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Subjects were free of clinical heart disease, diabetes, and renal impairment. The main measure was the presence of any CAC by computerized tomography (Agatston score &gt;0).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty-eight percent of the study participants were male and 45% were African-American. Mean (\u00b1 SD) age was 40 \u00b1 4 years, body mass index 28 \u00b1 6 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , Framingham risk score -0.7 \u00b1 5%, blood pressure 113 \u00b1 14\/75 \u00b1 11 mmHg, alcohol consumption 12 \u00b1 27 ml\/day, and sUA 297 \u00b1 89 \u03bcmol\/L (5.0 \u00b1 1.5 mg\/dL). Prevalence of CAC increased with sUA concentration among both men and women. Adjusted for age, gender, race, lipoproteins, triglycerides, smoking, blood pressure, presence of metabolic syndrome, C-reactive protein, waist circumference, alcohol use, creatinine, and serum albumin, the highest quartile of sUA (&gt;393 \u03bcmol\/L [6.6 mg\/dL] for men and &gt;274 \u03bcmol\/L [4.6 mg\/dL] for women) was associated with an odds ratio of 1.87 (1.19-2.93) compared to the lowest quartile (&lt;291 \u03bcmol\/L [4.9 mg\/dL] for men and &lt;196 \u03bcmol\/L [3.3 mg\/dL] for women). Among those with any CAC, each unit increase in sUA was associated with a 22% increase in Agatston score (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.008) after adjusting for the above covariates.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Hyperuricemia is an independent risk factor for subclinical atherosclerosis in young adults.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/ar3322","type":"journal-article","created":{"date-parts":[[2011,6,24]],"date-time":"2011-06-24T14:14:23Z","timestamp":1308924863000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":93,"title":["Hyperuricemia and the risk for subclinical coronary atherosclerosis - data from a prospective observational cohort study"],"prefix":"10.1186","volume":"13","author":[{"given":"Eswar","family":"Krishnan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhavik J","family":"Pandya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorinda","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Dabbous","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,4,18]]},"reference":[{"key":"3083_CR1","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1016\/j.amjmed.2005.03.043","volume":"118","author":"JF Baker","year":"2005","unstructured":"Baker JF, Krishnan E, Chen L, Schumacher HR: Serum uric acid and cardiovascular disease: recent developments, and where do they leave us?. 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