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The present study was an active case finding for CD in two IBS cohorts, one constituted by IBS\/FMS subjects and the other by people with isolated IBS.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Methods<\/jats:title>\n                        <jats:p>A total of 104 patients (89.4% females) fulfilling the 1990 ACR criteria for FMS and the Rome III criteria for IBS classification and 125 unrelated age- and sex-matched IBS patients without FMS underwent the following studies: haematological, coagulation and biochemistry tests, serological and genetic markers for CD (i.e., tissue transglutaminase 2 (tTG-2) and major histocompatibility complex HLA-DQ2\/HLA-DQ8), multiple gastric and duodenal biopsies, FMS tender points (TPs), Fibromyalgia Impact Questionnaire (FIQ), Health Assessment Questionnaire (HAQ), 36-Item Short Form Health Survey (SF-36) and Visual Analogue Scales (VASs) for tiredness and gastrointestinal complaints.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>As a whole, IBS\/FMS patients scored much worse in quality of life and VAS scores than those with isolated IBS (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Seven subjects (6.7%) from the IBS\/FMS group displayed HLA-DQ2\/HLA-DQ8 positivity, high tTG-2 serum levels and duodenal villous atrophy, concordant with CD. Interestingly enough, these seven patients were started on a gluten-free diet (GFD), showing a remarkable improvement in their digestive and systemic symptoms on follow-up.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusions<\/jats:title>\n                        <jats:p>The findings of this screening indicate that a non-negligible percentage of IBS\/FMS patients are CD patients, whose symptoms can improve and in whom long-term CD-related complications might possibly be prevented with a strict lifelong GFD.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/ar4391","type":"journal-article","created":{"date-parts":[[2013,11,27]],"date-time":"2013-11-27T14:01:38Z","timestamp":1385560898000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Remarkable prevalence of coeliac disease in patients with irritable bowel syndrome plus fibromyalgia in comparison with those with isolated irritable bowel syndrome: a case-finding study"],"prefix":"10.1186","volume":"15","author":[{"given":"Luis","family":"Rodrigo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Blanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Bobes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick J","family":"de Serres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,11,27]]},"reference":[{"key":"4061_CR1","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1111\/j.1445-5994.2006.01217.x","volume":"36","author":"NJ Talley","year":"2006","unstructured":"Talley NJ: Irritable bowel syndrome. 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