. Arthritis Rheum. 2007, 56: 2999-3009. 10.1002\/art.22836.","journal-title":"Arthritis Rheum"},{"key":"2903_CR53","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.joca.2007.09.004","volume":"16","author":"K Jaeger","year":"2008","unstructured":"Jaeger K, Selent C, Jaehme W, Mahr S, Goebel U, Ibrahim S, Vollmar B, Mueller-Hilke B: The genetics of osteoarthritis in STR\/ort mice. Osteoarthritis Cartilage. 2008, 16: 607-614. 10.1016\/j.joca.2007.09.004.","journal-title":"Osteoarthritis Cartilage"},{"key":"2903_CR54","doi-asserted-by":"publisher","first-page":"e3740","DOI":"10.1371\/journal.pone.0003740","volume":"3","author":"D Iliopoulos","year":"2008","unstructured":"Iliopoulos D, Malizos KN, Oikonomou P, Tsezou A: Integrative microRNA and proteomic approaches identify novel osteoarthritis genes and their collaborative metabolic and inflammatory networks. PLoS One. 2008, 3: e3740-10.1371\/journal.pone.0003740.","journal-title":"PLoS One"},{"key":"2903_CR55","first-page":"2431","volume":"26","author":"KD Brandt","year":"1999","unstructured":"Brandt KD, Heilman DK, Slemenda C, Katz BP, Mazzuca SA, Braunstein EM, Byrd D: Quadriceps strength in women with radiographically progressive osteoarthritis of the knee and those with stable radiographic changes. J Rheumatol. 1999, 26: 2431-2437.","journal-title":"J Rheumatol"},{"key":"2903_CR56","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1002\/art.24541","volume":"61","author":"NA Segal","year":"2009","unstructured":"Segal NA, Torner JC, Felson D, Niu J, Sharma L, Lewis CE, Nevitt M: Effect of thigh strength on incident radiographic and symptomatic knee osteoarthritis in a longitudinal cohort. Arthritis Rheum. 2009, 61: 1210-1217. 10.1002\/art.24541.","journal-title":"Arthritis Rheum"},{"key":"2903_CR57","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1002\/art.24182","volume":"60","author":"S Amin","year":"2009","unstructured":"Amin S, Baker K, Niu J, Clancy M, Goggins J, Guermazi A, Grigoryan M, Hunter DJ, Felson DT: Quadriceps strength and the risk of cartilage loss and symptom progression in knee osteoarthritis. Arthritis Rheum. 2009, 60: 189-198. 10.1002\/art.24182.","journal-title":"Arthritis Rheum"},{"key":"2903_CR58","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1023\/B:ABME.0000017541.82498.37","volume":"32","author":"TP Andriacchi","year":"2004","unstructured":"Andriacchi TP, Mundermann A, Smith RL, Alexander EJ, Dyrby CO, Koo S: A framework for the in vivo pathomechanics of osteoarthritis at the knee. Ann Biomed Eng. 2004, 32: 447-457. 10.1023\/B:ABME.0000017541.82498.37.","journal-title":"Ann Biomed Eng"},{"key":"2903_CR59","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1136\/ard.56.11.641","volume":"56","author":"MV Hurley","year":"1997","unstructured":"Hurley MV, Scott DL, Rees J, Newham DJ: Sensorimotor changes and functional performance in patients with knee osteoarthritis. Ann Rheum Dis. 1997, 56: 641-648. 10.1136\/ard.56.11.641.","journal-title":"Ann Rheum Dis"},{"key":"2903_CR60","first-page":"1446","volume":"26","author":"SP Messier","year":"1994","unstructured":"Messier SP: Osteoarthritis of the knee and associated factors of age and obesity: effects on gait. Med Sci Sports Exerc. 1994, 26: 1446-1452.","journal-title":"Med Sci Sports Exerc"},{"key":"2903_CR61","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1016\/j.jpainsymman.2008.05.009","volume":"37","author":"TJ Somers","year":"2008","unstructured":"Somers TJ, Keefe FJ, Pells JJ, Dixon KE, Waters SJ, Riordan PA, Blumenthal JA, McKee DC, Lacaille L, Tucker JM, Schmitt D, Caldwell DS, Kraus VB, Sims EL, Shelby RA, Rice JR: Pain catastrophizing and pain-related fear in osteoarthritis patients: relationships to pain and disability. J Pain Symptom Manage. 2008, 37: 863-872. 10.1016\/j.jpainsymman.2008.05.009.","journal-title":"J Pain Symptom Manage"},{"key":"2903_CR62","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1002\/art.22464","volume":"57","author":"DT Felson","year":"2007","unstructured":"Felson DT, Niu J, Clancy M, Sack B, Aliabadi P, Zhang Y: Effect of recreational physical activities on the development of knee osteoarthritis in older adults of different weights: the Framingham Study. Arthritis Rheum. 2007, 57: 6-12. 10.1002\/art.22464.","journal-title":"Arthritis Rheum"},{"key":"2903_CR63","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1002\/art.21534","volume":"54","author":"B Szebenyi","year":"2006","unstructured":"Szebenyi B, Hollander AP, Dieppe P, Quilty B, Duddy J, Clarke S, Kirwan JR: Associations between pain, function, and radiographic features in osteoarthritis of the knee. Arthritis Rheum. 2006, 54: 230-235. 10.1002\/art.21534.","journal-title":"Arthritis Rheum"},{"key":"2903_CR64","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1093\/rheumatology\/39.5.490","volume":"39","author":"P Creamer","year":"2000","unstructured":"Creamer P, Lethbridge-Cejku M, Hochberg MC: Factors associated with functional impairment in symptomatic knee osteoarthritis. Rheumatology (Oxford). 2000, 39: 490-496. 10.1093\/rheumatology\/39.5.490.","journal-title":"Rheumatology (Oxford)"},{"key":"2903_CR65","doi-asserted-by":"publisher","first-page":"R1288","DOI":"10.1152\/ajpregu.00234.2006","volume":"291","author":"A Legendre","year":"2006","unstructured":"Legendre A, Harris RB: Exaggerated response to mild stress in rats fed high-fat diet. Am J Physiol Regul Integr Comp Physiol. 2006, 291: R1288-R1294.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2903_CR66","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/S0896-6273(02)00653-0","volume":"34","author":"EJ Nestler","year":"2002","unstructured":"Nestler EJ, Barrot M, DiLeone RJ, Eisch AJ, Gold SJ, Monteggia LM: Neurobiology of depression. Neuron. 2002, 34: 13-25. 10.1016\/S0896-6273(02)00653-0.","journal-title":"Neuron"},{"key":"2903_CR67","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1038\/ijo.2008.268","volume":"33","author":"G Zhao","year":"2009","unstructured":"Zhao G, Ford ES, Dhingra S, Li C, Strine TW, Mokdad AH: Depression and anxiety among US adults: associations with body mass index. Int J Obes (Lond). 2009, 33: 257-266. 10.1038\/ijo.2008.268.","journal-title":"Int J Obes (Lond)"},{"key":"2903_CR68","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.pain.2008.01.008","volume":"138","author":"BW Smith","year":"2008","unstructured":"Smith BW, Zautra AJ: The effects of anxiety and depression on weekly pain in women with arthritis. Pain. 2008, 138: 354-361. 10.1016\/j.pain.2008.01.008.","journal-title":"Pain"},{"key":"2903_CR69","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1016\/j.jpain.2009.02.003","volume":"10","author":"W Wang","year":"2009","unstructured":"Wang W, Baghdoyan HA, Lydic R: Leptin replacement restores supraspinal cholinergic antinociception in leptin-deficient obese mice. J Pain. 2009, 10: 836-843. 10.1016\/j.jpain.2009.02.003.","journal-title":"J Pain"},{"key":"2903_CR70","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1111\/j.1601-183X.2008.00464.x","volume":"8","author":"J Alsio","year":"2009","unstructured":"Alsio J, Roman E, Olszewski PK, Jonsson P, Fredriksson R, Levine AS, Meyerson BJ, Hulting AL, Lindblom J, Schioth HB: Inverse association of high-fat diet preference and anxiety-like behavior: a putative role for urocortin 2. Genes Brain Behav. 2009, 8: 193-202. 10.1111\/j.1601-183X.2008.00464.x.","journal-title":"Genes Brain Behav"},{"key":"2903_CR71","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1126\/science.7678183","volume":"259","author":"GS Hotamisligil","year":"1993","unstructured":"Hotamisligil GS, Shargill NS, Spiegelman BM: Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science. 1993, 259: 87-91. 10.1126\/science.7678183.","journal-title":"Science"},{"key":"2903_CR72","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1111\/j.1463-1326.2008.00974.x","volume":"11","author":"JI Fenton","year":"2009","unstructured":"Fenton JI, Nunez NP, Yakar S, Perkins SN, Hord NG, Hursting SD: Diet-induced adiposity alters the serum profile of inflammation in C57BL\/6N mice as measured by antibody array. Diabetes Obes Metab. 2009, 11: 343-354. 10.1111\/j.1463-1326.2008.00974.x.","journal-title":"Diabetes Obes Metab"},{"key":"2903_CR73","doi-asserted-by":"publisher","first-page":"2306","DOI":"10.3899\/jrheum.080346","volume":"35","author":"M Daheshia","year":"2008","unstructured":"Daheshia M, Yao JQ: The interleukin 1beta pathway in the pathogenesis of osteoarthritis. J Rheumatol. 2008, 35: 2306-2312. 10.3899\/jrheum.080346.","journal-title":"J Rheumatol"},{"key":"2903_CR74","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1016\/j.joca.2007.12.008","volume":"16","author":"R Lago","year":"2008","unstructured":"Lago R, Gomez R, Otero M, Lago F, Gallego R, Dieguez C, Gomez-Reino JJ, Gualillo O: A new player in cartilage homeostasis: adiponectin induces nitric oxide synthase type II and pro-inflammatory cytokines in chondrocytes. Osteoarthritis Cartilage. 2008, 16: 1101-1109. 10.1016\/j.joca.2007.12.008.","journal-title":"Osteoarthritis Cartilage"},{"key":"2903_CR75","doi-asserted-by":"publisher","first-page":"3009","DOI":"10.1002\/art.11315","volume":"48","author":"RF Loeser","year":"2003","unstructured":"Loeser RF: Systemic and local regulation of articular cartilage metabolism: where does leptin fit in the puzzle?. Arthritis Rheum. 2003, 48: 3009-3012. 10.1002\/art.11315.","journal-title":"Arthritis Rheum"},{"key":"2903_CR76","doi-asserted-by":"publisher","first-page":"2935","DOI":"10.1002\/art.24854","volume":"60","author":"TM Griffin","year":"2009","unstructured":"Griffin TM, Huebner JL, Kraus VB, Guilak F: Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis. Arthritis Rheum. 2009, 60: 2935-2944. 10.1002\/art.24854.","journal-title":"Arthritis Rheum"},{"key":"2903_CR77","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.cmet.2006.10.008","volume":"4","author":"G Karsenty","year":"2006","unstructured":"Karsenty G: Convergence between bone and energy homeostases: leptin regulation of bone mass. Cell Metab. 2006, 4: 341-348. 10.1016\/j.cmet.2006.10.008.","journal-title":"Cell Metab"},{"key":"2903_CR78","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1139\/H09-037","volume":"34","author":"DJ Dyck","year":"2009","unstructured":"Dyck DJ: Adipokines as regulators of muscle metabolism and insulin sensitivity. Appl Physiol Nutr Metab. 2009, 34: 396-402. 10.1139\/H09-037.","journal-title":"Appl Physiol Nutr Metab"},{"key":"2903_CR79","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00296-002-0234-7","volume":"23","author":"O Adam","year":"2003","unstructured":"Adam O, Beringer C, Kless T, Lemmen C, Adam A, Wiseman M, Adam P, Klimmek R, Forth W: Anti-inflammatory effects of a low arachidonic acid diet and fish oil in patients with rheumatoid arthritis. Rheumatol Int. 2003, 23: 27-36.","journal-title":"Rheumatol Int"},{"key":"2903_CR80","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.rdc.2008.03.003","volume":"34","author":"SM Proudman","year":"2008","unstructured":"Proudman SM, Cleland LG, James MJ: Dietary omega-3 fats for treatment of inflammatory joint disease: efficacy and utility. Rheum Dis Clin North Am. 2008, 34: 469-479. 10.1016\/j.rdc.2008.03.003.","journal-title":"Rheum Dis Clin North Am"},{"key":"2903_CR81","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1002\/art.23823","volume":"59","author":"BW Lim","year":"2008","unstructured":"Lim BW, Hinman RS, Wrigley TV, Sharma L, Bennell KL: Does knee malalignment mediate the effects of quadriceps strengthening on knee adduction moment, pain, and function in medial knee osteoarthritis? A randomized controlled trial. Arthritis Rheum. 2008, 59: 943-951. 10.1002\/art.23823.","journal-title":"Arthritis Rheum"},{"key":"2903_CR82","doi-asserted-by":"publisher","first-page":"b3170","DOI":"10.1136\/bmj.b3170","volume":"339","author":"CM Jenkinson","year":"2009","unstructured":"Jenkinson CM, Doherty M, Avery AJ, Read A, Taylor MA, Sach TH, Silcocks P, Muir KR: Effects of dietary intervention and quadriceps strengthening exercises on pain and function in overweight people with knee pain: randomised controlled trial. BMJ. 2009, 339: b3170-10.1136\/bmj.b3170.","journal-title":"BMJ"},{"key":"2903_CR83","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1002\/art.20256","volume":"50","author":"SP Messier","year":"2004","unstructured":"Messier SP, Loeser RF, Miller GD, Morgan TM, Rejeski WJ, Sevick MA, Ettinger WH, Pahor M, Williamson JD: Exercise and dietary weight loss in overweight and obese older adults with knee osteoarthritis: the Arthritis, Diet, and Activity Promotion Trial. Arthritis Rheum. 2004, 50: 1501-1510. 10.1002\/art.20256.","journal-title":"Arthritis Rheum"},{"key":"2903_CR84","doi-asserted-by":"publisher","first-page":"345838","DOI":"10.1155\/2009\/345838","volume":"2009","author":"K Vuolteenaho","year":"2009","unstructured":"Vuolteenaho K, Koskinen A, Kukkonen M, Nieminen R, Paivarinta U, Moilanen T, Moilanen E: Leptin enhances synthesis of proinflammatory mediators in human osteoarthritic cartilage - mediator role of NO in leptin-induced PGE2, IL-6, and IL-8 production. Mediators Inflamm. 2009, 2009: 345838-10.1155\/2009\/345838.","journal-title":"Mediators Inflamm"},{"key":"2903_CR85","doi-asserted-by":"publisher","first-page":"2891","DOI":"10.1002\/art.22040","volume":"54","author":"K Hu","year":"2006","unstructured":"Hu K, Xu L, Cao L, Flahiff CM, Brussiau J, Ho K, Setton LA, Youn I, Guilak F, Olsen BR, Li Y: Pathogenesis of osteoarthritis-like changes in the joints of mice deficient in type IX collagen. Arthritis Rheum. 2006, 54: 2891-2900. 10.1002\/art.22040.","journal-title":"Arthritis Rheum"},{"key":"2903_CR86","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1093\/rheumatology\/41.8.848","volume":"41","author":"HJ Helminen","year":"2002","unstructured":"Helminen HJ, Saamanen AM, Salminen H, Hyttinen MM: Transgenic mouse models for studying the role of cartilage macromolecules in osteoarthritis. Rheumatology (Oxford). 2002, 41: 848-856. 10.1093\/rheumatology\/41.8.848.","journal-title":"Rheumatology (Oxford)"},{"key":"2903_CR87","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1053\/joca.2000.0363","volume":"9","author":"RM Mason","year":"2001","unstructured":"Mason RM, Chambers MG, Flannelly J, Gaffen JD, Dudhia J, Bayliss MT: The STR\/ort mouse and its use as a model of osteoarthritis. Osteoarthritis Cartilage. 2001, 9: 85-91. 10.1053\/joca.2000.0363.","journal-title":"Osteoarthritis Cartilage"},{"key":"2903_CR88","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1093\/jn\/85.1.117","volume":"85","author":"L Sokoloff","year":"1965","unstructured":"Sokoloff L, Mickelsen O: Dietary fat supplements, body weight and osteoarthritis in Dba-2jn mice. J Nutr. 1965, 85: 117-121.","journal-title":"J Nutr"},{"key":"2903_CR89","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1159\/000211491","volume":"11","author":"M Silberberg","year":"1965","unstructured":"Silberberg M, Silberberg R, Orcutt B: Modifying effect of linoleic acid on articular aging and osteoarthrosis in lard-fed mice. Gerontologia. 1965, 11: 179-187. 10.1159\/000211491.","journal-title":"Gerontologia"},{"key":"2903_CR90","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1093\/geronj\/12.1.9","volume":"12","author":"M Silberberg","year":"1957","unstructured":"Silberberg M, Silberberg R: Age factor and high-fat diets in the evolution of osteoarthritis in mice. J Gerontol. 1957, 12: 9-13.","journal-title":"J Gerontol"},{"key":"2903_CR91","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1038\/nature03369","volume":"434","author":"SS Glasson","year":"2005","unstructured":"Glasson SS, Askew R, Sheppard B, Carito B, Blanchet T, Ma HL, Flannery CR, Peluso D, Kanki K, Yang Z, Majumdar MK, Morris EA: Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis. Nature. 2005, 434: 644-648. 10.1038\/nature03369.","journal-title":"Nature"}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/ar3068.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/ar3068\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/ar3068.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T06:57:52Z","timestamp":1728370672000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/ar3068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7,6]]},"references-count":91,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2010,8]]}},"alternative-id":["2903"],"URL":"https:\/\/doi.org\/10.1186\/ar3068","relation":{},"ISSN":["1478-6354"],"issn-type":[{"value":"1478-6354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7,6]]},"assertion":[{"value":"18 March 2010","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2010","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 July 2010","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 July 2010","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"R130"}}