{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:31:16Z","timestamp":1780446676202,"version":"3.54.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2010,11,9]],"date-time":"2010-11-09T00:00:00Z","timestamp":1289260800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2010,11,9]],"date-time":"2010-11-09T00:00:00Z","timestamp":1289260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Introduction<\/jats:title>\n                        <jats:p>We sought to assess vascularity in wrist tenosynovitis by using power Doppler ultrasound (PDUS) and to compare detection of intra- and peritendinous vascularity with that of contrast-enhanced grey-scale ultrasound (CEUS).<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Methods<\/jats:title>\n                        <jats:p>Twenty-six tendons of 24 patients (nine men, 15 women; mean age \u00b1 SD, 54.4 \u00b1 11.8 years) with a clinical diagnosis of tenosynovitis were examined with B-mode ultrasonography, PDUS, and CEUS by using a second-generation contrast agent, SonoVue (Bracco Diagnostics, Milan, Italy) and a low-mechanical-index ultrasound technique. Thickness of synovitis, extent of vascularized pannus, intensity of peritendinous vascularisation, and detection of intratendinous vessels was incorporated in a 3-score grading system (grade 0 to 2). Interobserver variability was calculated.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>With CEUS, a significantly greater extent of vascularity could be detected than by using PDUS (<jats:italic>P<\/jats:italic> &lt; 0.001). In terms of peri- and intratendinous vessels, CEUS was significantly more sensitive in the detection of vascularization compared with PDUS (<jats:italic>P<\/jats:italic> &lt; 0.001). No significant correlation between synovial thickening and extent of vascularity could be found (<jats:italic>P<\/jats:italic> = 0.089 to 0.097). Interobserver reliability was calculated to be excellent when evaluating the grading score (\u03ba = 0.811 to 1.00).<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusions<\/jats:title>\n                        <jats:p>CEUS is a promising tool to detect tendon vascularity with higher sensitivity than PDUS by improved detection of intra- and peritendinous vascularity.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/ar3185","type":"journal-article","created":{"date-parts":[[2010,11,9]],"date-time":"2010-11-09T19:23:47Z","timestamp":1289330627000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Detection of vascularity in wrist tenosynovitis: power doppler ultrasound compared with contrast-enhanced grey-scale ultrasound"],"prefix":"10.1186","volume":"12","author":[{"given":"Andrea S","family":"Klauser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Franz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit","family":"Arora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gudrun M","family":"Feuchtner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johann","family":"Gruber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Schirmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner R","family":"Jaschke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus F","family":"Gabl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,11,9]]},"reference":[{"key":"3041_CR1","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S0889-857X(21)00458-0","volume":"21","author":"G Alarc\u00f3n","year":"1995","unstructured":"Alarc\u00f3n G: Epidemiology of rheumatoid arthritis. Rheum Dis Clin North Am. 1995, 21: 589-604.","journal-title":"Rheum Dis Clin North Am"},{"key":"3041_CR2","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1007\/s10067-004-0997-1","volume":"24","author":"H Genc","year":"2005","unstructured":"Genc H, Cakit B, Tuncbilek I, Erdem H: Ultrasonographic evaluation of tendons and enthesal sites in rheumatoid arthritis: comparison with ankylosing spondylitis and healthy subjects. Clin Rheumatol. 2005, 24: 272-277. 10.1007\/s10067-004-0997-1.","journal-title":"Clin Rheumatol"},{"key":"3041_CR3","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.2214\/AJR.07.2548","volume":"189","author":"N Boutry","year":"2007","unstructured":"Boutry N, Morel M, Flipo R, Demondion X, Cotten A: Early rheumatoid arthritis: a review of MRI and sonographic findings. AJR Am J Roentgenol. 2007, 189: 1502-1509. 10.2214\/AJR.07.2548.","journal-title":"AJR Am J Roentgenol"},{"key":"3041_CR4","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1111\/j.1749-6632.2009.04388.x","volume":"1154","author":"M Backhaus","year":"2009","unstructured":"Backhaus M: Ultrasound and structural changes in inflammatory arthritis: synovitis and tenosynovitis. Ann N Y Acad Sci. 2009, 1154: 139-151. 10.1111\/j.1749-6632.2009.04388.x.","journal-title":"Ann N Y Acad Sci"},{"key":"3041_CR5","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1148\/rg.252045111","volume":"25","author":"O Sommer","year":"2005","unstructured":"Sommer O, Kladosek A, Weiler V, Czembirek H, Boeck M, Stiskal M: Rheumatoid arthritis: a practical guide to state-of-the-art imaging, image interpretation, and clinical implications. Radiographics. 2005, 25: 381-398. 10.1148\/rg.252045111.","journal-title":"Radiographics"},{"issue":"Suppl 3","key":"3041_CR6","doi-asserted-by":"publisher","first-page":"S99","DOI":"10.1186\/ar582","volume":"4","author":"P Taylor","year":"2002","unstructured":"Taylor P: VEGF and imaging of vessels in rheumatoid arthritis. Arthritis Res. 2002, 4 (Suppl 3): S99-S107. 10.1186\/ar582.","journal-title":"Arthritis Res"},{"key":"3041_CR7","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1002\/1529-0131(199806)41:6<951::AID-ART2>3.0.CO;2-D","volume":"41","author":"A Koch","year":"1998","unstructured":"Koch A: Review: angiogenesis: implications for rheumatoid arthritis. Arthritis Rheum. 1998, 41: 951-962. 10.1002\/1529-0131(199806)41:6<951::AID-ART2>3.0.CO;2-D.","journal-title":"Arthritis Rheum"},{"key":"3041_CR8","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.jhsa.2007.09.002","volume":"33","author":"B Sivakumar","year":"2008","unstructured":"Sivakumar B, Akhavani M, Winlove C, Taylor P, Paleolog E, Kang N: Synovial hypoxia as a cause of tendon rupture in rheumatoid arthritis. J Hand Surg [Am]. 2008, 33: 49-58. 10.1016\/j.jhsa.2007.09.002.","journal-title":"J Hand Surg [Am]"},{"key":"3041_CR9","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/S0749-0712(21)00343-7","volume":"12","author":"D Ferlic","year":"1996","unstructured":"Ferlic D: Rheumatoid flexor tenosynovitis and rupture. Hand Clin. 1996, 12: 561-572.","journal-title":"Hand Clin"},{"key":"3041_CR10","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1002\/1529-0131(200108)44:8<1754::AID-ART310>3.0.CO;2-8","volume":"44","author":"A Jain","year":"2001","unstructured":"Jain A, Nanchahal J, Troeberg L, Green P, Brennan F: Production of cytokines, vascular endothelial growth factor, matrix metalloproteinases, and tissue inhibitor of metalloproteinases 1 by tenosynovium demonstrates its potential for tendon destruction in rheumatoid arthritis. Arthritis Rheum. 2001, 44: 1754-1760. 10.1002\/1529-0131(200108)44:8<1754::AID-ART310>3.0.CO;2-8.","journal-title":"Arthritis Rheum"},{"key":"3041_CR11","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1148\/radiol.2251011272","volume":"225","author":"M Walther","year":"2002","unstructured":"Walther M, Harms H, Krenn V, Radke S, Kirschner S, Gohlke F: Synovial tissue of the hip at power Doppler US: correlation between vascularity and power Doppler US signal. Radiology. 2002, 225: 225-231. 10.1148\/radiol.2251011272.","journal-title":"Radiology"},{"key":"3041_CR12","first-page":"35","volume":"35","author":"A Iagnocco","year":"2008","unstructured":"Iagnocco A, Filippucci E, Perella C, Ceccarelli F, Cassar\u00e0 E, Alessandri C, Sabatini E, Grassi W, Valesini G: Clinical and ultrasonographic monitoring of response to adalimumab treatment in rheumatoid arthritis. J Rheumatol. 2008, 35: 35-40.","journal-title":"J Rheumatol"},{"key":"3041_CR13","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.ultras.2003.12.026","volume":"42","author":"F Forsberg","year":"2004","unstructured":"Forsberg F, Ro R, Potoczek M, Liu J, Merritt C, James K, Dicker A, Nazarian L: Assessment of angiogenesis: implications for ultrasound imaging. Ultrasonics. 2004, 42: 325-330. 10.1016\/j.ultras.2003.12.026.","journal-title":"Ultrasonics"},{"key":"3041_CR14","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1007\/s00330-007-0623-0","volume":"17","author":"E Quaia","year":"2007","unstructured":"Quaia E: Microbubble ultrasound contrast agents: an update. Eur Radiol. 2007, 17: 1995-2008. 10.1007\/s00330-007-0623-0.","journal-title":"Eur Radiol"},{"key":"3041_CR15","doi-asserted-by":"publisher","first-page":"2404","DOI":"10.1007\/s00330-005-2884-9","volume":"15","author":"A Klauser","year":"2005","unstructured":"Klauser A, Demharter J, De Marchi A, Sureda D, Barile A, Masciocchi C, Faletti C, Schirmer M, Kleffel T, Bohndorf K: Contrast enhanced gray-scale sonography in assessment of joint vascularity in rheumatoid arthritis: results from the IACUS study group. Eur Radiol. 2005, 15: 2404-2410. 10.1007\/s00330-005-2884-9.","journal-title":"Eur Radiol"},{"key":"3041_CR16","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1136\/ard.2006.067462","volume":"67","author":"I Song","year":"2008","unstructured":"Song I, Althoff C, Hermann K, Scheel A, Knetsch T, Schoenharting M, Werner C, Burmester G, Backhaus M: Knee osteoarthritis efficacy of a new method of contrast-enhanced musculoskeletal ultrasonography in detection of synovitis in patients with knee osteoarthritis in comparison with magnetic resonance imaging. Ann Rheum Dis. 2008, 67: 19-25.","journal-title":"Ann Rheum Dis"},{"key":"3041_CR17","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1007\/s00276-004-0311-6","volume":"27","author":"M Morel","year":"2005","unstructured":"Morel M, Boutry N, Demondion X, Legroux-Gerot I, Cotten H, Cotten A: Normal anatomy of the heel entheses: anatomical and ultrasonographic study of their blood supply. Surg Radiol Anat. 2005, 27: 176-183. 10.1007\/s00276-004-0311-6.","journal-title":"Surg Radiol Anat"},{"key":"3041_CR18","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1002\/art.1780310302","volume":"31","author":"F Arnett","year":"1988","unstructured":"Arnett F, Edworthy S, Bloch D, McShane D, Fries J, Cooper N, Healey L, Kaplan S, Liang M, Luthra H: The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988, 31: 315-324. 10.1002\/art.1780310302.","journal-title":"Arthritis Rheum"},{"key":"3041_CR19","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1002\/art.1780341003","volume":"34","author":"M Dougados","year":"1991","unstructured":"Dougados M, van der Linden S, Juhlin R, Huitfeldt B, Amor B, Calin A, Cats A, Dijkmans B, Olivieri I, Pasero G: The European Spondylarthropathy Study Group preliminary criteria for the classification of spondylarthropathy. Arthritis Rheum. 1991, 34: 1218-1227. 10.1002\/art.1780341003.","journal-title":"Arthritis Rheum"},{"key":"3041_CR20","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1002\/art.1780270401","volume":"27","author":"S van der Linden","year":"1984","unstructured":"van der Linden S, Valkenburg H, Cats A: Evaluation of diagnostic criteria for ankylosing spondylitis: a proposal for modification of the New York criteria. Arthritis Rheum. 1984, 27: 361-368. 10.1002\/art.1780270401.","journal-title":"Arthritis Rheum"},{"key":"3041_CR21","first-page":"2485","volume":"32","author":"R Wakefield","year":"2005","unstructured":"Wakefield R, Balint P, Szkudlarek M, Filippucci E, Backhaus M, D'Agostino M, Sanchez E, Iagnocco A, Schmidt W, Bruyn G, Kane D, O'Connor P, Manger B, Joshua F, Koski J, Grassi W, Lassere M, Swen N, Kainberger F, Klauser A, Ostergaard M, Brown A, Machold K, Conaghan P: Musculoskeletal ultrasound including definitions for ultrasonographic pathology. J Rheumatol. 2005, 32: 2485-2487.","journal-title":"J Rheumatol"},{"key":"3041_CR22","volume-title":"Eur J Radiol","author":"MC Wick","year":"2010","unstructured":"Wick MC, Weiss RJ, Arora R, Gabl M, Gruber J, Jaschke W, Klauser AS: Enthesiopathy of the flexor carpi ulnaris at the pisiform: findings of high-frequency sonography. Eur J Radiol. 2010,"},{"key":"3041_CR23","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1002\/art.24369","volume":"61","author":"M D'agostino","year":"2009","unstructured":"D'agostino M, Aegerter P, Jousse-Joulin S, Chary-Valckenaere I, Lecoq B, Gaudin P, Brault I, Schmitz J, Dehaut F, Le Parc J, Breban M, Landais P: How to evaluate and improve the reliability of power Doppler ultrasonography for assessing enthesitis in spondylarthritis. Arthritis Rheum. 2009, 61: 61-69.","journal-title":"Arthritis Rheum"},{"key":"3041_CR24","doi-asserted-by":"publisher","first-page":"504","DOI":"10.2214\/AJR.05.2165","volume":"188","author":"C Schueller-Weidekamm","year":"2007","unstructured":"Schueller-Weidekamm C, Krestan C, Schueller G, Kapral T, Aletaha D, Kainberger F: Power Doppler sonography and pulse-inversion harmonic imaging in evaluation of rheumatoid arthritis synovitis. AJR Am J Roentgenol. 2007, 188: 504-508. 10.2214\/AJR.05.2165.","journal-title":"AJR Am J Roentgenol"},{"key":"3041_CR25","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1148\/radiol.2483071400","volume":"248","author":"R Adler","year":"2008","unstructured":"Adler R, Fealy S, Rudzki J, Kadrmas W, Verma N, Pearle A, Lyman S, Warren R: Rotator cuff in asymptomatic volunteers: contrast-enhanced US depiction of intratendinous and peritendinous vascularity. Radiology. 2008, 248: 954-961. 10.1148\/radiol.2483071400.","journal-title":"Radiology"},{"key":"3041_CR26","doi-asserted-by":"publisher","first-page":"96S","DOI":"10.1016\/j.jse.2007.07.004","volume":"17","author":"J Rudzki","year":"2008","unstructured":"Rudzki J, Adler R, Warren R, Kadrmas W, Verma N, Pearle A, Lyman S, Fealy S: Contrast-enhanced ultrasound characterization of the vascularity of the rotator cuff tendon: age- and activity-related changes in the intact asymptomatic rotator cuff. J Shoulder Elbow Surg. 2008, 17: 96S-100S. 10.1016\/j.jse.2007.07.004.","journal-title":"J Shoulder Elbow Surg"},{"key":"3041_CR27","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.jse.2009.04.004","volume":"19","author":"S Gamradt","year":"2010","unstructured":"Gamradt S, Gallo R, Adler R, Maderazo A, Altchek D, Warren R, Fealy S: Vascularity of the supraspinatus tendon three months after repair: characterization using contrast-enhanced ultrasound. J Shoulder Elbow Surg. 2010, 19: 73-80. 10.1016\/j.jse.2009.04.004.","journal-title":"J Shoulder Elbow Surg"},{"key":"3041_CR28","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1177\/0363546509332255","volume":"37","author":"P Sengkerij","year":"2009","unstructured":"Sengkerij P, de Vos R, Weir A, van Weelde B, Tol H: Interobserver reliability of neovascularization score using power Doppler ultrasonography in midportion Achilles tendinopathy. Am J Sports Med. 2009, 37: 1627-1631. 10.1177\/0363546509332255.","journal-title":"Am J Sports Med"},{"key":"3041_CR29","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1080\/02841850510021256","volume":"46","author":"J Milosavljevic","year":"2005","unstructured":"Milosavljevic J, Lindqvist U, Elvin A: Ultrasound and power Doppler evaluation of the hand and wrist in patients with psoriatic arthritis. Acta Radiol. 2005, 46: 374-385. 10.1080\/02841850510021256.","journal-title":"Acta Radiol"},{"key":"3041_CR30","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1093\/rheumatology\/ken318","volume":"47","author":"K Albrecht","year":"2008","unstructured":"Albrecht K, Grob K, Lange U, M\u00fcller-Ladner U, Strunk J: Reliability of different Doppler ultrasound quantification methods and devices in the assessment of therapeutic response in arthritis. Rheumatology (Oxford). 2008, 47: 1521-1526. 10.1093\/rheumatology\/ken318.","journal-title":"Rheumatology (Oxford)"},{"key":"3041_CR31","doi-asserted-by":"publisher","first-page":"1590","DOI":"10.1136\/ard.2005.051235","volume":"65","author":"J Koski","year":"2006","unstructured":"Koski J, Saarakkala S, Helle M, Hakulinen U, Heikkinen J, Hermunen H: Power Doppler ultrasonography and synovitis: correlating ultrasound imaging with histopathological findings and evaluating the performance of ultrasound equipment. Ann Rheum Dis. 2006, 65: 1590-1595. 10.1136\/ard.2005.051235.","journal-title":"Ann Rheum Dis"},{"key":"3041_CR32","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1046\/j.1469-7580.2001.19950503.x","volume":"199","author":"M Benjamin","year":"2001","unstructured":"Benjamin M, McGonagle D: The anatomical basis for disease localisation in seronegative spondyloarthropathy at entheses and related sites. J Anat. 2001, 199: 503-526. 10.1046\/j.1469-7580.2001.19950503.x.","journal-title":"J Anat"},{"key":"3041_CR33","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1007\/s00330-007-0771-2","volume":"18","author":"M De Maeseneer","year":"2008","unstructured":"De Maeseneer M, Marcelis S, Jager T, Lenchik L, Pouders C, Van Roy P: Sonography of the finger flexor and extensor system at the hand and wrist level: findings in volunteers and anatomical correlation in cadavers. Eur Radiol. 2008, 18: 600-607. 10.1007\/s00330-007-0771-2.","journal-title":"Eur Radiol"},{"key":"3041_CR34","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1111\/j.1749-6632.2009.04382.x","volume":"1154","author":"F McQueen","year":"2009","unstructured":"McQueen F: The MRI view of synovitis and tenosynovitis in inflammatory arthritis: implications for diagnosis and management. Ann N Y Acad Sci. 2009, 1154: 21-34. 10.1111\/j.1749-6632.2009.04382.x.","journal-title":"Ann N Y Acad Sci"},{"key":"3041_CR35","doi-asserted-by":"publisher","first-page":"3017","DOI":"10.1007\/s00330-007-0712-0","volume":"17","author":"J Bremerich","year":"2007","unstructured":"Bremerich J, Bilecen D, Reimer P: MR angiography with blood pool contrast agents. Eur Radiol. 2007, 17: 3017-3024. 10.1007\/s00330-007-0712-0.","journal-title":"Eur Radiol"}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/ar3185.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/ar3185\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/ar3185.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T11:19:24Z","timestamp":1728386364000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/ar3185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,9]]},"references-count":35,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2010,12]]}},"alternative-id":["3041"],"URL":"https:\/\/doi.org\/10.1186\/ar3185","relation":{},"ISSN":["1478-6354"],"issn-type":[{"value":"1478-6354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,9]]},"assertion":[{"value":"9 December 2009","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2010","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 November 2010","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 November 2010","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"R209"}}