{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:55:18Z","timestamp":1787165718842,"version":"build-2736575974"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2013,11,19]],"date-time":"2013-11-19T00:00:00Z","timestamp":1384819200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2013,11,19]],"date-time":"2013-11-19T00:00:00Z","timestamp":1384819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Pulmonary arterial hypertension (PAH) is a major cause of mortality in systemic sclerosis (SSc). Screening guidelines for PAH recommend multiple investigations, including annual echocardiography, which together have low specificity and may not be cost-effective. We sought to evaluate the predictive accuracy of serum N-terminal pro-brain natriuretic peptide (NT-proBNP) in combination with pulmonary function tests (PFT) (\u2018proposed\u2019 algorithm) in a screening algorithm for SSc-PAH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We evaluated our proposed algorithm (PFT with NT-proBNP) on 49 consecutive SSc patients with suspected pulmonary hypertension undergoing right heart catherisation (RHC). The predictive accuracy of the proposed algorithm was compared with existing screening recommendations, and is presented as sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 27 patients were found to have pulmonary hypertension (PH) at RHC, while 22 had no PH. The sensitivity, specificity, PPV and NPV of the proposed algorithm for PAH was 94.1%, 54.5%, 61.5% and 92.3%, respectively; current European Society of Cardiology (ESC)\/European Respiratory Society (ERS) guidelines achieved a sensitivity, specificity, PPV and NPV of 94.1%, 31.8%, 51.6% and 87.5%, respectively. In an alternate case scenario analysis, estimating a PAH prevalence of 10%, the proposed algorithm achieved a sensitivity, specificity, PPV and NPV for PAH of 94.1%, 54.5%, 18.7% and 98.8%, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The combination of NT-proBNP with PFT is a sensitive, yet simple and non-invasive, screening strategy for SSc-PAH. Patients with a positive screening result can be referred for echocardiography, and further confirmatory testing for PAH. In this way, it may be possible to shift the burden of routine screening away from echocardiography. The findings of this study should be confirmed in larger studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/ar4383","type":"journal-article","created":{"date-parts":[[2013,11,19]],"date-time":"2013-11-19T05:13:46Z","timestamp":1384838026000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["The inclusion of N-terminal pro-brain natriuretic peptide in a sensitive screening strategy for systemic sclerosis-related pulmonary arterial hypertension: a cohort study"],"prefix":"10.1186","volume":"15","author":[{"given":"Vivek","family":"Thakkar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Stevens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Prior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Youssef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny","family":"Liew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eli","family":"Gabbay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Roddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer G","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Zochling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Sahhar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Nash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Lester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen","family":"Rischmueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna M","family":"Proudman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandana","family":"Nikpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,11,19]]},"reference":[{"key":"4056_CR1","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1146\/annurev-pathol-011110-130312","volume":"6","author":"TR Katsumoto","year":"2011","unstructured":"Katsumoto TR, Whitfield ML, Connolly MK: The pathogenesis of systemic sclerosis. Annu Rev Pathol. 2011, 6: 509-537. 10.1146\/annurev-pathol-011110-130312.","journal-title":"Annu Rev Pathol"},{"key":"4056_CR2","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1136\/ard.2006.066068","volume":"66","author":"VD Steen","year":"2007","unstructured":"Steen VD, Medsger TA: Changes in causes of death in systemic sclerosis, 1972-2002. Ann Rheum Dis. 2007, 66: 940-944. 10.1136\/ard.2006.066068.","journal-title":"Ann Rheum Dis"},{"key":"4056_CR3","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1164\/rccm.200806-953OC","volume":"179","author":"R Condliffe","year":"2009","unstructured":"Condliffe R, Kiely DG, Peacock AJ, Corris PA, Gibbs JSR, Vrapi F, Das C, Elliot CA, Johnson M, DeSoyza J, Torpy C, Goldsmith K, Hodgkins D, Hughes RJ, Pepke-Zaba J, Coghlan JG: Connective tissue disease-associated pulmonary arterial hypertension in the modern treatment era. Am J Respir Crit Care Med. 2009, 179: 151-157. 10.1164\/rccm.200806-953OC.","journal-title":"Am J Respir Crit Care Med"},{"key":"4056_CR4","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1093\/rheumatology\/kep398","volume":"49","author":"D Launay","year":"2009","unstructured":"Launay D, Sitbon O, Le Pavec J, Savale L, Tcherakian C, Yaici A, Achouh L, Parent F, Jais X, Simonneau G, Humbert M: Long-term outcome of systemic sclerosis-associated pulmonary arterial hypertension treated with bosentan as first-line monotherapy followed or not by the addition of prostanoids or sildenafil. Rheumatology. 2009, 49: 490-500.","journal-title":"Rheumatology"},{"key":"4056_CR5","doi-asserted-by":"publisher","first-page":"2093","DOI":"10.1016\/S0140-6736(08)60919-8","volume":"371","author":"N Gali\u00e8","year":"2008","unstructured":"Gali\u00e8 N, Rubin LJ, Hoeper MM, Jansa P, Al-Hiti H, Meyer GMB, Chiossi E, Kusic-Pajic A, Simonneau G: Treatment of patients with mildly symptomatic pulmonary arterial hypertension with bosentan (EARLY study): a double-blind, randomised controlled trial. Lancet. 2008, 371: 2093-2100. 10.1016\/S0140-6736(08)60919-8.","journal-title":"Lancet"},{"key":"4056_CR6","doi-asserted-by":"publisher","first-page":"1026A","DOI":"10.1378\/chest.1456207","volume":"142","author":"L Rubin","year":"2012","unstructured":"Rubin L, Pulido T, Channick R, Delcroix M, Galie N, Ghofrani A, Jansa P, Le Brun FO, Mehta S, Mittelholzer C, Perchenet L, Sastry BKS, Sitbon O, Souza R, Torbicki A, Simonneau G: Effect of Macitentan on morbidity and mortality in pulmonary arterial hypertension (PAH): results from the SERAPHIN Trial. Chest. 2012, 142: 1026A-10.1378\/chest.1456207.","journal-title":"Chest"},{"key":"4056_CR7","doi-asserted-by":"publisher","first-page":"3522","DOI":"10.1002\/art.30541","volume":"63","author":"M Humbert","year":"2011","unstructured":"Humbert M, Yaici A, de Groote P, Montani D, Sitbon O, Launay D, Gressin V, Guillevin L, Clerson P, Simonneau G, Hachulla E: Screening for pulmonary arterial hypertension in patients with systemic sclerosis: clinical characteristics at diagnosis and long-term survival. Arthritis Rheum. 2011, 63: 3522-3530. 10.1002\/art.30541.","journal-title":"Arthritis Rheum"},{"key":"4056_CR8","doi-asserted-by":"publisher","first-page":"2493","DOI":"10.1093\/eurheartj\/ehp297","volume":"30","author":"N Galie","year":"2009","unstructured":"Galie N, Hoeper MM, Humbert M, Torbicki A, Vachiery JL, Barbera JA, Beghetti M, Corris P, Gaine S, Gibbs JS, Gomez-Sanchez MA, Jondeau G, Klepetko W, Opitz C, Peacock A, Rubin L, Zellweger M, Simonneau G: Guidelines for the diagnosis and treatment of pulmonary hypertension: the task force for the diagnosis and treatment of pulmonary hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT). Eur Heart J. 2009, 30: 2493-2537.","journal-title":"Eur Heart J"},{"key":"4056_CR9","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.1016\/j.jacc.2009.01.004","volume":"53","author":"VV McLaughlin","year":"2009","unstructured":"McLaughlin VV, Archer SL, Badesch DB, Barst RJ, Farber HW, Lindner JR, Mathier MA, McGoon MD, Park MH, Rosenson RS, Rubin LJ, Tapson VF, Varga J: ACCF\/AHA 2009 expert consensus document on pulmonary hypertension. J Am Coll Cardiol. 2009, 53: 1573-1619. 10.1016\/j.jacc.2009.01.004.","journal-title":"J Am Coll Cardiol"},{"key":"4056_CR10","doi-asserted-by":"publisher","first-page":"i1","DOI":"10.1136\/hrt.2007.132118","volume":"94","author":"National Pulmonary Hypertension Centres of the UK","year":"2008","unstructured":"National Pulmonary Hypertension Centres of the UK: Consensus statement on the management of pulmonary hypertension in clinical practice in the UK and Ireland. Heart. 2008, 94: i1-i41.","journal-title":"Heart"},{"key":"4056_CR11","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1093\/rheumatology\/keh067","volume":"43","author":"D Mukerjee","year":"2004","unstructured":"Mukerjee D, St George D, Knight C, Davar J, Wells AU, Du Bois RM, Black CM, Coghlan JG: Echocardiography and pulmonary function as screening tests for pulmonary arterial hypertension in systemic sclerosis. Rheumatology (Oxford). 2004, 43: 461-466. 10.1093\/rheumatology\/keh067.","journal-title":"Rheumatology (Oxford)"},{"key":"4056_CR12","doi-asserted-by":"publisher","first-page":"105","DOI":"10.3899\/jrheum.090661","volume":"37","author":"O Kowal-Bielecka","year":"2009","unstructured":"Kowal-Bielecka O, Avouac J, Pittrow D, Huscher D, Behrens F, Denton CP, Foeldvari I, Humbert M, Matucci-Cerinic M, Nash P, Opitz CF, Rubin LJ, Seibold JR, Strand V, Furst DE, Distler O: Echocardiography as an outcome measure in scleroderma-related pulmonary arterial hypertension: a systematic literature analysis by the EPOSS group. J Rheumatol. 2009, 37: 105-115.","journal-title":"J Rheumatol"},{"key":"4056_CR13","doi-asserted-by":"publisher","first-page":"2410","DOI":"10.3899\/jrheum.110512","volume":"38","author":"SC Mathai","year":"2011","unstructured":"Mathai SC, Sibley CT, Forfia PR, Mudd JO, Fisher MR, Tedford RJ, Lechtzin N, Boyce D, Hummers LK, Housten T, Zaiman AL, Girgis RE, Hassoun PM: Tricuspid annular plane systolic excursion is a robust outcome measure in systemic sclerosis-associated pulmonary arterial hypertension. J Rheumatol. 2011, 38: 2410-2418. 10.3899\/jrheum.110512.","journal-title":"J Rheumatol"},{"key":"4056_CR14","doi-asserted-by":"publisher","first-page":"R143","DOI":"10.1186\/ar3876","volume":"14","author":"V Thakkar","year":"2012","unstructured":"Thakkar V, Stevens WM, Prior D, Moore OA, Byron J, Liew D, Patterson K, Hissaria P, Roddy J, Zochling J, Sahhar J, Nash P, Tymms K, Celermajer D, Gabbay E, Youssef P, Proudman SM, Nikpour M: N-terminal pro-brain natriuretic peptide in a novel screening algorithm for pulmonary arterial hypertension in systemic sclerosis: a case-control study. Arthritis Res Ther. 2012, 14: R143-10.1186\/ar3876.","journal-title":"Arthritis Res Ther"},{"key":"4056_CR15","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1002\/art.23187","volume":"58","author":"Y Allanore","year":"2008","unstructured":"Allanore Y, Borderie D, Avouac J, Zerkak D, Meune C, Hachulla E, Mouthon L, Guillevin L, Meyer O, Ekindjian OG, Weber S, Kahan A: High N-terminal pro\u2013brain natriuretic peptide levels and low diffusing capacity for carbon monoxide as independent predictors of the occurrence of precapillary pulmonary arterial hypertension in patients with systemic sclerosis. Arthritis Rheum. 2008, 58: 284-291. 10.1002\/art.23187.","journal-title":"Arthritis Rheum"},{"key":"4056_CR16","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1016\/S0954-6111(03)00254-3","volume":"97","author":"D Mukerjee","year":"2003","unstructured":"Mukerjee D, Yap LB, Holmes AM, Nair D, Ayrton P, Black CM, Coghlan JG: Significance of plasma N-terminal pro-brain natriuretic peptide in patients with systemic sclerosis-related pulmonary arterial hypertension. Respir Med. 2003, 97: 1230-1236. 10.1016\/S0954-6111(03)00254-3.","journal-title":"Respir Med"},{"key":"4056_CR17","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1093\/eurheartj\/ehi891","volume":"27","author":"MH Williams","year":"2006","unstructured":"Williams MH, Handler CE, Akram R, Smith CJ, Das C, Smee J, Nair D, Denton CP, Black CM, Coghlan JG: Role of N-terminal brain natriuretic peptide (N-TproBNP) in scleroderma-associated pulmonary arterial hypertension. Eur Heart J. 2006, 27: 1485-1494.","journal-title":"Eur Heart J"},{"key":"4056_CR18","unstructured":"Coghlan JG, Denton CP, Grunig E, Bonderman D, Distler O, Khanna D, Muller-Ladner U, Pope JE, Vonk MC, Doelberg M, Chadha-Boreham H, Heinzl H, Rosenberg DM, McLaughlin VV, Seibold JR: Evidence-based detection of pulmonary arterial hypertension in systemic sclerosis: the DETECT study. Ann Rheum Dis. \u2009, \u2009: \u2009-in press"},{"key":"4056_CR19","doi-asserted-by":"publisher","first-page":"S641","DOI":"10.1002\/art.24350","volume":"60","author":"S Proudman","year":"2009","unstructured":"Proudman S, Byron J, Zochling J, Youssef P, Nash P, Tymms K, Chan M, Sturgess A, Schreiber L, Hill C, Celermajer D, Sahhar J, Stevens W: An on-line screening tool for cardiopulmonary complications of scleroderma-the Australian Scleroderma Screening Program. Arthritis Rheum. 2009, 60: S641-10.1002\/art.24350.","journal-title":"Arthritis Rheum"},{"key":"4056_CR20","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1002\/art.1780230510","volume":"23","author":"AT Masi","year":"1980","unstructured":"Masi AT, The Subcommittee for Scleroderma Criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee: Preliminary criteria for the classification of systemic sclerosis (scleroderma). Arthritis Rheum. 1980, 23: 581-10.1002\/art.1780230510.","journal-title":"Arthritis Rheum"},{"key":"4056_CR21","first-page":"1573","volume":"28","author":"EC LeRoy","year":"2001","unstructured":"LeRoy EC, Medsger TA: Criteria for the classification of early systemic sclerosis. J Rheumatol. 2001, 28: 1573-1576.","journal-title":"J Rheumatol"},{"key":"4056_CR22","doi-asserted-by":"publisher","first-page":"2290","DOI":"10.3899\/jrheum.100245","volume":"37","author":"J Avouac","year":"2010","unstructured":"Avouac J, Airo P, Meune C, Beretta L, Dieude P, Caramaschi P, Tiev K, Cappelli S, Diot E, Vacca A, Cracowski JL, Sibilia J, Kahan A, Matucci-Cerinic M, Allanore Y: Prevalence of pulmonary hypertension in systemic sclerosis in European Caucasians and metaanalysis of 5 studies. J Rheumatol. 2010, 37: 2290-2298. 10.3899\/jrheum.100245.","journal-title":"J Rheumatol"},{"key":"4056_CR23","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1183\/09031936.05.00034905","volume":"26","author":"N Macintyre","year":"2005","unstructured":"Macintyre N, Crapo RO, Viegi G, Johnson DC, van der Grinten CP, Brusasco V, Burgos F, Casaburi R, Coates A, Enright P, Gustafsson P, Hankinson J, Jensen R, McKay R, Miller MR, Navajas D, Pedersen OF, Pellegrino R, Wanger J: Standardisation of the single-breath determination of carbon monoxide uptake in the lung. Eur Respir J. 2005, 26: 720-735. 10.1183\/09031936.05.00034905.","journal-title":"Eur Respir J"},{"key":"4056_CR24","doi-asserted-by":"publisher","first-page":"3503","DOI":"10.1002\/art.11345","volume":"48","author":"Y Allanore","year":"2003","unstructured":"Allanore Y, Borderie D, Meune C, Cabanes L, Weber S, Ekindjian OG, Kahan A: N-terminal pro-brain natriuretic peptide as a diagnostic marker of early pulmonary artery hypertension in patients with systemic sclerosis and effects of calcium-channel blockers. Arthritis Rheum. 2003, 48: 3503-3508. 10.1002\/art.11345.","journal-title":"Arthritis Rheum"},{"key":"4056_CR25","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1002\/art.10775","volume":"48","author":"V Steen","year":"2003","unstructured":"Steen V, Medsger TA: Predictors of isolated pulmonary hypertension in patients with systemic sclerosis and limited cutaneous involvement. Arthritis Rheum. 2003, 48: 516-522. 10.1002\/art.10775.","journal-title":"Arthritis Rheum"},{"key":"4056_CR26","first-page":"458","volume":"35","author":"VM Hsu","year":"2008","unstructured":"Hsu VM, Moreyra AE, Wilson AC, Shinnar M, Shindler DM, Wilson JE, Desai A, Seibold JR: Assessment of pulmonary arterial hypertension in patients with systemic sclerosis: comparison of noninvasive tests with results of right-heart catheterization. J Rheumatol. 2008, 35: 458-465.","journal-title":"J Rheumatol"},{"key":"4056_CR27","doi-asserted-by":"publisher","first-page":"3103","DOI":"10.1161\/CIRCULATIONAHA.106.666255","volume":"115","author":"GW Moe","year":"2007","unstructured":"Moe GW, Howlett J, Januzzi JL, Zowall H: N-terminal pro-B-type natriuretic peptide testing improves the management of patients with suspected acute heart failure: primary results of the Canadian prospective randomized multicenter IMPROVE-CHF study. Circulation. 2007, 115: 3103-3110. 10.1161\/CIRCULATIONAHA.106.666255.","journal-title":"Circulation"},{"key":"4056_CR28","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1093\/eurheartj\/ehi811","volume":"27","author":"AA Chen","year":"2006","unstructured":"Chen AA, Wood MJ, Krauser DG, Baggish AL, Tung R, Anwaruddin S, Picard MH, Januzzi JL: NT-proBNP levels, echocardiographic findings, and outcomes in breathless patients: results from the ProBNP Investigation of Dyspnoea in the Emergency Department (PRIDE) echocardiographic substudy. Eur Heart J. 2006, 27: 839-845. 10.1093\/eurheartj\/ehi811.","journal-title":"Eur Heart J"},{"key":"4056_CR29","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.1161\/01.CIR.0000143059.68996.A7","volume":"110","author":"F Hartmann","year":"2004","unstructured":"Hartmann F, Packer M, Coats AJ, Fowler MB, Krum H, Mohacsi P, Rouleau JL, Tendera M, Castaigne A, Anker SD, Amann-Zalan I, Hoersch S, Katus HA: Prognostic impact of plasma N-terminal pro-brain natriuretic peptide in severe chronic congestive heart failure: a substudy of the Carvedilol Prospective Randomized Cumulative Survival (COPERNICUS) trial. Circulation. 2004, 110: 1780-1786. 10.1161\/01.CIR.0000143059.68996.A7.","journal-title":"Circulation"},{"key":"4056_CR30","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1183\/09031936.00145608","volume":"34","author":"G Kovacs","year":"2009","unstructured":"Kovacs G, Berghold A, Scheidl S, Olschewski H: Pulmonary arterial pressure during rest and exercise in healthy subjects: a systematic review. Eur Respir J. 2009, 34: 888-894. 10.1183\/09031936.00145608.","journal-title":"Eur Respir J"},{"key":"4056_CR31","doi-asserted-by":"publisher","first-page":"2064","DOI":"10.3899\/jrheum.090997","volume":"37","author":"L Cavagna","year":"2010","unstructured":"Cavagna L, Caporali R, Klersy C, Ghio S, Albertini R, Scelsi L, Moratti R, Bonino C, Montecucco C: Comparison of brain natriuretic peptide (BNP) and NT-proBNP in screening for pulmonary arterial hypertension in patients with systemic sclerosis. J Rheumatol. 2010, 37: 2064-2070. 10.3899\/jrheum.090997.","journal-title":"J Rheumatol"},{"key":"4056_CR32","first-page":"9","volume":"69","author":"M Ciurzynski","year":"2011","unstructured":"Ciurzynski M, Bienias P, Irzyk K, Rymarczyk Z, Kostrubiec M, Szewczyk A, Glinska-Wielochowska M, Zylkowska J, Kurzyna M, Pruszczyk P: Usefulness of echocardiography in the identification of an excessive increase in pulmonary arterial pressure in patients with systemic sclerosis. Kardiol Pol. 2011, 69: 9-15.","journal-title":"Kardiol Pol"},{"key":"4056_CR33","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1111\/j.1540-8175.2011.01467.x","volume":"28","author":"S Frea","year":"2011","unstructured":"Frea S, Capriolo M, Marra WG, Cannillo M, Fusaro E, Libertucci D, Morello M, Gaita F: Echo Doppler predictors of pulmonary artery hypertension in patients with systemic sclerosis. Echocardiogr. 2011, 28: 860-869. 10.1111\/j.1540-8175.2011.01467.x.","journal-title":"Echocardiogr"},{"key":"4056_CR34","doi-asserted-by":"publisher","first-page":"3792","DOI":"10.1002\/art.21433","volume":"52","author":"E Hachulla","year":"2005","unstructured":"Hachulla E, Gressin V, Guillevin L, Carpentier P, Diot E, Sibilia J, Kahan A, Cabane J, Franc\u00e8s C, Launay D, Mouthon L, Allanore Y, Tiev KP, Clerson P, de Groote P, Humbert M: Early detection of pulmonary arterial hypertension in systemic sclerosis: A French nationwide prospective multicenter study. Arthritis Rheum. 2005, 52: 3792-3800. 10.1002\/art.21433.","journal-title":"Arthritis Rheum"},{"key":"4056_CR35","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1002\/art.24525","volume":"60","author":"E Hachulla","year":"2009","unstructured":"Hachulla E, de Groote P, Gressin V, Sibilia J, Diot E, Carpentier P, Mouthon L, Hatron P-Y, Jego P, Allanore Y, Tiev KP, Agard C, Cosnes A, Cirstea D, Constans J, Farge D, Viallard JF, Harle JR, Patat F, Imbert B, Kahan A, Cabane J, Clerson P, Guillevin L, Humbert M: The three-year incidence of pulmonary arterial hypertension associated with systemic sclerosis in a multicenter nationwide longitudinal study in France. Arthritis Rheum. 2009, 60: 1831-1839. 10.1002\/art.24525.","journal-title":"Arthritis Rheum"},{"key":"4056_CR36","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1007\/s10067-011-1896-x","volume":"31","author":"P Jansa","year":"2011","unstructured":"Jansa P, Becvar R, Ambroz D, Palecek T, Tomcik M, Skacelova S, Aschermann M, Linhart A: Pulmonary arterial hypertension associated with systemic sclerosis in the Czech Republic. Clin Rheumatol. 2011, 31: 557-561.","journal-title":"Clin Rheumatol"},{"key":"4056_CR37","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1136\/ard.62.11.1088","volume":"62","author":"D Mukerjee","year":"2003","unstructured":"Mukerjee D, St George D, Coleiro B, Knight C, Denton CP, Davar J, Black CM, Coghlan JG: Prevalence and outcome in systemic sclerosis associated pulmonary arterial hypertension: application of a registry approach. Ann Rheum Dis. 2003, 62: 1088-1093. 10.1136\/ard.62.11.1088.","journal-title":"Ann Rheum Dis"},{"key":"4056_CR38","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1378\/chest.08-3042","volume":"136","author":"E Hachulla","year":"2009","unstructured":"Hachulla E, Launay D, Mouthon L, Sitbon O, Berezne A, Guillevin L, Hatron PY, Simonneau G, Clerson P, Humbert M: Is pulmonary arterial hypertension really a late complication of systemic sclerosis?. Chest. 2009, 136: 1211-1219. 10.1378\/chest.08-3042.","journal-title":"Chest"}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/ar4383.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/ar4383\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/ar4383.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T06:05:39Z","timestamp":1728367539000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/ar4383"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,19]]},"references-count":38,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2013,12]]}},"alternative-id":["4056"],"URL":"https:\/\/doi.org\/10.1186\/ar4383","relation":{},"ISSN":["1478-6354"],"issn-type":[{"value":"1478-6354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,19]]},"assertion":[{"value":"15 April 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 November 2013","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 November 2013","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"R193"}}