{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:06:01Z","timestamp":1791248761451,"version":"4.1.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2012,4,27]],"date-time":"2012-04-27T00:00:00Z","timestamp":1335484800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2012,4,27]],"date-time":"2012-04-27T00:00:00Z","timestamp":1335484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Introduction<\/jats:title>\n                        <jats:p>Two major gout-causing genes have been identified, the urate transport genes <jats:italic>SLC2A9<\/jats:italic> and <jats:italic>ABCG2<\/jats:italic>. Variation within the <jats:italic>SLC17A1<\/jats:italic> locus, which encodes sodium-dependent phosphate transporter 1, a renal transporter of uric acid, has also been associated with serum urate concentration. However, evidence for association with gout is equivocal. We investigated the association of the <jats:italic>SLC17A1<\/jats:italic> locus with gout in New Zealand sample sets.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Methods<\/jats:title>\n                        <jats:p>Five variants (<jats:italic>rs1165196, rs1183201, rs9358890, rs3799344, rs12664474<\/jats:italic>) were genotyped across a New Zealand sample set totaling 971 cases and 1,742 controls. Cases were ascertained according to American Rheumatism Association criteria. Two population groups were studied: Caucasian and Polynesian.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>At <jats:italic>rs1183201<\/jats:italic> (<jats:italic>SLC17A1<\/jats:italic>), evidence for association with gout was observed in both the Caucasian (odds ratio (OR) = 0.67, <jats:italic>P<\/jats:italic> = 3.0 \u00d7 10<jats:sup>-6<\/jats:sup>) and Polynesian (OR = 0.74, <jats:italic>P<\/jats:italic> = 3.0 \u00d7 10<jats:sup>-3<\/jats:sup>) groups. Meta-analysis confirmed association of <jats:italic>rs1183201<\/jats:italic> with gout at a genome-wide level of significance (OR = 0.70, <jats:italic>P<\/jats:italic> = 3.0 \u00d7 10<jats:sup>-8<\/jats:sup>). Haplotype analysis suggested the presence of a common protective haplotype.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusion<\/jats:title>\n                        <jats:p>We confirm the <jats:italic>SLC17A1<\/jats:italic> locus as the third associated with gout at a genome-wide level of significance.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/ar3816","type":"journal-article","created":{"date-parts":[[2012,4,27]],"date-time":"2012-04-27T14:14:44Z","timestamp":1335536084000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["The renal urate transporter SLC17A1 locus: confirmation of association with gout"],"prefix":"10.1186","volume":"14","author":[{"given":"Jade E","family":"Hollis-Moffatt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda J","family":"Phipps-Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett","family":"Chapman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory T","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"van Rij","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J","family":"Gow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew A","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Highton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter B","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant W","family":"Montgomery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa K","family":"Stamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Dalbeth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony R","family":"Merriman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,4,27]]},"reference":[{"key":"3567_CR1","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1093\/rheumatology\/33.10.932","volume":"33","author":"HA Simmonds","year":"1994","unstructured":"Simmonds HA, McBride MB, Hatfield PJ, Graham R, McCaskey J, Jackson M: Polynesian women are also at risk for hyperuricaemia and gout because of a genetic defect in renal urate handling. 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