{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T20:17:36Z","timestamp":1771964256796,"version":"3.50.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2003,6,30]],"date-time":"2003-06-30T00:00:00Z","timestamp":1056931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2003,6,30]],"date-time":"2003-06-30T00:00:00Z","timestamp":1056931200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arthritis Res Ther"],"DOI":"10.1186\/ar785","type":"journal-article","created":{"date-parts":[[2003,7,10]],"date-time":"2003-07-10T06:23:37Z","timestamp":1057818217000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["V\u03b39\/V\u03b42 T lymphocytes in Italian patients with Beh\u00e7et's disease - evidence for expansion, and tumour necrosis factor receptor II and interleukin-12 receptor \u03b21 expression in active disease"],"prefix":"10.1186","volume":"5","author":[{"given":"Giovanni","family":"Triolo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonina","family":"Accardo-Palumbo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Dieli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Ciccia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Ferrante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ennio","family":"Giardina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina Di","family":"Sano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Licata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2003,6,30]]},"reference":[{"key":"775_CR1","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/S0002-9394(14)71396-0","volume":"116","author":"N Mizuki","year":"1993","unstructured":"Mizuki N, Inoko H, Ando H, Nakamura S, Kashiwase K, Akara T, Fujino Y, Masuda K, Takiguchi M, Ohno S: Beh\u00e7et's disease associated with one of theHLA-B51 subantigens, HLA-B*5101. Am J Ophthalmol. 1993, 116: 406-409.","journal-title":"Am J Ophthalmol"},{"key":"775_CR2","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1002\/art.1780380321","volume":"38","author":"M Takeno","year":"1995","unstructured":"Takeno M, Kaiyone A, Yamashita N, Takiguchi M, Mizushima Y, Kaneoka H, Sakane T: Excessive function of peripheral blood neutrophils from patients with Beh\u00e7et's disease and from HLA-B51 transgenic mice. Arthritis Rheum. 1995, 38: 426-433.","journal-title":"Arthritis Rheum"},{"key":"775_CR3","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1002\/art.1780251110","volume":"25","author":"T Sakane","year":"1982","unstructured":"Sakane T, Kotani H, Takada S, Tsunematsu T: Functional aberration of T cell subsets in patients with Beh\u00e7et's disease. Arthritis Rheum. 1982, 25: 1343-1351.","journal-title":"Arthritis Rheum"},{"key":"775_CR4","first-page":"687","volume":"13","author":"L Emmi","year":"1995","unstructured":"Emmi L, Salvati G, Brugnolo F, Marchione T: Immunopathological aspects of Beh\u00e7et's disease. Clin Exp Rheumatol. 1995, 13: 687-691.","journal-title":"Clin Exp Rheumatol"},{"key":"775_CR5","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1006\/clim.1999.4687","volume":"91","author":"G Triolo","year":"1999","unstructured":"Triolo G, Accardo-Palumbo A, Triolo G, Carbone MC, Ferrante A, Giardina E: Enhancement of endothelial cell E-selectin expression by sera from patients with active Beh\u00e7et's disease: moderate correlation with anti-endothelial cell antibodies and myeloperoxidase levels. Clin Immunol. 1999, 91: 330-337. 10.1006\/clim.1999.4687.","journal-title":"Clin Immunol"},{"key":"775_CR6","first-page":"495","volume":"18","author":"A Accardo-Palumbo","year":"2000","unstructured":"Accardo-Palumbo A, Triolo G, Carbone MC, Ferrante A, Ciccia F, Giardina E, Triolo G: Polymorphonuclear leukocyte myeloperoxidase levels in patients with Beh\u00e7et's disease. Clin Exp Rheumatol. 2000, 18: 495-498.","journal-title":"Clin Exp Rheumatol"},{"key":"775_CR7","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1111\/j.1365-2133.1995.tb16946.x","volume":"132","author":"A Gul","year":"1995","unstructured":"Gul A, Esin S, Dilsen N, Konice E, Wigzell H, Biberfeld P: Immunohistology of skin pathergy reaction in Beh\u00e7et's disease. Br J Dermatol. 1995, 132: 901-907.","journal-title":"Br J Dermatol"},{"key":"775_CR8","doi-asserted-by":"publisher","first-page":"201","DOI":"10.3109\/08916939209148460","volume":"12","author":"DG Chateris","year":"1992","unstructured":"Chateris DG, Barton K, McCarthy AC, Lightman SL: CD4 + lymphocyte involvement in ocular Beh\u00e7et's disease. Autoimmunity. 1992, 12: 201-206.","journal-title":"Autoimmunity"},{"key":"775_CR9","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1111\/j.1365-2249.1990.tb05447.x","volume":"82","author":"F Fortune","year":"1990","unstructured":"Fortune F, Walker J, Lehner T: The expression of \u03b3\/\u03b4 T cell receptor and the prevalence of primed, activated and IgA-bound T cells in Beh\u00e7et's syndrome. Clin Exp Immunol. 1990, 82: 326-332.","journal-title":"Clin Exp Immunol"},{"key":"775_CR10","doi-asserted-by":"publisher","first-page":"6147","DOI":"10.1073\/pnas.92.13.6147","volume":"92","author":"H Komano","year":"1995","unstructured":"Komano H, Fujiura Y, Kawaguchi M, Matsumoto S, Hashimoto Y, Obana S, Mombaerts P, Tonegawa S, Yamamoto H, Itohara S: Homeostatic regulation of intestinal epithelia by intra epithelial \u03b3\/\u03b4 T cells. Proc Natl Acad Sci USA. 1995, 92: 6147-6151.","journal-title":"Proc Natl Acad Sci USA"},{"key":"775_CR11","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1146\/annurev.immunol.14.1.511","volume":"14","author":"Y-H Chien","year":"1996","unstructured":"Chien Y-H, Jores R, Crowley MP: Recognition by \u03b3\/\u03b4 T cells. Annu Rev Immunol. 1996, 14: 511-532. 10.1146\/annurev.immunol.14.1.511.","journal-title":"Annu Rev Immunol"},{"key":"775_CR12","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1038\/375155a0","volume":"375","author":"Y Tanaka","year":"1995","unstructured":"Tanaka Y, Morita CT, Tanaka Y, Nieves E, Brenner MB, Bloom BR: Natural and synthetic non peptide antigens recognized by human \u03b3\/\u03b4 T cells. Nature. 1995, 375: 155-158. 10.1038\/375155a0.","journal-title":"Nature"},{"key":"775_CR13","doi-asserted-by":"crossref","first-page":"2698","DOI":"10.4049\/jimmunol.152.6.2698","volume":"152","author":"F Dieli","year":"1994","unstructured":"Dieli F, Asherson GL, Romano GC, Sireci G, Gervasi F, Salerno A: IL-4 is essential for systemic transfer of delayed hypersensitivity by T cell lines. J Immunol. 1994, 152: 2698-2704.","journal-title":"J Immunol"},{"key":"775_CR14","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/373255a0","volume":"373","author":"DA Ferrick","year":"1995","unstructured":"Ferrick DA, Schrenzel MD, Mulvania T, Hsieh B, Ferlin WG, Lepper H: Differential production of interferon \u03b1 and inter-leukin 4 in response to Th1 and Th2-stimulating pathogens by \u03b3\u03b4 T cells in vivo. Nature. 1995, 373: 255-257. 10.1038\/373255a0.","journal-title":"Nature"},{"key":"775_CR15","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1111\/j.1365-2249.1997.274-ce1159.x","volume":"107","author":"G Inaba","year":"1997","unstructured":"Inaba G, Sakane T: Role of \u03b3\u03b4 T lymphocytes in the development of Beh\u00e7et's disease. Clin Exp Immunol. 1997, 107: 241-247. 10.1111\/j.1365-2249.1997.274-ce1159.x.","journal-title":"Clin Exp Immunol"},{"key":"775_CR16","first-page":"2301","volume":"21","author":"K Hamzaoui","year":"1994","unstructured":"Hamzaoui K, Hamzaoui A, Hentati F, Kahan A, Ayed K, Chabbou A, Ben Hamida M, Hamza M: Phenotype and functional profile of T cell expressing gamma delta receptor from patients with active Beh\u00e7et's disease. J Rheumatol. 1994, 21: 2301-2306.","journal-title":"J Rheumatol"},{"key":"775_CR17","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/S0140-6736(96)90868-5","volume":"347","author":"A Hasan","year":"1996","unstructured":"Hasan A, Fortune F, Wilson A, Warr K, Shinnick T, Mizushima Y, van der Zee R, Stanford MR, Sanderson J, Lehner T: Role of gamma delta T cells in pathogenesis and diagnosis of Beh\u00e7et's disease. Lancet. 1996, 347: 789-794. 10.1016\/S0140-6736(96)90868-5.","journal-title":"Lancet"},{"key":"775_CR18","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1615\/CritRevImmunol.v18.i4.30","volume":"18","author":"A Salerno","year":"1998","unstructured":"Salerno A, Dieli F: Role of gamma-delta T lymphocyte in immune response in humans and mice. Crit Rev Immunol. 1998, 18: 327-357.","journal-title":"Crit Rev Immunol"},{"key":"775_CR19","doi-asserted-by":"publisher","first-page":"2052","DOI":"10.1002\/eji.1830250737","volume":"25","author":"MR Burk","year":"1995","unstructured":"Burk MR, Mori L, De Libero G: Human V\u03b39-V\u03b42 cells are stimulated in a cros-reactive fashion by a variety of phosphorylated metabolites. Eur J Immunol. 1995, 25: 2052-2058.","journal-title":"Eur J Immunol"},{"key":"775_CR20","doi-asserted-by":"crossref","first-page":"998","DOI":"10.4049\/jimmunol.154.3.998","volume":"154","author":"JF Bukowski","year":"1995","unstructured":"Bukowski JF, Morita CT, Tanaka Y, Bloom BR, Brenner MB, Band H: V\u03b39-V\u03b42 TCR-dependent recognition of non-peptide antigens and Daudi cells analysed by TCR gene transfer. J Immunol. 1995, 154: 998-1006.","journal-title":"J Immunol"},{"key":"775_CR21","doi-asserted-by":"crossref","first-page":"5133","DOI":"10.4049\/jimmunol.153.11.5133","volume":"153","author":"JF Bukowski","year":"1994","unstructured":"Bukowski JF, Morita CT, Brenner MB: Recognition and destruction of virus-infected cells by human \u03b3\/\u03b4 CTL. J Immunol. 1994, 153: 5133-5140.","journal-title":"J Immunol"},{"key":"775_CR22","doi-asserted-by":"publisher","first-page":"3066","DOI":"10.1002\/eji.1830261237","volume":"26","author":"C Ueta","year":"1996","unstructured":"Ueta C, Kawasumi H, Fujiwara H: Interleukin-12 activates human \u03b3\/\u03b4 T cells: synergistic effect of tumor necrosis factor-\u03b1. Eur J Immunol. 1996, 26: 3066-3073.","journal-title":"Eur J Immunol"},{"key":"775_CR23","doi-asserted-by":"publisher","first-page":"1967","DOI":"10.1002\/1529-0131(199909)42:9<1967::AID-ANR24>3.0.CO;2-Z","volume":"42","author":"MA Frassanito","year":"1999","unstructured":"Frassanito MA, Dammacco R, Cafforio P, Dammacco F: Th1 polarization of the immune response in Beh\u00e7et's disease. Arthritis Rheum. 1999, 42: 1967-1974. 10.1002\/1529-0131(199909)42:9<1967::AID-ANR24>3.0.CO;2-Z.","journal-title":"Arthritis Rheum"},{"key":"775_CR24","first-page":"177","volume":"103","author":"International Study Group for Beh\u00e7et's Disease","year":"1990","unstructured":"International Study Group for Beh\u00e7et's Disease: Criteria for diagnosis of Beh\u00e7et's disease. Lancet. 1990, 103: 177-184.","journal-title":"Lancet"},{"key":"775_CR25","volume-title":"In Annual Report of Beh\u00e7et's Disease: Research Committee of Japan","author":"Beh\u00e7et's Disease Research Committee of Japan","year":"1994","unstructured":"Beh\u00e7et's Disease Research Committee of Japan: Criteria for activity of Beh\u00e7et's disease. In Annual Report of Beh\u00e7et's Disease: Research Committee of Japan. Edited by: Sakane T. 1994, Japan: Ministry of health and welfare of Japan"},{"key":"775_CR26","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1086\/315180","volume":"181","author":"F Dieli","year":"2000","unstructured":"Dieli F, Sireci G, Di Sano C, Romano A, Titone L, Di Carlo P, Ivanyi J, Fournie JJ, Salerno A: Ligand-specific \u03b1\u03b2 and \u03b3\u03b4 T cell responses in childhood tuberculosis. J Infect Dis. 2000, 181: 294-301. 10.1086\/315180.","journal-title":"J Infect Dis"},{"key":"775_CR27","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1046\/j.1365-2249.1999.00931.x","volume":"117","author":"H Direskeneli","year":"1999","unstructured":"Direskeneli H, Eksioglu-Demiralp E, Kibaroglu A, Yavuz S, Ergun T, Akoglu T: Oligoclonal T cell expansions in patients with Beh\u00e7et's disease. Clin Exp Immunol. 1999, 117: 166-170. 10.1046\/j.1365-2249.1999.00931.x.","journal-title":"Clin Exp Immunol"},{"key":"775_CR28","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/0167-5699(88)91267-4","volume":"9","author":"CA Janeway Jr","year":"1988","unstructured":"Janeway CA, Jones B, Hayday A: Specificity and function of T cells bearing \u03b3\u03b4 receptors. Immunol Today. 1988, 9: 73-76. 10.1016\/0167-5699(88)91267-4.","journal-title":"Immunol Today"},{"key":"775_CR29","first-page":"78","volume":"84","author":"E Keystone","year":"1991","unstructured":"Keystone E, Rittershaus C, Wood N, Snow K, Flatow J, Purvis J: Elevation of a \u03b3\u03b4 T cell subset in peripheral blood and synovial fluid of patients with rheumatoid arthritis. Clin Exp Immunol. 1991, 84: 78-82.","journal-title":"Clin Exp Immunol"},{"key":"775_CR30","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1111\/j.1365-2249.1993.tb03394.x","volume":"92","author":"IC Roura-Mir","year":"1993","unstructured":"Roura-Mir IC, Alcalde L, Vargas F, Tolosa E, Obiols G, Foz M, Jaraquemada D, Pujol-Borrell R: \u03b3\u03b4 T lymphocytes in endocrine autoimmunity: evidence for expansion in Graves disease but not in type 1 diabetes. Clin Exp Immunol. 1993, 92: 288-295.","journal-title":"Clin Exp Immunol"},{"key":"775_CR31","first-page":"988","volume":"23","author":"EBG Martins","year":"1996","unstructured":"Martins EBG, Graham AK, Chapman RW, Fleming KA: Elevation in \u03b3\u03b4 T lymphocytes in peripheral blood and livers of patients with primary sclerosing cholangitis and other autoimmune liver diseases. Hepatology. 1996, 23: 988-993.","journal-title":"Hepatology"},{"key":"775_CR32","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1073\/pnas.90.3.923","volume":"90","author":"R Shimonkevitz","year":"1993","unstructured":"Shimonkevitz R, Colburn C, Burham JA, Murray RS, Kotzin BL: Clonal expansion of activated \u03b3\u03b4 T cells in recent-onset multiple sclerosis. Proc Natl Acad Sci USA. 1993, 90: 923-927.","journal-title":"Proc Natl Acad Sci USA"},{"key":"775_CR33","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1046\/j.1365-2249.1999.01069.x","volume":"118","author":"J Freysdottir","year":"1999","unstructured":"Freysdottir J, Lau S, Fortune F: \u03b3\u03b4 T cells in Beh\u00e7et's disease (BD) and recurrent aphthous stomatitis (RAS). Clin Exp Immunol. 1999, 118: 451-457. 10.1046\/j.1365-2249.1999.01069.x.","journal-title":"Clin Exp Immunol"},{"key":"775_CR34","first-page":"321","volume":"23","author":"N Sayinalp","year":"1996","unstructured":"Sayinalp N, Ozcebe OI, Ozdemir O, Haznedaroglu IC, Dundar S, Kirazli S: Cytokines in Beh\u00e7et's disease. J Rheumatol. 1996, 23: 321-322.","journal-title":"J Rheumatol"},{"key":"775_CR35","first-page":"1544","volume":"20","author":"JL Mege","year":"1993","unstructured":"Mege JL, Dilsen N, Sanguedolce V, Gul A, Bongrand P, Roux H, Ocal L, Inanc M, Capo C: Overproduction of monocyte derived tumor necrosis factor \u03b1, interleukin (IL) 6, IL-8 and increased neutrophil superoxide generation in Beh\u00e7et's disease: a comparative study with familial Mediterranean fever and healthy subjects. J Rheumatol. 1993, 20: 1544-1549.","journal-title":"J Rheumatol"},{"key":"775_CR36","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s002960050091","volume":"19","author":"A Kosar","year":"1999","unstructured":"Kosar A, Haznedaroglu S, Karaaslan Y, Buyukasik Y, Haznedaroglu IC, Ozath D, Sayinalp N, Ozcebe O, Kirazli S, Dundar S: Effects of interferon-alpha2a treatment on serum levels of tumor necrosis factor-alpha, tumor necrosis alpha 2 receptor, interleukin-2, interleukin-2 receptor, and e-selectin in Beh\u00e7et's disease. Rheumatol Intern. 1999, 19: 11-14. 10.1007\/s002960050091.","journal-title":"Rheumatol Intern"},{"key":"775_CR37","doi-asserted-by":"crossref","first-page":"18542","DOI":"10.1016\/S0021-9258(17)46661-0","volume":"268","author":"LA Tartaglia","year":"1993","unstructured":"Tartaglia LA, Pennica D, Goeddel DV: Ligand passing: the 75-kDA tumor necrosis factor (TNF) receptor recruits TNF for signalling by the 55-kDA TNF receptor. J Biol Chem. 1993, 268: 18542-18548.","journal-title":"J Biol Chem"}],"container-title":["Arthritis Res Ther"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/ar785.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/ar785\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/ar785.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T16:44:03Z","timestamp":1714063443000},"score":1,"resource":{"primary":{"URL":"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/ar785"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,6,30]]},"references-count":37,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2003,10]]}},"alternative-id":["775"],"URL":"https:\/\/doi.org\/10.1186\/ar785","relation":{},"ISSN":["1478-6354"],"issn-type":[{"value":"1478-6354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,6,30]]},"assertion":[{"value":"14 November 2002","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 April 2003","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 May 2003","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 June 2003","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"R262"}}