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The spin trap compound phenyl-N-<jats:italic>tert<\/jats:italic>-butyl nitrone (PBN) has been shown to have both anti-inflammatory and antioxidant effects. The aim of this study was to assess the effect of combined systemic administration of PBN and cloxacillin on the development of<jats:italic>Staphylococcus aureus<\/jats:italic>arthritis.<\/jats:p><jats:p>Three days after Naval Medical Research Institute (NMRI) mice were infected intravenously with<jats:italic>S. aureus<\/jats:italic>LS-1, daily treatment was started with cloxacillin alone, PBN alone, or cloxacillin and PBN. Arthritis, weight loss and general condition were evaluated for each mouse, and joints were analyzed histopathologically. Systemic administration of PBN in conjunction with cloxacillin ameliorated the course of experimental<jats:italic>S. aureus<\/jats:italic>arthritis, as evidenced by an increased cure rate. 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