{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:24:42Z","timestamp":1792448682938,"version":"4.5.0"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2012,11,8]],"date-time":"2012-11-08T00:00:00Z","timestamp":1352332800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2012,11,8]],"date-time":"2012-11-08T00:00:00Z","timestamp":1352332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Introduction<\/jats:title>\n                        <jats:p>Systemic lupus erythematosus is a chronic autoimmune disease characterized by an abundance of autoantibodies against nuclear antigens. Bruton's tyrosine kinase (Btk) is a proximal transducer of the BCR signal that allows for B-cell activation and differentiation. Recently, selective inhibition of Btk by PCI-32765 has shown promise in limiting activity of multiple cells types in various models of cancer and autoimmunity. The aim of this study was to determine the effect of Btk inhibition by PCI-32765 on the development of lupus in lupus-prone B6.Sle1 and B6.Sle1.Sle3 mice.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Methods<\/jats:title>\n                        <jats:p>B6.Sle1 or B6.Sle1.Sle3 mice received drinking water containing either the Btk inhibitor PCI-32765 or vehicle for 56 days. Following treatment, mice were examined for clinical and pathological characteristics of lupus. The effect of PCI-32765 on specific cell types was also investigated.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>In this study, we report that Btk inhibition dampens humoral autoimmunity in B6.Sle1 monocongenic mice. Moreover, in B6.Sle1.Sle3 bicongenic mice that are prone to severe lupus, Btk inhibition also dampens humoral and cellular autoimmunity, as well as lupus nephritis.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusions<\/jats:title>\n                        <jats:p>These findings suggest that partial crippling of cell signaling in B cells and antigen presenting cells (APCs) may be a viable alternative to total depletion of these cells as a therapeutic modality for lupus.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/ar4086","type":"journal-article","created":{"date-parts":[[2012,11,8]],"date-time":"2012-11-08T17:14:08Z","timestamp":1352394848000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":87,"title":["Modulating proximal cell signaling by targeting Btk ameliorates humoral autoimmunity and end-organ disease in murine lupus"],"prefix":"10.1186","volume":"14","author":[{"given":"Jack","family":"Hutcheson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamala","family":"Vanarsa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Bashmakov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simer","family":"Grewal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deena","family":"Sajitharan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betty Y","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph J","family":"Buggy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin J","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne B","family":"Satterthwaite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandra","family":"Mohan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,11,8]]},"reference":[{"key":"3828_CR1","doi-asserted-by":"publisher","first-page":"40261","DOI":"10.1074\/jbc.M506063200","volume":"280","author":"S Iwaki","year":"2005","unstructured":"Iwaki S, Tkaczyk C, Satterthwaite AB, Halcomb K, Beaven MA, Metcalfe DD, Gilfillan AM: Btk plays a crucial role in the amplification of Fc epsilonRI-mediated mast cell activation by kit. J Biol Chem. 2005, 280: 40261-40270. 10.1074\/jbc.M506063200.","journal-title":"J Biol Chem"},{"key":"3828_CR2","doi-asserted-by":"publisher","first-page":"3118","DOI":"10.1182\/blood-2009-11-254185","volume":"115","author":"H Mueller","year":"2010","unstructured":"Mueller H, Stadtmann A, Van Aken H, Hirsch E, Wang D, Ley K, Zarbock A: Tyrosine kinase Btk regulates E-selectin-mediated integrin activation and neutrophil recruitment by controlling phospholipase C (PLC) gamma2 and PI3Kgamma pathways. Blood. 2010, 115: 3118-3127. 10.1182\/blood-2009-11-254185.","journal-title":"Blood"},{"key":"3828_CR3","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1182\/blood-2010-04-281170","volume":"117","author":"K Fiedler","year":"2011","unstructured":"Fiedler K, Sindrilaru A, Terszowski G, Kokai E, Feyerabend TB, Bullinger L, Rodewald HR, Brunner C: Neutrophil development and function critically depend on Bruton tyrosine kinase in a mouse model of X-linked agammaglobulinemia. Blood. 2011, 117: 1329-1339. 10.1182\/blood-2010-04-281170.","journal-title":"Blood"},{"key":"3828_CR4","doi-asserted-by":"publisher","first-page":"8048","DOI":"10.4049\/jimmunol.180.12.8048","volume":"180","author":"M Melcher","year":"2008","unstructured":"Melcher M, Unger B, Schmidt U, Rajantie IA, Alitalo K, Ellmeier W: Essential roles for the Tec family kinases Tec and Btk in M-CSF receptor signaling pathways that regulate macrophage survival. J Immunol. 2008, 180: 8048-8056.","journal-title":"J Immunol"},{"key":"3828_CR5","doi-asserted-by":"publisher","first-page":"817","DOI":"10.4049\/jimmunol.1003631","volume":"187","author":"V Vijayan","year":"2011","unstructured":"Vijayan V, Baumgart-Vogt E, Naidu S, Qian G, Immenschuh S: Bruton's tyrosine kinase is required for TLR-dependent heme oxygenase-1 gene activation via Nrf2 in macrophages. J Immunol. 2011, 187: 817-827. 10.4049\/jimmunol.1003631.","journal-title":"J Immunol"},{"key":"3828_CR6","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1002\/art.27233","volume":"62","author":"JT Merrill","year":"2010","unstructured":"Merrill JT, Neuwelt CM, Wallace DJ, Shanahan JC, Latinis KM, Oates JC, Utset TO, Gordon C, Isenberg DA, Hsieh HJ, Zhang D, Brunetta PG: Efficacy and safety of rituximab in moderately-to-severely active systemic lupus erythematosus: the randomized, double-blind, phase II\/III systemic lupus erythematosus evaluation of rituximab trial. Arthritis Rheum. 2010, 62: 222-233. 10.1002\/art.27233.","journal-title":"Arthritis Rheum"},{"key":"3828_CR7","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1084\/jem.191.10.1745","volume":"191","author":"JB Petro","year":"2000","unstructured":"Petro JB, Rahman SM, Ballard DW, Khan WN: Bruton's tyrosine kinase is required for activation of IkappaB kinase and nuclear factor kappaB in response to B cell receptor engagement. J Exp Med. 2000, 191: 1745-1754. 10.1084\/jem.191.10.1745.","journal-title":"J Exp Med"},{"key":"3828_CR8","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.1084\/jem.191.10.1735","volume":"191","author":"UD Bajpai","year":"2000","unstructured":"Bajpai UD, Zhang K, Teutsch M, Sen R, Wortis HH: Bruton's tyrosine kinase links the B cell receptor to nuclear factor kappaB activation. J Exp Med. 2000, 191: 1735-1744. 10.1084\/jem.191.10.1735.","journal-title":"J Exp Med"},{"key":"3828_CR9","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1111\/j.1600-065X.2008.00741.x","volume":"228","author":"AJ Mohamed","year":"2009","unstructured":"Mohamed AJ, Yu L, Backesjo CM, Vargas L, Faryal R, Aints A, Christensson B, Berglof A, Vihinen M, Nore BF, Smith CI: Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain. Immunol Rev. 2009, 228: 58-73. 10.1111\/j.1600-065X.2008.00741.x.","journal-title":"Immunol Rev"},{"key":"3828_CR10","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/0008-8749(87)90284-X","volume":"107","author":"MF Seldin","year":"1987","unstructured":"Seldin MF, Reeves JP, Scribner CL, Roths JB, Davidson WF, Morse HC, Steinberg AD: Effect of xid on autoimmune C3H-gld\/gld mice. Cell Immunol. 1987, 107: 249-255. 10.1016\/0008-8749(87)90284-X.","journal-title":"Cell Immunol"},{"key":"3828_CR11","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1172\/JCI110651","volume":"70","author":"BJ Steinberg","year":"1982","unstructured":"Steinberg BJ, Smathers PA, Frederiksen K, Steinberg AD: Ability of the xid gene to prevent autoimmunity in (NZB \u00d7 NZW)F1 mice during the course of their natural history, after polyclonal stimulation, or following immunization with DNA. J Clin Invest. 1982, 70: 587-597. 10.1172\/JCI110651.","journal-title":"J Clin Invest"},{"key":"3828_CR12","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1084\/jem.188.5.833","volume":"188","author":"AB Satterthwaite","year":"1998","unstructured":"Satterthwaite AB, Lowell CA, Khan WN, Sideras P, Alt FW, Witte ON: Independent and opposing roles for Btk and lyn in B and myeloid signaling pathways. J Exp Med. 1998, 188: 833-844. 10.1084\/jem.188.5.833.","journal-title":"J Exp Med"},{"key":"3828_CR13","doi-asserted-by":"publisher","first-page":"2643","DOI":"10.1002\/eji.201040521","volume":"40","author":"R Kersseboom","year":"2010","unstructured":"Kersseboom R, Kil L, Flierman R, van der Zee M, Dingjan GM, Middendorp S, Maas A, Hendriks RW: Constitutive activation of Bruton's tyrosine kinase induces the formation of autoreactive IgM plasma cells. Eur J Immunol. 2010, 40: 2643-2654. 10.1002\/eji.201040521.","journal-title":"Eur J Immunol"},{"key":"3828_CR14","doi-asserted-by":"publisher","first-page":"3744","DOI":"10.1182\/blood-2011-12-397919","volume":"119","author":"LP Kil","year":"2012","unstructured":"Kil LP, de Bruijn MJ, van Nimwegen M, Corneth OB, van Hamburg JP, Dingjan GM, Thaiss F, Rimmelzwaan GF, Elewaut D, Delsing D, van Loo PF, Hendriks RW: Btk levels set the threshold for B cell activation and negative selection of autoreactive B cells in mice. Blood. 2012, 119: 3744-3756. 10.1182\/blood-2011-12-397919.","journal-title":"Blood"},{"key":"3828_CR15","doi-asserted-by":"publisher","first-page":"1850","DOI":"10.4049\/jimmunol.171.4.1850","volume":"171","author":"LR Whyburn","year":"2003","unstructured":"Whyburn LR, Halcomb KE, Contreras CM, Lowell CA, Witte ON, Satterthwaite AB: Reduced dosage of Bruton's tyrosine kinase uncouples B cell hyperresponsiveness from autoimmunity in lyn-\/- mice. J Immunol. 2003, 171: 1850-1858.","journal-title":"J Immunol"},{"key":"3828_CR16","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1111\/j.1365-2249.1993.tb08218.x","volume":"94","author":"L Jansson","year":"1993","unstructured":"Jansson L, Holmdahl R: Genes on the X chromosome affect development of collagen-induced arthritis in mice. Clin Exp Immunol. 1993, 94: 459-465.","journal-title":"Clin Exp Immunol"},{"key":"3828_CR17","doi-asserted-by":"publisher","first-page":"13075","DOI":"10.1073\/pnas.1004594107","volume":"107","author":"LA Honigberg","year":"2010","unstructured":"Honigberg LA, Smith AM, Sirisawad M, Verner E, Loury D, Chang B, Li S, Pan Z, Thamm DH, Miller RA, Buggy JJ: The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci USA. 2010, 107: 13075-13080. 10.1073\/pnas.1004594107.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3828_CR18","doi-asserted-by":"crossref","unstructured":"Di Paolo JA, Huang T, Balazs M, Barbosa J, Barck KH, Bravo BJ, Carano RA, Darrow J, Davies DR, DeForge LE, Diehl L, Ferrando R, Gallion SL, Giannetti AM, Gribling P, Hurez V, Hymowitz SG, Jones R, Kropf JE, Lee WP, Maciejewski PM, Mitchell SA, Rong H, Staker BL, Whitney JA, Yeh S, Young WB, Yu C, Zhang J, Reif K, et al: Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis. Nat Chem Biol. 7: 41-50.","DOI":"10.1038\/nchembio.481"},{"key":"3828_CR19","doi-asserted-by":"publisher","first-page":"6287","DOI":"10.1182\/blood-2011-01-328484","volume":"117","author":"SE Herman","year":"2011","unstructured":"Herman SE, Gordon AL, Hertlein E, Ramanunni A, Zhang X, Jaglowski S, Flynn J, Jones J, Blum KA, Buggy JJ, Hamdy A, Johnson AJ, Byrd JC: Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765. Blood. 2011, 117: 6287-6296. 10.1182\/blood-2011-01-328484.","journal-title":"Blood"},{"key":"3828_CR20","doi-asserted-by":"publisher","first-page":"R115","DOI":"10.1186\/ar3400","volume":"13","author":"BY Chang","year":"2011","unstructured":"Chang BY, Huang MM, Francesco M, Chen J, Sokolove J, Magadala P, Robinson WH, Buggy JJ: The Bruton tyrosine kinase inhibitor PCI-32765 ameliorates autoimmune arthritis by inhibition of multiple effector cells. Arthritis Res Ther. 2011, 13: R115-10.1186\/ar3400.","journal-title":"Arthritis Res Ther"},{"key":"3828_CR21","first-page":"419","volume":"68","author":"UH Rudofsky","year":"1993","unstructured":"Rudofsky UH, Evans BD, Balaban SL, Mottironi VD, Gabrielsen AE: Differences in expression of lupus nephritis in New Zealand mixed H-2z homozygous inbred strains of mice derived from New Zealand black and New Zealand white mice. Origins and initial characterization. Lab Invest. 1993, 68: 419-426.","journal-title":"Lab Invest"},{"key":"3828_CR22","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/1074-7613(94)90100-7","volume":"1","author":"L Morel","year":"1994","unstructured":"Morel L, Rudofsky UH, Longmate JA, Schiffenbauer J, Wakeland EK: Polygenic control of susceptibility to murine systemic lupus erythematosus. Immunity. 1994, 1: 219-229. 10.1016\/1074-7613(94)90100-7.","journal-title":"Immunity"},{"key":"3828_CR23","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1172\/JCI728","volume":"101","author":"C Mohan","year":"1998","unstructured":"Mohan C, Alas E, Morel L, Yang P, Wakeland EK: Genetic dissection of SLE pathogenesis. Sle1 on murine chromosome 1 leads to a selective loss of tolerance to H2A\/H2B\/DNA subnucleosomes. J Clin Invest. 1998, 101: 1362-1372.","journal-title":"J Clin Invest"},{"key":"3828_CR24","doi-asserted-by":"publisher","first-page":"2694","DOI":"10.4049\/jimmunol.169.5.2694","volume":"169","author":"ES Sobel","year":"2002","unstructured":"Sobel ES, Satoh M, Chen Y, Wakeland EK, Morel L: The major murine systemic lupus erythematosus susceptibility locus Sle1 results in abnormal functions of both B and T cells. J Immunol. 2002, 169: 2694-2700.","journal-title":"J Immunol"},{"key":"3828_CR25","doi-asserted-by":"crossref","first-page":"6492","DOI":"10.4049\/jimmunol.162.11.6492","volume":"162","author":"C Mohan","year":"1999","unstructured":"Mohan C, Yu Y, Morel L, Yang P, Wakeland EK: Genetic dissection of Sle pathogenesis: Sle3 on murine chromosome 7 impacts T cell activation, differentiation, and cell death. J Immunol. 1999, 162: 6492-6502.","journal-title":"J Immunol"},{"key":"3828_CR26","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.1172\/JCI23049","volume":"115","author":"J Zhu","year":"2005","unstructured":"Zhu J, Liu X, Xie C, Yan M, Yu Y, Sobel ES, Wakeland EK, Mohan C: T cell hyperactivity in lupus as a consequence of hyperstimulatory antigen-presenting cells. J Clin Invest. 2005, 115: 1869-1878. 10.1172\/JCI23049.","journal-title":"J Clin Invest"},{"key":"3828_CR27","doi-asserted-by":"publisher","first-page":"3233","DOI":"10.4049\/jimmunol.176.5.3233","volume":"176","author":"B Mehrad","year":"2006","unstructured":"Mehrad B, Park SJ, Akangire G, Standiford TJ, Wu T, Zhu J, Mohan C: The lupus-susceptibility locus, Sle3, mediates enhanced resistance to bacterial infections. J Immunol. 2006, 176: 3233-3239.","journal-title":"J Immunol"},{"key":"3828_CR28","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1172\/JCI5827","volume":"103","author":"C Mohan","year":"1999","unstructured":"Mohan C, Morel L, Yang P, Watanabe H, Croker B, Gilkeson G, Wakeland EK: Genetic dissection of lupus pathogenesis: a recipe for nephrophilic autoantibodies. J Clin Invest. 1999, 103: 1685-1695. 10.1172\/JCI5827.","journal-title":"J Clin Invest"},{"key":"3828_CR29","volume-title":"53rd Annual Meeting of the American Society of Hematology: December 13, 2011","author":"S O'Brien","year":"2011","unstructured":"O'Brien S, Burger JA, Blum KA, Furman RR, Coutre SE, Sharman J, Flinn IW, Grant B, Heerema NA, Johnson AJ, Navarro T, Holmgren E, Hedrick E, Byrd JC: The Bruton's tyrosine kinase (BTK) inhibitor PCI-32765 induces durable responses in relapsed or refractory (R\/R) chronic lymphocytic leukemia\/small lymphocytic lymphoma (CLL\/SLL): Follow-up of a phase Ib\/II study. 53rd Annual Meeting of the American Society of Hematology: December 13, 2011. 2011, Blood (ASH Annual Meeting Abstracts)"},{"key":"3828_CR30","volume-title":"53rd Annual Meeting of the American Society of Hematology: 2011","author":"L Wang","year":"2011","unstructured":"Wang L, Martin P, Blum KA, Kahl BS, Maeda LS, Advani R, Williams ME, Rule S, Rodriguez S, Pang C-F, Hedrick E, Goy A: The Bruton's Tyrosine Kinase Inhibitor PCI-32765 Is Highly Active As Single-Agent Therapy in Previously-Treated Mantle Cell Lymphoma (MCL): Preliminary Results of a Phase II Trial [abstract]. 53rd Annual Meeting of the American Society of Hematology: 2011. 2011, Blood (ASH Annual Meeting Abstracts)"},{"key":"3828_CR31","doi-asserted-by":"publisher","first-page":"2186","DOI":"10.1172\/JCI30398","volume":"117","author":"T Wu","year":"2007","unstructured":"Wu T, Qin X, Kurepa Z, Kumar KR, Liu K, Kanta H, Zhou XJ, Satterthwaite AB, Davis LS, Mohan C: Shared signaling networks active in B cells isolated from genetically distinct mouse models of lupus. J Clin Invest. 2007, 117: 2186-2196. 10.1172\/JCI30398.","journal-title":"J Clin Invest"},{"key":"3828_CR32","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.molimm.2008.08.278","volume":"46","author":"KE Halcomb","year":"2008","unstructured":"Halcomb KE, Musuka S, Gutierrez T, Wright HL, Satterthwaite AB: Btk regulates localization, in vivo activation, and class switching of anti-DNA B cells. Mol Immunol. 2008, 46: 233-241. 10.1016\/j.molimm.2008.08.278.","journal-title":"Mol Immunol"},{"key":"3828_CR33","doi-asserted-by":"publisher","first-page":"6670","DOI":"10.1073\/pnas.97.12.6670","volume":"97","author":"L Morel","year":"2000","unstructured":"Morel L, Croker BP, Blenman KR, Mohan C, Huang G, Gilkeson G, Wakeland EK: Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains. Proc Natl Acad Sci USA. 2000, 97: 6670-6675. 10.1073\/pnas.97.12.6670.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3828_CR34","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1111\/j.1749-6632.2011.06263.x","volume":"1247","author":"MS Lo","year":"2012","unstructured":"Lo MS, Tsokos GC: Treatment of systemic lupus erythematosus: new advances in targeted therapy. Ann NY Acad Sci. 2012, 1247: 138-152. 10.1111\/j.1749-6632.2011.06263.x.","journal-title":"Ann NY Acad Sci"},{"key":"3828_CR35","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1097\/BOR.0b013e328349a242","volume":"23","author":"VC Kyttaris","year":"2011","unstructured":"Kyttaris VC, Tsokos GC: Targeting lymphocyte signaling pathways as a therapeutic approach to systemic lupus erythematosus. Curr Opin Rheumatol. 2011, 23: 449-453. 10.1097\/BOR.0b013e328349a242.","journal-title":"Curr Opin Rheumatol"},{"key":"3828_CR36","doi-asserted-by":"publisher","first-page":"2086","DOI":"10.1002\/art.27534","volume":"62","author":"GM Deng","year":"2010","unstructured":"Deng GM, Liu L, Bahjat FR, Pine PR, Tsokos GC: Suppression of skin and kidney disease by inhibition of spleen tyrosine kinase in lupus-prone mice. Arthritis Rheum. 2010, 62: 2086-2092.","journal-title":"Arthritis Rheum"},{"key":"3828_CR37","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/306270a0","volume":"306","author":"RR Hardy","year":"1983","unstructured":"Hardy RR, Hayakawa K, Parks DR, Herzenberg LA: Demonstration of B-cell maturation in X-linked immunodeficient mice by simultaneous three-colour immunofluorescence. Nature. 1983, 306: 270-272. 10.1038\/306270a0.","journal-title":"Nature"},{"key":"3828_CR38","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/1074-7613(95)90115-9","volume":"3","author":"JD Kerner","year":"1995","unstructured":"Kerner JD, Appleby MW, Mohr RN, Chien S, Rawlings DJ, Maliszewski CR, Witte ON, Perlmutter RM: Impaired expansion of mouse B cell progenitors lacking Btk. Immunity. 1995, 3: 301-312. 10.1016\/1074-7613(95)90115-9.","journal-title":"Immunity"},{"key":"3828_CR39","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1084\/jem.147.3.814","volume":"147","author":"DG Sieckmann","year":"1978","unstructured":"Sieckmann DG, Asofsky R, Mosier DE, Zitron IM, Paul WE: Activation of mouse lymphocytes by anti-immunoglobulin. I. Parameters of the proliferative response. J Exp Med. 1978, 147: 814-829. 10.1084\/jem.147.3.814.","journal-title":"J Exp Med"},{"key":"3828_CR40","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1084\/jem.172.6.1625","volume":"172","author":"NF Go","year":"1990","unstructured":"Go NF, Castle BE, Barrett R, Kastelein R, Dang W, Mosmann TR, Moore KW, Howard M: Interleukin 10, a novel B cell stimulatory factor: unresponsiveness of X chromosome-linked immunodeficiency B cells. J Exp Med. 1990, 172: 1625-1631. 10.1084\/jem.172.6.1625.","journal-title":"J Exp Med"},{"key":"3828_CR41","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1084\/jem.180.4.1217","volume":"180","author":"K Miyake","year":"1994","unstructured":"Miyake K, Yamashita Y, Hitoshi Y, Takatsu K, Kimoto M: Murine B cell proliferation and protection from apoptosis with an antibody against a 105-kD molecule: unresponsiveness of X-linked immunodeficient B cells. J Exp Med. 1994, 180: 1217-1224. 10.1084\/jem.180.4.1217.","journal-title":"J Exp Med"},{"key":"3828_CR42","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1093\/intimm\/7.2.163","volume":"7","author":"L Santos-Argumedo","year":"1995","unstructured":"Santos-Argumedo L, Lund FE, Heath AW, Solvason N, Wu WW, Grimaldi JC, Parkhouse RM, Howard M: CD38 unresponsiveness of xid B cells implicates Bruton's tyrosine kinase (btk) as a regular of CD38 induced signal transduction. Int Immunol. 1995, 7: 163-170. 10.1093\/intimm\/7.2.163.","journal-title":"Int Immunol"},{"key":"3828_CR43","doi-asserted-by":"publisher","first-page":"26258","DOI":"10.1074\/jbc.M301484200","volume":"278","author":"CA Jefferies","year":"2003","unstructured":"Jefferies CA, Doyle S, Brunner C, Dunne A, Brint E, Wietek C, Walch E, Wirth T, O'Neill LA: Bruton's tyrosine kinase is a Toll\/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4. J Biol Chem. 2003, 278: 26258-26264. 10.1074\/jbc.M301484200.","journal-title":"J Biol Chem"},{"key":"3828_CR44","doi-asserted-by":"publisher","first-page":"13152","DOI":"10.1073\/pnas.94.24.13152","volume":"94","author":"AB Satterthwaite","year":"1997","unstructured":"Satterthwaite AB, Cheroutre H, Khan WN, Sideras P, Witte ON: Btk dosage determines sensitivity to B cell antigen receptor cross-linking. Proc Natl Acad Sci USA. 1997, 94: 13152-13157. 10.1073\/pnas.94.24.13152.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3828_CR45","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/annonc\/mdr211","volume":"22","author":"RH Advani","year":"2011","unstructured":"Advani RH, Sharman JP, Smith SM, Boyd TE, Grant BW, Kolibaba KS, Furman RR, Buggy JJ, Loury DJ, Hedrick E, Izumi R, Hamdy AM, Fowler NH: The Btk Inhibitor Pci-32765 Is Highly Active and Well Tolerated in Patients (Pts) with Relapsed\/Refractory B Cell Malignancies: Final Results from a Phase I Study. Annals of Oncology. 2011, 22: 135-135.","journal-title":"Annals of Oncology"},{"key":"3828_CR46","doi-asserted-by":"publisher","first-page":"5716","DOI":"10.4049\/jimmunol.0804215","volume":"183","author":"R Vuyyuru","year":"2009","unstructured":"Vuyyuru R, Mohan C, Manser T, Rahman ZS: The lupus susceptibility locus Sle1 breaches peripheral B cell tolerance at the antibody-forming cell and germinal center checkpoints. J Immunol. 2009, 183: 5716-5727. 10.4049\/jimmunol.0804215.","journal-title":"J Immunol"},{"key":"3828_CR47","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.1002\/eji.200940043","volume":"40","author":"T Gutierrez","year":"2010","unstructured":"Gutierrez T, Halcomb KE, Coughran AJ, Li QZ, Satterthwaite AB: Separate checkpoints regulate splenic plasma cell accumulation and IgG autoantibody production in Lyn-deficient mice. Eur J Immunol. 2010, 40: 1897-1905. 10.1002\/eji.200940043.","journal-title":"Eur J Immunol"},{"key":"3828_CR48","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1073\/pnas.0509784103","volume":"103","author":"Y Kawakami","year":"2006","unstructured":"Kawakami Y, Inagaki N, Salek-Ardakani S, Kitaura J, Tanaka H, Nagao K, Xiao W, Nagai H, Croft M, Kawakami T: Regulation of dendritic cell maturation and function by Bruton's tyrosine kinase via IL-10 and Stat3. Proc Natl Acad Sci USA. 2006, 103: 153-158. 10.1073\/pnas.0509784103.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3828_CR49","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1084\/jem.187.8.1235","volume":"187","author":"D Hata","year":"1998","unstructured":"Hata D, Kawakami Y, Inagaki N, Lantz CS, Kitamura T, Khan WN, Maeda-Yamamoto M, Miura T, Han W, Hartman SE, Yao L, Nagai H, Goldfeld AE, Alt FW, Galli SJ, Witte ON, Kawakami T: Involvement of Bruton's tyrosine kinase in FcepsilonRI-dependent mast cell degranulation and cytokine production. J Exp Med. 1998, 187: 1235-1247. 10.1084\/jem.187.8.1235.","journal-title":"J Exp Med"},{"key":"3828_CR50","doi-asserted-by":"publisher","first-page":"457","DOI":"10.2353\/ajpath.2007.060554","volume":"170","author":"F Heller","year":"2007","unstructured":"Heller F, Lindenmeyer MT, Cohen CD, Brandt U, Draganovici D, Fischereder M, Kretzler M, Anders HJ, Sitter T, Mosberger I, Kerjaschki D, Regele H, Schlondorff D, Segerer S: The contribution of B cells to renal interstitial inflammation. Am J Pathol. 2007, 170: 457-468. 10.2353\/ajpath.2007.060554.","journal-title":"Am J Pathol"},{"key":"3828_CR51","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1038\/sj.ki.5002734","volume":"73","author":"S Segerer","year":"2008","unstructured":"Segerer S, Schlondorff D: B cells and tertiary lymphoid organs in renal inflammation. Kidney Int. 2008, 73: 533-537. 10.1038\/sj.ki.5002734.","journal-title":"Kidney Int"},{"key":"3828_CR52","doi-asserted-by":"publisher","first-page":"4393","DOI":"10.4049\/jimmunol.0903239","volume":"185","author":"B Renner","year":"2010","unstructured":"Renner B, Strassheim D, Amura CR, Kulik L, Ljubanovic D, Glogowska MJ, Takahashi K, Carroll MC, Holers VM, Thurman JM: B cell subsets contribute to renal injury and renal protection after ischemia\/reperfusion. J Immunol. 2010, 185: 4393-4400. 10.4049\/jimmunol.0903239.","journal-title":"J Immunol"},{"key":"3828_CR53","doi-asserted-by":"publisher","first-page":"6687","DOI":"10.1073\/pnas.110146697","volume":"97","author":"AB Satterthwaite","year":"2000","unstructured":"Satterthwaite AB, Willis F, Kanchanastit P, Fruman D, Cantley LC, Helgason CD, Humphries RK, Lowell CA, Simon M, Leitges M, Tarakhovsky A, Tedder TF, Lesche R, Wu H, Witte ON: A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase. Proc Natl Acad Sci USA. 2000, 97: 6687-6692. 10.1073\/pnas.110146697.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3828_CR54","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1016\/j.immuni.2006.04.005","volume":"24","author":"Y Sasaki","year":"2006","unstructured":"Sasaki Y, Derudder E, Hobeika E, Pelanda R, Reth M, Rajewsky K, Schmidt-Supprian M: Canonical NF-kappaB activity, dispensable for B cell development, replaces BAFF-receptor signals and promotes B cell proliferation upon activation. Immunity. 2006, 24: 729-739. 10.1016\/j.immuni.2006.04.005.","journal-title":"Immunity"},{"key":"3828_CR55","doi-asserted-by":"publisher","first-page":"10966","DOI":"10.1073\/pnas.93.20.10966","volume":"93","author":"JS Anderson","year":"1996","unstructured":"Anderson JS, Teutsch M, Dong Z, Wortis HH: An essential role for Bruton's [corrected] tyrosine kinase in the regulation of B-cell apoptosis. Proc Natl Acad Sci USA. 1996, 93: 10966-10971. 10.1073\/pnas.93.20.10966.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3828_CR56","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1182\/blood-2004-01-0207","volume":"104","author":"A Mangla","year":"2004","unstructured":"Mangla A, Khare A, Vineeth V, Panday NN, Mukhopadhyay A, Ravindran B, Bal V, George A, Rath S: Pleiotropic consequences of Bruton tyrosine kinase deficiency in myeloid lineages lead to poor inflammatory responses. Blood. 2004, 104: 1191-1197. 10.1182\/blood-2004-01-0207.","journal-title":"Blood"},{"key":"3828_CR57","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1111\/j.1365-2141.2006.06468.x","volume":"136","author":"F Uckun","year":"2007","unstructured":"Uckun F, Ozer Z, Vassilev A: Bruton's tyrosine kinase prevents activation of the anti-apoptotic transcription factor STAT3 and promotes apoptosis in neoplastic B-cells and B-cell precursors exposed to oxidative stress. Br J Haematol. 2007, 136: 574-589. 10.1111\/j.1365-2141.2006.06468.x.","journal-title":"Br J Haematol"},{"key":"3828_CR58","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1038\/ni.2234","volume":"13","author":"F Honda","year":"2012","unstructured":"Honda F, Kano H, Kanegane H, Nonoyama S, Kim ES, Lee SK, Takagi M, Mizutani S, Morio T: The kinase Btk negatively regulates the production of reactive oxygen species and stimulation-induced apoptosis in human neutrophils. Nat Immunol. 2012, 13: 369-378. 10.1038\/ni.2234.","journal-title":"Nat Immunol"}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/ar4086.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/ar4086\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/ar4086.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T10:47:59Z","timestamp":1728384479000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/ar4086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,8]]},"references-count":58,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2012,12]]}},"alternative-id":["3828"],"URL":"https:\/\/doi.org\/10.1186\/ar4086","relation":{},"ISSN":["1478-6354"],"issn-type":[{"value":"1478-6354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,8]]},"assertion":[{"value":"1 June 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2012","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2012","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 November 2012","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"R243"}}