{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T05:50:14Z","timestamp":1793512214367,"version":"4.5.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2013,8,30]],"date-time":"2013-08-30T00:00:00Z","timestamp":1377820800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2013,8,30]],"date-time":"2013-08-30T00:00:00Z","timestamp":1377820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Introduction<\/jats:title>\n                        <jats:p>The attainment of remission has become an important end point for clinical trials in juvenile idiopathic arthritis (JIA), although we do not yet have a full understanding of what remission is at the cell and molecular level.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Methods<\/jats:title>\n                        <jats:p>Two independent cohorts of patients with JIA and healthy child controls were studied. RNA was prepared separately from peripheral blood mononuclear cells (PBMC) and granulocytes to identify differentially expressed genes using whole genome microarrays. Expression profiling results for selected genes were confirmed by quantitative, real-time polymerase chain reaction (RT-PCR).<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>We found that remission in JIA induced by either methotrexate (MTX) or MTX plus a TNF inhibitor (etanercept, Et) (MTX + Et) is characterized by numerous differences in gene expression in peripheral blood mononuclear cells and in granulocytes compared with healthy control children; that is, remission is not a restoration of immunologic normalcy. Network analysis of the differentially expressed genes demonstrated that the steroid hormone receptor superfamily member hepatocyte nuclear factor 4 alpha (HNF4\u03b1) is a hub in several of the gene networks that distinguished children with arthritis from controls. Confocal microscopy revealed that HNF4a is present in both T lymphocytes and granulocytes, suggesting a previously unsuspected role for this transcription factor in regulating leukocyte function and therapeutic response in JIA.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusions<\/jats:title>\n                        <jats:p>These findings provide a framework from which to understand therapeutic response in JIA and, furthermore, may be used to develop strategies to increase the frequency with which remission is achieved in adult forms of rheumatoid arthritis.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/ar4280","type":"journal-article","created":{"date-parts":[[2013,8,30]],"date-time":"2013-08-30T10:15:11Z","timestamp":1377857711000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Genomic characterization of remission in juvenile idiopathic arthritis"],"prefix":"10.1186","volume":"15","author":[{"given":"Kaiyu","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark Barton","family":"Frank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanette","family":"Osban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James N","family":"Jarvis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,8,30]]},"reference":[{"key":"4049_CR1","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1097\/BOR.0b013e32825a6a68","volume":"19","author":"S Ringold","year":"2007","unstructured":"Ringold S, Wallace CA: Measuring clinical response and remission in juvenile idiopathic arthritis. Curr Opin Rheumatol. 2007, 19: 471-476. 10.1097\/BOR.0b013e32825a6a68.","journal-title":"Curr Opin Rheumatol"},{"key":"4049_CR2","doi-asserted-by":"publisher","first-page":"437","DOI":"10.3928\/0090-4481-20020701-08","volume":"31","author":"JN Jarvis","year":"2002","unstructured":"Jarvis JN: Juvenile rheumatoid arthritis: a guide for pediatricians. Pediatr Ann. 2002, 31: 437-446. 10.3928\/0090-4481-20020701-08.","journal-title":"Pediatr Ann"},{"key":"4049_CR3","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1007\/s11926-010-0085-2","volume":"12","author":"S Shenoi","year":"2010","unstructured":"Shenoi S, Wallace CA: Remission in juvenile idiopathic arthritis: current facts. Curr Rheumatol Reports. 2010, 12: 80-86. 10.1007\/s11926-010-0085-2.","journal-title":"Curr Rheumatol Reports"},{"key":"4049_CR4","first-page":"2290","volume":"31","author":"CA Wallace","year":"2004","unstructured":"Wallace CA, Ruperto N, Giannini E, Childhood Arthritis and Rheumatology Research Alliance, Pediatric Rheumatology International Trials Organization, Pediatric Rheumatology Collaborative Study Group: Preliminary criteria for clinical remission for select categories of juvenile idiopathic arthritis. J Rheumatol. 2004, 31: 2290-2294.","journal-title":"J Rheumatol"},{"key":"4049_CR5","doi-asserted-by":"publisher","first-page":"1488","DOI":"10.1002\/art.24450","volume":"60","author":"JN Jarvis","year":"2009","unstructured":"Jarvis JN, Jiang K, Frank MB, Knowlton N, Aggarwal A, Wallace CA, McKee R, Chaser B, Tung C, Smith LB, McGhee JL, Chen Y, Osban J, O'Neil KN, Centola M: Gene expression profiling in neutrophils of children with polyarticular juvenile idiopathic arthritis. Arthritis Rheum. 2009, 60: 1488-1495. 10.1002\/art.24450.","journal-title":"Arthritis Rheum"},{"key":"4049_CR6","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1002\/art.24298","volume":"60","author":"N Knowlton","year":"2009","unstructured":"Knowlton N, Jiang K, Frank MB, Aggarwal A, Wallace C, McKee R, Chaser B, Tung C, Smith L, Chen Y, Osban J, O'Neil K, Centola M, McGhee JL, Jarvis JN: The meaning of clinical remission in polyarticular juvenile idiopathic arthritis: gene expression profiling in peripheral blood mononuclear cells identifies distinct disease states. Arthritis Rheum. 2009, 60: 892-900. 10.1002\/art.24298.","journal-title":"Arthritis Rheum"},{"key":"4049_CR7","doi-asserted-by":"publisher","first-page":"3354","DOI":"10.1002\/art.21389","volume":"52","author":"CA Wallace","year":"2005","unstructured":"Wallace CA, Huang B, Bandeira M, Ravelli A, Giannini EH: Patterns of clinical remission in select categories of juvenile idiopathic arthritis. Arthritis Rheum. 2005, 52: 3354-3562.","journal-title":"Arthritis Rheum"},{"key":"4049_CR8","doi-asserted-by":"publisher","first-page":"367","DOI":"10.2165\/11532610-000000000-00000","volume":"12","author":"S Shenoi","year":"2010","unstructured":"Shenoi S, Wallace CA: Tumor necrosis factor inhibitors in the management of juvenile idiopathic arthritis: an evidence-based review. Paediatric Drugs. 2010, 12: 367-377. 10.2165\/11532610-000000000-00000.","journal-title":"Paediatric Drugs"},{"key":"4049_CR9","first-page":"390","volume":"31","author":"RE Petty","year":"2004","unstructured":"Petty RE, Southwood TR, Manners P, Baum J, Glass DN, Goldenberg J, He X, Maldonado-Cocco J, Orozco-Alcala J, Prieur AM, Suarez-Almazor ME, Woo P: International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision Edmonton, 2001. J Rheumatol. 2004, 31: 390-392.","journal-title":"J Rheumatol"},{"key":"4049_CR10","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1093\/nar\/gkg014","volume":"31","author":"M Diehn","year":"2003","unstructured":"Diehn M, Sherlock G, Binkley G, Jin H, Matese JC, Hernandez-Boussard T, Rees CA, Cherry JM, Botstein D, Brown PO, Alizadeh AA: SOURCE: a unified genomic resource of functional annotations, ontologies, and gene expression data. Nucleic Acids Research. 2003, 31: 219-223. 10.1093\/nar\/gkg014.","journal-title":"Nucleic Acids Research"},{"key":"4049_CR11","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/75556","volume":"25","author":"M Ashburner","year":"2000","unstructured":"Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, Harris MA, Hill DP, Issel-Tarver L, Kasarskis A, Lewis S, Matese JC, Richardson JE, Ringwald M, Rubin GM, Sherlock G: Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nature Genet. 2000, 25: 25-29. 10.1038\/75556.","journal-title":"Nature Genet"},{"key":"4049_CR12","doi-asserted-by":"publisher","first-page":"R80","DOI":"10.1186\/gb-2004-5-10-r80","volume":"5","author":"RC Gentleman","year":"2004","unstructured":"Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, Ellis B, Gautier L, Ge Y, Gentry J, Hornik K, Hothorn T, Huber W, Iacus S, Irizarry R, Leisch F, Li C, Maechler M, Rossini AJ, Sawitzki G, Smith C, Smyth G, Tierney L, Yang JY, Zhang J: Bioconductor: open software development for computational biology and bioinformatics. Genome Biology. 2004, 5: R80-10.1186\/gb-2004-5-10-r80.","journal-title":"Genome Biology"},{"key":"4049_CR13","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1006\/bbrc.1997.6976","volume":"236","author":"RP Piekorz","year":"1997","unstructured":"Piekorz RP, Nemetz C, Hocke GM: Members of the family of IL-6-type cytokines activate Stat5a in various cell types. Biochem Biophys Res Commun. 1997, 236: 438-443. 10.1006\/bbrc.1997.6976.","journal-title":"Biochem Biophys Res Commun"},{"key":"4049_CR14","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.mrfmmm.2003.12.020","volume":"549","author":"Q Huang","year":"2004","unstructured":"Huang Q, Jin X, Gaillard ET, Knight BL, Pack FD, Stoltz JH, Jayadev S, Blanchard KT: Gene expression profiling reveals multiple toxicity endpoints induced by hepatotoxicants. Mutat Res. 2004, 549: 147-167. 10.1016\/j.mrfmmm.2003.12.020.","journal-title":"Mutat Res"},{"key":"4049_CR15","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.tox.2008.11.016","volume":"256","author":"YJ Kim","year":"2009","unstructured":"Kim YJ, Song M, Ryu JC: Inflammation in methotrexate-induced pulmonary toxicity occurs via the p38 MAPK pathway. Toxicology. 2009, 256: 183-190. 10.1016\/j.tox.2008.11.016.","journal-title":"Toxicology"},{"key":"4049_CR16","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.4049\/jimmunol.156.7.2585","volume":"156","author":"LE Sower","year":"1996","unstructured":"Sower LE, Froelich CJ, Allegretto N, Rose PM, Hanna WD, Klimpel GR: Extracellular activities of human granzyme A. Monocyte activation by granzyme A versus alpha-thrombin. J Immunol. 1996, 156: 2585-2590.","journal-title":"J Immunol"},{"key":"4049_CR17","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/S1359-6101(00)00005-8","volume":"11","author":"K Takeda","year":"2000","unstructured":"Takeda K, Akira S: STAT family of transcription factors in cytokine-mediated biological responses. Cytokine Growth Factor Rev. 2000, 11: 199-207. 10.1016\/S1359-6101(00)00005-8.","journal-title":"Cytokine Growth Factor Rev"},{"key":"4049_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0014-4827(02)00027-7","volume":"283","author":"SY Proskuryakov","year":"2003","unstructured":"Proskuryakov SY, Konoplyannikov AG, Gabai VL: Necrosis: a specific form of programmed cell death?. Exp Cell Res. 2003, 283: 1-16. 10.1016\/S0014-4827(02)00027-7.","journal-title":"Exp Cell Res"},{"key":"4049_CR19","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.4049\/jimmunol.1102667","volume":"188","author":"E Lovo","year":"2012","unstructured":"Lovo E, Zhang M, Wang L, Ashton-Rickardt PG: Serine protease inhibitor 6 is required to protect dendritic cells from the kiss of death. J Immunol. 2012, 188: 1057-1063. 10.4049\/jimmunol.1102667.","journal-title":"J Immunol"},{"key":"4049_CR20","doi-asserted-by":"publisher","first-page":"671","DOI":"10.4049\/jimmunol.168.2.671","volume":"168","author":"CL Sutherland","year":"2002","unstructured":"Sutherland CL, Chalupny NJ, Schooley K, VandenBos T, Kubin M, Cosman D: UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells. J Immunol. 2002, 168: 671-679. 10.4049\/jimmunol.168.2.671.","journal-title":"J Immunol"},{"key":"4049_CR21","doi-asserted-by":"publisher","first-page":"2478","DOI":"10.2741\/1712","volume":"10","author":"E Andreakos","year":"2005","unstructured":"Andreakos E, Sacre S, Foxwell BM, Feldmann M: The toll-like receptor-nuclear factor kappaB pathway in rheumatoid arthritis. Front Biosci. 2005, 10: 2478-2488. 10.2741\/1712.","journal-title":"Front Biosci"},{"key":"4049_CR22","doi-asserted-by":"publisher","first-page":"R154","DOI":"10.1186\/ar2048","volume":"8","author":"JN Jarvis","year":"2006","unstructured":"Jarvis JN, Petty HR, Tang Y, Frank MB, Tessier PA, Dozmorov I, Jiang K, Kindzelski A, Chen Y, Cadwell C, Turner M, Szodoray P, McGhee JL, Centola M: Evidence for chronic peripheral activation of neutrophils in polyarticular juvenile rheumatoid arthritis. Arthritis Res Ther. 2006, 8: R154-10.1186\/ar2048.","journal-title":"Arthritis Res Ther"},{"key":"4049_CR23","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1093\/dnares\/dsl006","volume":"13","author":"N Nakamura","year":"2006","unstructured":"Nakamura N, Shimaoka Y, Tougan T, Onda H, Okuzaki D, Zhao H, Fujimori A, Yabuta N, Nagamori I, Tanigawa A, Sato J, Oda T, Hayashida K, Suzuki R, Yukioka M, Nojima H, Ochi T: Isolation and expression profiling of genes upregulated in bone marrow-derived mononuclear cells of rheumatoid arthritis patients. DNA Res. 2006, 13: 169-183. 10.1093\/dnares\/dsl006.","journal-title":"DNA Res"},{"key":"4049_CR24","doi-asserted-by":"publisher","first-page":"R38","DOI":"10.1186\/ar2644","volume":"11","author":"V Go\u00ebb","year":"2009","unstructured":"Go\u00ebb V, Thomas-L'Otellier M, Daveau R, Charlionet R, Fardellone P, Le Lo\u00ebt X, Tron F, Gilbert D, Vittecoq O: Candidate autoantigens identified by mass spectrometry in early rheumatoid arthritis are chaperones and citrullinated glycolytic enzymes. Arthritis Res Ther. 2009, 11: R38-10.1186\/ar2644.","journal-title":"Arthritis Res Ther"},{"key":"4049_CR25","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1093\/toxsci\/kfm067","volume":"97","author":"GS Belinsky","year":"2007","unstructured":"Belinsky GS, Parke AL, Huang Q, Blanchard K, Jayadev S, Stoll R, Rothe M, Achenie LE, Gupta RR, Wu GY, Rosenberg DW: The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007, 97: 582-594. 10.1093\/toxsci\/kfm067.","journal-title":"Toxicol Sci"},{"key":"4049_CR26","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/S1074-7613(00)80339-8","volume":"6","author":"JG Cyster","year":"1997","unstructured":"Cyster JG, Goodnow CC: Tuning antigen receptor signaling by CD22: integrating cues from antigens and the microenvironment. Immunity. 1997, 6: 509-517. 10.1016\/S1074-7613(00)80339-8.","journal-title":"Immunity"},{"key":"4049_CR27","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/S0960-9822(06)00057-1","volume":"7","author":"L Nitschke","year":"1997","unstructured":"Nitschke L, Carsetti R, Ocker B, K\u00f6hler G, Lamers MC: CD22 is a negative regulator of B-cell receptor signalling. Curr Biol. 1997, 7: 133-143. 10.1016\/S0960-9822(06)00057-1.","journal-title":"Curr Biol"},{"key":"4049_CR28","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1189\/jlb.1205758","volume":"80","author":"MG Netea","year":"2006","unstructured":"Netea MG, Azam T, Ferwerda G, Girardin SE, Kim SH, Dinarello CA: Triggering receptor expressed on myeloid cells-1 (TREM-1) amplifies the signals induced by the NACHT-LRR (NLR) pattern recognition receptors. J Leukoc Biol. 2006, 80: 1454-1461. 10.1189\/jlb.1205758.","journal-title":"J Leukoc Biol"},{"key":"4049_CR29","doi-asserted-by":"publisher","first-page":"3520","DOI":"10.4049\/jimmunol.180.5.3520","volume":"180","author":"K Dower","year":"2008","unstructured":"Dower K, Ellis DK, Saraf K, Jelinsky SA, Lin LL: Innate immune responses to TREM-1 activation: overlap, divergence, and positive and negative cross-talk with bacterial lipopolysaccharide. J Immunol. 2008, 180: 3520-3534. 10.4049\/jimmunol.180.5.3520.","journal-title":"J Immunol"},{"key":"4049_CR30","doi-asserted-by":"publisher","first-page":"47928","DOI":"10.1074\/jbc.M207509200","volume":"277","author":"V Modur","year":"2002","unstructured":"Modur V, Nagarajan R, Evers BM, Milbrandt J: FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression. Implications for PTEN mutation in prostate cancer. J Biol Chem. 2002, 277: 47928-47937. 10.1074\/jbc.M207509200.","journal-title":"J Biol Chem"},{"key":"4049_CR31","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.4049\/jimmunol.170.2.1027","volume":"170","author":"SA Renshaw","year":"2003","unstructured":"Renshaw SA, Parmar JS, Singleton V, Rowe SJ, Dockrell DH, Dower SK, Bingle CD, Chilvers ER, Whyte MK: Acceleration of human neutrophil apoptosis by TRAIL. J Immunol. 2003, 170: 1027-1033. 10.4049\/jimmunol.170.2.1027.","journal-title":"J Immunol"},{"key":"4049_CR32","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1093\/rheumatology\/keq045","volume":"49","author":"HL Wright","year":"2010","unstructured":"Wright HL, Moots RJ, Bucknall RC, Edwards SW: Neutrophil function in inflammation and inflammatory diseases. Rheumatology (Oxford). 2010, 49: 1618-1631. 10.1093\/rheumatology\/keq045.","journal-title":"Rheumatology (Oxford)"},{"key":"4049_CR33","first-page":"93","volume":"22","author":"SI Grivennikov","year":"2005","unstructured":"Grivennikov SI, Tumanov AV, Liepinsh DJ, Kruglov AA, Marakusha BI, Shakhov AN, Murakami T, Drutskaya LN, F\u00f6rster I, Clausen BE, Tessarollo L, Ryffel B, Kuprash DV, Nedospasov SA: Distinct and nonredundant in vivo functions of TNF produced by t cells and macrophages\/neutrophils: protective and deleterious effects. Immunity. 2005, 22: 93-104.","journal-title":"Immunity"},{"key":"4049_CR34","doi-asserted-by":"crossref","unstructured":"Salamone G, Giordano M, Trevani AS, Gamberale R, Vermeulen M, Schettinni J, Geffner JR: Promotion of neutrophil apoptosis by TNF-alpha. J Immunol. 2001, 3476-3483. 166","DOI":"10.4049\/jimmunol.166.5.3476"},{"key":"4049_CR35","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1189\/jlb.69.3.467","volume":"69","author":"JM van den Berg","year":"2001","unstructured":"van den Berg JM, Weyer S, Weening JJ, Roos D, Kuijpers TW: Divergent effects of tumor necrosis factor alpha on apoptosis of human neutrophils. J Leukoc Biol. 2001, 69: 467-473.","journal-title":"J Leukoc Biol"},{"key":"4049_CR36","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1182\/blood-2007-05-087833","volume":"111","author":"A Cross","year":"2008","unstructured":"Cross A, Moots RJ, Edwards SW: The dual effects of TNFalpha on neutrophil apoptosis are mediated via differential effects on expression of Mcl-1 and Bfl-1. Blood. 2008, 111: 878-884. 10.1182\/blood-2007-05-087833.","journal-title":"Blood"},{"key":"4049_CR37","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1126\/science.286.5439.509","volume":"286","author":"AL Barbasi","year":"1999","unstructured":"Barbasi AL, Albert A: Emergence of scaling in networks. Science. 1999, 286: 509-512. 10.1126\/science.286.5439.509.","journal-title":"Science"},{"key":"4049_CR38","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1038\/35036627","volume":"407","author":"H Jeong","year":"2000","unstructured":"Jeong H, Tombor B, Oltval ZN, Barabasi A-L: The large-scale organization of metabolic networks. Nature. 2000, 407: 651-654. 10.1038\/35036627.","journal-title":"Nature"},{"key":"4049_CR39","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/1755-8794-2-9","volume":"2","author":"MB Frank","year":"2009","unstructured":"Frank MB, Wang S, Aggarwal A, Knowlton N, Jiang K, Chen Y, McKee R, Chaser B, McGhee T, Osban J, Jarvis JN: Disease-associated pathophysiologic structures in pediatric rheumatic diseases show characteristics of scale-free networks seen in physiologic systems: implications for pathogenesis and treatment. BMC Med Genomics. 2009, 2: 9-23. 10.1186\/1755-8794-2-9.","journal-title":"BMC Med Genomics"},{"key":"4049_CR40","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1126\/science.1089769","volume":"303","author":"DT Odom","year":"2004","unstructured":"Odom DT, Zizlsperger N, Gordon DB, Bell GW, Rinaldi NJ, Murray HL, Volkert TL, Schreiber J, Rolfe PA, Gifford DK, Fraenkel E, Bell GI, Young RA: Control of pancreas and liver gene expression by HNF transcription factors. Science. 2004, 303: 1378-1381. 10.1126\/science.1089769.","journal-title":"Science"},{"key":"4049_CR41","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1016\/j.bbrc.2005.02.072","volume":"329","author":"A Ihara","year":"2005","unstructured":"Ihara A, Yamagata K, Nammo T, Miura A, Yuan M, Tanaka T, Sladek FM, Matsuzawa Y, Miyagawa J, Shimomura I: Functional characterization of the HNF4alpha isoform (HNF4alpha8) expressed in pancreatic beta-cells. Biochem Biophys Res Commun. 2005, 329: 984-990. 10.1016\/j.bbrc.2005.02.072.","journal-title":"Biochem Biophys Res Commun"},{"key":"4049_CR42","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1006\/geno.1998.5480","volume":"53","author":"M Richard","year":"1998","unstructured":"Richard M, Drouin R, Beaulieu AD: ABC50, a novel human ATP-binding cassette protein found in tumor necrosis factor-alpha-stimulated synoviocytes. Genomics. 1998, 53: 137-145. 10.1006\/geno.1998.5480.","journal-title":"Genomics"},{"key":"4049_CR43","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.4049\/jimmunol.156.4.1609","volume":"156","author":"HG Wisniewski","year":"1996","unstructured":"Wisniewski HG, Hua JC, Poppers DM, Naime D, VilEek J, Cronsteint BN: TNF\/IL-1 -inducible protein TSG-6 potentiates plasmin inhibition by inter-alpha-inhibitor and exerts a strong anti-inflammatory effect in vivo. J Immunol. 1996, 156: 1609-1615.","journal-title":"J Immunol"},{"key":"4049_CR44","doi-asserted-by":"publisher","first-page":"R100","DOI":"10.1186\/ar1985","volume":"8","author":"N Fujikado","year":"2006","unstructured":"Fujikado N, Saijo S, Iwakura Y: Identification of arthritis-related gene clusters by microarray analysis of two independent mouse models for rheumatoid arthritis. Arthritis Res Ther. 2006, 8: R100-10.1186\/ar1985.","journal-title":"Arthritis Res Ther"},{"key":"4049_CR45","doi-asserted-by":"publisher","first-page":"1850","DOI":"10.1002\/pmic.200800561","volume":"9","author":"A Chiarini","year":"2009","unstructured":"Chiarini A, Armato U, Pacchiana R, DalPra I: Proteomic analysis of GTP cyclohydrolase 1 multiprotein complexes in cultured normal adult human astrocytes under both basal and cytokine-activated conditions. Proteomics. 2009, 9: 1850-1860. 10.1002\/pmic.200800561.","journal-title":"Proteomics"},{"key":"4049_CR46","doi-asserted-by":"publisher","first-page":"30454","DOI":"10.1074\/jbc.M203312200","volume":"277","author":"MG Sanna","year":"2002","unstructured":"Sanna MG, da Silva Correia J, Luo Y, Chuang B, Paulson LM, Nguyen B, Deveraux QL, Ulevitch RJ: ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis. J Biol Chem. 2002, 277: 30454-30462. 10.1074\/jbc.M203312200.","journal-title":"J Biol Chem"},{"key":"4049_CR47","doi-asserted-by":"publisher","first-page":"14524","DOI":"10.1073\/pnas.0907131106","volume":"106","author":"A Krieg","year":"2009","unstructured":"Krieg A, Correa RG, Garrison JB, Le Negrate G, Welsh K, Huang Z, Knoefel WT, Reed JC: XIAP mediates NOD signaling via interaction with RIP2. Proc Natl Acad Sci USA. 2009, 106: 14524-14529. 10.1073\/pnas.0907131106.","journal-title":"Proc Natl Acad Sci USA"},{"key":"4049_CR48","doi-asserted-by":"publisher","first-page":"5369","DOI":"10.4049\/jimmunol.0803384","volume":"183","author":"A Montfort","year":"2009","unstructured":"Montfort A, de Badts B, Douin-Echinard V, Martin PG, Iacovoni J, Nevoit C, Therville N, Garcia V, Bertrand MA, Bessi\u00e8res MH, Trombe MC, Levade T, Benoist H, S\u00e9gui B: FAN stimulates TNF(alpha)-induced gene expression, leukocyte recruitment, and humoral response. J Immunol. 2009, 183: 5369-5378. 10.4049\/jimmunol.0803384.","journal-title":"J Immunol"},{"key":"4049_CR49","doi-asserted-by":"publisher","first-page":"2011","DOI":"10.1016\/S0006-2952(03)00586-0","volume":"66","author":"C Cheung","year":"2003","unstructured":"Cheung C, Akiyama TE, Kudo G, Gonzalez FJ: Hepatic expression of cytochrome P450s in hepatocyte nuclear factor 1-alpha (HNF1alpha)-deficient mice. Biochem Pharmacol. 2003, 66: 2011-2020. 10.1016\/S0006-2952(03)00586-0.","journal-title":"Biochem Pharmacol"},{"key":"4049_CR50","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1186\/1471-2164-12-128","volume":"12","author":"Z Wang","year":"2011","unstructured":"Wang Z, Bishop EP, Burke PA: Expression profile analysis of the inflammatory response regulated by hepatocyte nuclear factor 4 \u03b1. BMC Genomics. 2011, 12: 128-10.1186\/1471-2164-12-128.","journal-title":"BMC Genomics"},{"key":"4049_CR51","doi-asserted-by":"publisher","first-page":"6514","DOI":"10.1038\/sj.onc.1204035","volume":"19","author":"R Li","year":"2000","unstructured":"Li R, Pei H, Watson DK: Regulation of Ets function by protein-protein interactions. Oncogene. 2000, 19: 6514-6523. 10.1038\/sj.onc.1204035.","journal-title":"Oncogene"}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/ar4280.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/ar4280\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/ar4280.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T10:54:28Z","timestamp":1728384868000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/ar4280"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,30]]},"references-count":51,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2013,8]]}},"alternative-id":["4049"],"URL":"https:\/\/doi.org\/10.1186\/ar4280","relation":{},"ISSN":["1478-6354"],"issn-type":[{"value":"1478-6354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,30]]},"assertion":[{"value":"30 August 2013","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"R100"}}