{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T22:18:14Z","timestamp":1767824294982,"version":"3.49.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2002,10,24]],"date-time":"2002-10-24T00:00:00Z","timestamp":1035417600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2002,10,24]],"date-time":"2002-10-24T00:00:00Z","timestamp":1035417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"DOI":"10.1186\/ar610","type":"journal-article","created":{"date-parts":[[2003,1,7]],"date-time":"2003-01-07T15:47:36Z","timestamp":1041954456000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Heterogeneity of CD4 and CD8+ memory T cells in localized and generalized Wegener's granulomatosis"],"prefix":"10.1186","volume":"5","author":[{"given":"Peter","family":"Lamprecht","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anika","family":"Erdmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antje","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Csernok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Reinhold-Keller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstanze","family":"Holl-Ulrich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfred C","family":"Feller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilke","family":"Bruehl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang L","family":"Gross","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2002,10,24]]},"reference":[{"key":"608_CR1","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1002\/1529-0131(200005)43:5<1021::AID-ANR10>3.0.CO;2-J","volume":"43","author":"E Reinhold-Keller","year":"2000","unstructured":"Reinhold-Keller E, Beuge N, Latza U, De Groot K, Rudert H, Noelle B, Heller M, Gross WL: An interdisciplinary approach to the care of patients with Wegener's granulomatosis. Long-term outcome in 155 patients. Arthritis Rheum. 2000, 43: 1021-1032. 10.1002\/1529-0131(200005)43:5<1021::AID-ANR10>3.0.CO;2-J.","journal-title":"Arthritis Rheum"},{"issue":"Suppl 1","key":"608_CR2","first-page":"35","volume":"120","author":"WL Gross","year":"2000","unstructured":"Gross WL: Wegener's granulomatosis. Clin Exp Immunol. 2000, 120 (Suppl 1): 35-36.","journal-title":"Clin Exp Immunol"},{"key":"608_CR3","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1002\/1096-9896(2000)9999:9999<::AID-PATH656>3.0.CO;2-M","volume":"192","author":"A Mueller","year":"2000","unstructured":"Mueller A, Trabandt A, Glockner-Hofmann K, Seitzer U, Csernok E, Schonermarck U, Feller AC, Gross WL: Localized Wegner's granulomatosis: predominance of CD26 and IFN-\u03b3 expression. J Pathol. 2000, 192: 113-120. 10.1002\/1096-9896(2000)9999:9999<::AID-PATH656>3.0.CO;2-M.","journal-title":"J Pathol"},{"key":"608_CR4","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1046\/j.1365-2249.2001.125002332.x","volume":"125","author":"CEJ Balding","year":"2001","unstructured":"Balding CEJ, Howie AJ, Drake-Lee AB, Savage COS: Th2 dominance in nasal mucosa in patients with Wegener's granulomatosis. Clin Exp Immunol. 2001, 125: 332-339. 10.1046\/j.1365-2249.2001.125002332.x.","journal-title":"Clin Exp Immunol"},{"key":"608_CR5","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1097\/00002281-200201000-00004","volume":"14","author":"COS Savage","year":"2002","unstructured":"Savage COS, Harper L, Holland M: New findings in pathogenesis of antineutrophil cytoplasm antibody-associated vasculitis. Curr Opin Rheumatol. 2002, 14: 15-22. 10.1097\/00002281-200201000-00004.","journal-title":"Curr Opin Rheumatol"},{"key":"608_CR6","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1038\/84219","volume":"2","author":"P Loetscher","year":"2001","unstructured":"Loetscher P, Moser B: Lymphocyte traffic control by chemokines. Nature Immunol. 2001, 2: 123-128. 10.1038\/84219.","journal-title":"Nature Immunol"},{"key":"608_CR7","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1056\/NEJM200010053431407","volume":"343","author":"UH Von Andrian","year":"2000","unstructured":"Von Andrian UH, Mackay CR: T-cell function and migration. Two sides of the same coin. New Engl J Med. 2000, 343: 1020-1034. 10.1056\/NEJM200010053431407.","journal-title":"New Engl J Med"},{"key":"608_CR8","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/S0952-7915(00)00096-0","volume":"12","author":"JJ Campbell","year":"2000","unstructured":"Campbell JJ, Butcher EC: Chemokines in tissue-specific and microenvironment-specific lymphocyte homing. Curr Opin Immunol. 2000, 12: 336-341. 10.1016\/S0952-7915(00)00096-0.","journal-title":"Curr Opin Immunol"},{"key":"608_CR9","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1046\/j.1365-2567.1997.00267.x","volume":"91","author":"M Hargreaves","year":"1997","unstructured":"Hargreaves M, Bell EB: Identical expression of CD45R isoforms by CD45RC+ 'revertant' memory and CD45RC+ naive T cells. Immunology. 1997, 91: 323-330. 10.1046\/j.1365-2567.1997.00267.x.","journal-title":"Immunology"},{"key":"608_CR10","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1046\/j.1365-2249.2001.01614.x","volume":"125","author":"AL Vargas","year":"2001","unstructured":"Vargas AL, Lechner F, Kantzanou M, Phillips RE, Klenerman P: Ex vivo analysis of phenotype and TCR usage in relation to CD45 isoform expression on cytomegalovirus-specific CD8+ T lymphocytes. Clin Exp Immunol. 2001, 125: 432-439. 10.1046\/j.1365-2249.2001.01614.x.","journal-title":"Clin Exp Immunol"},{"key":"608_CR11","doi-asserted-by":"publisher","first-page":"8140","DOI":"10.1128\/JVI.74.17.8140-8150.2000","volume":"74","author":"GMA Gillespie","year":"2000","unstructured":"Gillespie GMA, Wills MR, Appay V, O'Callaghan CO, Murphy M, Smith N, Sissons P, Rowland-Jones S, Bell JI, Moss PAH: Functional heterogeneity and high frequencies of cytomegalovirus-specfic CD8+ T lymphocytes in healthy seropositive donors. J Virol. 2000, 74: 8140-8150. 10.1128\/JVI.74.17.8140-8150.2000.","journal-title":"J Virol"},{"key":"608_CR12","doi-asserted-by":"publisher","first-page":"877","DOI":"10.4049\/jimmunol.166.2.877","volume":"166","author":"JJ Campbell","year":"2001","unstructured":"Campbell JJ, Murphy KE, Kunkel EJ, Brightling CE, Soler D, Shen Z, Boisvert J, Greenberg HB, Vierra MA, Goodman SB, Genovese MC, Wardlaw AJ, Butcher EC, Wu L: CCR7 expression and memory T cell diversity in humans. J Immunol. 2001, 166: 877-884.","journal-title":"J Immunol"},{"key":"608_CR13","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1053\/hupa.2001.22757","volume":"32","author":"A Coulomb-L'Hermine","year":"2001","unstructured":"Coulomb-L'Hermine A, Capron F, Zou W, Piard F, Galateau F, Laurent P, Crevon MC, Galanaud P, Emilie D: Expression of the chemokine RANTES in pulmonary Wegener's granulomatosis. Hum Pathol. 2001, 32: 320-326. 10.1053\/hupa.2001.22757.","journal-title":"Hum Pathol"},{"key":"608_CR14","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1002\/art.1780330807","volume":"33","author":"RY Leavitt","year":"1990","unstructured":"Leavitt RY, Fauci AS, Bloch DA, Michel BA, Hunder GG, Arend WP, Calabrese LH, Fries JF, Lie JT, Lightfoot RW, Masi AT, McShane DJ, Mills JA, Wallace SL, Zvaifler NJ: The American College of Rheumatology 1990 criteria for the classification of Wegener's granulomatosis. Arthritis Rheum. 1990, 33: 1101-1107.","journal-title":"Arthritis Rheum"},{"key":"608_CR15","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1002\/art.1780370206","volume":"37","author":"JC Jennette","year":"1994","unstructured":"Jennette JC, Falk RJ, Andrassy K, Bacon PA, Churg J, Gross WL, Hagen EC, Hoffman GS, Hunder GG, Kallenberg CG, McCluskey RT, Sinico RA, Rees AJ, van Es LA, Waldherr R, Wiik A: Nomenclature of systemic vasculitides. Proposal of an international consensus conference. Arthritis Rheum. 1994, 37: 187-192.","journal-title":"Arthritis Rheum"},{"key":"608_CR16","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1097\/00002281-200101000-00008","volume":"13","author":"D Jayne","year":"2000","unstructured":"Jayne D: Update on the European vasculitis study group trials. Curr Opin Rheumatol. 2000, 13: 48-55. 10.1097\/00002281-200101000-00008.","journal-title":"Curr Opin Rheumatol"},{"key":"608_CR17","first-page":"31","volume":"55","author":"K DeGroot","year":"2001","unstructured":"DeGroot K, Gross WL, Herlyn K, Reinhold-Keller E: Development and validation of a disease extent index for Wegener's granulomatosis. Clin Nephrol. 2001, 55: 31-38.","journal-title":"Clin Nephrol"},{"key":"608_CR18","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1097\/00002281-200201000-00005","volume":"14","author":"RA Luqmani","year":"2002","unstructured":"Luqmani RA: Assessing disease activity in systemic vasculitides. Curr Opin Rheumatol. 2002, 14: 23-28. 10.1097\/00002281-200201000-00005.","journal-title":"Curr Opin Rheumatol"},{"key":"608_CR19","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1681\/ASN.V7140","volume":"7","author":"H Haller","year":"1996","unstructured":"Haller H, Eichhorn J, Pieper K, Gobel U, Luft FC: Circulating leukocyte integrin expression in Wegener's granulomatosis. J Am Soc Nephrol. 1996, 7: 40-48.","journal-title":"J Am Soc Nephrol"},{"key":"608_CR20","doi-asserted-by":"crossref","first-page":"3513","DOI":"10.1182\/blood.V88.9.3513.bloodjournal8893513","volume":"88","author":"D Hamann","year":"1996","unstructured":"Hamann D, Baars PA, Hooibrink B, van Lier RW: Heterogeneity of the human CD4+ T-cell population: two distinct CD4+ T-cell subsets characterized by coexpression of CD45RA and CD45RO isoforms. Blood. 1996, 88: 3513-3521.","journal-title":"Blood"},{"key":"608_CR21","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1084\/jem.186.9.1407","volume":"186","author":"D Hamann","year":"1997","unstructured":"Hamann D, Baars PA, Rep MH, Hooibrink B, Kerkhof-Garde SR, Klein MR, van Lier RA: Phenotyoic and functional separation of memory and effector human CD8+ T-cells. J Exp Med. 1997, 186: 1407-1418. 10.1084\/jem.186.9.1407.","journal-title":"J Exp Med"},{"key":"608_CR22","doi-asserted-by":"publisher","first-page":"5455","DOI":"10.4049\/jimmunol.168.11.5455","volume":"168","author":"MR Wills","year":"2002","unstructured":"Wills MR, Okecha G, Weekes MP, Gandhi MK, Sissons PJG, Carmichael AJ: Identification of naive or antigen-experienced human CD8+ T-cells by expression of costimulation and chemokine receptors: Analysis of the human cytomegalovirus-specific CD8+ T cell response. J Immunol. 2002, 168: 5455-5464.","journal-title":"J Immunol"},{"key":"608_CR23","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1038\/nm0402-379","volume":"8","author":"V Appay","year":"2002","unstructured":"Appay V, Dunbar PR, Callan M, Klenerman P, Gillespie GMA, Papgano L, Ogg GS, King A, Lechner F, Spina CA, Little S, Havlir DV, Richman DD, Gruener N, Pape G, Waters A, Easterbrook P, Salio M, Cerundolo V, McMichael AJ, Rowland-Jones SL: Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections. Nature Med. 2002, 8: 379-385. 10.1038\/nm0402-379.","journal-title":"Nature Med"},{"key":"608_CR24","doi-asserted-by":"publisher","first-page":"5538","DOI":"10.4049\/jimmunol.168.11.5538","volume":"168","author":"H Tomiyama","year":"2002","unstructured":"Tomiyama H, Matsuda T, Takiguchi M: Differentiation of human CD8+ T cells from a memory to memory\/effector phenotype. J Immunol. 2002, 168: 5538-5550.","journal-title":"J Immunol"},{"key":"608_CR25","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/BF00262300","volume":"14","author":"M Schlesier","year":"1995","unstructured":"Schlesier M, Kaspar T, Gutfleisch J, Wolff-Vorbeck G, Peter HH: Activated CD4+ and CD8+ T-cell subsets in Wegener's granulomatosis. Rheumatol Int. 1995, 14: 213-219. 10.1007\/BF00262300.","journal-title":"Rheumatol Int"},{"key":"608_CR26","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1023\/A:1023230722874","volume":"18","author":"R Giscombe","year":"1998","unstructured":"Giscombe R, Nityanand S, Lewin N, Grunewald J, Lefvert AK: Expanded T cell populations in patients with Wegener's granulomatosis: characteristics and correlates with disease activity. J Clin Immunol. 1998, 18: 404-413. 10.1023\/A:1023230722874.","journal-title":"J Clin Immunol"},{"key":"608_CR27","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1136\/thorax.56.10.751","volume":"56","author":"P Lamprecht","year":"2001","unstructured":"Lamprecht P, Moosig F, Csernok E, Seitzer U, Schnabel A, Mueller A, Gross WL: CD28 negative T cells are enriched in granulomatous lesions of the respiratory tract in Wegener's granulomatosis. Thorax. 2001, 56: 751-757. 10.1136\/thorax.56.10.751.","journal-title":"Thorax"},{"key":"608_CR28","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1016\/S0002-9440(10)61118-2","volume":"160","author":"A Komocsi","year":"2002","unstructured":"Komocsi A, Lamprecht P, Csernok E, Mueller A, Holl-Ulrich K, Seitzer U, Moosig F, Schnabel A, Gross WL: Peripheral blood and granuloma CD4+CD28- T-cells are a major source of IFN-\u03b3 and TNF-\u03b1 in Wegener's granulomatosis. Am J Pathol. 2002, 160: 1717-1724.","journal-title":"Am J Pathol"},{"key":"608_CR29","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1159\/000055933","volume":"68","author":"M De Martins","year":"2000","unstructured":"De Martins M, Modesti M, Profeta VF, Tullio M, Loreto MF, Ginaldi L, Quaglino D: CD50 and CD62L adhesion receptor expression on naive (CD45RA+) and memory (CD45RO+) T lymphocytes in the elderly. Pathobiology. 2000, 68: 245-250. 10.1159\/000055933.","journal-title":"Pathobiology"},{"key":"608_CR30","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1046\/j.1365-2249.2002.01801.x","volume":"128","author":"P Lamprecht","year":"2002","unstructured":"Lamprecht P, Kumanovics G, Mueller A, Csernok E, Komocsi A, Trabandt A, Gross WL, Schnabel A: Elevated monocytic IL-12 and TNF-alpha production in Wegener's granulomatosis is normalized by cyclophosphamide and corticosteroid therapy. Clin Exp Immunol. 2002, 128: 181-186. 10.1046\/j.1365-2249.2002.01801.x.","journal-title":"Clin Exp Immunol"},{"key":"608_CR31","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1016\/S0091-6749(99)70434-3","volume":"103","author":"E Popa","year":"1999","unstructured":"Popa E, Stegeman CA, Bos NA, Kallenberg GC, Tervaert JW: Differential B- and T-cell activation in Wegener's granulomatosis. Allergy Clin Immunol. 1999, 103: 885-894.","journal-title":"Allergy Clin Immunol"},{"key":"608_CR32","doi-asserted-by":"publisher","first-page":"65","DOI":"10.4049\/jimmunol.168.1.65","volume":"168","author":"LM Ebert","year":"2002","unstructured":"Ebert LM, McColl SR: Up-regulation of CCR5 and CCR6 on distinct subpopulations of antigen-activated CD4+ T lymphocytes. J Immunol. 2002, 168: 65-72.","journal-title":"J Immunol"},{"key":"608_CR33","first-page":"227","volume":"19","author":"E Reinhold-Keller","year":"2001","unstructured":"Reinhold-Keller E, Lamprecht P, Feller AC, Gross WL: Polyarthritis following interferon alpha treatment in a patient with localized Wegener's granulomatosis [letter]. Clin Exp Rheumatol. 2001, 19: 227-228.","journal-title":"Clin Exp Rheumatol"}],"container-title":["Arthritis Res Ther"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/ar610.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/ar610\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/ar610.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T16:08:48Z","timestamp":1714061328000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/ar610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,10,24]]},"references-count":33,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2002,2]]}},"alternative-id":["608"],"URL":"https:\/\/doi.org\/10.1186\/ar610","relation":{},"ISSN":["1478-6354"],"issn-type":[{"value":"1478-6354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,10,24]]},"assertion":[{"value":"30 May 2002","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 September 2002","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 October 2002","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 October 2002","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"R25"}}