{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:27:00Z","timestamp":1780471620934,"version":"3.54.1"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2014,3,31]],"date-time":"2014-03-31T00:00:00Z","timestamp":1396224000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2014,3,31]],"date-time":"2014-03-31T00:00:00Z","timestamp":1396224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Introduction<\/jats:title>\n                        <jats:p>Our objective was to evaluate longitudinally the main bone-mass and quality predictors in young juvenile idiopathic arthritis (JIA) patients by using lumbar spine dual-energy X-ray absorptiometry (DXA) scan, radius peripheral quantitative computed tomography (pQCT), and phalangeal quantitative ultrasonography (QUS) at the same time.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Methods<\/jats:title>\n                        <jats:p>In total, 245 patients (172 females, 73 males; median age, 15.6\u00a0years: 148 oligoarticular, 55 polyarticular, 20 systemic, and 22 enthesitis-related-arthritis (ERA) onset) entered the study. Of these, 166 patients were evaluated longitudinally. Data were compared with two age- and sex-matched control groups.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>In comparison with controls, JIA patients, but not with ERA, had a reduced spine bone-mineral apparent density (BMAD) standard deviation score (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and musculoskeletal deficits, with significantly lower levels of trabecular bone mineral density (TrabBMD) (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001), muscle cross-sectional area (CSA) (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.005), and density-weighted polar section modulus (SSIp) (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). In contrast, JIA showed fat CSA significantly higher than controls (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). Finally, JIA patients had a significant reduced amplitude-dependent speed of sound (AD-SoS) (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and QUS <jats:italic>z<\/jats:italic> score (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.005).<\/jats:p>\n                        <jats:p>Longitudinally, we did not find any difference in all JIA patients in comparison with baseline, except for the SSIp value that normalized. Analyzing the treatments, a significant negative correlation among spine BMAD values, TrabBMD, AD-SoS, and systemic and\/or intraarticular corticosteroids, and a positive correlation among TNF-\u03b1-blocking agents and spine BMAD, TrabBMD, and AD-SoS were observed.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusions<\/jats:title>\n                        <jats:p>JIA patients have a low bone mass that, after a first increase due to the therapy, does not reach the normal condition over time. The pronounced bone deficits in JIA are greater than would be expected because of reduction in muscle cross-sectional area. Thus, bone alterations in JIA likely represent a mixed defect of bone accrual and lower muscle forces.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/ar4525","type":"journal-article","created":{"date-parts":[[2014,3,31]],"date-time":"2014-03-31T09:02:07Z","timestamp":1396256527000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Bone mass and quality in patients with juvenile idiopathic arthritis: longitudinal evaluation of bone-mass determinants by using dual-energy x-ray absorptiometry, peripheral quantitative computed tomography, and quantitative ultrasonography"],"prefix":"10.1186","volume":"16","author":[{"given":"Stefano","family":"Stagi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loredana","family":"Cavalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Signorini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Bertini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Matucci","family":"Cerinic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luisa","family":"Brandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Falcini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,3,31]]},"reference":[{"key":"4171_CR1","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1007\/s00431-007-0484-1","volume":"166","author":"J Roth","year":"2007","unstructured":"Roth J, Bechtold S, Borte G, Dressler F, Girschick HJ, Borte M: Osteoporosis in juvenile idiopathic arthritis: a practical approach to diagnosis and therapy. Eur J Pediatr. 2007, 166: 775-784. 10.1007\/s00431-007-0484-1.","journal-title":"Eur J Pediatr"},{"key":"4171_CR2","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1002\/art.1780390506","volume":"39","author":"PH Pepmueller","year":"1996","unstructured":"Pepmueller PH, Cassidy JT, Allen SH, Hillman LS: Bone mineralization and bone mineral metabolism in children with juvenile rheumatoid arthritis. Arthritis Rheum. 1996, 39: 746-757. 10.1002\/art.1780390506.","journal-title":"Arthritis Rheum"},{"key":"4171_CR3","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.3899\/jrheum.091241","volume":"37","author":"S Stagi","year":"2010","unstructured":"Stagi S, Masi L, Capannini S, Cimaz R, Tonini G, Matucci-Cerinic M, de Martino M, Falcini F: Cross-sectional and longitudinal evaluation of bone mass in children and young adults with juvenile idiopathic arthritis: the role of bone mass determinants in a large cohort of patients. J Rheumatol. 2010, 37: 1935-1943. 10.3899\/jrheum.091241.","journal-title":"J Rheumatol"},{"key":"4171_CR4","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1136\/ard.61.suppl_2.ii84","volume":"61","author":"EM Gravallese","year":"2002","unstructured":"Gravallese EM: Bone destruction in arthritis. Ann Rheum Dis. 2002, 61: 84-86.","journal-title":"Ann Rheum Dis"},{"key":"4171_CR5","first-page":"10","volume":"43","author":"V Strand","year":"2004","unstructured":"Strand V, Kavanaugh AF: The role of interleukin-1 in bone resorption in rheumatoid arthritis. Rheumatology (Oxford). 2004, 43: 10-16.","journal-title":"Rheumatology (Oxford)"},{"key":"4171_CR6","doi-asserted-by":"publisher","first-page":"2518","DOI":"10.1002\/art.23683","volume":"58","author":"JM Burnham","year":"2008","unstructured":"Burnham JM, Shults J, Dubner SE, Sembhi H, Zemel BS, Leonard MB: Bone density, structure, and strength in juvenile idiopathic arthritis: importance of disease severity and muscle deficits. Arthritis Rheum. 2008, 58: 2518-2527. 10.1002\/art.23683.","journal-title":"Arthritis Rheum"},{"key":"4171_CR7","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1093\/rheumatology\/keh387","volume":"43","author":"AG Cleary","year":"2004","unstructured":"Cleary AG, Lancaster GA, Annan F, Sills JA, Davidson JE: Nutritional impairment in juvenile idiopathic arthritis. Rheumatology (Oxford). 2004, 43: 1569-1573. 10.1093\/rheumatology\/keh387.","journal-title":"Rheumatology (Oxford)"},{"key":"4171_CR8","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1093\/rheumatology\/kem100","volume":"46","author":"J Roth","year":"2007","unstructured":"Roth J, Linge M, Tzaribachev N, Schweizer R, Kuemmerle-Deschner J: Musculoskeletal abnormalities in juvenile idiopathic arthritis: a 4-year longitudinal study. Rheumatology (Oxford). 2007, 46: 1180-1184. 10.1093\/rheumatology\/kem100.","journal-title":"Rheumatology (Oxford)"},{"key":"4171_CR9","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1136\/ard.2003.013003","volume":"63","author":"A H\u00e4kkinen","year":"2004","unstructured":"H\u00e4kkinen A, Sokka T, Kautiainen H, Kotaniemi A, Hannonen P: Sustained maintenance of exercise induced muscle strength gains and normal bone mineral density in patients with early rheumatoid arthritis: a 5\u00a0year follow up. Ann Rheum Dis. 2004, 63: 910-916. 10.1136\/ard.2003.013003.","journal-title":"Ann Rheum Dis"},{"key":"4171_CR10","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1007\/BF03349860","volume":"19","author":"F Falcini","year":"1996","unstructured":"Falcini F, Trapani S, Civinini R, Capone A, Ermini M, Bartolozzi G: The primary role of steroids on the osteoporosis in juvenile rheumatoid arthritis patients evaluated by dual energy X-ray absorptiometry. J Endocrinol Invest. 1996, 19: 165-169. 10.1007\/BF03349860.","journal-title":"J Endocrinol Invest"},{"key":"4171_CR11","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s00296-002-0265-0","volume":"23","author":"R Celiker","year":"2003","unstructured":"Celiker R, Bal S, Bakkalo\u011flu A, Ozaydin E, Coskun T, Cetin A, Din\u00e7er F: Factors playing a role in the development of decreased bone mineral density in juvenile chronic arthritis. Rheumatol Int. 2003, 23: 127-129.","journal-title":"Rheumatol Int"},{"key":"4171_CR12","doi-asserted-by":"publisher","first-page":"S5","DOI":"10.1590\/S0036-36342009000700004","volume":"51","author":"JP Bonjour","year":"2009","unstructured":"Bonjour JP, Chevalley T, Ferrari S, Rizzoli R: The importance and relevance of peak bone mass in the prevalence of osteoporosis. Salud Publica Mex. 2009, 51: S5-S17.","journal-title":"Salud Publica Mex"},{"key":"4171_CR13","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/BF02555248","volume":"41","author":"S Varonos","year":"1987","unstructured":"Varonos S, Ansell BM, Reeve J: Vertebral collapse in juvenile chronic arthritis: its relationship with glucocorticoid therapy. Calcif Tissue Int. 1987, 41: 75-78.","journal-title":"Calcif Tissue Int"},{"key":"4171_CR14","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1016\/S0889-857X(05)70112-5","volume":"25","author":"CJ Henderson","year":"1999","unstructured":"Henderson CJ, Panush RS: Diets, dietary supplements, and nutritional therapies in rheumatic diseases. Rheum Dis Clin North Am. 1999, 25: 937-968. 10.1016\/S0889-857X(05)70112-5. ix","journal-title":"Rheum Dis Clin North Am"},{"key":"4171_CR15","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1210\/jc.2010-0889","volume":"96","author":"HE Wey","year":"2011","unstructured":"Wey HE, Binkley TL, Beare TM, Wey CL, Specker BL: Cross-sectional versus longitudinal associations of lean and fat mass with pQCT bone outcomes in children. J Clin Endocrinol Metab. 2011, 96: 106-114. 10.1210\/jc.2010-0889.","journal-title":"J Clin Endocrinol Metab"},{"key":"4171_CR16","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.bone.2005.12.010","volume":"39","author":"GI Baroncelli","year":"2006","unstructured":"Baroncelli GI, Federico G, Vignolo M, Valerio G, del Puente A, Maghnie M, Baserga M, Farello G, Saggese G, Phalangeal Quantitative Ultrasound Group: Cross-sectional reference data for phalangeal quantitative ultrasound from early childhood to young-adulthood according to gender, age, skeletal growth, and pubertal development. Bone. 2006, 39: 159-173. 10.1016\/j.bone.2005.12.010.","journal-title":"Bone"},{"key":"4171_CR17","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s00223001090","volume":"67","author":"F Falcini","year":"2000","unstructured":"Falcini F, Bindi G, Ermini M, Galluzzi F, Poggi G, Rossi S, Masi L, Cimaz R, Brandi ML: Comparison of quantitative calcaneal ultrasound and dual energy X-ray absorptiometry in the evaluation of osteoporotic risk in children with chronic rheumatic diseases. Calcif Tissue Int. 2000, 67: 19-23. 10.1007\/s00223001090.","journal-title":"Calcif Tissue Int"},{"key":"4171_CR18","first-page":"54","volume":"10","author":"A G\u00f3rska","year":"2008","unstructured":"G\u00f3rska A, Urban M, Bartnicka M, Zelazowska-Rutkowska B, Wysocka J: Bone mineral metabolism in children with juvenile idiopathic arthritis: preliminary report. Ortop Traumatol Rehabil. 2008, 10: 54-62.","journal-title":"Ortop Traumatol Rehabil"},{"key":"4171_CR19","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/03009749950155733","volume":"28","author":"A Kotaniemi","year":"1999","unstructured":"Kotaniemi A, Savolainen A, Kr\u00f6ger H, Kautiainen H, Isom\u00e4ki H: Weight-bearing physical activity, calcium intake, systemic glucocorticoids, chronic inflammation, and body constitution as determinants of lumbar and femoral bone mineral in juvenile chronic arthritis. Scand J Rheumatol. 1999, 28: 19-26.","journal-title":"Scand J Rheumatol"},{"key":"4171_CR20","first-page":"224","volume":"60","author":"A Lurati","year":"2008","unstructured":"Lurati A, Cimaz R, Gattinara M, Gerloni V, Teruzzi B, Salmaso A, Fantini F: Skeletal mineralization in a prepubertal female population affected by juvenile idiopathic arthritis. Reumatismo. 2008, 60: 224-229.","journal-title":"Reumatismo"},{"key":"4171_CR21","first-page":"495","volume":"16","author":"RM Pereira","year":"1998","unstructured":"Pereira RM, Corrente JE, Chahade WH, Yoshinari NH: Evaluation by dual X-ray absorptiometry (DXA) of bone mineral density in children with juvenile chronic arthritis. Clin Exp Rheumatol. 1998, 16: 495-501.","journal-title":"Clin Exp Rheumatol"},{"key":"4171_CR22","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1002\/art.20963","volume":"52","author":"G Lien","year":"2005","unstructured":"Lien G, Selvaag AM, Flat\u00f8 B, Haugen M, Vinje O, S\u00f8rskaar D, Dale K, Egeland T, F\u00f8rre \u00d8: A two-year prospective controlled study of bone mass and bone turnover in children with early juvenile idiopathic arthritis. Arthritis Rheum. 2005, 52: 833-840. 10.1002\/art.20963.","journal-title":"Arthritis Rheum"},{"key":"4171_CR23","first-page":"390","volume":"31","author":"RE Petty","year":"2004","unstructured":"Petty RE, Southwood TR, Manners P, Baum J, Glass DN, Goldenberg J, He X, Maldonado-Cocco J, Orozco-Alcala J, Prieur AM, Suarez-Almazor ME, Woo P, International League of Associations for Rheumatology: International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001. J Rheumatol. 2004, 31: 390-392.","journal-title":"J Rheumatol"},{"key":"4171_CR24","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1007\/BF03344156","volume":"29","author":"E Cacciari","year":"2006","unstructured":"Cacciari E, Milani S, Balsamo A, Spada E, Bona G, Cavallo L, Cerutti F, Gargantini L, Greggio N, Tonini G, Cicognani A: Italian cross-sectional growth charts for height, weight and BMI (2 to 20\u00a0yr). J Endocrinol Invest. 2006, 29: 581-593. 10.1007\/BF03344156.","journal-title":"J Endocrinol Invest"},{"key":"4171_CR25","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1136\/adc.51.3.170","volume":"51","author":"JM Tanner","year":"1976","unstructured":"Tanner JM, Whitehouse RH: Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. Arch Dis Child. 1976, 51: 170-179. 10.1136\/adc.51.3.170.","journal-title":"Arch Dis Child"},{"key":"4171_CR26","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/0169-6009(92)90712-M","volume":"17","author":"H Kr\u00f6ger","year":"1992","unstructured":"Kr\u00f6ger H, Kotaniemi A, Vainio P, Alhava E: Bone densitometry of the spine and femur in children by dual-energy x-ray absorptiometry. Bone Miner. 1992, 17: 75-85.","journal-title":"Bone Miner"},{"key":"4171_CR27","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/S8756-3282(95)00162-X","volume":"17","author":"H Kr\u00f6ger","year":"1995","unstructured":"Kr\u00f6ger H, Vainio P, Nieminen J, Kotaniemi A: Comparison of different models for interpreting bone mineral density measurements using DXA and MRI technology. Bone. 1995, 17: 157-159. 10.1016\/S8756-3282(95)00162-X.","journal-title":"Bone"},{"key":"4171_CR28","first-page":"234","volume":"6","author":"G D\u2019Elia","year":"2009","unstructured":"D\u2019Elia G, Caracchini G, Cavalli L, Innocenti P: Bone fragility and imaging techniques. Clin Cases Miner Bone Metab. 2009, 6: 234-246.","journal-title":"Clin Cases Miner Bone Metab"},{"key":"4171_CR29","first-page":"1058","volume":"29","author":"HI Brunner","year":"2002","unstructured":"Brunner HI, Lovell DJ, Finck BK, Giannini EH: Preliminary definition of disease flare in juvenile rheumatoid arthritis. J Rheumatol. 2002, 29: 1058-1064.","journal-title":"J Rheumatol"},{"key":"4171_CR30","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1002\/art.20128","volume":"50","author":"J Roth","year":"2004","unstructured":"Roth J, Palm C, Scheunemann I, Ranke MB, Schweizer R, Dannecker GE: Musculoskeletal abnormalities of the forearm in patients with juvenile idiopathic arthritis relate mainly to bone geometry. Arthritis Rheum. 2004, 50: 1277-1285. 10.1002\/art.20128.","journal-title":"Arthritis Rheum"},{"key":"4171_CR31","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1002\/art.22420","volume":"56","author":"EM Felin","year":"2007","unstructured":"Felin EM, Prahalad S, Askew EW, Moyer-Mileur LJ: Musculoskeletal abnormalities of the tibia in juvenile rheumatoid arthritis. Arthritis Rheum. 2007, 56: 984-994. 10.1002\/art.22420.","journal-title":"Arthritis Rheum"},{"key":"4171_CR32","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1093\/rheumatology\/keh592","volume":"44","author":"G Simonini","year":"2005","unstructured":"Simonini G, Giani T, Stagi S, de Martino M, Falcini F: Bone status over 1\u00a0yr of etanercept treatment in juvenile idiopathic arthritis. Rheumatology (Oxford). 2005, 44: 777-780. 10.1093\/rheumatology\/keh592.","journal-title":"Rheumatology (Oxford)"},{"key":"4171_CR33","doi-asserted-by":"publisher","first-page":"3573","DOI":"10.1002\/art.22181","volume":"54","author":"B Flat\u00f8","year":"2006","unstructured":"Flat\u00f8 B, Hoffmann-Vold AM, Reiff A, F\u00f8rre \u00d8, Lien G, Vinje O: Long-term outcome and prognostic factors in enthesitis-related arthritis: a case\u2013control study. Arthritis Rheum. 2006, 54: 3573-3582. 10.1002\/art.22181.","journal-title":"Arthritis Rheum"},{"key":"4171_CR34","doi-asserted-by":"publisher","first-page":"2319","DOI":"10.1002\/1529-0131(199911)42:11<2319::AID-ANR9>3.0.CO;2-G","volume":"42","author":"J Gratac\u00f3s","year":"1999","unstructured":"Gratac\u00f3s J, Collado A, Pons F, Osaba M, Sanmart\u00ed R, Roqu\u00e9 M, Larrosa M, M\u00fa\u00f1oz-G\u00f3mez J: Significant loss of bone mass in patients with early, active ankylosing spondylitis: a followup study. Arthritis Rheum. 1999, 42: 2319-2324. 10.1002\/1529-0131(199911)42:11<2319::AID-ANR9>3.0.CO;2-G.","journal-title":"Arthritis Rheum"},{"key":"4171_CR35","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1111\/j.1600-065X.2012.01154.x","volume":"249","author":"G Matarese","year":"2012","unstructured":"Matarese G, Procaccini C, De Rosa V: At the crossroad of T cells, adipose tissue, and diabetes. Immunol Rev. 2012, 249: 116-134. 10.1111\/j.1600-065X.2012.01154.x.","journal-title":"Immunol Rev"},{"key":"4171_CR36","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1186\/1476-511X-10-110","volume":"10","author":"M Mei","year":"2011","unstructured":"Mei M, Zhao L, Li Q, Chen Y, Huang A, Varghese Z, Moorhead JF, Zhang S, Powis SH, Li Q, Ruan XZ: Inflammatory stress exacerbates ectopic lipid deposition in C57BL\/6\u00a0J mice. Lipids Health Dis. 2011, 10: 110-10.1186\/1476-511X-10-110.","journal-title":"Lipids Health Dis"},{"key":"4171_CR37","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/BF00310168","volume":"55","author":"C Gl\u00fcer","year":"1994","unstructured":"Gl\u00fcer C, Wu C, Jergas M, Goldstein S, Genant H: Three quantitative ultrasound parameters reflect bone structure. Calcif Tissue Int. 1994, 55: 45-52.","journal-title":"Calcif Tissue Int"},{"key":"4171_CR38","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.2214\/ajr.157.6.1950872","volume":"157","author":"KG Faulkner","year":"1991","unstructured":"Faulkner KG, Gl\u00fcer CC, Majumdar S, Lang P, Engelke K, Genant HK: Noninvasive measurements of bone mass, structure, and strength: current methods and experimental techniques. AJR Am J Roentgenol. 1991, 157: 1229-1237. 10.2214\/ajr.157.6.1950872.","journal-title":"AJR Am J Roentgenol"}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/ar4525.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/ar4525\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/ar4525.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T10:14:30Z","timestamp":1728382470000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/ar4525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,31]]},"references-count":38,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,4]]}},"alternative-id":["4171"],"URL":"https:\/\/doi.org\/10.1186\/ar4525","relation":{},"ISSN":["1478-6354"],"issn-type":[{"value":"1478-6354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,31]]},"assertion":[{"value":"15 September 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 March 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 March 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"R83"}}