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This study aimed to test the hypothesis that the <jats:italic>ABCG2<\/jats:italic> gout risk allele 141\u00a0K promotes the hyperuricaemic response to fructose loading.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Methods<\/jats:title>\n                        <jats:p>Healthy volunteers (n\u2009=\u200974) provided serum and urine samples immediately before and 30, 60, 120 and 180\u00a0minutes after ingesting a 64\u00a0g fructose solution. Data were analyzed based on the presence or absence of the <jats:italic>ABCG2<\/jats:italic> 141\u00a0K gout risk allele.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>The 141\u00a0K risk allele was present in 23 participants (31%). Overall, serum urate (SU) concentrations during the fructose load were similar in those with and without the 141\u00a0K allele (<jats:italic>P<\/jats:italic><jats:sub>SNP<\/jats:sub>\u2009=\u20090.15). However, the 141\u00a0K allele was associated with a smaller increase in SU following fructose intake (<jats:italic>P<\/jats:italic><jats:sub>SNP<\/jats:sub> &lt;0.0001). Those with the 141\u00a0K allele also had a smaller increase in serum glucose following the fructose load (<jats:italic>P<\/jats:italic><jats:sub>SNP<\/jats:sub>\u2009=\u20090.002). Higher fractional excretion of uric acid (FEUA) at baseline and throughout the fructose load was observed in those with the 141\u00a0K risk allele (<jats:italic>P<\/jats:italic><jats:sub>SNP<\/jats:sub> &lt;0.0001). However, the change in FEUA in response to fructose was not different in those with and without the 141\u00a0K risk allele (<jats:italic>P<\/jats:italic><jats:sub>SNP<\/jats:sub>\u2009=\u20090.39). The 141\u00a0K allele effects on serum urate and glucose were more pronounced in Polynesian participants and in those with a body mass index \u226525\u00a0kg\/m<jats:sup>2<\/jats:sup>.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusions<\/jats:title>\n                        <jats:p>In contrast to the predicted responses for a hyperuricemia\/gout risk allele, the 141\u00a0K allele is associated with smaller increases in SU and higher FEUA following a fructose load. The results suggest that <jats:italic>ABCG2<\/jats:italic> interacts with extra-renal metabolic pathways in a complex manner to regulate SU and gout risk.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Clinical Trials Registration<\/jats:title>\n                        <jats:p>The study was registered by the Australian Clinical Trials Registry (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.anzctr.org.au\/Trial\/Registration\/TrialReview.aspx?id=336266\">ACTRN12610001036000<\/jats:ext-link>).<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/ar4463","type":"journal-article","created":{"date-parts":[[2014,1,30]],"date-time":"2014-01-30T10:02:53Z","timestamp":1391076173000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Influence of the ABCG2 gout risk 141\u00a0K allele on urate metabolism during a fructose challenge"],"prefix":"10.1186","volume":"16","author":[{"given":"Nicola","family":"Dalbeth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meaghan E","family":"House","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory D","family":"Gamble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bregina","family":"Pool","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Horne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Purvis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn","family":"Merriman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murray","family":"Cadzow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Phipps-Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony R","family":"Merriman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,1,30]]},"reference":[{"key":"4112_CR1","doi-asserted-by":"publisher","first-page":"1953","DOI":"10.1016\/S0140-6736(08)61343-4","volume":"372","author":"A Dehghan","year":"2008","unstructured":"Dehghan A, Kottgen A, Yang Q, Hwang SJ, Kao WL, Rivadeneira F, Boerwinkle E, Levy D, Hofman A, Astor BC, Benjamin EJ, van Duijn CM, Witteman JC, Coresh J, Fox CS: Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study. 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