{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:24:14Z","timestamp":1791350654607,"version":"4.3.1"},"reference-count":70,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2014,5,16]],"date-time":"2014-05-16T00:00:00Z","timestamp":1400198400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2014,5,16]],"date-time":"2014-05-16T00:00:00Z","timestamp":1400198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Introduction<\/jats:title>\n                        <jats:p>Microsomal prostaglandin E synthase 1 (mPGES-1) catalyzes the terminal step in the biosynthesis of PGE<jats:sub>2<\/jats:sub>, a critical mediator in the pathophysiology of osteoarthritis (OA). Histone methylation plays an important role in epigenetic gene regulation. In this study, we investigated the roles of histone H3 lysine 9 (H3K9) methylation in interleukin 1\u03b2 (IL-1\u03b2)-induced mPGES-1 expression in human chondrocytes.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Methods<\/jats:title>\n                        <jats:p>Chondrocytes were stimulated with IL-1\u03b2, and the expression of mPGES-1 mRNA was evaluated using real-time RT-PCR. H3K9 methylation and the recruitment of the histone demethylase lysine-specific demethylase 1 (LSD1) to the mPGES-1 promoter were evaluated using chromatin immunoprecipitation assays. The role of LSD1 was further evaluated using the pharmacological inhibitors tranylcypromine and pargyline and small interfering RNA (siRNA)-mediated gene silencing. The LSD1 level in cartilage was determined by RT-PCR and immunohistochemistry.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>The induction of mPGES-1 expression by IL-1\u03b2 correlated with decreased levels of mono- and dimethylated H3K9 at the mPGES-1 promoter. These changes were concomitant with the recruitment of the histone demethylase LSD1. Treatment with tranylcypromine and pargyline, which are potent inhibitors of LSD1, prevented IL-1\u03b2-induced H3K9 demethylation at the mPGES-1 promoter and expression of mPGES-1. Consistently, LSD1 gene silencing with siRNA prevented IL-1\u03b2-induced H3K9 demethylation and mPGES-1 expression, suggesting that LSD1 mediates IL-1\u03b2-induced mPGES-1 expression via H3K9 demethylation. We show that the level of LSD1 was elevated in OA compared to normal cartilage.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusion<\/jats:title>\n                        <jats:p>These results indicate that H3K9 demethylation by LSD1 contributes to IL-1\u03b2-induced mPGES-1 expression and suggest that this pathway could be a potential target for pharmacological intervention in the treatment of OA and possibly other arthritic conditions.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/ar4564","type":"journal-article","created":{"date-parts":[[2014,5,16]],"date-time":"2014-05-16T09:19:57Z","timestamp":1400231997000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Lysine-specific demethylase 1-mediated demethylation of histone H3 lysine 9 contributes to interleukin 1\u03b2-induced microsomal prostaglandin E synthase 1 expression in human osteoarthritic chondrocytes"],"prefix":"10.1186","volume":"16","author":[{"given":"Fatima Ezzahra","family":"El Mansouri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salwa-Sarah","family":"Nebbaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohit","family":"Kapoor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Afif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanne","family":"Martel-Pelletier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Pelletier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Benderdour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Fahmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,5,16]]},"reference":[{"key":"4194_CR1","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1002\/1529-0131(199805)41:5<778::AID-ART4>3.0.CO;2-V","volume":"41","author":"RC Lawrence","year":"1998","unstructured":"Lawrence RC, Helmick CG, Arnett FC, Deyo RA, Felson DT, Giannini EH, Heyse SP, Hirsch R, Hochberg MC, Hunder GG, Hunder GG, Liang MH, Pillemer SR, Steen VD, Wolfe F: Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States. Arthritis Rheum. 1998, 41: 778-799. 10.1002\/1529-0131(199805)41:5<778::AID-ART4>3.0.CO;2-V.","journal-title":"Arthritis Rheum"},{"key":"4194_CR2","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.1002\/art.34453","volume":"64","author":"RF Loeser","year":"2012","unstructured":"Loeser RF, Goldring SR, Scanzello CR, Goldring MB: Osteoarthritis: a disease of the joint as an organ. Arthritis Rheum. 2012, 64: 1697-1707. 10.1002\/art.34453.","journal-title":"Arthritis Rheum"},{"key":"4194_CR3","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1097\/BOR.0b013e328349c2b1","volume":"23","author":"MB Goldring","year":"2011","unstructured":"Goldring MB, Otero M: Inflammation in osteoarthritis. Curr Opin Rheumatol. 2011, 23: 471-478. 10.1097\/BOR.0b013e328349c2b1.","journal-title":"Curr Opin Rheumatol"},{"key":"4194_CR4","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1002\/jbmr.5650070407","volume":"7","author":"RJ O\u2019Keefe","year":"1992","unstructured":"O\u2019Keefe RJ, Crabb ID, Puzas JE, Rosier RN: Influence of prostaglandins on DNA and matrix synthesis in growth plate chondrocytes. J Bone Miner Res. 1992, 7: 397-404. 10.1002\/jbmr.5650071406.","journal-title":"J Bone Miner Res"},{"key":"4194_CR5","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1172\/JCI119280","volume":"99","author":"AR Amin","year":"1997","unstructured":"Amin AR, Attur M, Patel RN, Thakker GD, Marshall PJ, Rediske J, Stuchin SA, Patel IR, Abramson SB: Superinduction of cyclooxygenase-2 activity in human osteoarthritis-affected cartilage. Influence of nitric oxide. J Clin Invest. 1997, 99: 1231-1237. 10.1172\/JCI119280.","journal-title":"J Clin Invest"},{"key":"4194_CR6","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1002\/art.10356","volume":"46","author":"MM Hardy","year":"2002","unstructured":"Hardy MM, Seibert K, Manning PT, Currie MG, Woerner BM, Edwards D, Koki A, Tripp CS: Cyclooxygenase 2-dependent prostaglandin E2 modulates cartilage proteoglycan degradation in human osteoarthritis explants. Arthritis Rheum. 2002, 46: 1789-1803. 10.1002\/art.10356.","journal-title":"Arthritis Rheum"},{"key":"4194_CR7","doi-asserted-by":"crossref","first-page":"3570","DOI":"10.4049\/jimmunol.155.7.3570","volume":"155","author":"K Mehindate","year":"1995","unstructured":"Mehindate K, al-Daccak R, Dayer JM, Kennedy BP, Kris C, Borgeat P, Poubelle PE, Mourad W: Superantigen-induced collagenase gene expression in human IFN-\u03b3-treated fibroblast-like synoviocytes involves prostaglandin E2: evidence for a role of cyclooxygenase-2 and cytosolic phospholipase A2. J Immunol. 1995, 155: 3570-3577.","journal-title":"J Immunol"},{"key":"4194_CR8","doi-asserted-by":"publisher","first-page":"6244","DOI":"10.4049\/jimmunol.0903315","volume":"185","author":"M Gosset","year":"2010","unstructured":"Gosset M, Pigenet A, Salvat C, Berenbaum F, Jacques C: Inhibition of matrix metalloproteinase-3 and -13 synthesis induced by IL-1\u03b2 in chondrocytes from mice lacking microsomal prostaglandin E synthase-1. J Immunol. 2010, 185: 6244-6252. 10.4049\/jimmunol.0903315.","journal-title":"J Immunol"},{"key":"4194_CR9","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1053\/joca.1999.0266","volume":"8","author":"M Miwa","year":"2000","unstructured":"Miwa M, Saura R, Hirata S, Hayashi Y, Mizuno K, Itoh H: Induction of apoptosis in bovine articular chondrocyte by prostaglandin E2 through cAMP-dependent pathway. Osteoarthritis Cartilage. 2000, 8: 17-24. 10.1053\/joca.1999.0266.","journal-title":"Osteoarthritis Cartilage"},{"key":"4194_CR10","first-page":"14","volume":"31","author":"J Martel-Pelletier","year":"2004","unstructured":"Martel-Pelletier J, Pelletier JP, Fahmi H: New insights into prostaglandin biology. J Rheumatol. 2004, 31: 14-16.","journal-title":"J Rheumatol"},{"key":"4194_CR11","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/S0049-0172(03)00134-3","volume":"33","author":"J Martel-Pelletier","year":"2003","unstructured":"Martel-Pelletier J, Pelletier JP, Fahmi H: Cyclooxygenase-2 and prostaglandins in articular tissues. Semin Arthritis Rheum. 2003, 33: 155-167. 10.1016\/S0049-0172(03)00134-3.","journal-title":"Semin Arthritis Rheum"},{"key":"4194_CR12","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1097\/01.bor.0000129664.81052.8e","volume":"16","author":"H Fahmi","year":"2004","unstructured":"Fahmi H: mPGES-1 as a novel target for arthritis. Curr Opin Rheumatol. 2004, 16: 623-627. 10.1097\/01.bor.0000129664.81052.8e.","journal-title":"Curr Opin Rheumatol"},{"key":"4194_CR13","doi-asserted-by":"publisher","first-page":"32775","DOI":"10.1074\/jbc.M003504200","volume":"275","author":"T Tanioka","year":"2000","unstructured":"Tanioka T, Nakatani Y, Semmyo N, Murakami M, Kudo I: Molecular identification of cytosolic prostaglandin E2 synthase that is functionally coupled with cyclooxygenase-1 in immediate prostaglandin E2 biosynthesis. J Biol Chem. 2000, 275: 32775-32782.","journal-title":"J Biol Chem"},{"key":"4194_CR14","doi-asserted-by":"publisher","first-page":"32783","DOI":"10.1074\/jbc.M003505200","volume":"275","author":"M Murakami","year":"2000","unstructured":"Murakami M, Naraba H, Tanioka T, Semmyo N, Nakatani Y, Kojima F, Ikeda T, Fueki M, Ueno A, Oh S, Kudo I: Regulation of prostaglandin E2 biosynthesis by inducible membrane-associated prostaglandin E2 synthase that acts in concert with cyclooxygenase-2. J Biol Chem. 2000, 275: 32783-32792.","journal-title":"J Biol Chem"},{"key":"4194_CR15","doi-asserted-by":"publisher","first-page":"2931","DOI":"10.1002\/art.11271","volume":"48","author":"Y Murakami","year":"2003","unstructured":"Murakami Y, Akahoshi T, Hayashi I, Endo H, Hashimoto A, Kono S, Kondo H, Kawai S, Inoue M, Kitasato H: Inhibition of monosodium urate monohydrate crystal-induced acute inflammation by retrovirally transfected prostaglandin D synthase. Arthritis Rheum. 2003, 48: 2931-2941. 10.1002\/art.11271.","journal-title":"Arthritis Rheum"},{"key":"4194_CR16","first-page":"887","volume":"32","author":"X Li","year":"2005","unstructured":"Li X, Afif H, Cheng S, Martel-Pelletier J, Pelletier JP, Ranger P, Fahmi H: Expression and regulation of microsomal prostaglandin E synthase-1 in human osteoarthritic cartilage and chondrocytes. J Rheumatol. 2005, 32: 887-895.","journal-title":"J Rheumatol"},{"key":"4194_CR17","doi-asserted-by":"publisher","first-page":"R355","DOI":"10.1186\/ar1195","volume":"6","author":"F Kojima","year":"2004","unstructured":"Kojima F, Naraba H, Miyamoto S, Beppu M, Aoki H, Kawai S: Membrane-associated prostaglandin E synthase-1 is upregulated by proinflammatory cytokines in chondrocytes from patients with osteoarthritis. Arthritis Res Ther. 2004, 6: R355-R365. 10.1186\/ar1195.","journal-title":"Arthritis Res Ther"},{"key":"4194_CR18","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.1002\/art.20286","volume":"50","author":"M Korotkova","year":"2004","unstructured":"Korotkova M, af Klint E, Stark A, Audoly LP, Klareskog L, Ulfgren AK, Jakobsson PJ: Expression of microsomal prostaglandin E synthase 1 in rheumatoid arthritis synovium. Arthritis Rheum. 2004, 50: 1774-1780. 10.1002\/art.20286.","journal-title":"Arthritis Rheum"},{"key":"4194_CR19","doi-asserted-by":"publisher","first-page":"4738","DOI":"10.4049\/jimmunol.170.9.4738","volume":"170","author":"D Claveau","year":"2003","unstructured":"Claveau D, Sirinyan M, Guay J, Gordon R, Chan CC, Bureau Y, Riendeau D, Mancini JA: Microsomal prostaglandin E synthase-1 is a major terminal synthase that is selectively up-regulated during cyclooxygenase-2-dependent prostaglandin E2 production in the rat adjuvant-induced arthritis model. J Immunol. 2003, 170: 4738-4744. 10.4049\/jimmunol.170.9.4738.","journal-title":"J Immunol"},{"key":"4194_CR20","doi-asserted-by":"publisher","first-page":"9044","DOI":"10.1073\/pnas.1332766100","volume":"100","author":"CE Trebino","year":"2003","unstructured":"Trebino CE, Stock JL, Gibbons CP, Naiman BM, Wachtmann TS, Umland JP, Pandher K, Lapointe JM, Saha S, Roach ML, Carter D, Thomas NA, Durtschi BA, McNeish JD, Hambor JE, Jakobsson PJ, Carty TJ, Perez JR, Audoly LP: Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase. Proc Natl Acad Sci U S A. 2003, 100: 9044-9049. 10.1073\/pnas.1332766100.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4194_CR21","doi-asserted-by":"publisher","first-page":"33684","DOI":"10.1074\/jbc.M400199200","volume":"279","author":"D Kamei","year":"2004","unstructured":"Kamei D, Yamakawa K, Takegoshi Y, Mikami-Nakanishi M, Nakatani Y, Oh-Ishi S, Yasui H, Azuma Y, Hirasawa N, Ohuchi K, Kawaguchi H, Ishikawa Y, Ishii T, Uematsu S, Akira S, Murakami M, Kudo I: Reduced pain hypersensitivity and inflammation in mice lacking microsomal prostaglandin E synthase-1. J Biol Chem. 2004, 279: 33684-33695. 10.1074\/jbc.M400199200.","journal-title":"J Biol Chem"},{"key":"4194_CR22","doi-asserted-by":"publisher","first-page":"8361","DOI":"10.4049\/jimmunol.180.12.8361","volume":"180","author":"F Kojima","year":"2008","unstructured":"Kojima F, Kapoor M, Yang L, Fleishaker EL, Ward MR, Monrad SU, Kottangada PC, Pace CQ, Clark JA, Woodward JG, Crofford LJ: Defective generation of a humoral immune response is associated with a reduced incidence and severity of collagen-induced arthritis in microsomal prostaglandin E synthase-1 null mice. J Immunol. 2008, 180: 8361-8368. 10.4049\/jimmunol.180.12.8361.","journal-title":"J Immunol"},{"key":"4194_CR23","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.4049\/jimmunol.177.3.1879","volume":"177","author":"M Inada","year":"2006","unstructured":"Inada M, Matsumoto C, Uematsu S, Akira S, Miyaura C: Membrane-bound prostaglandin E synthase-1-mediated prostaglandin E2 production by osteoblast plays a critical role in lipopolysaccharide-induced bone loss associated with inflammation. J Immunol. 2006, 177: 1879-1885. 10.4049\/jimmunol.177.3.1879.","journal-title":"J Immunol"},{"key":"4194_CR24","doi-asserted-by":"publisher","first-page":"2829","DOI":"10.1002\/art.20437","volume":"50","author":"K Masuko-Hongo","year":"2004","unstructured":"Masuko-Hongo K, Berenbaum F, Humbert L, Salvat C, Goldring MB, Thirion S: Up-regulation of microsomal prostaglandin E synthase 1 in osteoarthritic human cartilage: critical roles of the ERK-1\/2 and p38 signaling pathways. Arthritis Rheum. 2004, 50: 2829-2838. 10.1002\/art.20437.","journal-title":"Arthritis Rheum"},{"key":"4194_CR25","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1038\/cr.2011.22","volume":"21","author":"AJ Bannister","year":"2011","unstructured":"Bannister AJ, Kouzarides T: Regulation of chromatin by histone modifications. Cell Res. 2011, 21: 381-395. 10.1038\/cr.2011.22.","journal-title":"Cell Res"},{"key":"4194_CR26","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1038\/nsmb.2470","volume":"20","author":"GE Zentner","year":"2013","unstructured":"Zentner GE, Henikoff S: Regulation of nucleosome dynamics by histone modifications. Nat Struct Mol Biol. 2013, 20: 259-266. 10.1038\/nsmb.2470.","journal-title":"Nat Struct Mol Biol"},{"key":"4194_CR27","doi-asserted-by":"publisher","first-page":"641","DOI":"10.2217\/epi.12.56","volume":"4","author":"W Fischle","year":"2012","unstructured":"Fischle W: One, two, three: how histone methylation is read. Epigenomics. 2012, 4: 641-653. 10.2217\/epi.12.56.","journal-title":"Epigenomics"},{"key":"4194_CR28","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.molcel.2012.11.006","volume":"48","author":"JC Black","year":"2012","unstructured":"Black JC, Van Rechem C, Whetstine JR: Histone lysine methylation dynamics: establishment, regulation, and biological impact. Mol Cell. 2012, 48: 491-507. 10.1016\/j.molcel.2012.11.006.","journal-title":"Mol Cell"},{"key":"4194_CR29","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1042\/BC20110028","volume":"103","author":"L Verrier","year":"2011","unstructured":"Verrier L, Vandromme M, Trouche D: Histone demethylases in chromatin cross-talks. Biol Cell. 2011, 103: 381-401. 10.1042\/BC20110028.","journal-title":"Biol Cell"},{"key":"4194_CR30","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/j.cell.2004.12.012","volume":"119","author":"Y Shi","year":"2004","unstructured":"Shi Y, Lan F, Matson C, Mulligan P, Whetstine JR, Cole PA, Casero RA, Shi Y: Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell. 2004, 119: 941-953. 10.1016\/j.cell.2004.12.012.","journal-title":"Cell"},{"key":"4194_CR31","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/nature04021","volume":"437","author":"MG Lee","year":"2005","unstructured":"Lee MG, Wynder C, Cooch N, Shiekhattar R: An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation. Nature. 2005, 437: 432-435.","journal-title":"Nature"},{"key":"4194_CR32","doi-asserted-by":"publisher","first-page":"3691","DOI":"10.1038\/onc.2010.120","volume":"29","author":"S Amente","year":"2010","unstructured":"Amente S, Bertoni A, Morano A, Lania L, Avvedimento EV, Majello B: LSD1-mediated demethylation of histone H3 lysine 4 triggers Myc-induced transcription. Oncogene. 2010, 29: 3691-3702. 10.1038\/onc.2010.120.","journal-title":"Oncogene"},{"key":"4194_CR33","doi-asserted-by":"publisher","first-page":"e62192","DOI":"10.1371\/journal.pone.0062192","volume":"8","author":"H Ouyang","year":"2013","unstructured":"Ouyang H, Qin Y, Liu Y, Xie Y, Liu J: Prox1 directly interacts with LSD1 and recruits the LSD1\/NuRD complex to epigenetically co-repress CYP7A1 transcription. PLoS One. 2013, 8: e62192-10.1371\/journal.pone.0062192.","journal-title":"PLoS One"},{"key":"4194_CR34","doi-asserted-by":"publisher","first-page":"e66294","DOI":"10.1371\/journal.pone.0066294","volume":"8","author":"D Pan","year":"2013","unstructured":"Pan D, Mao C, Wang YX: Suppression of gluconeogenic gene expression by LSD1-mediated histone demethylation. PLoS One. 2013, 8: e66294-10.1371\/journal.pone.0066294.","journal-title":"PLoS One"},{"key":"4194_CR35","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nature04020","volume":"437","author":"E Metzger","year":"2005","unstructured":"Metzger E, Wissmann M, Yin N, M\u00fcller JM, Schneider R, Peters AHFM, G\u00fcnther T, Buettner R, Sch\u00fcle R: LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. Nature. 2005, 437: 436-439.","journal-title":"Nature"},{"key":"4194_CR36","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/ncb1546","volume":"9","author":"M Wissmann","year":"2007","unstructured":"Wissmann M, Yin N, M\u00fcller JM, Greschik H, Fodor BD, Jenuwein T, Vogler C, Schneider R, G\u00fcnther T, Buettner R, Metzger E, Sch\u00fcle R: Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression. Nat Cell Biol. 2007, 9: 347-353. 10.1038\/ncb1546.","journal-title":"Nat Cell Biol"},{"key":"4194_CR37","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.cell.2006.12.038","volume":"128","author":"I Garcia-Bassets","year":"2007","unstructured":"Garcia-Bassets I, Kwon YS, Telese F, Prefontaine GG, Hutt KR, Cheng CS, Ju BG, Ohgi KA, Wang J, Escoubet-Lozach L, Rose DW, Glass CK, Fu XD, Rosenfeld MG: Histone methylation-dependent mechanisms impose ligand dependency for gene activation by nuclear receptors. Cell. 2007, 128: 505-518. 10.1016\/j.cell.2006.12.038.","journal-title":"Cell"},{"key":"4194_CR38","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1038\/nm.2051","volume":"15","author":"Y Liang","year":"2009","unstructured":"Liang Y, Vogel JL, Narayanan A, Peng H, Kristie TM: Inhibition of the histone demethylase LSD1 blocks \u03b1-herpesvirus lytic replication and reactivation from latency. Nat Med. 2009, 15: 1312-1317. 10.1038\/nm.2051.","journal-title":"Nat Med"},{"key":"4194_CR39","doi-asserted-by":"publisher","first-page":"31","DOI":"10.3109\/03009748709102175","volume":"65","author":"RD Altman","year":"1987","unstructured":"Altman RD: Criteria for the classification of osteoarthritis of the knee and hip. Scand J Rheumatol Suppl. 1987, 65: 31-39.","journal-title":"Scand J Rheumatol Suppl"},{"key":"4194_CR40","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1002\/art.27762","volume":"63","author":"FE El Mansouri","year":"2010","unstructured":"El Mansouri FE, Chabane N, Zayed N, Kapoor M, Benderdour M, Martel-Pelletier J, Pelletier JP, Duval N, Fahmi H: H3K4 methylation by Set1A contributes to IL-1\u2013induced COX-2 and iNOS expression in human OA chondrocytes. Arthritis Rheum. 2010, 63: 168-79.","journal-title":"Arthritis Rheum"},{"key":"4194_CR41","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1002\/jcb.22027","volume":"106","author":"N Chabane","year":"2009","unstructured":"Chabane N, Li X, Fahmi H: HDAC4 contributes to IL-1-induced mPGES-1 expression in human synovial fibroblasts through up-regulation of Egr-1 transcriptional activity. J Cell Biochem. 2009, 106: 453-463. 10.1002\/jcb.22027.","journal-title":"J Cell Biochem"},{"key":"4194_CR42","doi-asserted-by":"publisher","first-page":"19666","DOI":"10.1074\/jbc.M611527200","volume":"282","author":"C Lambert","year":"2007","unstructured":"Lambert C, Li J, Jonscher K, Yang TC, Reigan P, Quintana M, Harvey J, Freed BM: Acrolein inhibits cytokine gene expression by alkylating cysteine and arginine residues in the NF-\u03baB1 DNA binding domain. J Biol Chem. 2007, 282: 19666-19675. 10.1074\/jbc.M611527200.","journal-title":"J Biol Chem"},{"key":"4194_CR43","doi-asserted-by":"publisher","first-page":"9569","DOI":"10.1074\/jbc.M109.071241","volume":"285","author":"ID Mascanfroni","year":"2010","unstructured":"Mascanfroni ID, del Mar Montesinos M, Alamino VA, Susperreguy S, Nicola JP, Ilarregui JM, Masini-Repiso AM, Rabinovich GA, Pellizas CG: Nuclear factor (NF)-\u03baB-dependent thyroid hormone receptor \u03b21 expression controls dendritic cell function via Akt signaling. J Biol Chem. 2010, 285: 9569-9582. 10.1074\/jbc.M109.071241.","journal-title":"J Biol Chem"},{"key":"4194_CR44","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.cell.2006.03.027","volume":"125","author":"K Yamane","year":"2006","unstructured":"Yamane K, Toumazou C, Tsukada Y, Erdjument-Bromage H, Tempst P, Wong J, Zhang Y: JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor. Cell. 2006, 125: 483-495. 10.1016\/j.cell.2006.03.027.","journal-title":"Cell"},{"key":"4194_CR45","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1101\/gad.1864410","volume":"24","author":"Y Tsukada","year":"2010","unstructured":"Tsukada Y, Ishitani T, Nakayama KI: KDM7 is a dual demethylase for histone H3 Lys 9 and Lys 27 and functions in brain development. Genes Dev. 2010, 24: 432-437. 10.1101\/gad.1864410.","journal-title":"Genes Dev"},{"key":"4194_CR46","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1038\/nsmb.1778","volume":"17","author":"W Feng","year":"2010","unstructured":"Feng W, Yonezawa M, Ye J, Jenuwein T, Grummt I: PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1\/2 demethylation. Nat Struct Mol Biol. 2010, 17: 445-450. 10.1038\/nsmb.1778.","journal-title":"Nat Struct Mol Biol"},{"key":"4194_CR47","doi-asserted-by":"publisher","first-page":"9322","DOI":"10.1074\/jbc.C109.097667","volume":"285","author":"H Wen","year":"2010","unstructured":"Wen H, Li J, Song T, Lu M, Kan PY, Lee MG, Sha B, Shi X: Recognition of histone H3K4 trimethylation by the plant homeodomain of PHF2 modulates histone demethylation. J Biol Chem. 2010, 285: 9322-9326. 10.1074\/jbc.C109.097667.","journal-title":"J Biol Chem"},{"key":"4194_CR48","doi-asserted-by":"publisher","first-page":"2203","DOI":"10.1016\/j.febslet.2005.03.015","volume":"579","author":"F Forneris","year":"2005","unstructured":"Forneris F, Binda C, Vanoni MA, Mattevi A, Battaglioli E: Histone demethylation catalysed by LSD1 is a flavin-dependent oxidative process. FEBS Lett. 2005, 579: 2203-2207. 10.1016\/j.febslet.2005.03.015.","journal-title":"FEBS Lett"},{"key":"4194_CR49","doi-asserted-by":"publisher","first-page":"6395","DOI":"10.1128\/MCB.00723-06","volume":"26","author":"MG Lee","year":"2006","unstructured":"Lee MG, Wynder C, Bochar DA, Hakimi MA, Cooch N, Shiekhattar R: Functional interplay between histone demethylase and deacetylase enzymes. Mol Cell Biol. 2006, 26: 6395-6402. 10.1128\/MCB.00723-06.","journal-title":"Mol Cell Biol"},{"key":"4194_CR50","doi-asserted-by":"publisher","first-page":"4408","DOI":"10.1021\/bi0618621","volume":"46","author":"DMZ Schmidt","year":"2007","unstructured":"Schmidt DMZ, McCafferty DG: trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1. Biochemistry. 2007, 46: 4408-4416. 10.1021\/bi0618621.","journal-title":"Biochemistry"},{"key":"4194_CR51","doi-asserted-by":"publisher","first-page":"2219","DOI":"10.1101\/gad.232502","volume":"16","author":"S Saccani","year":"2002","unstructured":"Saccani S, Natoli G: Dynamic changes in histone H3 Lys 9 methylation occurring at tightly regulated inducible inflammatory genes. Genes Dev. 2002, 16: 2219-2224. 10.1101\/gad.232502.","journal-title":"Genes Dev"},{"key":"4194_CR52","doi-asserted-by":"publisher","first-page":"461","DOI":"10.4049\/jimmunol.175.1.461","volume":"175","author":"C Chan","year":"2005","unstructured":"Chan C, Li L, McCall CE, Yoza BK: Endotoxin tolerance disrupts chromatin remodeling and NF-\u03baB transactivation at the IL-1\u03b2 promoter. J Immunol. 2005, 175: 461-468. 10.4049\/jimmunol.175.1.461.","journal-title":"J Immunol"},{"key":"4194_CR53","doi-asserted-by":"publisher","first-page":"32198","DOI":"10.1074\/jbc.M803446200","volume":"283","author":"M El Gazzar","year":"2008","unstructured":"El Gazzar M, Yoza BK, Chen X, Hu J, Hawkins GA, McCall CE: G9a and HP1 couple histone and DNA methylation to TNF\u03b1 transcription silencing during endotoxin tolerance. J Biol Chem. 2008, 283: 32198-32208. 10.1074\/jbc.M803446200.","journal-title":"J Biol Chem"},{"key":"4194_CR54","doi-asserted-by":"publisher","first-page":"5496","DOI":"10.1128\/MCB.24.12.5496-5509.2004","volume":"24","author":"Z Ma","year":"2004","unstructured":"Ma Z, Shah RC, Chang MJ, Benveniste EN: Coordination of cell signaling, chromatin remodeling, histone modifications, and regulator recruitment in human matrix metalloproteinase 9 gene transcription. Mol Cell Biol. 2004, 24: 5496-5509. 10.1128\/MCB.24.12.5496-5509.2004.","journal-title":"Mol Cell Biol"},{"key":"4194_CR55","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.2337\/db08-1666","volume":"58","author":"D Brasacchio","year":"2009","unstructured":"Brasacchio D, Okabe J, Tikellis C, Balcerczyk A, George P, Baker EK, Calkin AC, Brownlee M, Cooper ME, El-Osta A: Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail. Diabetes. 2009, 58: 1229-1236. 10.2337\/db08-1666.","journal-title":"Diabetes"},{"key":"4194_CR56","doi-asserted-by":"publisher","first-page":"9047","DOI":"10.1073\/pnas.0803623105","volume":"105","author":"LM Villeneuve","year":"2008","unstructured":"Villeneuve LM, Reddy MA, Lanting LL, Wang M, Meng L, Natarajan R: Epigenetic histone H3 lysine 9 methylation in metabolic memory and inflammatory phenotype of vascular smooth muscle cells in diabetes. Proc Natl Acad Sci U S A. 2008, 105: 9047-9052. 10.1073\/pnas.0803623105.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4194_CR57","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.molcel.2006.12.010","volume":"25","author":"Y Shi","year":"2007","unstructured":"Shi Y, Whetstine JR: Dynamic regulation of histone lysine methylation by demethylases. Mol Cell. 2007, 25: 1-14. 10.1016\/j.molcel.2006.12.010.","journal-title":"Mol Cell"},{"key":"4194_CR58","doi-asserted-by":"publisher","first-page":"2559","DOI":"10.2337\/db12-1141","volume":"62","author":"Q Zhong","year":"2013","unstructured":"Zhong Q, Kowluru RA: Regulation of matrix metalloproteinase-9 by epigenetic modifications and the development of diabetic retinopathy. Diabetes. 2013, 62: 2559-2568. 10.2337\/db12-1141.","journal-title":"Diabetes"},{"key":"4194_CR59","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.molonc.2013.01.003","volume":"7","author":"V Kashyap","year":"2013","unstructured":"Kashyap V, Ahmad S, Nilsson EM, Helczynski L, Kenna S, Persson JL, Gudas LJ, Mongan NP: The lysine specific demethylase-1 (LSD1\/KDM1A) regulates VEGF-A expression in prostate cancer. Mol Oncol. 2013, 7: 555-566. 10.1016\/j.molonc.2013.01.003.","journal-title":"Mol Oncol"},{"key":"4194_CR60","doi-asserted-by":"publisher","first-page":"4084","DOI":"10.1002\/art.23136","volume":"56","author":"C Grimmer","year":"2007","unstructured":"Grimmer C, Pfander D, Swoboda B, Aigner T, Mueller L, Hennig FF, Gelse K: Hypoxia-inducible factor 1\u03b1 is involved in the prostaglandin metabolism of osteoarthritic cartilage through up-regulation of microsomal prostaglandin E synthase 1 in articular chondrocytes. Arthritis Rheum. 2007, 56: 4084-4094. 10.1002\/art.23136.","journal-title":"Arthritis Rheum"},{"key":"4194_CR61","doi-asserted-by":"publisher","first-page":"26731","DOI":"10.1074\/jbc.M113.483958","volume":"288","author":"H Xia","year":"2013","unstructured":"Xia H, Wang C, Chen W, Zhang H, Chaudhury L, Zhou Z, Liu R, Chen C: Kruppel-like factor 5 transcription factor promotes microsomal prostaglandin E2 synthase 1 gene transcription in breast cancer. J Biol Chem. 2013, 288: 26731-26740. 10.1074\/jbc.M113.483958.","journal-title":"J Biol Chem"},{"key":"4194_CR62","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.canlet.2014.02.013","volume":"347","author":"Y Qin","year":"2014","unstructured":"Qin Y, Zhu W, Xu W, Zhang B, Shi S, Ji S, Liu J, Long J, Liu C, Liu L, Xu J, Yu X: LSD1 sustains pancreatic cancer growth via maintaining HIF1\u03b1-dependent glycolytic process. Cancer Lett. 2014, 347: 225-32. 10.1016\/j.canlet.2014.02.013.","journal-title":"Cancer Lett"},{"key":"4194_CR63","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.stem.2010.02.014","volume":"6","author":"DLC van den Berg","year":"2010","unstructured":"van den Berg DLC, Snoek T, Mullin NP, Yates A, Bezstarosti K, Demmers J, Chambers I, Poot RA: An Oct4-centered protein interaction network in embryonic stem cells. Cell Stem Cell. 2010, 6: 369-381. 10.1016\/j.stem.2010.02.014.","journal-title":"Cell Stem Cell"},{"key":"4194_CR64","doi-asserted-by":"publisher","first-page":"1997","DOI":"10.1128\/MCB.01116-09","volume":"30","author":"G Sun","year":"2010","unstructured":"Sun G, Alzayady K, Stewart R, Ye P, Yang S, Li W, Shi Y: Histone demethylase LSD1 regulates neural stem cell proliferation. Mol Cell Biol. 2010, 30: 1997-2005. 10.1128\/MCB.01116-09.","journal-title":"Mol Cell Biol"},{"key":"4194_CR65","doi-asserted-by":"publisher","first-page":"3995","DOI":"10.1128\/MCB.02030-07","volume":"28","author":"A Yokoyama","year":"2008","unstructured":"Yokoyama A, Takezawa S, Schule R, Kitagawa H, Kato S: Transrepressive function of TLX requires the histone demethylase LSD1. Mol Cell Biol. 2008, 28: 3995-4003. 10.1128\/MCB.02030-07.","journal-title":"Mol Cell Biol"},{"key":"4194_CR66","doi-asserted-by":"publisher","first-page":"1904","DOI":"10.1093\/nar\/gkr857","volume":"40","author":"V Le Douce","year":"2012","unstructured":"Le Douce V, Colin L, Redel L, Cherrier T, Herbein G, Aunis D, Rohr O, Van Lint C, Schwartz C: LSD1 cooperates with CTIP2 to promote HIV-1 transcriptional silencing. Nucleic Acids Res. 2012, 40: 1904-1915. 10.1093\/nar\/gkr857.","journal-title":"Nucleic Acids Res"},{"key":"4194_CR67","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1038\/nature05671","volume":"446","author":"J Wang","year":"2007","unstructured":"Wang J, Scully K, Zhu X, Cai L, Zhang J, Prefontaine GG, Krones A, Ohgi KA, Zhu P, Garcia-Bassets I, Garcia-Bassets I, Liu F, Taylor H, Lozach J, Jayes FL, Korach KS, Glass CK, Fu XD, Rosenfeld MG: Opposing LSD1 complexes function in developmental gene activation and repression programmes. Nature. 2007, 446: 882-887. 10.1038\/nature05671.","journal-title":"Nature"},{"key":"4194_CR68","doi-asserted-by":"publisher","first-page":"7347","DOI":"10.1158\/0008-5472.CAN-08-4898","volume":"69","author":"L Escoubet-Lozach","year":"2009","unstructured":"Escoubet-Lozach L, Lin IL, Jensen-Pergakes K, Brady HA, Gandhi AK, Schafer PH, Muller GW, Worland PJ, Chan KWH, Verhelle D: Pomalidomide and lenalidomide induce p21WAF-1 expression in both lymphoma and multiple myeloma through a LSD1-mediated epigenetic mechanism. Cancer Res. 2009, 69: 7347-7356. 10.1158\/0008-5472.CAN-08-4898.","journal-title":"Cancer Res"},{"key":"4194_CR69","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1016\/S0960-9822(03)00432-9","volume":"13","author":"B Lehnertz","year":"2003","unstructured":"Lehnertz B, Ueda Y, Derijck AAHA, Braunschweig U, Perez-Burgos L, Kubicek S, Chen T, Li E, Jenuwein T, Peters AH: Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin. Curr Biol. 2003, 13: 1192-1200. 10.1016\/S0960-9822(03)00432-9.","journal-title":"Curr Biol"},{"key":"4194_CR70","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1038\/ncb1353","volume":"8","author":"N Feldman","year":"2006","unstructured":"Feldman N, Gerson A, Fang J, Li E, Zhang Y, Shinkai Y, Cedar H, Bergman Y: G9a-mediated irreversible epigenetic inactivation of Oct-3\/4 during early embryogenesis. Nat Cell Biol. 2006, 8: 188-194. 10.1038\/ncb1353.","journal-title":"Nat Cell Biol"}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/ar4564.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/ar4564\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/ar4564.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T16:16:26Z","timestamp":1728922586000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/ar4564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,16]]},"references-count":70,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,6]]}},"alternative-id":["4194"],"URL":"https:\/\/doi.org\/10.1186\/ar4564","relation":{},"ISSN":["1478-6354"],"issn-type":[{"value":"1478-6354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,16]]},"assertion":[{"value":"19 November 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 April 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 May 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"R113"}}