{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:10:19Z","timestamp":1791429019809,"version":"4.3.3"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2010,7,16]],"date-time":"2010-07-16T00:00:00Z","timestamp":1279238400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2010,7,16]],"date-time":"2010-07-16T00:00:00Z","timestamp":1279238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The objective of this study was to assess natural microbial agents, history and risk factors for total joint arthroplasty (TJA) infections in patients receiving tumor necrosis factor (TNF)\u03b1-blockers, through the French RATIO registry and a case-control study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cases were TJA infections during TNF\u03b1-blocker treatments. Each case was compared to two controls (with TJA and TNF\u03b1-blocker therapy, but without TJA infection) matched on age (\u00b115 years), TJA localization, type of rheumatic disorder and disease duration (\u00b115 years). Statistical analyses included univariate and multivariate analyses with conditional logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the 20 cases (18 rheumatoid arthritis), TJA infection concerned principally the knee (<jats:italic>n<\/jats:italic>= 12, 60%) and the hip (<jats:italic>n<\/jats:italic>= 5, 25%).<jats:italic>Staphylococcus<\/jats:italic>was the more frequent microorganism involved (<jats:italic>n<\/jats:italic>= 15, 75%). Four patients (20%) were hospitalized in an intensive care unit and two died from infection. Eight cases (40%) versus 5 controls (13%) had undergone primary TJA or TJA revision for the joint subsequently infected during the last year (<jats:italic>P<\/jats:italic>= 0.03). Of these procedures, 5 cases versus 1 control were performed without withdrawing TNF\u03b1-blockers (<jats:italic>P<\/jats:italic>= 0.08). In multivariate analysis, predictors of infection were primary TJA or TJA revision for the joint subsequently infected within the last year (odds ratio, OR = 88.3; 95%CI 1.1-7,071.6;<jats:italic>P<\/jats:italic>= 0.04) and increased daily steroid intake (OR = 5.0 per 5 mg\/d increase; 1.1-21.6;<jats:italic>P<\/jats:italic>= 0.03). Case-control comparisons showed similar distribution between TNF\u03b1-blockers (<jats:italic>P<\/jats:italic>= 0.70).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients receiving TNF\u03b1-blockers, TJA infection is rare but potentially severe. Important risk factors are primary TJA or TJA revision within the last year, particularly when TNF\u03b1-blockers are not interrupted before surgery, and the daily steroid intake.<\/jats:p><\/jats:sec>","DOI":"10.1186\/ar3087","type":"journal-article","created":{"date-parts":[[2010,7,19]],"date-time":"2010-07-19T16:46:54Z","timestamp":1279558014000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Risk factors for total joint arthroplasty infection in patients receiving tumor necrosis factor \u03b1-blockers: a case-control study"],"prefix":"10.1186","volume":"12","author":[{"given":"M\u00e9lanie","family":"Gilson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Gossec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Mariette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalenda","family":"Gherissi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-H\u00e9l\u00e8ne","family":"Guyot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marie","family":"Berthelot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Wendling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Michelet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Dellamonica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Tubach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Dougados","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Salmon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,7,16]]},"reference":[{"key":"2922_CR1","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1002\/1529-0131(199809)41:9<1552::AID-ART5>3.0.CO;2-W","volume":"41","author":"RN Maini","year":"1998","unstructured":"Maini RN, Breedveld FC, Kalden JR, Smolen JS, David D, Macfarlane JD, Antoni C, Leeb B, Elliott MJ, Woody JN, Schaible TF, Feldmann M: Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor alpha monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis. Arthritis Rheum. 1998, 41: 1552-1563. 10.1002\/1529-0131(199809)41:9<1552::AID-ART5>3.0.CO;2-W.","journal-title":"Arthritis Rheum"},{"key":"2922_CR2","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1056\/NEJMoa012664","volume":"346","author":"JD Gorman","year":"2002","unstructured":"Gorman JD, Sack KE, Davis JC: Treatment of ankylosing spondylitis by inhibition of tumor necrosis factor alpha. N Engl J Med. 2002, 346: 1349-1356. 10.1056\/NEJMoa012664.","journal-title":"N Engl J Med"},{"issue":"Suppl 3","key":"2922_CR3","doi-asserted-by":"crossref","first-page":"iii37","DOI":"10.1136\/ard.60.90003.iii37","volume":"60","author":"PJ Mease","year":"2001","unstructured":"Mease PJ: Cytokine blockers in psoriatic arthritis. Ann Rheum Dis. 2001, 60 (Suppl 3): iii37-40.","journal-title":"Ann Rheum Dis"},{"key":"2922_CR4","doi-asserted-by":"publisher","first-page":"S126","DOI":"10.1002\/art.23364","volume":"58","author":"YP Goekoop-Ruiterman","year":"2008","unstructured":"Goekoop-Ruiterman YP, de Vries-Bouwstra JK, Allaart CF, van Zeben D, Kerstens PJ, Hazes JM, Zwinderman AH, Ronday HK, Han KH, Westedt ML, Gerards AH, van Groenendael JH, Lems WF, van Krugten MV, Breedveld FC, Dijkmans BA: Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study): A randomized, controlled trial. Arthritis Rheum. 2008, 58: S126-135. 10.1002\/art.23364.","journal-title":"Arthritis Rheum"},{"key":"2922_CR5","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1002\/art.20217","volume":"50","author":"EC Keystone","year":"2004","unstructured":"Keystone EC, Kavanaugh AF, Sharp JT, Tannenbaum H, Hua Y, Teoh LS, Fischkoff SA, Chartash EK: Radiographic, clinical, and functional outcomes of treatment with adalimumab (a human anti-tumor necrosis factor monoclonal antibody) in patients with active rheumatoid arthritis receiving concomitant methotrexate therapy: a randomized, placebo-controlled, 52-week trial. Arthritis Rheum. 2004, 50: 1400-1411. 10.1002\/art.20217.","journal-title":"Arthritis Rheum"},{"key":"2922_CR6","doi-asserted-by":"publisher","first-page":"3928","DOI":"10.1002\/art.23141","volume":"56","author":"D Van der Heijde","year":"2007","unstructured":"Van der Heijde D, Klareskog L, Landew\u00e9 R, Bruyn GA, Cantagrel A, Durez P, Herrero-Beaumont G, Molad Y, Codreanu C, Valentini G, Zahora R, Pedersen R, MacPeek D, Wajdula J, Fatenejad S: Disease remission and sustained halting of radiographic progression with combination etanercept and methotrexate in patients with rheumatoid arthritis. Arthritis Rheum. 2007, 56: 3928-3939. 10.1002\/art.23141.","journal-title":"Arthritis Rheum"},{"key":"2922_CR7","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1136\/ard.2005.049957","volume":"65","author":"SM Verstappen","year":"2006","unstructured":"Verstappen SM, Hoes JN, Ter Borg EJ, Bijlsma JW, Blaauw AA, van Albada-Kuipers GA, van Booma-Frankfort C, Jacobs JW: Joint surgery in the Utrecht rheumatoid arthritis cohort: the effect of treatment strategy. Ann Rheum Dis. 2006, 65: 1506-1511. 10.1136\/ard.2005.049957.","journal-title":"Ann Rheum Dis"},{"key":"2922_CR8","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1002\/art.10998","volume":"49","author":"E Da Silva","year":"2003","unstructured":"Da Silva E, Doran MF, Crowson CS, O'Fallon WM, Matteson EL: Declining use of orthopedic surgery in patients with rheumatoid arthritis? Results of a long-term, population-based assessment. Arthritis Rheum. 2003, 49: 216-220. 10.1002\/art.10998.","journal-title":"Arthritis Rheum"},{"key":"2922_CR9","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1056\/NEJMoa011110","volume":"345","author":"J Keane","year":"2001","unstructured":"Keane J, Gershon S, Wise RP, Mirabile-Levens E, Kasznica J, Schwieterman WD, Siegel JN, Braun MM: Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent. N Engl J Med. 2001, 345: 1098-1104. 10.1056\/NEJMoa011110.","journal-title":"N Engl J Med"},{"key":"2922_CR10","doi-asserted-by":"publisher","first-page":"1884","DOI":"10.1002\/art.24632","volume":"60","author":"F Tubach","year":"2009","unstructured":"Tubach F, Salmon D, Ravaud P, Allanore Y, Goupille P, Br\u00e9ban M, Pallot-Prades B, Pouplin S, Sacchi A, Chichemanian RM, Bretagne S, Emilie D, Lemann M, Lortholary O, Mariette X, Research Axed on Tolerance of Biotherapies Group: Risk of tuberculosis is higher with anti-tumor necrosis factor monoclonal antibody therapy than with soluble tumor necrosis factor receptor therapy: The three-year prospective French Research Axed on Tolerance of Biotherapies registry. Arthritis Rheum. 2009, 60: 1884-1894. 10.1002\/art.24632.","journal-title":"Arthritis Rheum"},{"key":"2922_CR11","doi-asserted-by":"publisher","first-page":"2275","DOI":"10.1001\/jama.295.19.2275","volume":"295","author":"T Bongartz","year":"2006","unstructured":"Bongartz T, Sutton AJ, Sweeting MJ, Buchan I, Matteson EL, Montori V: Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and meta-analysis of rare harmful effects in randomized controlled trials. JAMA. 2006, 295: 2275-2285. 10.1001\/jama.295.19.2275.","journal-title":"JAMA"},{"key":"2922_CR12","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1136\/ard.2008.091025","volume":"68","author":"JP Leombruno","year":"2009","unstructured":"Leombruno JP, Einarson TR, Keystone EC: The safety of anti-Tumor Necrosis Factor treatments in rheumatoid arthritis: meta and exposure-adjusted pooled analyses of serious adverse events. Ann Rheum Dis. 2009, 68: 1136-1145. 10.1136\/ard.2008.091025.","journal-title":"Ann Rheum Dis"},{"key":"2922_CR13","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1093\/rheumatology\/kel236","volume":"46","author":"C Salliot","year":"2007","unstructured":"Salliot C, Gossec L, Ruyssen-Witrand A, Luc M, Duclos M, Guignard S, Dougados M: Infections during tumour necrosis factor-\u03b1 blocker therapy for rheumatic diseases in daily practice: a systematic retrospective study of 709 patients. Rheumatology. 2007, 46: 327-334. 10.1093\/rheumatology\/kel236.","journal-title":"Rheumatology"},{"key":"2922_CR14","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1002\/art.22504","volume":"56","author":"JR Curtis","year":"2007","unstructured":"Curtis JR, Patkar N, Xie A, Martin C, Allison JJ, Saag M, Shatin D, Saag KG: Risk of serious bacterial infections among rheumatoid arthritis patients exposed to tumor necrosis factor \u03b1 antagonists. Arthritis Rheum. 2007, 56: 1125-1133. 10.1002\/art.22504.","journal-title":"Arthritis Rheum"},{"key":"2922_CR15","doi-asserted-by":"publisher","first-page":"2368","DOI":"10.1002\/art.21978","volume":"54","author":"WG Dixon","year":"2006","unstructured":"Dixon WG, Watson K, Lunt M, Hyrich KL, Silman AJ, Symmons DP: British Society for Rheumatology Biologics Registry. Rates of serious infection, including site-specific and bacterial intracellular infection, in rheumatoid arthritis patients receiving anti-tumor necrosis factor therapy: results from the British Society for Rheumatology Biologics Registry. Arthritis Rheum. 2006, 54: 2368-2376. 10.1002\/art.21978.","journal-title":"Arthritis Rheum"},{"key":"2922_CR16","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1002\/art.22600","volume":"56","author":"S Schneeweiss","year":"2007","unstructured":"Schneeweiss S, Setoguchi S, Weinblatt ME, Katz JN, Avorn J, Sax PE, Levin R, Solomon DH: Anti-tumor necrosis factor alpha therapy and the risk of serious bacterial infections in elderly patients with rheumatoid arthritis. Arthritis Rheum. 2007, 56: 1754-1764. 10.1002\/art.22600.","journal-title":"Arthritis Rheum"},{"key":"2922_CR17","doi-asserted-by":"publisher","first-page":"1950","DOI":"10.1001\/jama.1995.03520480070043","volume":"273","author":"NIH consensus development panel on total hip replacement","year":"1995","unstructured":"NIH consensus development panel on total hip replacement: NIH consensus conference: total hip replacement. JAMA. 1995, 273: 1950-1956. 10.1001\/jama.273.24.1950.","journal-title":"JAMA"},{"key":"2922_CR18","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1097\/00003086-200101000-00028","volume":"382","author":"JW Sperling","year":"2001","unstructured":"Sperling JW, Kosak TK, Hanssen AD, Cofield RH: Infection after shoulder arthroplasty. Clin Orthop. 2001, 382: 206-216. 10.1097\/00003086-200101000-00028.","journal-title":"Clin Orthop"},{"key":"2922_CR19","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1056\/NEJM199009203231206","volume":"323","author":"WH Harris","year":"1990","unstructured":"Harris WH, Sledge CB: Total hip and total knee replacement. N Engl J Med. 1990, 323: 801-807. 10.1056\/NEJM199009203231206.","journal-title":"N Engl J Med"},{"key":"2922_CR20","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1016\/S0035-1040(07)92680-X","volume":"93","author":"R Debarge","year":"2007","unstructured":"Debarge R, Nicolle MC, Pinaroli A, Ait Si Selmi T, Neyret P: Surgical site infection after total knee arthroplasty: a monocenter analysis of 923 first-intention implantations. Rev Chir Orthop Reparatrice Appar Mot. 2007, 93: 582-587.","journal-title":"Rev Chir Orthop Reparatrice Appar Mot"},{"key":"2922_CR21","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1002\/art.24060","volume":"59","author":"T Bongartz","year":"2008","unstructured":"Bongartz T, Halligan CS, Osmon DR, Reinalda MS, Bamlet WR, Crowson CS, Hanssen AD, Matteson EL: Incidence and risk factors of prosthetic joint infection after total hip or knee replacement in patients with rheumatoid arthritis. Arthritis Rheum. 2008, 59: 1713-1720. 10.1002\/art.24060.","journal-title":"Arthritis Rheum"},{"key":"2922_CR22","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.arth.2007.05.052","volume":"23","author":"D Chesney","year":"2008","unstructured":"Chesney D, Sales J, Elton R, Brenkel IJ: Infection after knee arthroplasty a prospective study of 1509 cases. J Arthroplasty. 2008, 23: 355-359. 10.1016\/j.arth.2007.05.052.","journal-title":"J Arthroplasty"},{"key":"2922_CR23","first-page":"653","volume":"34","author":"T Bongartz","year":"2007","unstructured":"Bongartz T: Elective orthopedic surgery and perioperative DMARD management: many questions, fewer answers, and some opinions. J Rheumatol. 2007, 34: 653-655.","journal-title":"J Rheumatol"},{"key":"2922_CR24","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1136\/ard.2004.028365","volume":"64","author":"SC Talwalkar","year":"2005","unstructured":"Talwalkar SC, Grennan DM, Gray J, Johnson P, Hayton MJ: Tumour necrosis factor alpha antagonists and early postoperative complications in patients with inflammatory joint disease undergoing elective orthopaedic surgery. Ann Rheum Dis. 2005, 64: 650-651. 10.1136\/ard.2004.028365.","journal-title":"Ann Rheum Dis"},{"key":"2922_CR25","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1177\/107110070402500510","volume":"25","author":"C Bibbo","year":"2004","unstructured":"Bibbo C, Goldberg JW: Infectious and healing complications after elective orthopaedic foot and ankle surgery during tumor necrosis factor-alpha inhibition therapy. Foot Ankle Int. 2004, 25: 331-335.","journal-title":"Foot Ankle Int"},{"key":"2922_CR26","first-page":"667","volume":"29","author":"WJ Shergy","year":"2002","unstructured":"Shergy WJ, Isern RA, Cooley DA, Harshbarger JL, Huffstutter JE, Hughes GM, Spencer-Smith EA, Goldman AL, Roth SH, Toder JS, Warner D, Quinn A, Keenan GF, Schaible TF, PROMPT Study Group.Profiling Remicade Onset with MTX in a Prospective Trial: Open label study to assess infliximab safety and timing of onset of clinical benefit among patients with rheumatoid arthritis. J Rheumatol. 2002, 29: 667-677.","journal-title":"J Rheumatol"},{"key":"2922_CR27","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1002\/art.21841","volume":"55","author":"JT Giles","year":"2006","unstructured":"Giles JT, Bartlett SJ, Gelber AC, Nanda S, Fontaine K, Ruffing V, Bathon JM: Tumor necrosis factor inhibitor therapy and risk of serious postoperative orthopedic infection in rheumatoid arthritis. Arthritis Rheum. 2006, 55: 333-337. 10.1002\/art.21841.","journal-title":"Arthritis Rheum"},{"key":"2922_CR28","first-page":"430","volume":"25","author":"A Ruyssen-Witrand","year":"2007","unstructured":"Ruyssen-Witrand A, Gossec L, Salliot C, Luc M, Duclos M, Guignard S, Dougados M: Complication rates of 127 surgical procedures performed in rheumatic patients receiving tumor necrosis factor alpha blockers. Clin Exp Rheumatol. 2007, 25: 430-436.","journal-title":"Clin Exp Rheumatol"},{"key":"2922_CR29","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1086\/514991","volume":"27","author":"EF Berbari","year":"1998","unstructured":"Berbari EF, Hanssen AD, Duffy MC, Steckelberg JM, Ilstrup DM, Harmsen WS, Osmon DR: Risk factors for prosthetic joint infection: case-control study. Clin Infect Dis. 1998, 27: 1247-1254. 10.1086\/514991.","journal-title":"Clin Infect Dis"},{"key":"2922_CR30","unstructured":"The RATIO: Registry of Infections and Lymphoma in Patients Treated With TNF-a Antagonists. [http:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT00224562?term=NCT00224562%26rank=1]"},{"key":"2922_CR31","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1016\/j.jbspin.2005.10.004","volume":"72","author":"F Tubach","year":"2005","unstructured":"Tubach F, Salmon-C\u00e9ron D, Ravaud P, Mariette X pour le groupe RATIO: The RATIO observatory: a French registry of opportunistic infections, severe bacterial infections and complicating anti TNF therapy. Joint Bone Spine. 2005, 72: 456-460. 10.1016\/j.jbspin.2005.10.004.","journal-title":"Joint Bone Spine"},{"key":"2922_CR32","unstructured":"SPILF - Infectiologie - Accueil. [http:\/\/www.infectiologie.com\/site\/index.php]"},{"key":"2922_CR33","unstructured":"Le Club Rhumatismes et Inflammations. [http:\/\/www.cri-net.com\/]"},{"key":"2922_CR34","first-page":"705","volume":"26","author":"AM Van Gestel","year":"1999","unstructured":"Van Gestel AM, Anderson JJ, van Riel PL, Boers M, Haagsma CJ, Rich B, Wells G, Lange ML, Felson DT: ACR and EULAR improvement criteria have comparable validity in rheumatoid arthritis trials. American College of Rheumatology European League of Associations for Rheumatology. J Rheumatol. 1999, 26: 705-711.","journal-title":"J Rheumatol"},{"key":"2922_CR35","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/0196-6553(88)90053-3","volume":"16","author":"JS Garner","year":"1988","unstructured":"Garner JS, Jarvis WR, Emori TG, Horan TC, Hughes JM: CDC definitions for nosocomial infections, 1988. Am J Infect Control. 1988, 16: 128-140. 10.1016\/0196-6553(88)90053-3.","journal-title":"Am J Infect Control"},{"key":"2922_CR36","doi-asserted-by":"crossref","first-page":"512","DOI":"10.2106\/00004623-199604000-00005","volume":"78","author":"DT Tsukayama","year":"1996","unstructured":"Tsukayama DT, Estrada R, Gustilo RB: Infection after total hip arthroplasty. A study of the treatment of one hundred and six infections. J Bone Joint Surg Am. 1996, 78: 512-523.","journal-title":"J Bone Joint Surg Am"},{"key":"2922_CR37","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.2106\/00004623-199910000-00008","volume":"81","author":"H Segawa","year":"1999","unstructured":"Segawa H, Tsukayama DT, Kyle R, Becker D, Gustilo R: Infection after total knee arthroplasty. J Bone Joint Surg Am. 1999, 81: 1434-1445.","journal-title":"J Bone Joint Surg Am"},{"key":"2922_CR38","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1086\/498507","volume":"42","author":"EF Berbari","year":"2006","unstructured":"Berbari EF, Osmon DR, Duffy MC, Harmssen RN, Mandrekar JN, Hanssen AD, Steckelberg JM: Outcome of prosthetic joint infection in patients with rheumatoid arthritis: the impact of medical and surgical therapy in 200 episodes. Clin Infect Dis. 2006, 42: 216-223. 10.1086\/498507.","journal-title":"Clin Infect Dis"},{"key":"2922_CR39","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1097\/00000658-199002000-00002","volume":"211","author":"DP Mooney","year":"1990","unstructured":"Mooney DP, O'Reilly M, Gamelli RL: Tumor necrosis factor and wound healing. Ann Surg. 1990, 211: 124-129. 10.1097\/00000658-199002000-00002.","journal-title":"Ann Surg"},{"key":"2922_CR40","doi-asserted-by":"publisher","first-page":"2294","DOI":"10.1002\/art.10529","volume":"46","author":"MF Doran","year":"2002","unstructured":"Doran MF, Crowson CS, Pond GR, O'Fallon WM, Gabriel SE: Predictors of infection in rheumatoid arthritis. Arthritis Rheum. 2002, 46: 2294-2300. 10.1002\/art.10529.","journal-title":"Arthritis Rheum"},{"key":"2922_CR41","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1093\/rheumatology\/kem076","volume":"46","author":"S Bernatsky","year":"2007","unstructured":"Bernatsky S, Hudson M, Suissa S: Anti-rheumatic drug use and risk of serious infections in rheumatoid arthritis?. Rheumatology. 2007, 46: 1157-1160. 10.1093\/rheumatology\/kem076.","journal-title":"Rheumatology"},{"key":"2922_CR42","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1002\/hep.20206","volume":"39","author":"S Naveau","year":"2004","unstructured":"Naveau S, Chollet-Martin S, Dharancy S, Mathurin P, Jouet P, Piquet MA, Davion T, Oberti F, Bro\u00ebt P, Emilie D, Foie-Alcool group of the Association Fran\u00e7aise pour l'Etude du Foie: A double-blind randomized controlled trial of infliximab associated with prednisolone in acute alcoholic hepatitis. Hepatology. 2004, 39: 1390-1397. 10.1002\/hep.20206.","journal-title":"Hepatology"},{"key":"2922_CR43","first-page":"689","volume":"34","author":"AA Den Broeder","year":"2007","unstructured":"Den Broeder AA, Creemers MC, Fransen J, de Jong E, de Rooij DJ, Wymenga A, de Waal-Malefijt M, van den Hoogen FH: Risk factors for surgical site infections and other complications in elective surgery in patients with rheumatoid arthritis with special attention for anti-tumor necrosis factor: a large retrospective study. J Rheumatol. 2007, 34: 689-695.","journal-title":"J Rheumatol"},{"key":"2922_CR44","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.jbspin.2006.04.001","volume":"73","author":"B Fautrel","year":"2006","unstructured":"Fautrel B, Constantin A, Morel J, Vittecoq O, Cantagrel A, Combe B, Dougados M, Le Lo\u00ebt X, Mariette X, Pham T, Pu\u00e9chal X, Sibilia J, Soubrier M, Ravaud P, Rheumatism and Inflammation Club (CRI) and of the French Society for Rheumatology: Recommendations of the French Society for Rheumatology. TNFalpha antagonist therapy in rheumatoid arthritis. Joint Bone Spine. 2006, 73: 433-441. 10.1016\/j.jbspin.2006.04.001.","journal-title":"Joint Bone Spine"},{"key":"2922_CR45","volume-title":"Medicijnen: het toepassen van TNF blokkade in de behandeling reumato\u00efde artritis","author":"Nederlandse Vereniging voor Rheumatologie","year":"2003","unstructured":"Nederlandse Vereniging voor Rheumatologie: Medicijnen: het toepassen van TNF blokkade in de behandeling reumato\u00efde artritis. 2003, Utrecht: Dutch Society for Rheumatology"},{"key":"2922_CR46","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1302\/0301-620X.77B2.7706354","volume":"77","author":"P Went","year":"1995","unstructured":"Went P, Krismer M, Frischhut B: Recurrence of infection after revision of infected hip arthroplasty. J Bone Joint Surg Br. 1995, 77: 307-309.","journal-title":"J Bone Joint Surg Br"},{"key":"2922_CR47","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1093\/rheumatology\/keh464","volume":"44","author":"J Ledingham","year":"2005","unstructured":"Ledingham J, Deighton C, on behalf the British Society for Rheumatology Standards, Guidelines and Audit Working Group: Update on the British Society for Rheumatology Guidelines for prescribing TNF\u03b1 blockers in adults with rheumatoid arthritis (update of previous guidelines of April 2001). Rheumatology. 2005, 44: 157-163. 10.1093\/rheumatology\/keh464.","journal-title":"Rheumatology"},{"key":"2922_CR48","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1136\/ard.60.3.214","volume":"60","author":"DM Grennan","year":"2001","unstructured":"Grennan DM, Gray J, Loudon J, Fear S: Methotrexate and early postoperative complications in patients with rheumatoid arthritis undergoing elective orthopaedic surgery. Ann Rheum Dis. 2001, 60: 214-217. 10.1136\/ard.60.3.214.","journal-title":"Ann Rheum Dis"},{"key":"2922_CR49","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3928\/0147-7447-19960301-09","volume":"19","author":"MT Carpenter","year":"1996","unstructured":"Carpenter MT, West SG, Vogelgesang SA, Casey Jones DE: Postoperative joint infections in rheumatoid arthritis patients on methotrexate therapy. Orthopedics. 1996, 19: 207-210.","journal-title":"Orthopedics"},{"key":"2922_CR50","first-page":"984","volume":"18","author":"SL Bridges","year":"1991","unstructured":"Bridges SL, Lopez-Mendez A, Han KH, Tracy IC, Alarcon GS: Should methotrexate be discontinued before elective orthopedic surgery in patients with rheumatoid arthritis?. J Rheumatol. 1991, 18: 984-988.","journal-title":"J Rheumatol"},{"key":"2922_CR51","doi-asserted-by":"publisher","first-page":"831","DOI":"10.3109\/00365540903186207","volume":"41","author":"A Stef\u00e1nsd\u00f3ttir","year":"2009","unstructured":"Stef\u00e1nsd\u00f3ttir A, Johansson D, Knutson K, Lidgren L, Robertsson O: Microbiology of the infected knee arthroplasty: report from the Swedish Knee Arthroplasty Register on 426 surgically revised cases. Scand J Infect Dis. 2009, 41: 831-840. 10.3109\/00365540903186207.","journal-title":"Scand J Infect Dis"},{"key":"2922_CR52","doi-asserted-by":"publisher","first-page":"639","DOI":"10.3109\/17453670903506658","volume":"80","author":"H Dale","year":"2009","unstructured":"Dale H, Hallan G, Espehaug B, Havelin LI, Engesaeter LB: Increasing risk of revision due to deep infection after hip arthroplasty. Acta Orthop. 2009, 80: 639-645. 10.3109\/17453670903506658.","journal-title":"Acta Orthop"}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/ar3087.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/ar3087\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/ar3087.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T03:56:32Z","timestamp":1740282992000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/ar3087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7,16]]},"references-count":52,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2010,8]]}},"alternative-id":["2922"],"URL":"https:\/\/doi.org\/10.1186\/ar3087","relation":{},"ISSN":["1478-6354"],"issn-type":[{"value":"1478-6354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7,16]]},"assertion":[{"value":"20 November 2009","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2010","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2010","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2010","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"R145"}}