{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:03:24Z","timestamp":1790870604743,"version":"4.1.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2011,6,22]],"date-time":"2011-06-22T00:00:00Z","timestamp":1308700800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2011,6,22]],"date-time":"2011-06-22T00:00:00Z","timestamp":1308700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Postmenopausal osteoporosis may modulate bone response to wear debris. In this article, we evaluate the influence of oestrogen deficiency on experimental particle-induced osteolysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Polyethylene (PE) particles were implanted onto the calvaria of normal controls, sham-ovariectomized (OVX), OVX mice and OVX mice supplemented with oestrogen (OVX+E). After 14 days, seven skulls per group were analyzed using a high-resolution micro-computed tomography (micro-CT) and histomorphometry, and for tartrate-specific alkaline phosphatase. Five calvariae per group were cultured for the assay of IL-1\u03b2, IL-6, TNF-\u03b1 and receptor activator of the nuclear factor \u03baB (RANKL) secretion using quantitative ELISA. Serum IL-6 concentrations were obtained. The expression of RANKL and osteoprotegerin (OPG) mRNA were evaluated using real-time PCR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>As assessed by \u03bcCT and by histomorphometry, PE particles induced extensive bone resorption and an intense inflammatory reaction in normal controls, sham-OVX and OVX+E mice, but not in the OVX mice group. In normal controls, sham-OVX and OVX+E mice, PE particles induced an increase in serum IL-6, in TNF-\u03b1 and RANKL local concentrations, and resulted in a significant increase in RANKL\/OPG messenger RNA (mRNA) ratio. Conversely, these parameters remained unchanged in OVX mice after PE implantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Oestrogen privation in the osteolysis murine model ultimately attenuated osteolytic response to PE particles, suggesting a protective effect. This paradoxical phenomenon was associated with a down-regulation of pro-resorptive cytokines. It is hypothesized that excessive inflammatory response was controlled, illustrated by the absence of increase of serum IL-6 in OVX mice after PE implantation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/ar3381","type":"journal-article","created":{"date-parts":[[2011,6,23]],"date-time":"2011-06-23T02:23:30Z","timestamp":1308795810000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Oestrogen deficiency modulates particle-induced osteolysis"],"prefix":"10.1186","volume":"13","author":[{"given":"Christophe","family":"Nich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Langlois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Marchadier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Vidal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Cohen-Solal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Petite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moussa","family":"Hamadouche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,6,22]]},"reference":[{"key":"3122_CR1","first-page":"95","volume":"258","author":"HG Willert","year":"1990","unstructured":"Willert HG, Bertram H, Buchhorn GH: Osteolysis in alloarthroplasty of the hip. The role of ultra-high molecular weight polyethylene wear particles. Clin Orthop Relat Res. 1990, 258: 95-107.","journal-title":"Clin Orthop Relat Res"},{"key":"3122_CR2","first-page":"390","volume":"4","author":"EM Schwarz","year":"2004","unstructured":"Schwarz EM, O'Keefe RJ, Looney RJ: Bone implant interface, osteolysis and potential therapies. J Musculoskelet Neuronal Interact. 2004, 4: 390-392.","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"3122_CR3","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.2106\/00004623-199711000-00002","volume":"79","author":"S Kobayashi","year":"1997","unstructured":"Kobayashi S, Takaoka K, Saito N, Hisa K: Factors affecting aseptic failure of fixation after primary Charnley total hip arthroplasty. Multivariate survival analysis. J Bone Joint Surg Am. 1997, 79: 1618-1627.","journal-title":"J Bone Joint Surg Am"},{"key":"3122_CR4","doi-asserted-by":"publisher","first-page":"4675","DOI":"10.1016\/j.biomaterials.2004.02.069","volume":"25","author":"M von Knoch","year":"2004","unstructured":"von Knoch M, Jewison DE, Sibonga JD, Turner RT, Morrey BF, Loer F, Berry DJ, Scully SP: Decrease in particle-induced osteolysis in obese (ob\/ob) mice. Biomaterials. 2004, 25: 4675-4681. 10.1016\/j.biomaterials.2004.02.069.","journal-title":"Biomaterials"},{"key":"3122_CR5","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/s00011-007-7040-3","volume":"57","author":"C Zhang","year":"2008","unstructured":"Zhang C, Tang T, Ren W, Zhang X, Dai K: Influence of mouse genetic background on wear particle-induced in vivo inflammatory osteolysis. Inflamm Res. 2008, 57: 211-215. 10.1007\/s00011-007-7040-3.","journal-title":"Inflamm Res"},{"key":"3122_CR6","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/jor.20987","volume":"28","author":"C Nich","year":"2010","unstructured":"Nich C, Marchadier A, Sedel L, Petite H, Vidal C, Hamadouche M: Decrease in particle-induced osteolysis in ovariectomized mice. J Orthop Res. 2010, 28: 178-183.","journal-title":"J Orthop Res"},{"key":"3122_CR7","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1002\/(SICI)1097-4636(19970605)35:3<399::AID-JBM14>3.0.CO;2-A","volume":"35","author":"N Ishiguro","year":"1997","unstructured":"Ishiguro N, Kojima T, Ito T, Saga S, Anma H, Kurokouchi K, Iwahori Y, Iwase T, Iwata H: Macrophage activation and migration in interface tissue around loosening total hip arthroplasty components. J Biomed Mater Res. 1997, 35: 399-406. 10.1002\/(SICI)1097-4636(19970605)35:3<399::AID-JBM14>3.0.CO;2-A.","journal-title":"J Biomed Mater Res"},{"key":"3122_CR8","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1002\/1097-4636(200009)53:5<490::AID-JBM7>3.0.CO;2-7","volume":"53","author":"TR Green","year":"2000","unstructured":"Green TR, Fisher J, Matthews JB, Stone MH, Ingham E: Effect of size and dose on bone resorption activity of macrophages by in vitro clinically relevant ultra high molecular weight polyethylene particles. J Biomed Mater Res. 2000, 53: 490-497. 10.1002\/1097-4636(200009)53:5<490::AID-JBM7>3.0.CO;2-7.","journal-title":"J Biomed Mater Res"},{"key":"3122_CR9","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.cytogfr.2003.10.005","volume":"15","author":"S Kwan Tat","year":"2004","unstructured":"Kwan Tat S, Padrines M, Theoleyre S, Heymann D, Fortun Y: IL-6, RANKL, TNFalpha\/IL-1: interrelations in bone resorption pathophysiology. Cytokine Growth Factor Rev. 2004, 15: 49-60. 10.1016\/j.cytogfr.2003.10.005.","journal-title":"Cytokine Growth Factor Rev"},{"key":"3122_CR10","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1007\/BF02556007","volume":"45","author":"TJ Wronski","year":"1989","unstructured":"Wronski TJ, Dann LM, Scott KS, Cintr\u00f3n M: Long-term effects of ovariectomy and aging on the rat skeleton. Calcif Tissue Int. 1989, 45: 360-366. 10.1007\/BF02556007.","journal-title":"Calcif Tissue Int"},{"key":"3122_CR11","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1210\/en.133.2.822","volume":"133","author":"G Passeri","year":"1993","unstructured":"Passeri G, Girasole G, Jilka RL, Manolagas SC: Increased interleukin-6 production by murine bone marrow and bone cells after estrogen withdrawal. Endocrinology. 1993, 133: 822-828. 10.1210\/en.133.2.822.","journal-title":"Endocrinology"},{"key":"3122_CR12","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1210\/mend.13.6.0299","volume":"13","author":"TC Spelsberg","year":"1999","unstructured":"Spelsberg TC, Subramaniam M, Riggs BL, Khosla S: The actions and interactions of sex steroids and growth factors\/cytokines on the skeleton. Mol Endocrinol. 1999, 13: 819-828. 10.1210\/me.13.6.819.","journal-title":"Mol Endocrinol"},{"key":"3122_CR13","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/S8756-3282(98)00068-4","volume":"23","author":"R M\u00fcller","year":"1998","unstructured":"M\u00fcller R, van Campenhout H, van Damme B, Van Der Perre G, Dequeker J, Hildebrand T, R\u00fcegsegger P: Morphometric analysis of human bone biopsies: a quantitative structural comparison of histological sections and micro-computed tomography. Bone. 1998, 23: 59-66. 10.1016\/S8756-3282(98)00068-4.","journal-title":"Bone"},{"key":"3122_CR14","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1136\/ard.52.12.862","volume":"52","author":"HR van den Brink","year":"1993","unstructured":"van den Brink HR, van Everdingen AA, van Wijk MJ, Jacobs JW, Bijlsma JW: Adjuvant oestrogen therapy does not improve disease activity in postmenopausal patients with rheumatoid arthritis. Ann Rheum Dis. 1993, 52: 862-865. 10.1136\/ard.52.12.862.","journal-title":"Ann Rheum Dis"},{"key":"3122_CR15","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1136\/ard.53.2.112","volume":"53","author":"GM Hall","year":"1994","unstructured":"Hall GM, Daniels M, Huskisson EC, Spector TD: A randomized controlled trial of the effect of hormone replacement therapy on disease activity in postmenopausal rheumatoid arthritis. Ann Rheum Dis. 1994, 53: 112-116. 10.1136\/ard.53.2.112.","journal-title":"Ann Rheum Dis"},{"key":"3122_CR16","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1186\/ar761","volume":"5","author":"HF D'Elia","year":"2003","unstructured":"D'Elia HF, Mattsson LA, Ohlsson C, Nordborg E, Carlsten H: Hormone replacement therapy in rheumatoid arthritis is associated with lower serum levels of soluble IL-6 receptor and higher insulin-like growth factor 1. Arthritis Res Ther. 2003, 5: 202-209. 10.1186\/ar788.","journal-title":"Arthritis Res Ther"},{"key":"3122_CR17","doi-asserted-by":"publisher","first-page":"2384","DOI":"10.1210\/en.2003-1536","volume":"145","author":"T Yoneda","year":"2004","unstructured":"Yoneda T, Ishimaru N, Arakaki R, Kobayashi M, Izawa T, Moriyama K, Hayashi Y: Estrogen deficiency accelerates murine autoimmune arthritis associated with receptor activator of nuclear factor-kappa B ligand-mediated osteoclastogenesis. Endocrinology. 2004, 145: 2384-2391. 10.1210\/en.2003-1536.","journal-title":"Endocrinology"},{"key":"3122_CR18","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.clim.2005.01.006","volume":"115","author":"S Subramanian","year":"2005","unstructured":"Subramanian S, Tovey M, Afentoulis M, Krogstad A, Vandenbark AA, Offner H: Ethinyl estradiol treats collagen-induced arthritis in DBA\/1LacJ mice by inhibiting the production of TNF-alpha and IL-1beta. Clin Immunol. 2005, 115: 162-172. 10.1016\/j.clim.2005.01.006.","journal-title":"Clin Immunol"},{"key":"3122_CR19","first-page":"791","volume":"21","author":"JA da Silva","year":"1994","unstructured":"da Silva JA, Willoughby DA: The influence of sex in arthritis: is cartilage an overlooked factor?. J Rheumatol. 1994, 21: 791-796.","journal-title":"J Rheumatol"},{"key":"3122_CR20","doi-asserted-by":"publisher","first-page":"28890","DOI":"10.1074\/jbc.271.46.28890","volume":"271","author":"RB Kimble","year":"1996","unstructured":"Kimble RB, Srivastava S, Ross FP, Matayoshi A, Pacifici R: Estrogen deficiency increases the ability of stromal cells to support murine osteoclastogenesis via an interleukin-1 and tumor necrosis factor-mediated stimulation of macrophage colony-stimulating factor production. J Biol Chem. 1996, 271: 28890-28897. 10.1074\/jbc.271.46.28890.","journal-title":"J Biol Chem"},{"key":"3122_CR21","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1038\/46303","volume":"402","author":"YY Kong","year":"1999","unstructured":"Kong YY, Feige U, Sarosi I, Bolon B, Tafuri A, Morony S, Capparelli C, Li J, Elliott R, Mc Cabe S, Wong T, Campagnuolo G, Moran E, Bogoch ER, Van G, Nguyen LT, Ohashi PS, Lacey DL, Fish E, Boyle WJ, Penninger JM: Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature. 1999, 402: 304-309. 10.1038\/46303.","journal-title":"Nature"},{"key":"3122_CR22","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1073\/pnas.97.4.1566","volume":"97","author":"J Li","year":"2000","unstructured":"Li J, Sarosi I, Yan XQ, Morony S, Capparelli C, Tan HL, McCabe S, Elliott R, Scully S, Van G, Kaufman S, Juan SC, Sun Y, Tarpley J, Martin L, Christensen K, Mc Cabe J, Kostenuik P, Hsu H, Fletcher F, Dunstan CR, Lacey DL, Boyle WJ: RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism. Proc Natl Acad Sci USA. 2000, 97: 1566-1571. 10.1073\/pnas.97.4.1566.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3122_CR23","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1007\/s007740070007","volume":"18","author":"SL Teitelbaum","year":"2000","unstructured":"Teitelbaum SL: Osteoclasts, integrins, and osteoporosis. J Bone Miner Metab. 2000, 18: 344-349. 10.1007\/s007740070007.","journal-title":"J Bone Miner Metab"},{"key":"3122_CR24","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/j.cell.2007.07.025","volume":"130","author":"T Nakamura","year":"2007","unstructured":"Nakamura T, Imai Y, Matsumoto T, Sato S, Takeuchi K, Igarashi K, Harada Y, Azuma Y, Krust A, Yamamoto Y, Nishina H, Takeda S, Takayanagi H, Metzger D, Kanno J, Takaoka K, Martin TJ, Chambon P, Kato S: Estrogen prevents bone loss via oestrogen receptor alpha and induction of Fas ligand in osteoclasts. Cell. 2007, 130: 811-823. 10.1016\/j.cell.2007.07.025.","journal-title":"Cell"},{"key":"3122_CR25","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1359\/jbmr.2001.16.2.338","volume":"16","author":"LM Childs","year":"2001","unstructured":"Childs LM, Goater JJ, O'Keefe RJ, Schwarz EM: Efficacy of etanercept for wear debris-induced osteolysis. J Bone Miner Res. 2001, 16: 338-347. 10.1359\/jbmr.2001.16.2.338.","journal-title":"J Bone Miner Res"},{"key":"3122_CR26","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1074\/jbc.M008198200","volume":"276","author":"YH Zhang","year":"2001","unstructured":"Zhang YH, Heulsmann A, Tondravi MM, Mukherjee A, Abu-Amer Y: Tumor necrosis factor-alpha (TNF) stimulates RANKL-induced osteoclastogenesis via coupling of TNF type 1 receptor and RANK signaling pathways. J Biol Chem. 2001, 276: 563-568.","journal-title":"J Biol Chem"},{"key":"3122_CR27","doi-asserted-by":"publisher","first-page":"3054","DOI":"10.1210\/en.136.7.3054","volume":"136","author":"RB Kimble","year":"1995","unstructured":"Kimble RB, Matayoshi AB, Vannice JL, Kung VT, Williams C, Pacifici R: Simultaneous block of interleukin-1 and tumor necrosis factor is required to completely prevent bone loss in the early postovariectomy period. Endocrinology. 1995, 136: 3054-3061. 10.1210\/en.136.7.3054.","journal-title":"Endocrinology"},{"key":"3122_CR28","doi-asserted-by":"publisher","first-page":"13960","DOI":"10.1073\/pnas.251534698","volume":"98","author":"C Roggia","year":"2001","unstructured":"Roggia C, Gao Y, Cenci S, Weitzmann MN, Toraldo G, Isaia G, Pacifici R: Up-regulation of TNF-producing T cells in the bone marrow: a key mechanism by which oestrogen deficiency induces bone loss in vivo. Proc Natl Acad Sci USA. 2001, 98: 13960-13965. 10.1073\/pnas.251534698.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3122_CR29","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1016\/j.bone.2006.12.053","volume":"40","author":"N Taki","year":"2007","unstructured":"Taki N, Tatro JM, Lowe R, Goldberg VM, Greenfield EM: Comparison of the roles of IL-1, IL-6, and TNFalpha in cell culture and murine models of aseptic loosening. Bone. 2007, 40: 1276-1283. 10.1016\/j.bone.2006.12.053.","journal-title":"Bone"},{"key":"3122_CR30","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1177\/154405910608500704","volume":"85","author":"UH Lerner","year":"2006","unstructured":"Lerner UH: Inflammation-induced bone remodeling in periodontal disease and the influence of post-menopausal osteoporosis. J Dent Res. 2006, 85: 596-607. 10.1177\/154405910608500704.","journal-title":"J Dent Res"},{"key":"3122_CR31","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1172\/JCI11089","volume":"106","author":"J Lorenzo","year":"2000","unstructured":"Lorenzo J: Interactions between immune and bone cells: new insights with many remaining questions. J Clin Invest. 2000, 106: 749-752. 10.1172\/JCI11089.","journal-title":"J Clin Invest"},{"key":"3122_CR32","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1097\/00003086-199909000-00018","volume":"366","author":"P Hernigou","year":"1999","unstructured":"Hernigou P, Intrator L, Bahrami T, Bensussan A, Farcet JP: Interleukin-6 in the blood of patients with total hip arthroplasty without loosening. Clin Orthop Relat Res. 1999, 366: 147-154.","journal-title":"Clin Orthop Relat Res"},{"key":"3122_CR33","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1016\/j.arth.2005.03.034","volume":"20","author":"R Tanaka","year":"2005","unstructured":"Tanaka R, Yasunaga Y, Hisatome T, Yamasaki T, Iwamori H, Ochi M: Serum interleukin 8 levels correlate with synovial fluid levels in patients with aseptic loosening of hip prosthesis. J Arthroplasty. 2005, 20: 1049-1054. 10.1016\/j.arth.2005.03.034.","journal-title":"J Arthroplasty"},{"key":"3122_CR34","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1172\/JCI11066","volume":"106","author":"S Cenci","year":"2000","unstructured":"Cenci S, Weitzmann MN, Roggia C, Namba N, Novack D, Woodring J, Pacifici R: Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-alpha. J Clin Invest. 2000, 106: 1229-1237. 10.1172\/JCI11066.","journal-title":"J Clin Invest"},{"key":"3122_CR35","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1111\/j.0105-2896.2005.00324.x","volume":"208","author":"MN Weitzmann","year":"2005","unstructured":"Weitzmann MN, Pacifici R: The role of T lymphocytes in bone metabolism. Immunol Rev. 2005, 208: 154-168. 10.1111\/j.0105-2896.2005.00324.x.","journal-title":"Immunol Rev"},{"key":"3122_CR36","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1002\/jbmr.5650110802","volume":"11","author":"R Pacifici","year":"1996","unstructured":"Pacifici R: Estrogen, cytokines, and pathogenesis of postmenopausal osteoporosis. J Bone Miner Res. 1996, 11: 1043-1051.","journal-title":"J Bone Miner Res"},{"key":"3122_CR37","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s00774-006-0723-y","volume":"25","author":"T Sato","year":"2007","unstructured":"Sato T, Watanabe K, Masuhara M, Hada N, Hakeda Y: Production of IL-7 is increased in ovariectomized mice, but not RANKL mRNA expression by osteoblasts\/stromal cells in bone, and IL-7 enhances generation of osteoclast precursors in vitro. J Bone Miner Metab. 2007, 25: 19-27.","journal-title":"J Bone Miner Metab"},{"key":"3122_CR38","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1038\/nm1207-1409","volume":"13","author":"KD Kim","year":"2007","unstructured":"Kim KD, Zhao J, Auh S, Yang X, Du P, Tang H, Fu YX: Adaptive immune cells temper initial innate responses. Nat Med. 2007, 13: 1248-1252. 10.1038\/nm1633.","journal-title":"Nat Med"},{"key":"3122_CR39","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1038\/nature08100","volume":"460","author":"G Guarda","year":"2009","unstructured":"Guarda G, Dostert C, Staehli F, Cabalzar K, Castillo R, Tardivel A, Schneider P, Tschopp J: T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes. Nature. 2009, 460: 269-273. 10.1038\/nature08100.","journal-title":"Nature"},{"key":"3122_CR40","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/j.bbadis.2009.05.004","volume":"1792","author":"V Everts","year":"2009","unstructured":"Everts V, de Vries TJ, Helfrich MH: Osteoclast heterogeneity: lessons from osteopetrosis and inflammatory conditions. Biochim Biophys Acta. 2009, 1792: 757-765.","journal-title":"Biochim Biophys Acta"},{"key":"3122_CR41","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s00223-010-9418-4","volume":"88","author":"AP de Souza Faloni","year":"2011","unstructured":"de Souza Faloni AP, Schoenmaker T, Azari A, Katchburian E, Cerri PS, de Vries TJ, Everts V: Jaw and long bone marrows have a different osteoclastogenic potential. Calcif Tissue Int. 2011, 88: 63-74. 10.1007\/s00223-010-9418-4.","journal-title":"Calcif Tissue Int"},{"key":"3122_CR42","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1359\/jbmr.060614","volume":"21","author":"V Everts","year":"2006","unstructured":"Everts V, Korper W, Hoeben KA, Jansen ID, Bromme D, Cleutjens KB, Heeneman S, Peters C, Reinheckel T, Saftig P, Beertsen W: Osteoclastic bone degradation and the role of different cysteine proteinases and matrix metalloproteinases: differences between calvaria and long bone. J Bone Miner Res. 2006, 21: 1399-1408. 10.1359\/jbmr.060614.","journal-title":"J Bone Miner Res"},{"key":"3122_CR43","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/s00223-005-0289-z","volume":"79","author":"S Perez-Amodio","year":"2006","unstructured":"Perez-Amodio S, Jansen DC, Schoenmaker T, Vogels IM, Reinheckel T, Hayman AR, Cox TM, Saftig P, Beertsen W, Everts V: Calvarial osteoclasts express a higher level of tartrate-resistant acid phosphatase than long bone osteoclasts and activation does not depend on cathepsin K or L activity. Calcif Tissue Int. 2006, 79: 245-254. 10.1007\/s00223-005-0289-z.","journal-title":"Calcif Tissue Int"},{"key":"3122_CR44","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.bone.2008.05.009","volume":"43","author":"T van de Bos","year":"2008","unstructured":"van de Bos T, Speijer D, Bank RA, Bromme D, Everts V: Differences in matrix composition between calvaria and long bone in mice suggest differences in biomechanical properties and resorption: Special emphasis on collagen. Bone. 2008, 43: 459-468. 10.1016\/j.bone.2008.05.009.","journal-title":"Bone"},{"key":"3122_CR45","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/S8756-3282(03)00196-0","volume":"33","author":"H Libouban","year":"2003","unstructured":"Libouban H, Moreau MF, Basl\u00e9 MF, Bataille R, Chappard D: Increased bone remodeling due to ovariectomy dramatically increases tumoral growth in the 5T2 multiple myeloma mouse model. Bone. 2003, 33: 283-292. 10.1016\/S8756-3282(03)00196-0.","journal-title":"Bone"},{"key":"3122_CR46","doi-asserted-by":"publisher","first-page":"297","DOI":"10.2152\/jmi.55.297","volume":"55","author":"S Takata","year":"2008","unstructured":"Takata S, Takao S, Yoshida S, Hayashi F, Yasui N: Therapeutic effects of one-year alendronate treatment in three cases of osteoporosis with pari\u00e9tal thinning of skull. J Med Invest. 2008, 55: 297-302. 10.2152\/jmi.55.297.","journal-title":"J Med Invest"}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/ar3381.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/ar3381\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/ar3381.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T07:04:56Z","timestamp":1728371096000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/ar3381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6,22]]},"references-count":46,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2011,6]]}},"alternative-id":["3122"],"URL":"https:\/\/doi.org\/10.1186\/ar3381","relation":{},"ISSN":["1478-6354"],"issn-type":[{"value":"1478-6354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6,22]]},"assertion":[{"value":"4 January 2011","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 May 2011","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2011","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2011","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"R100"}}