{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T22:57:59Z","timestamp":1781305079712,"version":"3.54.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2001,9,12]],"date-time":"2001-09-12T00:00:00Z","timestamp":1000252800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2001,9,12]],"date-time":"2001-09-12T00:00:00Z","timestamp":1000252800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"DOI":"10.1186\/ar328","type":"journal-article","created":{"date-parts":[[2002,9,26]],"date-time":"2002-09-26T12:07:27Z","timestamp":1033042047000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["High frequency of association of rheumatic\/autoimmune diseases and untreated male hypogonadism with severe testicular dysfunction"],"prefix":"10.1186","volume":"3","author":[{"given":"F Javier","family":"Jimenez-Balderas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Tapia-Serrano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Eugenia","family":"Fonseca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Arellano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Beltran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Ya\u00f1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo","family":"Camargo-Coronel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Fraga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2001,9,12]]},"reference":[{"key":"328_CR1","first-page":"982","volume":"14","author":"EJ Goldsteyn","year":"1987","unstructured":"Goldsteyn EJ, Fritzer MJ: Review: the role of the thymus-hypothalamus-pituitary-gonadal axis in normal immune processes and autoimmunity. J Rheumatol. 1987, 14: 982-990.","journal-title":"J Rheumatol"},{"key":"328_CR2","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1016\/S0140-6736(67)92543-3","volume":"1","author":"MB Vallatton","year":"1967","unstructured":"Vallatton MB, Forbes AP: Autoimmunity in gonadal dysgenesis and Klinefelter's syndrome. Lancet. 1967, 1: 648-651.","journal-title":"Lancet"},{"key":"328_CR3","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1056\/NEJM196404162701601","volume":"270","author":"DE Williams","year":"1964","unstructured":"Williams DE, Engel MB, Forbes AP: Thyroiditis and gonadal dysgenesis. New Engl J Med. 1964, 270: 805-810.","journal-title":"New Engl J Med"},{"key":"328_CR4","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1002\/art.1780120312","volume":"12","author":"C Ortie-Neu","year":"1969","unstructured":"Ortie-Neu C, Le Roy EC: The coincidence of Klinefelter's syndrome and systemic lupus erythematosus. Arthritis Rheum. 1969, 12: 241-246.","journal-title":"Arthritis Rheum"},{"key":"328_CR5","first-page":"351","volume":"98","author":"SH Tsumg","year":"1974","unstructured":"Tsumg SH, Heckman MG: Klinefelter's syndrome, immunological disorders, and malignant neoplasm. Arch Pathol. 1974, 98: 351-354.","journal-title":"Arch Pathol"},{"key":"328_CR6","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1002\/art.1780200103","volume":"20","author":"R Stern","year":"1997","unstructured":"Stern R, Fishman J, Brusman H, Kunkel HG: Systemic lupus erythematosus associated with Klinefelter's syndrome. Arthritis Rheum. 1997, 20: 18-22.","journal-title":"Arthritis Rheum"},{"key":"328_CR7","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1002\/art.1780250726","volume":"25","author":"RG Lahita","year":"1982","unstructured":"Lahita RG, Bradlow L, Fishman J, Kunkel HG: Estrogen metabolism in systemic lupus erythematosus. Arthritis Rheum. 1982, 25: 843-846.","journal-title":"Arthritis Rheum"},{"key":"328_CR8","first-page":"920","volume":"20","author":"JM Durand","year":"1993","unstructured":"Durand JM, Quiles N, Kaplanski G, Soubeyrand J: Lupus anticoagulant and Klinefelter's syndrome. J Rheumatol. 1993, 20: 920-921.","journal-title":"J Rheumatol"},{"key":"328_CR9","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1136\/pgmj.58.683.575","volume":"58","author":"DJ O'Donoghue","year":"1982","unstructured":"O'Donoghue DJ: Klinefelter's syndrome associated with systemic sclerosis. Postrheumatic\/autoimmune diseases. Postgrad Med J. 1982, 58: 575-576.","journal-title":"Postgrad Med J"},{"key":"328_CR10","first-page":"605","volume":"12","author":"NS Nowlin","year":"1985","unstructured":"Nowlin NS, Zwillich SH, Brick JE, Carson HE: Male hypogonadism and scleroderma. J Rheumatol. 1985, 12: 605-606.","journal-title":"J Rheumatol"},{"key":"328_CR11","first-page":"1613","volume":"16","author":"F De Keyser","year":"1989","unstructured":"De Keyser F, Mielants H, Veys EM: Klinefelter's syndrome and scleroderma. J Rheumatol. 1989, 16: 1613-1614.","journal-title":"J Rheumatol"},{"key":"328_CR12","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1007\/BF02208039","volume":"10","author":"S Kobayashi","year":"1991","unstructured":"Kobayashi S, Shimamoto T, Taniguchi O, Hashimoto H, Hirose S: Klinefelter's syndrome associated with progressive systemic sclerosis: Report of a case and review of the literature. Clin Rheumatol. 1991, 10: 84-86.","journal-title":"Clin Rheumatol"},{"key":"328_CR13","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1007\/BF02242951","volume":"13","author":"S Kobayashi","year":"1994","unstructured":"Kobayashi S, Yamamoto S, Tanaka M, Hashimoto H, Hirose S: Klinefelter's syndrome and rheumatoid arthritis. Report of a case and review of the literature. Clin Rheumatol. 1994, 13: 500-503.","journal-title":"Clin Rheumatol"},{"key":"328_CR14","first-page":"261","volume":"27","author":"J Couloumere","year":"1975","unstructured":"Couloumere J, Ayraud N, Cohen J, Ziegler G: Syndrome de Klinefelter associe a une spondylarthrite ankylosante. Rheumatologie. 1975, 27: 261-","journal-title":"Rheumatologie"},{"key":"328_CR15","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1093\/rheumatology\/24.3.277","volume":"24","author":"RD Armstrong","year":"1985","unstructured":"Armstrong RD, MacFarlane DG, Panayi GS: Ankylosing spondylitis and Klinefelter's syndrome: does the X chromosome modify disease expression?. Br J Rheumatol. 1985, 24: 277-281.","journal-title":"Br J Rheumatol"},{"key":"328_CR16","first-page":"178","volume":"19","author":"M Parges","year":"1990","unstructured":"Parges M, Laroche S, Lassoued S, Pages P, Mazieres B, Arlet J: Association d'une spondylarthrite B27 positive et d'un syndrome de Klinefelter [letter]. Presse Med. 1990, 19: 178-","journal-title":"Presse Med"},{"key":"328_CR17","doi-asserted-by":"publisher","first-page":"60","DOI":"10.2169\/naika.77.530","volume":"77","author":"M Murakami","year":"1988","unstructured":"Murakami M, Kishino B, Fushimi H, Sakata Y, Matsuyuki Y: The first report of Klinefelter's syndrome associated with polymyositis. J Jap Soc Intern Med. 1988, 77: 60-65.","journal-title":"J Jap Soc Intern Med"},{"key":"328_CR18","first-page":"61","volume":"4","author":"P Balestrazzi","year":"1968","unstructured":"Balestrazzi P, Ferraccioli GF, Ambanelli U, Giovannelli G: Juvenile rheumatoid arthritis in Turner's syndrome. Clin Exp Rheumatol. 1968, 4: 61-62.","journal-title":"Clin Exp Rheumatol"},{"key":"328_CR19","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1136\/bmj.309.6954.606","volume":"309","author":"AM Scammell","year":"1994","unstructured":"Scammell AM: Juvenile onset inflammatory bowel disease. Is more common in people with Turner's syndrome [letter]. BMJ. 1994, 309: 606-","journal-title":"BMJ"},{"key":"328_CR20","first-page":"21","volume-title":"Infertility in the Male. 2nd edn. Edited by Lipshultz LI, Howards SS. St Louis, MO, USA: Mosby-Year Book;","author":"AR Glass","year":"1991","unstructured":"Glass AR, Vigersky RA: Pituitary-testicular axis. Infertility in the Male. 2nd edn. Edited by Lipshultz LI, Howards SS. St Louis, MO, USA: Mosby-Year Book;. 1991, 21-36."},{"key":"328_CR21","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/0026-0495(86)90206-4","volume":"35","author":"C Longcope","year":"1986","unstructured":"Longcope C, Baker R, Johnston CC: Androgen and estrogen metabolism: relationship to obesity. Metabolism. 1986, 35: 235-237.","journal-title":"Metabolism"},{"key":"328_CR22","first-page":"453","volume-title":"In Primer on the Rheumatic Diseases. Edited by Klippel JH, Weyand CM, Wortmann RL. Atlanta, GA, USA: The Arthritis Foundation;","author":"JH Klippel","year":"1997","unstructured":"Klippel JH, Weyand CM, Wortmann RL: Appendix I: criteria for the classification and diagnosis of the rheumatic diseases. In Primer on the Rheumatic Diseases. Edited by Klippel JH, Weyand CM, Wortmann RL. Atlanta, GA, USA: The Arthritis Foundation;. 1997, 453-464."},{"key":"328_CR23","first-page":"803","volume":"38","author":"T Matsuda","year":"1992","unstructured":"Matsuda T, Horii Y, Ogura K, Nonomura M, Okada K, Yoshida O: Chromosomal survey of 1001 subfertile males: incidence and clinical features of males with chromosomal anomalies. Hinyokika Kiyo. 1992, 38: 803-809.","journal-title":"Hinyokika Kiyo"},{"key":"328_CR24","first-page":"85","volume":"26","author":"E Zeuthen","year":"1978","unstructured":"Zeuthen E, Nielsen J: Prevalence of Klinefelter's syndrome (47,XXY) in a general male population. J Genet Hum. 1978, 26: 85-97.","journal-title":"J Genet Hum"},{"key":"328_CR25","doi-asserted-by":"crossref","first-page":"33","DOI":"10.5694\/j.1326-5377.1980.tb131810.x","volume":"2","author":"OM Garson","year":"1980","unstructured":"Garson OM, Robson MK, Weste SM, Baikie AG: Clinical findings in patients with numerical abnormalities of the X chromosome: a three-year survey of consecutive admissions to a general hospital. Med J Aust. 1980, 2: 33-35.","journal-title":"Med J Aust"},{"key":"328_CR26","first-page":"155","volume":"29","author":"J Nielsen","year":"1975","unstructured":"Nielsen J: Chromosome mosaicism in a population sample. Humangenetik. 1975, 29: 155-159.","journal-title":"Humangenetik"},{"key":"328_CR27","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1136\/jmg.5.1.40","volume":"5","author":"H Marquez-Monter","year":"1968","unstructured":"Marquez-Monter H, Santiago-Payan H, Kofman-Alfaro S: Sex chromatin survey in mentally handicapped children in Mexico. J Med Gene. 1968, 5: 40-44.","journal-title":"J Med Gene"},{"key":"328_CR28","first-page":"251","volume":"22","author":"C Zavala","year":"1970","unstructured":"Zavala C, Mora G, Lisker R: Estudios cromosomicos en una prision mexicana. Rev Invest Clin. 1970, 22: 251-256.","journal-title":"Rev Invest Clin"},{"key":"328_CR29","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1111\/j.1600-0447.1981.tb00674.x","volume":"63","author":"J Schroder","year":"1981","unstructured":"Schroder J, de la Chapelle A, Hakola P, Virkkunen M: The frequency of XYY and XXY men among criminal offenders. Acta Psychiatr Scand. 1981, 63: 272-276.","journal-title":"Acta Psychiatr Scand"},{"key":"328_CR30","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1046\/j.1365-2249.2000.01329.x","volume":"121","author":"IH Kocar","year":"2000","unstructured":"Kocar IH, Yesilova Z, Ozata M, Turan M, Sengul A, Ozdemir I: The effect of testosterone replacement treatment on immunological features of patients with Klinefelter's syndrome. Clin Exp Immunol. 2000, 121: 448-452. 10.1046\/j.1365-2249.2000.01329.x.","journal-title":"Clin Exp Immunol"},{"key":"328_CR31","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1210\/jcem-64-1-32","volume":"64","author":"A Bizzarro","year":"1987","unstructured":"Bizzarro A, Valentini G, Di Martino G, DaPonte A, De Bellis A, Iacono G: Influence of testosterone therapy on clinical and immunological features of autoimmune diseases associated with Klinefelter's syndrome. J Clin Endocrinol Metab. 1987, 64: 32-36.","journal-title":"J Clin Endocrinol Metab"},{"key":"328_CR32","first-page":"73","volume":"32","author":"FJ Jimenez-Balderas","year":"1973","unstructured":"Jimenez-Balderas FJ, Katona G: Frecuencia de las enfermedades reumaticas en el servicio de consulta externa del Hospital General, SSA de la Ciudad de Mexico. Rev Med Hosp Gral. 1973, 32: 73-92.","journal-title":"Rev Med Hosp Gral"},{"key":"328_CR33","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1111\/j.1399-0039.1984.tb00019.x","volume":"23","author":"J Arellano","year":"1984","unstructured":"Arellano J, Vallejo M, Jimenez J, Mintz G, Kretschmer RR: HLA-B27 and ankylosing spondylitis in the Mexican Mestizo population. Tissue Antigens. 1984, 23: 112-116.","journal-title":"Tissue Antigens"},{"key":"328_CR34","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1136\/ard.59.9.657","volume":"59","author":"M Cutolo","year":"2000","unstructured":"Cutolo M, Straub R: Recent aspects of gonadal hormones and neurotransmitter interactions with synovial cells in rheumatoid arthritis. Ann Rheum Dis. 2000, 59: 657-661. 10.1136\/ard.59.9.657.","journal-title":"Ann Rheum Dis"},{"key":"328_CR35","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/S0889-857X(05)70171-X","volume":"26","author":"M Cutolo","year":"2000","unstructured":"Cutolo M, Wilder R: Different roles for androgens and estrogens in the susceptibility to autoimmune rheumatic diseases. Rheum Dis Clin North Am. 2000, 26: 825-839.","journal-title":"Rheum Dis Clin North Am"},{"key":"328_CR36","first-page":"856","volume":"23","author":"RH Straub","year":"1996","unstructured":"Straub RH, Zeuner M, Antiniou E, Scholmerich J, Lang B: Dehydroepiandrosterone sulfate is positively correlated with soluble interleukin 2 receptor and soluble intercellular adhesion molecule in systemic lupus erythematosus. J Rheumatol. 1996, 23: 856-861.","journal-title":"J Rheumatol"},{"key":"328_CR37","first-page":"3052","volume":"80","author":"A Purohit","year":"1995","unstructured":"Purohit A, Ghilchick MW, Duncan L, Wang DY, Singh A, Walker MM, Reed MJ: Aromatase activity and interleukin-6 production by normal and malignant breast tissues. J Clin Endocrinol Metab. 1995, 80: 3052-3058.","journal-title":"J Clin Endocrinol Metab"},{"key":"328_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/art.1780340102","volume":"34","author":"M Cutolo","year":"1991","unstructured":"Cutolo M, Balleari E, Giusti M, Intra E, Accardo S: Androgen replacement therapy in male patients with rheumatoid arthritis. Arthritis Rheum. 1991, 34: 1-5.","journal-title":"Arthritis Rheum"},{"key":"328_CR39","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/S0165-5728(97)00214-2","volume":"84","author":"BF Bebo Jr","year":"1998","unstructured":"Bebo BF, Zelinka-Vincent E, Adamus G, Amundson D, Vandenbark AA, Offner H: Gonadal hormones influence the immune response to PLP 139\u2013151 and the clinical course of relapsing experimental autoimmune encephalomyelitis. J Neuroimmunol. 1998, 84: 122-130. 10.1016\/S0165-5728(97)00214-2.","journal-title":"J Neuroimmunol"},{"key":"328_CR40","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1016\/0002-9343(87)90645-0","volume":"83","author":"GB Appel","year":"1987","unstructured":"Appel GB, Cohen DJ, Pirani CL, Meltzer JI, Estes D: Long-term follow-up of patients with lupus nephritis. A study based on the classification of the World Health Organization. Am J Med. 1987, 83: 877-885.","journal-title":"Am J Med"}],"container-title":["Arthritis Research & Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/ar328.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/ar328\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/ar328.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T16:38:30Z","timestamp":1714063110000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/ar328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,9,12]]},"references-count":40,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2001,9]]}},"alternative-id":["328"],"URL":"https:\/\/doi.org\/10.1186\/ar328","relation":{},"ISSN":["1478-6362"],"issn-type":[{"value":"1478-6362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,9,12]]},"assertion":[{"value":"10 January 2001","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 July 2001","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2001","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2001","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"362"}}