{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:29:23Z","timestamp":1791822563434,"version":"4.3.4"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2011,12,22]],"date-time":"2011-12-22T00:00:00Z","timestamp":1324512000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2011,12,22]],"date-time":"2011-12-22T00:00:00Z","timestamp":1324512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"abstract":"<jats:title>Abstract\n<\/jats:title><jats:sec>\n                        <jats:title>Introduction\n<\/jats:title>\n                        <jats:p>Several reports have found the onset or activity of inflammatory myopathies to show spatial clustering and seasonal association. We recently detected autoantibodies against melanoma differentiation-associated gene 5 (MDA-5) in more than 20% of patients with dermatomyositis. Anti-MDA-5 antibodies were associated with the presence of rapidly progressive interstitial lung disease in clinically amyopathic dermatomyositis (CADM). The present study aims to assess the growing prevalence of CADM and the geographical incidence of anti-MDA-5-positive patients.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Methods\n<\/jats:title>\n                        <jats:p>We reviewed medical charts and examined the presence of anti-MDA-5 antibodies in 95 patients, including 36 CADM patients. Sera were obtained from 1994 through 2011. Statistical analyses were performed to assess whether CADM development and the presence of anti-MDA-5 antibodies were associated with various parameters, including age at disease onset, season of onset, annual positivity, and population of resident city.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results\n<\/jats:title>\n                        <jats:p>Tertiles based on the year when the sera were collected showed increasing tendencies of CADM and anti-MDA-5-positive patients among all of the dermatomyositis patients. From 1994 to 2010, the relative prevalence of CADM and anti-MDA-5 antibody-positive patients significantly increased. Interestingly, the presence of anti-MDA-5 antibodies in 26 patients was inversely associated with the population of their city of residence.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusions\n<\/jats:title>\n                        <jats:p>This is the first study to examine the distribution of anti-MDA-5-positive dermatomyositis phenotypes in Japan. Regional differences in the incidences of these phenotypes would suggest that environmental factors contribute to the production of antibodies against MDA-5, which triggers innate antiviral responses.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/ar3547","type":"journal-article","created":{"date-parts":[[2011,12,22]],"date-time":"2011-12-22T19:28:07Z","timestamp":1324582087000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["Epidemiologic study of clinically amyopathic dermatomyositis and anti-melanoma differentiation-associated gene 5 antibodies in central Japan"],"prefix":"10.1186","volume":"13","author":[{"given":"Yoshinao","family":"Muro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazumitsu","family":"Sugiura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Hoshino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Akiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Tamakoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,12,22]]},"reference":[{"key":"3297_CR1","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1002\/art.1780341108","volume":"34","author":"RL Leff","year":"1991","unstructured":"Leff RL, Burgess SH, Miller FW, Love LA, Targoff IN, Dalakas MC, Joffe MM, Plotz PH: Distinct seasonal patterns in the onset of adult idiopathic inflammatory myopathy in patients with anti-Jo-1 and anti-signal recognition particle autoantibodies. Arthritis Rheum. 1991, 34: 1391-1396.","journal-title":"Arthritis Rheum"},{"key":"3297_CR2","doi-asserted-by":"publisher","first-page":"2433","DOI":"10.1002\/art.21198","volume":"52","author":"K Sarkar","year":"2005","unstructured":"Sarkar K, Weinberg CR, Oddis CV, Medsger TA, Plotz PH, Reveille JD, Arnett FC, Targoff IN, Genth E, Love LA, Miller FW: Seasonal influence on the onset of idiopathic inflammatory myopathies in serologically defined groups. Arthritis Rheum. 2005, 52: 2433-2438. 10.1002\/art.21198.","journal-title":"Arthritis Rheum"},{"key":"3297_CR3","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1007\/s004150200036","volume":"249","author":"BA Phillips","year":"2002","unstructured":"Phillips BA, Zilko PJ, Garlepp MJ, Mastaglia FL: Seasonal occurrence of relapses in inflammatory myopathies: a preliminary study. J Neurol. 2002, 249: 441-444. 10.1007\/s004150200036.","journal-title":"J Neurol"},{"key":"3297_CR4","doi-asserted-by":"publisher","first-page":"2285","DOI":"10.1002\/art.11090","volume":"48","author":"S Okada","year":"2003","unstructured":"Okada S, Weatherhead E, Targoff IN, Wesley R, Miller FW, International Myositis Collaborative Study Group: Global surface ultraviolet radiation intensity may modulate the clinical and immunologic expression of autoimmune muscle disease. Arthritis Rheum. 2003, 48: 2285-2293. 10.1002\/art.11090.","journal-title":"Arthritis Rheum"},{"key":"3297_CR5","doi-asserted-by":"publisher","first-page":"2499","DOI":"10.1002\/art.24702","volume":"60","author":"LA Love","year":"2009","unstructured":"Love LA, Weinberg CR, McConnaughey DR, Oddis CV, Medsger TA, Reveille JD, Arnett FC, Targoff IN, Miller FW: Ultraviolet radiation intensity predicts the relative distribution of dermatomyositis and anti-Mi-2 autoantibodies in women. Arthritis Rheum. 2009, 60: 2499-2504. 10.1002\/art.24702.","journal-title":"Arthritis Rheum"},{"key":"3297_CR6","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1067\/mjd.2002.120621","volume":"46","author":"RD Sontheimer","year":"2002","unstructured":"Sontheimer RD: Would a new name hasten the acceptance of amyopathic dermatomyositis (dermatomyositis sin\u00e9 myositis) as a distinctive subset within the idiopathic inflammatory dermatomyopathies spectrum of clinical illness?. J Am Acad Dermatol. 2002, 46: 626-636. 10.1067\/mjd.2002.120621.","journal-title":"J Am Acad Dermatol"},{"key":"3297_CR7","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1097\/BOR.0b013e32833f1987","volume":"22","author":"S Sato","year":"2010","unstructured":"Sato S, Kuwana M: Clinically amyopathic dermatomyositis. Curr Opin Rheumatol. 2010, 22: 639-643. 10.1097\/BOR.0b013e32833f1987.","journal-title":"Curr Opin Rheumatol"},{"key":"3297_CR8","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1002\/art.21023","volume":"52","author":"S Sato","year":"2005","unstructured":"Sato S, Hirakata M, Kuwana M, Suwa A, Inada S, Mimori T, Nishikawa T, Oddis CV, Ikeda Y: Autoantibodies to a 140-kd polypeptide, CADM-140, in Japanese patients with clinically amyopathic dermatomyositis. Arthritis Rheum. 2005, 52: 1571-1576. 10.1002\/art.21023.","journal-title":"Arthritis Rheum"},{"key":"3297_CR9","doi-asserted-by":"publisher","first-page":"2193","DOI":"10.1002\/art.24621","volume":"60","author":"S Sato","year":"2009","unstructured":"Sato S, Hoshino K, Satoh T, Fujita T, Kawakami Y, Fujita T, Kuwana M: RNA helicase encoded by melanoma differentiation-associated gene 5 is a major autoantigen in patients with clinically amyopathic dermatomyositis: association with rapidly progressive interstitial lung disease. Arthritis Rheum. 2009, 60: 2193-2200. 10.1002\/art.24621.","journal-title":"Arthritis Rheum"},{"key":"3297_CR10","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1093\/rheumatology\/kep375","volume":"49","author":"R Nakashima","year":"2010","unstructured":"Nakashima R, Imura Y, Kobayashi S, Yukawa N, Yoshifuji H, Nojima T, Kawabata D, Ohmura K, Usui T, Fujii T, Okawa K, Mimori T: The RIG-I-like receptor IFIH1\/MDA5 is a dermatomyositis-specific autoantigen identified by the anti-CADM-140 antibody. Rheumatology (Oxford). 2010, 49: 433-440. 10.1093\/rheumatology\/kep375.","journal-title":"Rheumatology (Oxford)"},{"key":"3297_CR11","doi-asserted-by":"publisher","first-page":"1726","DOI":"10.1093\/rheumatology\/keq153","volume":"49","author":"K Hoshino","year":"2010","unstructured":"Hoshino K, Muro Y, Sugiura K, Tomita Y, Nakashima R, Mimori T: Anti-MDA5 and anti-TIF1-\u03b3 antibodies have clinical significance for patients with dermatomyositis. Rheumatology (Oxford). 2010, 49: 1726-1733. 10.1093\/rheumatology\/keq153.","journal-title":"Rheumatology (Oxford)"},{"key":"3297_CR12","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/nature04734","volume":"441","author":"H Kato","year":"2006","unstructured":"Kato H, Takeuchi O, Sato S, Yoneyama M, Yamamoto M, Matsui K, Uematsu S, Jung A, Kawai T, Ishii KJ, Yamaguchi O, Otsu K, Tsujimura T, Koh CS, Reis e Sousa C, Matsuura Y, Fujita T, Akira S: Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature. 2006, 441: 101-105. 10.1038\/nature04734.","journal-title":"Nature"},{"key":"3297_CR13","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1097\/00005792-197707000-00001","volume":"56","author":"A Bohan","year":"1977","unstructured":"Bohan A, Peter JB, Bowman RL, Pearson CM: A computer-assisted analysis of 153 patients with polymyositis and dermatomyositis. Medicine (Baltimore). 1977, 56: 255-286.","journal-title":"Medicine (Baltimore)"},{"key":"3297_CR14","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.jpeds.2010.11.033","volume":"158","author":"I Kobayashi","year":"2011","unstructured":"Kobayashi I, Okura Y, Yamada M, Kawamura N, Kuwana M, Ariga T: Anti-melanoma differentiation-associated gene 5 antibody is a diagnostic and predictive marker for interstitial lung diseases associated with juvenile dermatomyositis. J Pediatr. 2011, 158: 675-677. 10.1016\/j.jpeds.2010.11.033.","journal-title":"J Pediatr"},{"key":"3297_CR15","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1001\/archdermatol.2011.52","volume":"147","author":"Y Hamaguchi","year":"2011","unstructured":"Hamaguchi Y, Kuwana M, Hoshino K, Hasegawa M, Kaji K, Matsushita T, Komura K, Nakamura M, Kodera M, Suga N, Higashi A, Ogusu K, Tsutsui K, Furusaki A, Tanabe H, Sasaoka S, Muro Y, Yoshikawa M, Ishiguro N, Ayano M, Muroi E, Fujikawa K, Umeda Y, Kawase M, Mabuchi E, Asano Y, Sodemoto K, Seishima M, Yamada H, Sato S, Takehara K, Fujimoto M: Clinical correlations with dermatomyositis-specific autoantibodies in adult Japanese patients with dermatomyositis: a multicenter cross-sectional study. Arch Dermatol. 2011, 147: 391-398. 10.1001\/archdermatol.2011.52.","journal-title":"Arch Dermatol"},{"key":"3297_CR16","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1002\/art.1780291109","volume":"29","author":"ML Christensen","year":"1986","unstructured":"Christensen ML, Pachman LM, Schneiderman R, Patel DC, Friedman JM: Prevalence of Coxsackie B virus antibodies in patients with juvenile dermatomyositis. Arthritis Rheum. 1986, 29: 1365-1370. 10.1002\/art.1780291109.","journal-title":"Arthritis Rheum"},{"key":"3297_CR17","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1111\/j.1348-0421.1995.tb02245.x","volume":"39","author":"N Tani","year":"1995","unstructured":"Tani N, Dohi Y, Kurumatani N, Yonemasu K: Seasonal distribution of adenoviruses, enteroviruses and reoviruses in urban river water. Microbiol Immunol. 1995, 39: 577-580.","journal-title":"Microbiol Immunol"},{"key":"3297_CR18","doi-asserted-by":"publisher","first-page":"A330","DOI":"10.1016\/j.autrev.2009.11.006","volume":"9","author":"S Prieto","year":"2010","unstructured":"Prieto S, Grau JM: The geoepidemiology of autoimmune muscle disease. Autoimmun Rev. 2010, 9: A330-A334. 10.1016\/j.autrev.2009.11.006.","journal-title":"Autoimmun Rev"}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/ar3547.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/ar3547\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/ar3547.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T10:25:30Z","timestamp":1728383130000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/ar3547"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,22]]},"references-count":18,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2011,12]]}},"alternative-id":["3297"],"URL":"https:\/\/doi.org\/10.1186\/ar3547","relation":{},"ISSN":["1478-6354"],"issn-type":[{"value":"1478-6354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,22]]},"assertion":[{"value":"23 August 2011","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 November 2011","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 December 2011","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 December 2011","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"R214"}}