{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:16:34Z","timestamp":1791087394215,"version":"4.1.0"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2011,3,16]],"date-time":"2011-03-16T00:00:00Z","timestamp":1300233600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1186\/ar3283","type":"journal-article","created":{"date-parts":[[2011,3,17]],"date-time":"2011-03-17T19:17:29Z","timestamp":1300389449000},"source":"Crossref","is-referenced-by-count":35,"title":["Bone resorption and remodeling in murine collagenase-induced osteoarthritis after administration of glucosamine"],"prefix":"10.1186","volume":"13","author":[{"given":"Nina","family":"Ivanovska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petya","family":"Dimitrova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,3,16]]},"reference":[{"key":"9727_CR1","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0014-5793(02)03058-2","volume":"524","author":"M Uldry","year":"2002","unstructured":"Uldry M, Ibberson M, Hosokawa M, Thorens B: GLUT2 is a high affinity glucosamine transporter. FEBS Lett. 2002, 524: 199-203. 10.1016\/S0014-5793(02)03058-2.","journal-title":"FEBS Lett"},{"key":"9727_CR2","doi-asserted-by":"crossref","first-page":"10148","DOI":"10.1016\/S0021-9258(18)99202-1","volume":"266","author":"RR Traxinger","year":"1991","unstructured":"Traxinger RR, Marshall S: Coordinated regulation of glutamine:fructose-6-phosphate amidotransferase activity by insulin, glucose, and glutamine. Role of hexosamine biosynthesis in enzyme regulation. J Biol Chem. 1991, 266: 10148-10154.","journal-title":"J Biol Chem"},{"key":"9727_CR3","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.2337\/diabetes.49.9.1492","volume":"49","author":"J Tang","year":"2000","unstructured":"Tang J, Neidigh JL, Cooksey RC, McClain DA: Transgenic mice with increased hexosamine flux specifically targeted to beta-cells exhibit hyperinsulinemia and peripheral insulin resistance. Diabetes. 2000, 49: 1492-1499. 10.2337\/diabetes.49.9.1492.","journal-title":"Diabetes"},{"key":"9727_CR4","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1053\/joca.1998.0146","volume":"6","author":"C Bassleer","year":"1998","unstructured":"Bassleer C, Rovati L, Franchimont P: Stimulation of proteoglycan production by glucosamine sulfate in chondrocytes isolated from human osteoarthritic articular cartilage in vitro. Osteoarthritis Cartilage. 1998, 6: 427-434. 10.1053\/joca.1998.0146.","journal-title":"Osteoarthritis Cartilage"},{"key":"9727_CR5","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/S0014-5793(01)03255-0","volume":"510","author":"J Gouze","year":"2002","unstructured":"Gouze J, Bianchi A, Becuwe P, Dauca M, Netter P, Magdalou J, Terlain B, Bordji K: Glucosamine modulates IL-1-induced activation of rat chondrocytes at a receptor level, and by inhibiting the NF-kappa B pathway. FEBS Lett. 2002, 510: 166-170. 10.1016\/S0014-5793(01)03255-0.","journal-title":"FEBS Lett"},{"key":"9727_CR6","doi-asserted-by":"crossref","first-page":"R173","DOI":"10.1186\/ar2082","volume":"8","author":"JN Gouze","year":"2006","unstructured":"Gouze JN, Gouze E, Popp M, Bush M, Dacanay E, Kay J, Levings P, Patel K, Saran JP, Watson R, Ghivizzani SC: Exogenous glucosamine globally protects chondrocytes from the arthritogenic effects of IL-1beta. Arthritis Res Ther. 2006, 8: R173-10.1186\/ar2082.","journal-title":"Arthritis Res Ther"},{"key":"9727_CR7","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/S1063-4584(03)00028-1","volume":"11","author":"R Largo","year":"2003","unstructured":"Largo R, Alvarez-Soria M, Diez-Ortego I, Calvo E, Sanchez-Pernaute O, Egido J, Herrero-Beaumont G: Glucosamine inhibits IL-1beta-induced NFkappaB activation in human osteoarthritic chondrocytes. Osteoarthritis Cartilage. 2003, 11: 290-298. 10.1016\/S1063-4584(03)00028-1.","journal-title":"Osteoarthritis Cartilage"},{"key":"9727_CR8","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0144-8617(01)00281-8","volume":"48","author":"Y Tamai","year":"2002","unstructured":"Tamai Y, Miyatake K, Okamoto Y, Takamori Y, Sakamoto H, Minami S: Enhanced healing of cartilaginous injuries by glucosamine hydrochloride. Carbohydrate Polymers. 2002, 48: 369-378. 10.1016\/S0144-8617(01)00281-8.","journal-title":"Carbohydrate Polymers"},{"key":"9727_CR9","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.joca.2005.01.003","volume":"13","author":"P Chan","year":"2005","unstructured":"Chan P, Caron J, Rosa G, Orth M: Glucosamine and chondroitin sulfate regulate gene expression and synthesis of nitric oxide and prostaglandin E2 in articular cartilage explants. Osteoarthritis Cartilage. 2005, 13: 387-394. 10.1016\/j.joca.2005.01.003.","journal-title":"Osteoarthritis Cartilage"},{"key":"9727_CR10","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1006\/bbrc.2000.3912","volume":"279","author":"CJ Meininger","year":"2000","unstructured":"Meininger CJ, Kelly KA, Li H, Haynes TE, Wu G: Glucosamine inhibits inducible nitric oxide synthesis. Biochem Biophys Res Commun. 2000, 279: 234-239. 10.1006\/bbrc.2000.3912.","journal-title":"Biochem Biophys Res Commun"},{"key":"9727_CR11","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1189\/jlb.71.4.632","volume":"71","author":"J Hua","year":"2002","unstructured":"Hua J, Sakamoto K, Nagaoka I: Inhibitory actions of glucosamine, a therapeutic agent for osteoarthritis, on the functions of neutrophils. J Leukoc Biol. 2002, 71: 632-640.","journal-title":"J Leukoc Biol"},{"key":"9727_CR12","doi-asserted-by":"crossref","first-page":"39343","DOI":"10.1074\/jbc.M204924200","volume":"277","author":"L Ma","year":"2002","unstructured":"Ma L, Rudert WA, Harnaha J, Wright M, Machen J, Lakomy R, Qian S, Lu L, Robbins PD, Trucco M, Giannoukakis N: Immunosuppressive Effects of Glucosamine. J Biol Chem. 2002, 277: 39343-39349. 10.1074\/jbc.M204924200.","journal-title":"J Biol Chem"},{"key":"9727_CR13","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.fct.2004.11.006","volume":"43","author":"JW Anderson","year":"2005","unstructured":"Anderson JW, Nicolosi RJ, Borzelleca JF: Glucosamine effects in humans: a review of effects on glucose metabolism, side effects, safety considerations and efficacy. Food Chem Toxicol. 2005, 43: 187-201. 10.1016\/j.fct.2004.11.006.","journal-title":"Food Chem Toxicol"},{"key":"9727_CR14","first-page":"699","volume":"51","author":"I Setnikar","year":"2001","unstructured":"Setnikar I, Rovati LC: Absorption, distribution, metabolism and excretion of glucosamine sulfate. A review. Arzneimittelforschung. 2001, 51: 699-725.","journal-title":"Arzneimittelforschung"},{"key":"9727_CR15","first-page":"729","volume":"36","author":"I Setnikar","year":"1986","unstructured":"Setnikar I, Giacchetti C, Zanolo G: Pharmacokinetics of glucosamine in the dog and in man. Arzneimittelforschung. 1986, 36: 729-735.","journal-title":"Arzneimittelforschung"},{"key":"9727_CR16","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S1063-4584(05)80007-X","volume":"2","author":"H Muller-Fassbender","year":"1994","unstructured":"Muller-Fassbender H, Bach G, Haase W, Rovati L, Setnikar I: Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee. Osteoarthritis Cartilage. 1994, 2: 61-69. 10.1016\/S1063-4584(05)80007-X.","journal-title":"Osteoarthritis Cartilage"},{"key":"9727_CR17","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0140-6736(00)03610-2","volume":"357","author":"J Reginster","year":"2001","unstructured":"Reginster J, Deroisy R, Rovati L, Lee R, Lejeune E, Bruyere O, Giacovelli G, Henrotin Y, Dacre J, Gossett C: Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial. Lancet. 2001, 357: 251-256. 10.1016\/S0140-6736(00)03610-2.","journal-title":"Lancet"},{"key":"9727_CR18","first-page":"CD002946","volume-title":"Cochrane Database Syst Rev","author":"TE Towheed","year":"2005","unstructured":"Towheed TE, Maxwell L, Anastassiades TP, Shea B, Houpt J, Robinson V, Hochberg MC, Wells G: Glucosamine therapy for treating osteoarthritis. Cochrane Database Syst Rev. 2005, CD002946-"},{"key":"9727_CR19","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1001\/archinte.163.13.1514","volume":"163","author":"F Richy","year":"2003","unstructured":"Richy F, Bruyere O, Ethgen O, Cucherat M, Henrotin Y, Reginster JY: Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis. Arch Intern Med. 2003, 163: 1514-1522. 10.1001\/archinte.163.13.1514.","journal-title":"Arch Intern Med"},{"key":"9727_CR20","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1056\/NEJMoa052771","volume":"354","author":"DO Clegg","year":"2006","unstructured":"Clegg DO, Reda DJ, Harris CL, Klein MA, O'Dell JR, Hooper MM, Bradley JD, Bingham CO, Weisman MH, Jackson CG, Lane NE, Cush JJ, Moreland LW, Schumacher HR, Oddis CV, Wolfe F, Molitor JA, Yocum DE, Schnitzer TJ, Furst DE, Sawitzke AD, Shi H, Brandt KD, Moskowitz RW, Williams H: Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. New Engl J Med. 2006, 354: 795-808. 10.1056\/NEJMoa052771.","journal-title":"New Engl J Med"},{"key":"9727_CR21","doi-asserted-by":"crossref","first-page":"268","DOI":"10.7326\/0003-4819-148-4-200802190-00005","volume":"148","author":"RM Rozendaal","year":"2008","unstructured":"Rozendaal RM, Koes BW, van Osch GJ, Uitterlinden EJ, Garling EH, Willemsen SP, Ginai AZ, Verhaar JA, Weinans H, Bierma-Zeinstra SM: Effect of glucosamine sulfate on hip osteoarthritis. Ann Intern Med. 2008, 148: 268-277.","journal-title":"Ann Intern Med"},{"key":"9727_CR22","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1002\/1529-0131(199804)41:4<634::AID-ART10>3.0.CO;2-1","volume":"41","author":"FA van de Loo","year":"1998","unstructured":"van de Loo FA, Arntz OJ, van Enckevort FH, van Lent PL, van den Berg WB: Reduced cartilage proteoglycan loss during zymosan-induced gonarthritis in NOS2-deficient mice and in anti-interleukin-1-treated wild-type mice with unabated joint inflammation. Arthritis Rheum. 1998, 41: 634-646. 10.1002\/1529-0131(199804)41:4<634::AID-ART10>3.0.CO;2-1.","journal-title":"Arthritis Rheum"},{"key":"9727_CR23","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.joca.2005.07.014","volume":"14","author":"KP Pritzker","year":"2006","unstructured":"Pritzker KP, Gay S, Jimenez SA, Ostergaard K, Pelletier JP, Revell PA, Salter D, van den Berg WB: Osteoarthritis cartilage histopathology: grading and staging. Osteoarthritis Cartilage. 2006, 14: 13-29. 10.1016\/j.joca.2005.07.014.","journal-title":"Osteoarthritis Cartilage"},{"key":"9727_CR24","doi-asserted-by":"crossref","first-page":"573","DOI":"10.2165\/00002512-200724070-00005","volume":"24","author":"O Bruyere","year":"2007","unstructured":"Bruyere O, Reginster JY: Glucosamine and chondroitin sulfate as therapeutic agents for knee and hip osteoarthritis. Drugs Aging. 2007, 24: 573-580. 10.2165\/00002512-200724070-00005.","journal-title":"Drugs Aging"},{"key":"9727_CR25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0889-857X(05)70116-2","volume":"26","author":"JC Delafuente","year":"2000","unstructured":"Delafuente JC: Glucosamine in the treatment of osteoarthritis. Rheum Dis Clin North Am. 2000, 26: 1-11. 10.1016\/S0889-857X(05)70116-2. vii","journal-title":"Rheum Dis Clin North Am"},{"key":"9727_CR26","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1016\/j.joca.2008.06.006","volume":"16","author":"D Uebelhart","year":"2008","unstructured":"Uebelhart D: Clinical review of chondroitin sulfate in osteoarthritis. Osteoarthritis Cartilage. 2008, 16: S19-21. 10.1016\/j.joca.2008.06.006.","journal-title":"Osteoarthritis Cartilage"},{"key":"9727_CR27","first-page":"504","volume":"2","author":"E D'Ambrosio","year":"1981","unstructured":"D'Ambrosio E, Casa B, Bompani R, Scali G, Scali M: Glucosamine sulphate: a controlled clinical investigation in arthrosis. Pharmatherapeutica. 1981, 2: 504-508.","journal-title":"Pharmatherapeutica"},{"key":"9727_CR28","first-page":"5","volume":"144","author":"K Pavelka","year":"2004","unstructured":"Pavelka K: Symptomatic treatment of osteoarthritis: paracetamol or NSAIDs?. Int J Clin Pract Suppl. 2004, 144: 5-12.","journal-title":"Int J Clin Pract Suppl"},{"key":"9727_CR29","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1002\/art.22728","volume":"56","author":"SC Vlad","year":"2007","unstructured":"Vlad SC, LaValley MP, McAlindon TE, Felson DT: Glucosamine for pain in osteoarthritis: why do trial results differ?. Arthritis Rheum. 2007, 56: 2267-2277. 10.1002\/art.22728.","journal-title":"Arthritis Rheum"},{"key":"9727_CR30","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1002\/glia.21058","volume":"58","author":"SY Hwang","year":"2010","unstructured":"Hwang SY, Shin JH, Hwang JS, Kim SY, Shin JA, Oh ES, Oh S, Kim JB, Lee JK, Han IO: Glucosamine exerts a neuroprotective effect via suppression of inflammation in rat brain ischemia\/reperfusion injury. Glia. 2010, 58: 1881-1892. 10.1002\/glia.21058.","journal-title":"Glia"},{"key":"9727_CR31","first-page":"237","volume":"39","author":"J Fernandes","year":"2002","unstructured":"Fernandes J, Martel-Pelletier J, Pelletier J: The role of cytokines in osteoarthritis pathophysiology. Biorheology. 2002, 39: 237-246.","journal-title":"Biorheology"},{"key":"9727_CR32","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1097\/01.blo.0000144854.66565.8f","volume":"427","author":"S Goldring","year":"2004","unstructured":"Goldring S, Goldring M: The role of cytokines in cartilage matrix degeneration in osteoarthritis. Clin Orthop Relat Res. 2004, 427: S27-S36. 10.1097\/01.blo.0000144854.66565.8f.","journal-title":"Clin Orthop Relat Res"},{"key":"9727_CR33","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.bone.2006.09.023","volume":"40","author":"M Asagiri","year":"2007","unstructured":"Asagiri M, Takayanagi H: The molecular understanding of osteoclast differentiation. Bone. 2007, 40: 251-264. 10.1016\/j.bone.2006.09.023.","journal-title":"Bone"},{"key":"9727_CR34","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.bone.2007.05.016","volume":"41","author":"SG-K Mohamed","year":"2007","unstructured":"Mohamed SG-K, Sugiyama E, Shinoda K, Taki H, Hounoki H, Abdel-Aziz HO, Maruyama M, Kobayashi M, Ogawa H, Miyahara T: Interleukin-10 inhibits RANKL-mediated expression of NFATc1 in part via suppression of c-Fos and c-Jun in RAW264.7 cells and mouse bone marrow cells. Bone. 2007, 41: 592-602. 10.1016\/j.bone.2007.05.016.","journal-title":"Bone"},{"key":"9727_CR35","doi-asserted-by":"crossref","first-page":"11535","DOI":"10.1074\/jbc.M607999200","volume":"283","author":"F Yoshitake","year":"2008","unstructured":"Yoshitake F, Itoh S, Narita H, Ishihara K, Ebisu S: Interleukin-6 directly inhibits osteoclast differentiation by suppressing receptor activator of NF-\u03baB signaling pathways. J Biol Chem. 2008, 283: 11535-11540. 10.1074\/jbc.M607999200.","journal-title":"J Biol Chem"},{"key":"9727_CR36","doi-asserted-by":"crossref","first-page":"3353","DOI":"10.4049\/jimmunol.169.6.3353","volume":"169","author":"P Palmqvist","year":"2002","unstructured":"Palmqvist P, Persson E, Conaway HH, Lerner UH: IL-6, leukemia inhibitory factor, and oncostatin M stimulate bone resorption and regulate the expression of receptor activator of NF-kappa B ligand, osteoprotegerin, and receptor activator of NF-kappa B in mouse calvariae. J Immunol. 2002, 169: 3353-3362.","journal-title":"J Immunol"},{"key":"9727_CR37","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/jbmr.5650110113","volume":"11","author":"S Kotake","year":"1996","unstructured":"Kotake S, Sato K, Kim KJ, Takahashi N, Udagawa N, Nakamura I, Yamaguchi A, Kishimoto T, Suda T, Kashiwazaki S: Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation. J Bone Miner Res. 1996, 11: 88-95. 10.1002\/jbmr.5650110113.","journal-title":"J Bone Miner Res"},{"key":"9727_CR38","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1093\/rheumatology\/ken363","volume":"47","author":"M Hashizume","year":"2008","unstructured":"Hashizume M, Hayakawa N, Mihara M: IL-6 trans-signalling directly induces RANKL on fibroblast-like synovial cells and is involved in RANKL induction by TNF-{alpha} and IL-17. Rheumatology. 2008, 47: 1635-1640. 10.1093\/rheumatology\/ken363.","journal-title":"Rheumatology"},{"key":"9727_CR39","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0092-8674(00)81569-X","volume":"93","author":"DL Lacey","year":"1998","unstructured":"Lacey DL, Timms E, Tan HL, Kelley MJ, Dunstan CR, Burgess T, Elliott R, Colombero A, Elliott G, Scully S, Hsu H, Sullivan J, Hawkins N, Davy E, Capparelli C, Eli A, Qian YX, Kaufman S, Sarosi I, Shalhoub V, Senaldi G, Guo J, Delaney J, Boyle WJ: Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell. 1998, 93: 165-176. 10.1016\/S0092-8674(00)81569-X.","journal-title":"Cell"},{"key":"9727_CR40","doi-asserted-by":"crossref","first-page":"36846","DOI":"10.1074\/jbc.M606656200","volume":"281","author":"A Hikita","year":"2006","unstructured":"Hikita A, Yana I, Wakeyama H, Nakamura M, Kadono Y, Oshima Y, Nakamura K, Seiki M, Tanaka S: Negative regulation of osteoclastogenesis by ectodomain shedding of receptor activator of NF-kappaB ligand. J Biol Chem. 2006, 281: 36846-36855. 10.1074\/jbc.M606656200.","journal-title":"J Biol Chem"},{"key":"9727_CR41","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1210\/endo.142.4.8070","volume":"142","author":"T Ikeda","year":"2001","unstructured":"Ikeda T, Kasai M, Utsuyama M, Hirokawa K: Determination of three isoforms of the receptor activator of nuclear factor-kappaB ligand and their differential expression in bone and thymus. Endocrinology. 2001, 142: 1419-1426. 10.1210\/en.142.4.1419.","journal-title":"Endocrinology"},{"key":"9727_CR42","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/46303","volume":"402","author":"YY Kong","year":"1999","unstructured":"Kong YY, Feige U, Sarosi I, Bolon B, Tafuri A, Morony S, Capparelli C, Li J, Elliott R, McCabe S, Wong T, Campagnuolo G, Moran E, Bogoch ER, Van G, Nguyen LT, Ohashi PS, Lacey DL, Fish E, Boyle WJ, Penninger JM: Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature. 1999, 402: 304-309. 10.1038\/46303.","journal-title":"Nature"},{"key":"9727_CR43","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1002\/1529-0131(200105)44:5<1003::AID-ANR179>3.0.CO;2-#","volume":"44","author":"S Kotake","year":"2001","unstructured":"Kotake S, Udagawa N, Hakoda M, Mogi M, Yano K, Tsuda E, Takahashi K, Furuya T, Ishiyama S, Kim KJ, Saito S, Nishikawa T, Takahashi N, Togari A, Tomatsu T, Suda T, Kamatani N: Activated human T cells directly induce osteoclastogenesis from human monocytes: possible role of T cells in bone destruction in rheumatoid arthritis patients. Arthritis Rheum. 2001, 44: 1003-1012. 10.1002\/1529-0131(200105)44:5<1003::AID-ANR179>3.0.CO;2-#.","journal-title":"Arthritis Rheum"},{"key":"9727_CR44","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1136\/ard.57.7.395","volume":"57","author":"T Boegard","year":"1998","unstructured":"Boegard T, Rudling O, Petersson IF, Jonsson K: Correlation between radiographically diagnosed osteophytes and magnetic resonance detected cartilage defects in the patellofemoral joint. Ann Rheum Dis. 1998, 57: 395-400. 10.1136\/ard.57.7.395.","journal-title":"Ann Rheum Dis"},{"key":"9727_CR45","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1097\/00115550-199924040-00012","volume":"24","author":"TJ Lamer","year":"1999","unstructured":"Lamer TJ: Lumbar spine pain originating from vertebral osteophytes. Reg Anesth Pain Med. 1999, 24: 347-351.","journal-title":"Reg Anesth Pain Med"},{"key":"9727_CR46","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.joca.2006.11.006","volume":"15","author":"PM van der Kraan","year":"2007","unstructured":"van der Kraan PM, van den Berg WB: Osteophytes: relevance and biology. Osteoarthritis Cartilage. 2007, 15: 237-244. 10.1016\/j.joca.2006.11.006.","journal-title":"Osteoarthritis Cartilage"},{"key":"9727_CR47","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1053\/joca.1998.0129","volume":"6","author":"HM van Beuningen","year":"1998","unstructured":"van Beuningen HM, Glansbeek HL, van der Kraan PM, van den Berg WB: Differential effects of local application of BMP-2 or TGF-beta 1 on both articular cartilage composition and osteophyte formation. Osteoarthritis Cartilage. 1998, 6: 306-317. 10.1053\/joca.1998.0129.","journal-title":"Osteoarthritis Cartilage"},{"key":"9727_CR48","doi-asserted-by":"crossref","first-page":"4065","DOI":"10.1002\/art.23034","volume":"56","author":"EN Blaney Davidson","year":"2007","unstructured":"Blaney Davidson EN, Vitters EL, van Beuningen HM, van de Loo FA, van den Berg WB, van der Kraan PM: Resemblance of osteophytes in experimental osteoarthritis to transforming growth factor beta-induced osteophytes: limited role of bone morphogenetic protein in early osteoarthritic osteophyte formation. Arthritis Rheum. 2007, 56: 4065-4073. 10.1002\/art.23034.","journal-title":"Arthritis Rheum"},{"key":"9727_CR49","doi-asserted-by":"crossref","first-page":"R115","DOI":"10.1186\/ar2518","volume":"10","author":"M Daans","year":"2008","unstructured":"Daans M, Lories RJ, Luyten FP: Dynamic activation of bone morphogenetic protein signaling in collagen-induced arthritis supports their role in joint homeostasis and disease. Arthritis Res Ther. 2008, 10: R115-10.1186\/ar2518.","journal-title":"Arthritis Res Ther"},{"key":"9727_CR50","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1136\/ard.2005.045971","volume":"65","author":"EN Blaney Davidson","year":"2006","unstructured":"Blaney Davidson EN, Vitters EL, van der Kraan PM, van den Berg WB: Expression of transforming growth factor-beta (TGFbeta) and the TGFbeta signalling molecule SMAD-2P in spontaneous and instability-induced osteoarthritis: role in cartilage degradation, chondrogenesis and osteophyte formation. Ann Rheum Dis. 2006, 65: 1414-1421. 10.1136\/ard.2005.045971.","journal-title":"Ann Rheum Dis"},{"key":"9727_CR51","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.devcel.2005.02.017","volume":"8","author":"2nd Glass DA","year":"2005","unstructured":"Glass DA 2nd, Bialek P, Ahn JD, Starbuck M, Patel MS, Clevers H, Taketo MM, Long F, McMahon AP, Lang RA, Karsenty G: Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell. 2005, 8: 751-764. 10.1016\/j.devcel.2005.02.017.","journal-title":"Dev Cell"},{"key":"9727_CR52","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1172\/JCI28551","volume":"116","author":"V Krishnan","year":"2006","unstructured":"Krishnan V, Bryant HU, MacDougald OA: Regulation of bone mass by Wnt signaling. J Clin Invest. 2006, 116: 1202-1209. 10.1172\/JCI28551.","journal-title":"J Clin Invest"},{"key":"9727_CR53","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1242\/jcs.02883","volume":"119","author":"GJ Spencer","year":"2006","unstructured":"Spencer GJ, Utting JC, Etheridge SL, Arnett TR, Genever PG: Wnt signalling in osteoblasts regulates expression of the receptor activator of NFkappaB ligand and inhibits osteoclastogenesis in vitro. J Cell Sci. 2006, 119: 1283-1296. 10.1242\/jcs.02883.","journal-title":"J Cell Sci"},{"key":"9727_CR54","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.bone.2006.03.017","volume":"39","author":"J Li","year":"2006","unstructured":"Li J, Sarosi I, Cattley RC, Pretorius J, Asuncion F, Grisanti M, Morony S, Adamu S, Geng Z, Qiu W, Kostenuik P, Lacey DL, Simonet WS, Bolon B, Qian X, Shalhoub V, Ominsky MS, Zhu Ke H, Li X, Richards WG: Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia. Bone. 2006, 39: 754-766. 10.1016\/j.bone.2006.03.017.","journal-title":"Bone"},{"key":"9727_CR55","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1359\/jbmr.060311","volume":"21","author":"F Morvan","year":"2006","unstructured":"Morvan F, Boulukos K, Cl\u00e9ment-Lacroix P, Roman Roman S, Suc-Royer I, Vayssi\u00e8re B, Ammann P, Martin P, Pinho S, Pognonec P, Mollat P, Niehrs C, Baron R, Rawadi G: Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass. J Bone Miner Res. 2006, 21: 934-945. 10.1359\/jbmr.060311.","journal-title":"J Bone Miner Res"},{"key":"9727_CR56","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/nm1538","volume":"13","author":"D Diarra","year":"2007","unstructured":"Diarra D, Stolina M, Polzer K, Zwerina J, Ominsky MS, Dwyer D, Korb A, Smolen J, Hoffmann M, Scheinecker C, van der Heide D, Landewe R, Lacey D, Richards WG, Schett G: Dickkopf-1 is a master regulator of joint remodeling. Nat Med. 2007, 13: 156-163. 10.1038\/nm1538.","journal-title":"Nat Med"},{"key":"9727_CR57","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/1476-4598-6-71","volume":"6","author":"K Fujita","year":"2007","unstructured":"Fujita K, Janz S: Attenuation of WNT signaling by DKK-1 and -2 regulates BMP2-induced osteoblast differentiation and expression of OPG, RANKL and M-CSF. Molecular Cancer. 2007, 6: 71-10.1186\/1476-4598-6-71.","journal-title":"Molecular Cancer"},{"key":"9727_CR58","doi-asserted-by":"crossref","first-page":"989","DOI":"10.4049\/jimmunol.149.3.989","volume":"149","author":"RR Kew","year":"1992","unstructured":"Kew RR, Grimaldi CM, Furie MB, Fleit HB: Human neutrophil Fc gamma RIIIB and formyl peptide receptors are functionally linked during formyl-methionyl-leucyl-phenylalanine-induced chemotaxis. J Immunol. 1992, 149: 989-997.","journal-title":"J Immunol"},{"key":"9727_CR59","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1186\/ar2137","volume":"9","author":"PE Poubelle","year":"2007","unstructured":"Poubelle PE, Chakravarti A, Fernandes MJ, Doiron K, Marceau AA: Differential expression of RANK, RANK-L, and osteoprotegerin by synovial fluid neutrophils from patients with rheumatoid arthritis and by healthy human blood neutrophils. Arthritis Res Ther. 2007, 9: R25-10.1186\/ar2137.","journal-title":"Arthritis Res Ther"},{"key":"9727_CR60","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1182\/blood-2008-09-178301","volume":"114","author":"A Chakravarti","year":"2009","unstructured":"Chakravarti A, Raquil MA, Tessier P, Poubelle PE: Surface RANKL of Toll-like receptor 4-stimulated human neutrophils activates osteoclastic bone resorption. Blood. 2009, 114: 1633-1644. 10.1182\/blood-2008-09-178301.","journal-title":"Blood"},{"key":"9727_CR61","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/art.22369","volume":"56","author":"LI Sakkas","year":"2007","unstructured":"Sakkas LI, Platsoucas CD: The role of T cells in the pathogenesis of osteoarthritis. Arthritis & Rheumatism. 2007, 56: 409-424.","journal-title":"Arthritis & Rheumatism"},{"key":"9727_CR62","doi-asserted-by":"crossref","first-page":"4113","DOI":"10.1182\/blood-2004-04-1607","volume":"104","author":"Y Takada","year":"2004","unstructured":"Takada Y, Aggarwal BB: Evidence that genetic deletion of the TNF receptor p60 or p80 in macrophages modulates RANKL-induced signaling. Blood. 2004, 104: 4113-4121. 10.1182\/blood-2004-04-1607.","journal-title":"Blood"},{"key":"9727_CR63","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1084\/jem.20082900","volume":"206","author":"RA Maldonado","year":"2009","unstructured":"Maldonado RA, Soriano MA, Perdomo LC, Sigrist K, Irvine DJ, Decker T, Glimcher LH: Control of T helper cell differentiation through cytokine receptor inclusion in the immunological synapse. J Exp Med. 2009, 206: 877-892. 10.1084\/jem.20082900.","journal-title":"J Exp Med"},{"key":"9727_CR64","doi-asserted-by":"crossref","first-page":"R187","DOI":"10.1186\/ar2099","volume":"8","author":"J Bondeson","year":"2006","unstructured":"Bondeson J, Wainwright SD, Lauder S, Amos N, Hughes CE: The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis. Arthritis Res Ther. 2006, 8: R187-10.1186\/ar2099.","journal-title":"Arthritis Res Ther"},{"key":"9727_CR65","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.joca.2004.03.003","volume":"12","author":"AB Blom","year":"2004","unstructured":"Blom AB, van Lent PL, Holthuysen AE, van der Kraan PM, Roth J, van Rooijen N, van den Berg WB: Synovial lining macrophages mediate osteophyte formation during experimental osteoarthritis. Osteoarthritis Cartilage. 2004, 12: 627-635. 10.1016\/j.joca.2004.03.003.","journal-title":"Osteoarthritis Cartilage"}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/ar3283.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/ar3283\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/ar3283.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T20:16:54Z","timestamp":1685996214000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/ar3283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,16]]},"references-count":65,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["9727"],"URL":"https:\/\/doi.org\/10.1186\/ar3283","relation":{},"ISSN":["1478-6362"],"issn-type":[{"value":"1478-6362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,16]]},"article-number":"R44"}}