{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:11:38Z","timestamp":1790122298141,"version":"4.0.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2014,8,6]],"date-time":"2014-08-06T00:00:00Z","timestamp":1407283200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2014,8,6]],"date-time":"2014-08-06T00:00:00Z","timestamp":1407283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The arthritis-specific Work Productivity Survey (WPS) was developed to evaluate productivity limitations associated with arthritis within and outside the home. There is an unmet need for an instrument assessing similar productivity limitations in axial spondyloarthritis (axSpA), including nonradiographic axSpA and ankylosing spondylitis. Following its validation in rheumatoid and psoriatic arthritis, we aimed to assess psychometric properties of WPS in adult-onset active axSpA in this analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Psychometric properties were assessed using data from the RAPID-axSpA trial (NCT01087762) in which researchers investigated certolizumab pegol efficacy and safety in axSpA. WPS was completed at baseline and every 4\u00a0weeks until week 24. Validity was evaluated at study baseline via known-groups defined by the first and third quartile cutoffs of patient scores to Ankylosing Spondylitis Disease Activity Score (ASDAS), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), back pain, Bath Ankylosing Spondylitis Functional Index (BASFI), Short Form 36 health survey (SF-36) and Ankylosing Spondylitis Quality of Life Scale (ASQoL). Responsiveness and reliability were assessed by comparing WPS mean changes in ASAS 20% improvement criteria (ASAS20), BASDAI50, ASDAS clinically important improvement\/major improvement (CII\/MI) and BASFI minimum clinically important difference (MCID) responders versus nonresponders at week 12. All comparisons were conducted on observed cases in the randomized set using a nonparametric bootstrap-t method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results confirmed the psychometric properties of WPS. AxSpA patients with a worse health state had significantly more days of household work lost, household work with reduced productivity, social activities missed and outside help hired, as well as a higher interference rate of arthritis, than patients with a better health state. Similarly, employed patients with a worse health state had significantly more work days lost or with productivity reduced, and a higher interference of arthritis on work productivity. Similar findings were also observed in the nonradiographic (nr) axSpA and AS subpopulations. The WPS was responsive to clinical changes, with responders reporting larger improvements at week 12 in WPS scores versus nonresponders. Effect sizes in responders were generally moderate to large (standardized response mean &gt;0.5).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These analyses demonstrate that WPS is a valid, responsive and reliable instrument for the measurement of productivity within and outside the home in adult-onset axSpA, as well as the in subpopulations of AS and nr-axSpA.<\/jats:p><\/jats:sec>","DOI":"10.1186\/ar4680","type":"journal-article","created":{"date-parts":[[2014,8,6]],"date-time":"2014-08-06T09:06:22Z","timestamp":1407315982000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Discriminant validity, responsiveness and reliability of the arthritis-specific Work Productivity Survey assessing workplace and household productivity within and outside the home in patients with axial spondyloarthritis, including nonradiographic axial spondyloarthritis and ankylosing spondylitis"],"prefix":"10.1186","volume":"16","author":[{"given":"Jane T","family":"Osterhaus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oana","family":"Purcaru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,8,6]]},"reference":[{"key":"4379_CR1","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1002\/art.24483","volume":"60","author":"M Rudwaleit","year":"2009","unstructured":"Rudwaleit M, Haibel H, Baraliakos X, Listing J, M\u00e4rker-Hermann E, Zeidler H, Braun J, Sieper J: The early disease stage in axial spondylarthritis: results from the German Spondyloarthritis Inception Cohort. Arthritis Rheum. 2009, 60: 717-727.","journal-title":"Arthritis Rheum"},{"key":"4379_CR2","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1002\/art.1780270401","volume":"27","author":"S van der Linden","year":"1984","unstructured":"van der Linden S, Valkenburg HA, Cats A: Evaluation of diagnostic criteria for ankylosing spondylitis: a proposal for modification of the New York criteria. Arthritis Rheum. 1984, 27: 361-368.","journal-title":"Arthritis Rheum"},{"key":"4379_CR3","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1136\/ard.44.6.359","volume":"44","author":"JT Gran","year":"1985","unstructured":"Gran JT, Husby G, Hordvik M: Prevalence of ankylosing spondylitis in males and females in a young middle-aged population of Tromso, northern Norway. Ann Rheum Dis. 1985, 44: 359-367.","journal-title":"Ann Rheum Dis"},{"key":"4379_CR4","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1080\/03009740510018679","volume":"34","author":"J Braun","year":"2005","unstructured":"Braun J, Baraliakos X, Godolias G, B\u00f6hm H: Therapy of ankylosing spondylitis\u2013a review. Part I: Conventional medical treatment and surgical therapy. Scand J Rheumatol. 2005, 34: 97-108.","journal-title":"Scand J Rheumatol"},{"key":"4379_CR5","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1002\/acr.21621","volume":"64","author":"JD Reveille","year":"2012","unstructured":"Reveille JD, Witter JP, Weisman MH: Prevalence of axial spondylarthritis in the United States: estimates from a cross-sectional survey. Arthritis Care Res. 2012, 64: 905-910.","journal-title":"Arthritis Care Res"},{"key":"4379_CR6","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00296-002-0237-4","volume":"23","author":"E Feldtkeller","year":"2003","unstructured":"Feldtkeller E, Khan MA, van der Heijde D, van der Linden S, Braun J: Age at disease onset and diagnosis delay in HLA-B27 negative vs. positive patients with ankylosing spondylitis. Rheumatol Int. 2003, 23: 61-66.","journal-title":"Rheumatol Int"},{"key":"4379_CR7","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1002\/art.20910","volume":"53","author":"H Dagfinrud","year":"2005","unstructured":"Dagfinrud H, Vollestad NK, Loge JH, Kvien TK, Mengshoel AM: Fatigue in patients with ankylosing spondylitis: a comparison with the general population and associations with clinical and self-reported measures. Arthritis Rheum. 2005, 53: 5-11.","journal-title":"Arthritis Rheum"},{"key":"4379_CR8","first-page":"764","volume":"30","author":"KL Haywood","year":"2003","unstructured":"Haywood KL, Garratt AM, Dziedzic K, Dawes PT: Patient centered assessment of ankylosing spondylitis-specific health related quality of life: evaluation of the Patient Generated Index. J Rheumatol. 2003, 30: 764-773.","journal-title":"J Rheumatol"},{"key":"4379_CR9","first-page":"S118","volume":"27","author":"LC Franke","year":"2009","unstructured":"Franke LC, Ament AJ, van de Laar MA, Boonen A, Severens JL: Cost-of-illness of rheumatoid arthritis and ankylosing spondylitis. Clin Exp Rheumatol. 2009, 27: S118-S123.","journal-title":"Clin Exp Rheumatol"},{"key":"4379_CR10","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1136\/ard.2009.116764","volume":"69","author":"A Boonen","year":"2010","unstructured":"Boonen A, Brinkhuizen T, Landew\u00e9 R, van der Heijde D, Severens JL: Impact of ankylosing spondylitis on sick leave, presenteeism and unpaid productivity, and estimation of the societal cost. Ann Rheum Dis. 2010, 69: 1123-1128.","journal-title":"Ann Rheum Dis"},{"key":"4379_CR11","first-page":"1056","volume":"28","author":"A Boonen","year":"2001","unstructured":"Boonen A, de Vet H, van der Heijde D, van der Linden S: Work status and its determinants among patients with ankylosing spondylitis: a systematic literature review. J Rheumatol. 2001, 28: 1056-1062.","journal-title":"J Rheumatol"},{"key":"4379_CR12","doi-asserted-by":"crossref","first-page":"iv65","DOI":"10.1136\/ard.2005.042440","volume":"64","author":"A Kavanaugh","year":"2005","unstructured":"Kavanaugh A: Health economics: implications for novel antirheumatic therapies. Ann Rheum Dis. 2005, 64: iv65-iv69.","journal-title":"Ann Rheum Dis"},{"key":"4379_CR13","first-page":"1372","volume":"34","author":"R Escorpizo","year":"2007","unstructured":"Escorpizo R, Bombardier C, Boonen A, Hazes JM, Lacaille D, Strand V, Beaton D: Worker productivity outcome measures in arthritis. J Rheumatol. 2007, 34: 1372-1380.","journal-title":"J Rheumatol"},{"key":"4379_CR14","doi-asserted-by":"publisher","first-page":"225","DOI":"10.2165\/00019053-200422040-00002","volume":"22","author":"M Prasad","year":"2004","unstructured":"Prasad M, Wahlqvist P, Shikiar R, Shih YC: A review of self-report instruments measuring health-related work productivity: a patient-reported outcomes perspective. Pharmacoeconomics. 2004, 22: 225-244.","journal-title":"Pharmacoeconomics"},{"key":"4379_CR15","first-page":"211","volume":"13","author":"S Mattke","year":"2007","unstructured":"Mattke S, Balakrishnan A, Bergamo G, Newberry SJ: A review of methods to measure health-related productivity loss. Am J Manag Care. 2007, 13: 211-217.","journal-title":"Am J Manag Care"},{"key":"4379_CR16","doi-asserted-by":"publisher","first-page":"165","DOI":"10.2165\/00019053-200422030-00003","volume":"22","author":"JH Lofland","year":"2004","unstructured":"Lofland JH, Pizzi L, Frick KD: A review of health-related workplace productivity loss instruments. Pharmacoeconomics. 2004, 22: 165-184.","journal-title":"Pharmacoeconomics"},{"key":"4379_CR17","doi-asserted-by":"publisher","first-page":"R73","DOI":"10.1186\/ar2702","volume":"11","author":"JT Osterhaus","year":"2009","unstructured":"Osterhaus JT, Purcaru O, Richard L: Discriminant validity, responsiveness and reliability of the rheumatoid arthritis-specific Work Productivity Survey (WPS-RA). Arthritis Res Ther. 2009, 11: R73-","journal-title":"Arthritis Res Ther"},{"key":"4379_CR18","doi-asserted-by":"publisher","first-page":"A601","DOI":"10.1016\/j.jval.2013.08.1705","volume":"16","author":"JT Osterhaus","year":"2013","unstructured":"Osterhaus JT, Purcaru O: Validity, responsiveness and reliability of the arthritis-specific Work Productivity Survey assessing work productivity within and outside the home in patients with psoriatic arthritis. Value Health. 2013, 16: A601-","journal-title":"Value Health"},{"key":"4379_CR19","doi-asserted-by":"publisher","first-page":"R140","DOI":"10.1186\/ar4602","volume":"16","author":"JT Osterhaus","year":"2014","unstructured":"Osterhaus JT, Purcaru O: Discriminant validity, responsiveness and realiability of the arthritis-specific Work Productivity Survey assessing workplace and household productivity in patients with psoriatic arthritis. Arthritis Res Ther. 2014, 16: R140-","journal-title":"Arthritis Res Ther"},{"key":"4379_CR20","doi-asserted-by":"publisher","first-page":"2100","DOI":"10.3899\/jrheum.090366","volume":"36","author":"D Beaton","year":"2009","unstructured":"Beaton D, Bombardier C, Escorpizo R, Zhang W, Lacaille D, Boonen A, Osborne RH, Anis AH, Strand CV, Tugwell PS: Measuring worker productivity: frameworks and measures. J Rheumatol. 2009, 36: 2100-2109.","journal-title":"J Rheumatol"},{"key":"4379_CR21","first-page":"S336","volume":"64","author":"RBM Landew\u00e9","year":"2012","unstructured":"Landew\u00e9 RBM, Rudwaleit M, van der Heijde D, Dougados M, Maksymowych WP, Braun J, Deodhar AA, Stach C, Hoepken B, Coteur G, Kielar D, Fichtner A, Arledge T, Sieper J: Effect of certolizumab pegol on signs and symptoms of ankylosing spondyltitis and non-radiographic axial spondyloarthritis: 24 week results of a double blind randomized placebo-controlled phase 3 axial spondyloarthritis study [Abstract 777]. Arthritis Rheum. 2012, 64: S336-S337.","journal-title":"Arthritis Rheum"},{"key":"4379_CR22","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1002\/art.1780360601","volume":"36","author":"DT Felson","year":"1993","unstructured":"Felson DT, Anderson JJ, Boers M, Bombardier C, Chernoff M, Fried B, Furst D, Goldsmith C, Kieszak S, Lightfoot R, Paulus H, Tugwell P, Weinblatt M, Widmark R, Williams HJ, Wolfe F: Committee on Outcome Measures in Rheumatoid Arthritis Clinical Trials: The American College of Rheumatology preliminary core set of disease activity measures for rheumatoid arthritis clinical trials. Arthritis Rheum. 1993, 36: 729-740.","journal-title":"Arthritis Rheum"},{"key":"4379_CR23","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1002\/art.1780350502","volume":"35","author":"MC Hochberg","year":"1992","unstructured":"Hochberg MC, Chang RW, Dwosh I, Lindsey S, Pincus T, Wolfe F: The American College of Rheumatology 1991 revised criteria for the classification of global functional status in rheumatoid arthritis. Arthritis Rheum. 1992, 35: 498-502.","journal-title":"Arthritis Rheum"},{"key":"4379_CR24","doi-asserted-by":"publisher","first-page":"1811","DOI":"10.1136\/ard.2008.100826","volume":"68","author":"D van der Heijde","year":"2009","unstructured":"van der Heijde D, Lie E, Kvien TK, Sieper J, Van den Bosch F, Listing J, Braun J, Landew\u00e9 R: ASDAS, a highly discriminatory ASAS-endorsed disease activity score in patients with ankylosing spondylitis. Ann Rheum Dis. 2009, 68: 1811-1818.","journal-title":"Ann Rheum Dis"},{"key":"4379_CR25","first-page":"2281","volume":"21","author":"A Calin","year":"1994","unstructured":"Calin A, Garrett S, Whitelock H, Kennedy LG, O\u2019Hea J, Mallorie P, Jenkinson T: A new approach to defining functional ability in ankylosing spondylitis: the development of the Bath Ankylosing Spondylitis Functional Index. J Rheumatol. 1994, 21: 2281-2285.","journal-title":"J Rheumatol"},{"key":"4379_CR26","first-page":"80","volume":"32","author":"S Pavy","year":"2005","unstructured":"Pavy S, Brophy S, Calin A: Establishment of the minimum clinically important difference for the bath ankylosing spondylitis indices: a prospective study. J Rheumatol. 2005, 32: 80-85.","journal-title":"J Rheumatol"},{"key":"4379_CR27","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1136\/ard.62.1.20","volume":"62","author":"LC Doward","year":"2003","unstructured":"Doward LC, Spoorenberg A, Cook SA, Whalley D, Helliwell PS, Kay LJ, McKenna SP, Tennant A, van der Heijde D, Chamberlain MA: Development of the ASQoL: a quality of life instrument specific to ankylosing spondylitis. Ann Rheum Dis. 2003, 62: 20-26.","journal-title":"Ann Rheum Dis"},{"key":"4379_CR28","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1097\/00005650-199206000-00002","volume":"30","author":"JE Ware Jr","year":"1992","unstructured":"Ware JE, Sherbourne CD: The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care. 1992, 30: 473-483.","journal-title":"Med Care"},{"key":"4379_CR29","doi-asserted-by":"publisher","first-page":"1876","DOI":"10.1002\/1529-0131(200108)44:8<1876::AID-ART326>3.0.CO;2-F","volume":"44","author":"JJ Anderson","year":"2001","unstructured":"Anderson JJ, Baron G, Van Der Heijde D, Felson DT, Dougados M: Ankylosing spondylitis assessment group preliminary definition of short-term improvement in ankylosing spondylitis. Arthritis Rheum. 2001, 44: 1876-1886.","journal-title":"Arthritis Rheum"},{"key":"4379_CR30","doi-asserted-by":"publisher","first-page":"3219","DOI":"10.1002\/1097-0258(20001215)19:23<3219::AID-SIM623>3.0.CO;2-P","volume":"19","author":"JA Barber","year":"2000","unstructured":"Barber JA, Thompson SG: Analysis of cost data in randomized trials: an application of the non-parametric bootstrap. Stat Med. 2000, 19: 3219-3236.","journal-title":"Stat Med"},{"key":"4379_CR31","first-page":"1752","volume":"26","author":"MR Cohen","year":"1999","unstructured":"Cohen MR, Reda DJ, Clegg DO, Department of Veterans Affairs Cooperative Study Group on Seronegative Spondyloarthropathies: Baseline relationships between psoriasis and psoriatic arthritis: analysis of 221 patients with active psoriatic arthritis. J Rheumatol. 1999, 26: 1752-1756.","journal-title":"J Rheumatol"},{"key":"4379_CR32","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.1002\/art.24828","volume":"61","author":"A Kavanaugh","year":"2009","unstructured":"Kavanaugh A, Smolen JS, Emery P, Purcaru O, Keystone E, Richard L, Strand V, van Vollenhoven RF: Effect of certolizumab pegol with methotrexate on home and work place productivity and social activities in patients with active rheumatoid arthritis. Arthritis Care Res. 2009, 61: 1592-1600.","journal-title":"Arthritis Care Res"},{"key":"4379_CR33","doi-asserted-by":"publisher","first-page":"1900","DOI":"10.1093\/rheumatology\/keq109","volume":"49","author":"JM Hazes","year":"2010","unstructured":"Hazes JM, Taylor P, Strand V, Purcaru O, Coteur G, Mease P: Physical function improvements and relief from fatigue and pain are associated with increased productivity at work and at home in rheumatoid arthritis patients treated with certolizumab pegol. Rheumatology. 2010, 49: 1900-1910.","journal-title":"Rheumatology"},{"key":"4379_CR34","first-page":"868","volume":"30","author":"J Kirwan","year":"2003","unstructured":"Kirwan J, Heiberg T, Hewlett S, Hughes R, Kvien T, Ahlmen M, Boers M, Minnock P, Saag K, Shea B, Suarez Almazor M, Taal E: Outcomes from the Patient Perspective Workshop at OMERACT 6. J Rheumatol. 2003, 30: 868-872.","journal-title":"J Rheumatol"},{"key":"4379_CR35","first-page":"2250","volume":"32","author":"JR Kirwan","year":"2005","unstructured":"Kirwan JR, Hewlett SE, Heiberg T, Hughes RA, Carr M, Hehir M, Kvien TK, Minnock P, Newman SP, Quest EM, Taal E, Wale J: Incorporating the patient perspective into outcome assessment in rheumatoid arthritis\u2013progress at OMERACT 7. J Rheumatol. 2005, 32: 2250-2256.","journal-title":"J Rheumatol"},{"key":"4379_CR36","first-page":"2273","volume":"34","author":"WP Maksymowych","year":"2007","unstructured":"Maksymowych WP, Gladman D, Rahman P, Boonen A, Bykerk V, Choquette D, Dimond S, Fortin P, Karsh J, Klinkhoff AV, Mosher D, Mulholland K, Olszynski WP, Russell AS, Savage L, Shanner L, Shojania K, Starr M, Thomson G, Zummer M, Inman R, Canadian Rheumatology Association\/Spondyloarthritis Research Consortium of Canada: The Canadian Rheumatology Association\/Spondyloarthritis Research Consortium of Canada treatment recommendations for the management of spondyloarthritis: a national multidisciplinary stakeholder project. J Rheumatol. 2007, 34: 2273-2284.","journal-title":"J Rheumatol"},{"key":"4379_CR37","doi-asserted-by":"publisher","first-page":"1776","DOI":"10.3899\/jrheum.110405","volume":"38","author":"K Tang","year":"2011","unstructured":"Tang K, Escorpizo R, Beaton DE, Bombardier C, Lacaille D, Zhang W, Anis AH, Boonen A, Verstappen SM, Buchbinder R, Osborne RH, Fautrel B, Gignac MA, Tugwell PS: Measuring the impact of arthritis on worker productivity: perspectives, methodologic issues, and contextual factors. J Rheumatol. 2011, 38: 1776-1790.","journal-title":"J Rheumatol"},{"key":"4379_CR38","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1093\/rheumatology\/kep457","volume":"49","author":"MC Reilly","year":"2010","unstructured":"Reilly MC, Gooch KL, Wong RL, Kupper H, van der Heijde D: Validity, reliability and responsiveness of the Work Productivity and Activity Impairment Questionnaire in ankylosing spondylitis. Rheumatology (Oxford). 2010, 49: 812-819.","journal-title":"Rheumatology (Oxford)"},{"key":"4379_CR39","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1136\/ard.2009.108217","volume":"68","author":"M Rudwaleit","year":"2009","unstructured":"Rudwaleit M, Landew\u00e9 R, van der Heijde D, Listing J, Brandt J, Braun J, Burgos-Vargas R, Collantes-Estevez E, Davis J, Dijkmans B, Dougados M, Emery P, van der Horst-Bruinsma IE, Inman R, Khan MA, Leirisalo-Repo M, van der Linden S, Maksymowych WP, Mielants H, Olivieri I, Sturrock R, de Vlam K, Sieper J: The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part I): classification of paper patients by expert opinion including uncertainty appraisal. Ann Rheum Dis. 2009, 68: 770-776. A published erratum appears in Ann Rheum Dis 2011, 70:1519","journal-title":"Ann Rheum Dis"}],"container-title":["Arthritis Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/ar4680.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/ar4680\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/ar4680.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T02:42:29Z","timestamp":1746326549000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/ar4680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,6]]},"references-count":39,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2014,8]]}},"alternative-id":["4379"],"URL":"https:\/\/doi.org\/10.1186\/ar4680","relation":{},"ISSN":["1478-6354"],"issn-type":[{"value":"1478-6354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,6]]},"assertion":[{"value":"19 December 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 July 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 August 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"R164"}}