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However, they are associated with two different vasculitides (\n                      <jats:italic>HLA-B*51<\/jats:italic>\n                      in Beh\u00e7et's disease and\n                      <jats:italic>HLA-B*52<\/jats:italic>\n                      in Takayasu's arteritis (TAK)) and with major clinical and immunological differences. In this study, we aimed to screen a large cohort of TAK patients from Turkey for the presence of\n                      <jats:italic>HLA-B*51<\/jats:italic>\n                      and\n                      <jats:italic>HLA-B*52<\/jats:italic>\n                      as susceptibility and severity factors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      TAK patients (\n                      <jats:italic>n<\/jats:italic>\n                      = 330) followed at a total of 15 centers were included in the study. The mean age of the patients was 37.8 years, and 86% were women. DNA samples from the patients and healthy controls (HC;\n                      <jats:italic>n<\/jats:italic>\n                      = 210) were isolated, and the presence of\n                      <jats:italic>HLA-B*51<\/jats:italic>\n                      or\n                      <jats:italic>HLA-B*52<\/jats:italic>\n                      was screened for by using PCR with sequence-specific primers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We found a significant association of\n                      <jats:italic>HLA-B*52<\/jats:italic>\n                      with TAK (20.9% vs HC = 6.7%,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.000, OR = 3.7, 95% CI = 2.02 to 6.77). The distribution of\n                      <jats:italic>HLA-B*51<\/jats:italic>\n                      did not differ between TAK patients and HCs (22.7% vs 24.8%, OR = 0.9, 95% CI = 0.60 to 1.34). The presence of\n                      <jats:italic>HLA-B*52<\/jats:italic>\n                      decreased in late-onset patients (&gt; 40 years of age; 12.0%,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.024, OR = 0.43, 95% CI = 0.20 to 0.91). Patients with angiographic type I disease with limited aortic involvement also had a lower presence of\n                      <jats:italic>HLA-B*52<\/jats:italic>\n                      compared to those with all other disease subtypes (13.1% vs 26%,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.005, OR = 0.43, 95% CI = 0.23 to 0.78).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      In this study, the previously reported association of TAK with\n                      <jats:italic>HLA-B*52<\/jats:italic>\n                      in other populations was confirmed in patients from Turkey. The functional relevance of\n                      <jats:italic>HLA-B*52<\/jats:italic>\n                      in TAK pathogenesis needs to be explored further.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/ar3730","type":"journal-article","created":{"date-parts":[[2013,9,9]],"date-time":"2013-09-09T12:24:48Z","timestamp":1378729488000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Takayasu's arteritis is associated with HLA-B*52, but not with HLA-B*51, in Turkey"],"prefix":"10.1186","volume":"14","author":[{"given":"Ziver","family":"Sahin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muge","family":"B\u0131cakc\u0131gil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenan","family":"Aksu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevil","family":"Kamali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Servet","family":"Akar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatos","family":"Onen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omer","family":"Karadag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynep","family":"Ozbalkan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Askin","family":"Ates","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huseyin TE","family":"Ozer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vuslat","family":"Yilmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emire","family":"Seyahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet A","family":"Ozturk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayse","family":"Cefle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veli","family":"Cobankara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A Mesut","family":"Onat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ercan","family":"Tunc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nursen","family":"D\u00fczg\u00fcn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibel Z","family":"Aydin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neslihan","family":"Yilmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130zzet","family":"Fresko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasar","family":"Karaaslan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sedat","family":"Kiraz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurullah","family":"Akkoc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Inanc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gokhan","family":"Keser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F Aytul","family":"Uyar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haner","family":"Direskeneli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcher","family":"Saruhan-Direskeneli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Turkish Takayasu Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,2,6]]},"reference":[{"key":"3462_CR1","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1038\/nrrheum.2010.82","volume":"6","author":"JC Mason","year":"2010","unstructured":"Mason JC: Takayasu arteritis: advances in diagnosis and management. 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